Steroid-like compounds in Chinese medicines promote blood circulation via inhibition of Na+/K+-ATPase

Acta Pharmacologica Sinica

Volumn 31, Issue 6, 2010, Pages 696-702

  Chen, Ronald J Y ^a   Chung, Tse Yu ^a   Li, Feng Yin ^a   Yang, Wei Hung ^a,b   Jinn, Tzyy Rong ^b   Tzen, Jason T C ^a,b,c  

^a NATIONAL CHUNG HSING UNIVERSITY   (Taiwan)

^b CHINA MEDICAL UNIVERSITY   (Taiwan)

^c AGRICULTURAL BIOTECHNOLOGY RESEARCH CENTER   (Taiwan)

Author keywords

Cardiac glycoside; Molecular modeling; Na+ K+ ATPase; Ouabain; Steroid like; Traditional Chinese Medicine

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ASTRAGALOSIDE 3; BUFALIN; CHOLIC ACID; GINSENOSIDE RH 2; GLYCYRRHIZIC ACID; JUJUBOSIDE B; OLEANOLIC ACID; OUABAIN; PLANT GLYCOSIDE; POLYGALACIC ACID; SAIKOSAPONIN A; SARSASAPOGENIN; UNCLASSIFIED DRUG; URSOLIC ACID;

ANIMAL TISSUE; ARTICLE; BINDING SITE; BRAIN CORTEX; CHINESE MEDICINE; CIRCULATION; CONTROLLED STUDY; DRUG MECHANISM; DRUG POTENCY; DRUG STRUCTURE; ENZYME INHIBITION; HYDROGEN BOND; MOLECULAR DOCKING; NONHUMAN; SWINE;

ANIMALS; BLOOD CIRCULATION; CARDIAC GLYCOSIDES; DRUGS, CHINESE HERBAL; ENZYME INHIBITORS; MODELS, MOLECULAR; MOLECULAR STRUCTURE; OUABAIN; SODIUM-POTASSIUM-EXCHANGING ATPASE; STEROIDS; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77953246193     PISSN: 16714083     EISSN: 17457254     Source Type: Journal    
DOI: 10.1038/aps.2010.61     Document Type: Article

References (40)

1. Gong X, Sucher NJ. Stroke therapy in traditional Chinese medicine (TCM): prospects for drug discovery and development. Trends Pharmacol Sci 1999; 20: 191-196
2. Kim H. Neuroprotective herbs for stroke therapy in traditional eastern medicine. Neurol Res 2005; 27: 287-301.
3. Li-Saw-Hee FL, Lip GY. Digoxin revisted. QJM 1998; 91: 259-264
4. Schönfeld W, Menke KH, Schönfeld R, Repke KR. 5 Beta, 14 betaandrostane-beta, 14-diol binds to the digitalis receptor site on Na/ K-ATPase. J Enzyme Inhib 1987; 2: 37-45.
5. Z hou J. Bioactive glycosides from Chinese medicines. Mem Inst Oswaldo Cruz 1991; 86: 231-234
6. Chen RJ, Chung TY, Li FY, Lin NH, Tzen JT. Effect of sugar positions in ginsenosides and their inhibitory potency on Na+/K+-ATPase activity. Acta Pharmacol Sin 2009; 30: 61-69
7. Morth JP, Pedersen BP, Toustrup-Jensen MS, Sørensen TL, Petersen J, Andersen JP, et al. Crystal structure of the sodium-potassium pump. Nature 2007; 450: 1043-1049
8. Ogawa H, Shinoda T, Cornelius F, Toyoshima C. Crystal structure of the sodium-potassium pump (Na+,K+-ATPase) with bound potassium and ouabain. Proc Natl Acad Sci USA 2009; 106: 13742-13747
9. Brooks BR, Bruccoleri RE, Olafson BD, States DJ, Swaminathan S, Karplus M. CHARMM: A program for macromolecular energy minimization and dynamics calculations. J Comp Chem 1983; 4: 187-217.
10. Qiu LY, Krieger E, Schaftenaar G, Swarts HG, Willems PH, De Pont JJ, et al. Reconstruction of the complete ouabain-binding pocket of Na,KATPase in gastric H,K-ATPase by substitution of only seven amino acids. J Biol Chem 2005; 280: 32349-32355
11. Dixon SL, Merz KM Jr. One-dimensional molecular representations and similarity calculations: methodology and validation. J Med Chem 2001; 44: 3795-3809
12. Rao SN, Head MS, Kulkarni A, LaLonde JM. Validation studies of the site-directed docking program LibDock. J Chem Inf Model 2007; 47: 2159-2171
13. Yang Z, Luo H, Wang H, Hou H. Preparative isolation of bufalin and cinobufagin from Chinese traditional medicine ChanSu. J Chromatogr Sci 2008; 46: 81-85
14. Jia WW, Bu X, Philips D, Yan H, Liu G, Chen X, et al. Rh2, a compound extracted from ginseng, hypersensitizes multidrug-resistant tumor cells to chemotherapy. Can J Physiol Pharmacol 2004; 82: 431-437
15. Lee IK, Kim do H, Lee SY, Kim KR, Choi SU, Hong JK, et al. Triterpenoic acids of Prunella vulgaris var lilacina and their cytotoxic activities in vitro. Arch Pharm Res 2008; 31: 1578-1583
16. Tan LL, Cai X, Hu ZH, Ni XL. Localization and dynamic change of saikosaponin in root of Bupleurum chinense. J Integr Plant Biol 2008; 50: 951-957
17. Z hou QL, Zhang ZQ, Nagasawa T, Hiai S. The structure activity relationship of saikosaponins and glycyrrhizin derivatives for Na+,K+-ATPase inhibiting action. Yao Xue Xue Bao 1996; 31: 496-501. Chinese.
18. Wang FS, Xu LX, Zhao YJ, Liu AR, Jin LZ, Zhang XQ. Determination of bile acids in bear gall drainage by thin layer chromatographic scanning. Yao Xue Xue Bao 1989; 24: 397-400. Chinese.
19. Liu Y, Chen W, Qiao C, Zhao N. Determination of sarsasapogenin in Anemarrhena asphodeloides Bunge by GC. Zhongguo Zhong Yao Za Zhi 1999; 24: 554-555 Chinese.
20. Fu WW, Hou WB, Dou DQ, Hua HM, Gui MH, Fu R, et al. Saponins of polygalacic acid type from Platycodon grandiflorum. Yao Xue Xue Bao 2006; 41: 358-360 Chinese.
21. Z hang M, Zhang Y, Xie J. Simultaneous determination of jujuboside A, B and betulinic acid in semen Ziziphi spinosae by high performance liquid chromatography-evaporative light scattering detection. J Pharm Biomed Anal 2008; 48: 1467-1470
22. Sun ZR, Zhai MP, Wang WQ, Li YR. Effects of density on seedling growth and glycyrrhizinic acid content in Glycyrrhiza uralensis. Zhongguo Zhong Yao Za Zhi 2007; 32: 2222-2226 Chinese.
23. Xu Q, Ma X, Liang X. Determination of astragalosides in the roots of Astragalus spp using liquid chromatography tandem atmospheric pressure chemical ionization mass spectrometry. Phytochem Anal 2007; 18: 419-427 (Pubitemid 47422798)
24. Fai YM, Tao CC. A review of presence of oleanolic acid in natural products. Natura Proda Medica 2009; 2: 77-290.
25. Liu J. Oleanolic acid and ursolic acid: research perspectives. J Ethnopharmacol 2005; 100: 92-94
26. Liu J. Pharmacology of oleanolic acid and ursolic acid. J Ethnopharmacol 1995; 49: 57-68.
27. Z heng J, He J, Ji B, Li Y, Zhang X. Antihyperglycemic activity of Prunella vulgaris L in streptozotocin-induced diabetic mice.e Asia Pac J Clin Nutr 2007; 16: 427-431
28. Kageyama S, Kurokawa M, Shiraki K. Extract of Prunella vulgaris spikes inhibits HIV replication at reverse transcription in vitro and can be absorbed from intestine in vivo.d Antivir Chem Chemother 2000; 11: 157-164
29. Psotová J, Kolár M, Sousek J, Svagera Z, Vicar J, Ulrichová J. Biological activities of Prunella vulgaris extract. Phytother Res 2003; 17: 1082-1087
30. Psotová J, Chlopcíková S, Miketová P, Simánek V. Cytoprotectivity of Prunella vulgaris on doxorubicin-treated rat cardiomyocytes. Fitoterapia 2005; 76: 556-561
31. Kajima H, Ogura H. Triterpenoids from Prunella vulgaris. Phytochemistry 1986; 25: 729-733
32. Kobashi K, Akao T. Relation of intestinal bacteria to pharmacological effects of glycosides. Biosci Microflora 1997; 16: 1-7.
33. Akao T, Hayashi T, Kobashi K, Kanaoka M, Kato H, Kobayashi M, et al. Intestinal bacterial hydrolysis is indispensable to absorption of 18 beta-glycyrrhetic acid after oral administration of glycyrrhizin in rats. J Pharm Pharmacol 1994; 46: 135-137
34. Attele AS, Wu JA, Yuan CS. Ginseng pharmacology: multiple constituents and multiple actions. Biochem Pharmacol 1999; 58: 1685-1693
35. Rose AM, Qazzaz HM, Zolotarjova N, Mellett BJ, Martin AW, Valdes R Jr. Sodium pump isoforms in xenotransplantation: importance of biochemical compatibility. Clin Chem 2000; 46: 234-241
36. Prassas I, Diamandis EP. Novel therapeutic applications of cardiac glycosides. Nat Rev Drug Discov 2008; 7: 926-935
37. Wang JK, Portbury S, Thomas MB, Barney S, Ricca DJ, Morris DL, et al. Cardiac glycosides provide neuroprotection against ischemic stroke: discovery by a brain slice-based compound screening platform. Proc Natl Acad Sci USA 2006; 103: 10461-10466
38. Tzen JT, Jinn TR, Chen YC, Li FY, Cheng FC, Shi LS, et al. Magnesium lithospermate B possesses inhibitory activity on Na+,K+-ATPase and neuroprotective effects against ischemic stroke. Acta Pharmacol Sin 2007; 28: 609-615
39. Cho SO, Ban JY, Kim JY, Ju HS, Lee IS, Song KS, et al. Anti-ischemic activities of aralia cordata and its active component, oleanolic acid. Arch Pharm Res 2009; 32: 923-932
40. Annunziato L, editor. New strategies in stroke intervention. New York: Springer; 2009.