Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascades

Biochemical Pharmacology

Volumn 86, Issue 11, 2013, Pages 1564-1575

  Chan, She Hung ^a   Leu, Wohn Jenn ^a   Hsu, Lih Ching ^a   Chang, Hsun Shuo ^b   Hwang, Tsong Long ^c   Chen, Ih Sheng ^b   Chen, Ching Shih ^d   Guh, Jih Hwa ^a  

^a NATIONAL TAIWAN UNIVERSITY   (Taiwan)

^b KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^c CHANG GUNG UNIVERSITY   (Taiwan)

^d OHIO STATE UNIVERSITY   (United States)

Author keywords

Bcl 2 family of protein; Mitochondrial damage; Na+ K+ ATPase 3 subunit; Reevesioside F; Survivin

Indexed keywords

7 CHLORO 5 (2 CHLOROPHENYL) 1,5 DIHYDRO 4,1 BENZOTHIAZEPIN 2(3H) ONE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA3; ANTINEOPLASTIC AGENT; CARDIAC GLYCOSIDE; CASPASE; CASPASE 3; CASPASE 3 INHIBITOR; CYTOCHROME C; REEVESIOSIDE F; UNCLASSIFIED DRUG;

ANTIPROLIFERATIVE ACTIVITY; APOPTOSIS; ARTICLE; CELL MEMBRANE; CONTROLLED STUDY; DOWN REGULATION; HUMAN; HUMAN CELL; LEUKEMIA CELL; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; PRIORITY JOURNAL; UPREGULATION;

BCL-2 FAMILY OF PROTEIN; MITOCHONDRIAL DAMAGE; NA(+)/K(+)-ATPASE Α(3) SUBUNIT; REEVESIOSIDE F; SURVIVIN;

ANTINEOPLASTIC AGENTS, PHYTOGENIC; APOPTOSIS; CASPASE 3; CELL LINE, TUMOR; CELL PROLIFERATION; HUMANS; INHIBITOR OF APOPTOSIS PROTEINS; MALVACEAE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MYELOID CELL LEUKEMIA SEQUENCE 1 PROTEIN; OXIDATIVE STRESS; SAPONINS; SIGNAL TRANSDUCTION; SODIUM-POTASSIUM-EXCHANGING ATPASE;

EID: 84887438906     PISSN: 00062952     EISSN: 18732968     Source Type: Journal    
DOI: 10.1016/j.bcp.2013.09.021     Document Type: Article

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