Oleandrin-mediated inhibition of human tumor cell proliferation: Importance of Na,K-ATPase α subunits as drug targets

Molecular Cancer Therapeutics

Volumn 8, Issue 8, 2009, Pages 2319-2328

  Yang, Peiying ^a   Menter, David G ^a   Cartwright, Carrie ^a   Chan, Diana ^a   Dixon, Susan ^a   Suraokar, Milind ^a   Mendoza, Gabriela ^a   Llansa, Norma ^a   Newman, Robert A ^a  

^a UNIVERSITY OF TEXAS   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CARDIAC GLYCOSIDE; COMPLEMENTARY DNA; OLEANDRIN; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CANCER CELL CULTURE; CANCER INHIBITION; CELL PROLIFERATION; CELL VIABILITY; DRUG CYTOTOXICITY; ENZYME INHIBITION; ENZYME SUBUNIT; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; MITOCHONDRION; MOUSE; NONHUMAN; PANCREAS CANCER; PRIORITY JOURNAL; PROTEIN EXPRESSION; SPECIES DIFFERENCE;

ANIMALS; ANTINEOPLASTIC AGENTS; CARDENOLIDES; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; MICE; MICROSCOPY, FLUORESCENCE; PROTEIN SUBUNITS; RNA, SMALL INTERFERING; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRANSFECTION;

EID: 68849107545     PISSN: 15357163     EISSN: None     Source Type: Journal    
DOI: 10.1158/1535-7163.MCT-08-1085     Document Type: Article

References (48)

1. Kjeldsen K, Norgaard A, Gheorghiade M. Myocardial Na K-ATPase: the molecular basis for the thermodynamic effect of digoxin therapy in congestive heart failure. Cardiovasc Res 2002;55:710-3.
2. Steinkvist B. Is digitalis a therapy for breast carcinoma? Oncol Rep 1999;6:493-6.
3. Yeh JH, Huang WJ, Kann SF, Wang PS. Inhibitory effects of digitalis on the proliferation of androgen dependent and independent prostate cancer cells. J Urol 2001;166:1937-42.
4. Haux J. Digitoxin is a potential anticancer agent for several types of cancer. Med Hypothesis 1999;53:543-8.
5. 2+ increases and apoptosis in androgen-independent, metastatic human prostate adenocarcinoma cells. Cancer Res 2000;60:3807-12.
6. Turan N, Akgun-Dar K, Kuruca SE, et al. Cytotoxic effects of lead, stem and root extracts of Nerium oleander on leukemia a cell lines and role of the p-glycoprotein in this effect. J Exp Ther Oncol 2006;6:31-8.
7. Frese S, Frese-Schaper M, Andres A, Miescher D, Zumkehr B, Schmid RA. Cardiac glycosides initiate Apo2L/TRAIL-induced apoptosis in non-small cell lung cancer cells by up-regulation of death receptors 4 and 5. Cancer Res 2006;66:5867-74.
8. Sen P, Asha M, Satya N, Virendra K, Newman RA. Anvizel TM, an extract of Nerium oleander, induces cell death in human but not murine cancer cells. Anticancer Drug 2000;11:455-63.
9. Raghavendra PB, Screenivasan Y, Manna SK. Oleandrin induces apoptosis in human, but not in murine cells: dephosphorylation of Akt, expression of FasL, alteration of membrane fluidity. Mol Immunol 2007;44:2292-02.
10. Sreenivasan Y, Raghavebdram PB, Manna SK. Oleandrin-mediated expression of Fas potentiates apoptosis in tumor cells. J Clin Immunol 2006;26:308-22.
11. Smith JA, Madden T, Vijjeswarapu M, Newman RA. Inhibition of export of fibroblast growth factor-2 (EGF-1) fromth e prostate cancer cell lines PC3 and DU145 by anvirzel and it cardiac glycoside component, oleandrin. Biochem Pharmacol 2001;62:469-72.
12. Newman RA, Yang P, Hittelman WN, et al. Oleandrin-mediated oxidative stress inhuman melanoma cells. J Exp Ther Oncol 2006;5:167-81.
13. Srivastava M, Eidelman O, Zhang J, et al. Digitoxin mimics gene therapy with CFTR and suppresses hypersecretion of IL-8 fromcystic fibrosis lung epithelial cells. Proc Natl Acad Sci U S A 2004;101:7693-8.
14. Yang Q, Huang W, Jozwik C, et al. Cardiac glycosides inhibit TNF-α/ NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor. Proc Natl Acad Sci U S A 2005;102:9631-6.
15. Hauptman PJ, Garg R, Kelly RA. Cardiac glycosides in the next millieum. Prog Cardiovasc Dis 1999;41:247-54.
16. Rose AM, Valdes R. Understanding the sodiump ump and its relevance to disease. Clin Chem1994;40:1674 -85.
17. +-ATPase-mediated signal transduction: from protein interaction to cellular function. Mol Interv 2003;3:157-68.
18. Mijatovic T, Quaquebeke EV, Belest B, Debeir O, Darro F, Kiss R. Cardiotinic steroids on the road to anti-cancer therapy. Biochim Biophys Acta 2007;1776:32-57.
19. Newman RA, Yang P, Pawlus AD, Block KI. Cardiac glycosides as novel cancer therapeutic agents. Mol Interv 2008;8:36-49.
20. Blanco G, Mercer RW. Isozymes of the Na, K-ATPase: heterogeneity in structure, diversity in function. Am J Physiol 1998;275 (Renal Physiol. 44):F633-50.
21. Rajasekaran SA, Ball WJ, Bander NH, Pardee JD, Rajasekaran AK. Reduced expression of β subunit of Na/K-APTase in human clear cell renal cell carcinoma. J Urol 1999;162:574-80.
22. Avila J, Lecuona E, Morales M, Soriano A, Alonso T, Martin-Vasallo P. Opposite expression pattern of the human Na/K-ATPase β-1 isoformin stomach and colon adenocarcinomas. Ann N Y Acad Sci 1997;834:633-5.
23. Espineda C, Seligson DB, Ball WJ, et al. Analysis of the Na K-ATPase α- and β-subunit expression profiles of bladder cancer using tissue microarrays. Cancer 2003;97:1851-68.
24. Jung MH, Kim SC, Jeon GA, et al. Identification of differentially expressed genes in normal and tumor human gastric tissue. Genomics 2000;69:281-6.
25. Blanco G. Na K-ATPase subunit heterogeneity as a mechanism for tissue specific ion regulation. Semin Nephrol 2005;25:292-303.
26. Rajasekaran SR, Barwe SP, Rajasekaran AK. Multiple functions of Na K-ATPase in epithelial cells. Semin Nephrol 2005;25:328-34.
27. Mosmann T. Rapid colorimetric assay for cellular growth and survival: application to proliferation and cytotoxic assays. J Immunol Methods 1983;65:55-6.
28. Sweadner KJ. Enzymatic properties of separated isozymes of the Na K-ATPase. Substrate affinities, kinetic cooperativity, and ion transport stoichiometry. J Biol Chem 1985;260:11508-13.
29. Nesher M, Shpolansky U, Rosen H, Lichtstein D. The digitalis-like steroid hormones: new mechanisms of action and biological significance. Life Sci 2007;80:2093-07.
30. Keenan SM, Delisle RK, Welsh WJ, Paula S, Ball WJ. Elucidation of the Na+, K+-ATPase digitalis binding site. J Mol Graph Model 2005;23:465-75.
31. Berrebi-Bertrand I, Maixent JM. Immunodetection and enzymatic characterization of the α3 isoformof Na, K-ATPase in dog heart. FEBS Lett 1994;348:55-60.
32. 3H] ouabain binding sites in human brain, platelet and erythrocyte. J Neurochem1985;44:1704 -8.
33. Juhanszova M, Blasustein MP. Na+ pump low and high ouabain affinity α subunit isoforms are differently distributed in cells. Proc Natl Acad Sci U S A 1997;94:1800-5.
34. Mijatovic T, Roland I, Quaquebeke EV, et al. The α-1 subunit of the sodium pump could represent a novel target to combat non-small-cell lung cancers. J Pathol 2007;212:170-9.
35. Seligson DB, Rajasekaran SA, Yu H, et al. Na, K-andenosine triphosphatase α1-subunit predicts survival of renal clear cell carcinoma. J Urol 2008;179:338-45.
36. +-ATPase α subunit in the synaptic plasma membrane of rat brain. Neurosci Lett 2007;413:42-5.
37. Arystarkhova E, Sweadner KJ. Hormomal and neurogenic control of Na K-ATPase and myosin isoforms in neonatal rat cardia myocytes. Am J Physiol 1997;273:C489-99.
38. Sharabani-Yosef O, Bak A, Langzam L, et al. Rat skeletal muscle in culture expresses the α1 but not the α2 protein subunit isoformof the Na+/K+ pump. J Cell Physiol 1999;180:236-44.
39. Mobasheri A, Fox R, Evans I, Cullinham F, Martin-Vasallo P, Foster CS. Epithelial Na/K-ATPase is down-regulated in canine prostate cancer: a possible consequence of metabolic transformation in the process of prostate malignancy. Cancer Cell Int 2003;13:8-17.
40. Zahler RM, Brines M, Kashgarian M, Benz EJ, Gilmore-Hebert M. Na, K-ATPase isoformgene expression in normal and hypertrophied dog heart. Basic Res Cardiol 1996;91:256-66.
41. +-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle. J Biol Chem 1992;267:5040-3.
42. Lucchesi PA, Sweadner KJ. Postnatal changes in Na, K-ATPase isoforms expression in rat cardiac ventricle. J Biol Chem 1991;266:9327-31.
43. Weidemann H. Na/K-ATPase, endogenous digitalis-like compounds and cancer development - a hypothesis. Front Biosci 2005;10:2165-76.
44. Akopyanz NS, Broude NE, Beckman EP, Marzen EO, Sverdlov ED. Tissue specific expression of Na K-ATPase β-subunit: does β2 expression correlate with tumorigenesis. FEBS Lett 1991;289:8-10.
45. Sakai H, Suzuki T, Maeda M, et al. Up-regulation of Na+, K+-ATPase α3-isoformand down-regulation of the α1-isoformin human colorectal cancer. FEBS Lett 2004;563:151-4.
46. Banerjee SP, Bosmann HB, Morgan HR. Oncogenic transformation of chick-embryo fibroblasts by rous sarcoma virus alters rubidium uptake and ouabain binding. Exp Cell Res 1977;104:111-7.
47. Kimelberg HK, Mayhew E. Increased ouabain-sensitive 86Rb+ update and sodiumand potassiumion-activated adenosine triphosphastase activity in transformed cell lines. J Biol Chem 1975;250:100-40.
48. Shen SS, Hamamoto ST, Bern HA, Steinhardt RA. Alteration of sodium transport in mouse mammary epithelium associated with neoplastic transformation. Cancer Res 1978;38:1356-61.