C-peptide increases Na,K-ATPase expression via PKC- and MAP kinase-dependent activation of transcription factor ZEB in human renal tubular cells

PLoS ONE

Volumn 6, Issue 12, 2011, Pages

  Galuska, Dana ^a   Pirkmajer, Sergej ^a   Barrès, Romain ^a   Ekberg, Karin ^a   Wahren, John ^a   Chibalin, Alexander V ^a  

^a KAROLINSKA INSTITUTE   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM) ALPHA1 SUBUNIT; C PEPTIDE; GLUCOSE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; PROTEIN KINASE C; PROTEIN KINASE C EPSILON; RUBIDIUM 86; SMALL INTERFERING RNA; TRANSCRIPTION FACTOR; TRANSCRIPTION FACTOR ZEB; UNCLASSIFIED DRUG; HOMEODOMAIN PROTEIN; ISOPROTEIN; OUABAIN; PEPTIDE; PROTEIN KINASE C ALPHA; PROTEIN KINASE C DELTA; SODIUM; ZEB1 PROTEIN, HUMAN;

ARTICLE; BASOLATERAL MEMBRANE; CONTROLLED STUDY; DRUG EFFECT; ENZYME ACTIVITY; ENZYME PHOSPHORYLATION; GENE SILENCING; HUMAN; HUMAN CELL; HYPERGLYCEMIA; KIDNEY CELL CULTURE; KIDNEY TUBULE CELL; LONG TERM EXPOSURE; PROTEIN DNA BINDING; PROTEIN EXPRESSION; BIOLOGICAL MODEL; BIOSYNTHESIS; CELL NUCLEUS; CHEMISTRY; GENE EXPRESSION REGULATION; KIDNEY TUBULE; METABOLISM; PHOSPHORYLATION; SIGNAL TRANSDUCTION;

C-PEPTIDE; CELL NUCLEUS; EXTRACELLULAR SIGNAL-REGULATED MAP KINASES; GENE EXPRESSION REGULATION, ENZYMOLOGIC; GENE SILENCING; HOMEODOMAIN PROTEINS; HUMANS; HYPERGLYCEMIA; KIDNEY TUBULES; MAP KINASE SIGNALING SYSTEM; MODELS, BIOLOGICAL; OUABAIN; PEPTIDES; PHOSPHORYLATION; PROTEIN ISOFORMS; PROTEIN KINASE C; PROTEIN KINASE C-ALPHA; PROTEIN KINASE C-DELTA; PROTEIN KINASE C-EPSILON; SIGNAL TRANSDUCTION; SODIUM; SODIUM-POTASSIUM-EXCHANGING ATPASE; TRANSCRIPTION FACTORS;

EID: 82655179949     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0028294     Document Type: Article

References (37)

1. Samnegård B, Jacobson S, Jaremko G, Johansson B-L, Sjöquist M, (2001) Effects of C-peptide on glomerular and renal size and renal function in diabetic rats. Kidney International 60: 1258-1265.
2. Nordquist L, Shimada K, Ishii T, Furuya DT, Kamikawa A, et al. (2010) Proinsulin C-peptide prevents type-1 diabetes-induced decrease of renal Na,K-ATPase α1-subunit in rats. Diabetes Metabolism Research and Reviews 26: 193-199.
3. Sima AA, Zhang W, Sugimoto K, Henry D, Li Z, et al. (2001) C-peptide prevents and improves chronic Type I diabetic polyneuropathy in the BB/Wor rat. Diabetologia 44: 889-897.
4. Johansson B-L, Borg K, Fernqvist-Forbes E, Kernell A, Odergren T, et al. (2000) Beneficial effects of C-peptide on incipient nephropathy and neuropathy in patients with type I diabetes. Diabetic Medicine 17: 181-189.
5. Ekberg K, Brismar T, Johansson B-L, Jonsson B, Lindström P, et al. (2003) Amelioration of sensory nerve dysfunction by C-peptide in patients with type 1 diabetes. Diabetes 52: 536-541.
6. Li Z, Zhang W, Sima A, (2002) C-peptide prevents hippocampal apoptosis in type 1 diabetes. International Journal of Experimental Diabetes Research 3: 241-245.
7. Li Z, Zhang W, Sima A, (2003) C-peptide enhances insulin-mediated cell growth and protection against high glucose-induced apoptosis in SH-SY5Y cells. Diabetes Metab Res Rev 19: 375-385.
8. Zhong Z, Davidescu A, Ehrén I, Ekberg K, Jörnvall H, et al. (2005) C-peptide stimulates ERK1/2 and JNK MAP kinases via activation of protein kinase C in human renal tubular cells. Diabetologia 48: 187-197.
9. Rigler R, Pramanik A, Jonasson P, Kratz G, Jansson OT, et al. (1999) Specific binding of proinsulin C-peptide to human cell membranes. PNAS 96: 13318-13323.
10. Grunberger G, Qiang X, Li Z, Mathews S, Sbrissa D, et al. (2001) Molecular basis for the insulinomimetic effects of C-peptide. Diabetologia 44: 1247-1257.
11. Ohtomo Y, Aperia A, Sahlgren B, Johansson BL, Wahren J, (1996) C-peptide stimulates rat renal tubular Na,K-ATPase activity in synergism with neuropeptide Y. Diabetologia 39: 199-205.
12. Zhong Z, Kotova O, Davidescu A, Ehrén I, Ekberg K, et al. (2004) C-peptide stimulates Na,K-ATPase via activation of ERK1/2 MAP kinases in human renal tubular cells. Cellular and Molecular Life Sciences 61: 2782-2790.
13. Kjeldsen K, Braendgaard H, Sidenius P, Larsen JS, Norgaard A, (1987) Diabetes decreases Na-K pump concentration in skeletal muscles, heart ventricular muscle, and peripheral nerves of rat. Diabetes 36: 842-848.
14. Greene DA, Yagihashi S, Lattimer SA, Sima AA, (1984) Nerve Na,K-ATPase, conduction, and myo-inositol in the insulin- deficient BB rat. Am J Physiol Endocrinol Metab 247: E534-539.
15. Kowluru R, Jirousek M, Stramm L, Farid N, Engerman R, et al. (1998) Abnormalities of retinal metabolism in diabetes or experimental galactosemia: V. Relationship between protein kinase C and ATPases. Diabetes 47: 464-469.
16. Perez GO, Lespier L, Knowles R, Oster JR, Vaamonde CA, (1977) Potassium homeostasis in chronic diabetes mellitus. Arch Intern Med 137: 1018-1022.
17. Sugimoto K, Murakawa Y, Sima AA, (2000) Diabetic neuropathy- a continuing enigma. Diabetes Metab Res Rev 16: 408-433.
18. Fink DJ, Datta S, Mata M, (1994) Isoform specific reductions in Na,K-ATPase catalytic alpha subunits in the nerve of rats with streptozotocin-induced diabetes. J Neurochem 63: 1782-1786.
19. Lingrel J, Kuntzweiler T, (1994) Na,K-ATPase. J Biol Chem 269: 19659-19662.
20. Feraille E, Doucet A, (2001) Sodium-potassium-adenosinetriphosphatase-dependent sodium transport in the kidney: hormonal control. Physiol Rev 81: 345-418.
21. Thompson C, McDonough A, (1996) Skeletal muscle Na,K-ATPase alpha and beta subunit protein levels respond to hypokalemic challenge with isoform and muscle type specificity. J Biol Chem 271: 32653-32658.
22. Schmidt TA, Hasselbalch S, Farrell PA, Vestergaard H, Kjeldsen K, (1994) Human and rodent muscle Na,K-ATPase in diabetes related to insulin, starvation, and training. J Appl Physiol 76: 2140-2146.
23. Watanabe Y, Kawakami K, Hirayama Y, Nagano K, (1993) Transcription factors positively and negatively regulating the Na,K-ATPase alpha 1 subunit gene. J Biochem (Tokyo) 114: 849-855.
24. Upadhyay D, Lecuona E, Comellas A, Kamp DW, Sznajder JI, (2003) Fibroblast growth factor-10 upregulates Na,K-ATPase via the MAPK pathway. FEBS Letters 545: 173-176.
25. Ikeda K, Kawakami K, (1995) DNA binding through distinct domains of zinc-finger-homeodomain protein AREB6 has different effects on gene transcription. Eur J Biochem 233: 73-82.
26. Tsimaratos M, Roger F, Chabardès D, Mordasini D, Hasler U, et al. (2003) C-Peptide stimulates Na,K-ATPase activity via PKC alpha in rat medullary thick ascending limb. Diabetologia 46: 124-131.
27. Ekberg K, Brismar T, Johansson BL, Lindstrom P, Juntti-Berggren L, et al. (2007) C-Peptide replacement therapy and sensory nerve function in type 1 diabetic neuropathy. Diabetes Care 30: 71-76.
28. Chibalin AV, (2007) Regulation of the Na,K-ATPase: Special implications for cardiovascular complications of metabolic syndrome. Pathophysiology 14: 153-158.
29. Chibalin AV, Pedemonte CH, Katz AI, Feraille E, Berggren PO, et al. (1998) Phosphorylation of the catalyic alpha-subunit constitutes a triggering signal for Na,K-ATPase endocytosis. J Biol Chem 273: 8814-8819.
30. Craven PA, DeRubertis FR, (1989) Protein kinase C is activated in glomeruli from streptozotocin diabetic rats. Possible mediation by glucose. J Clin Invest 83: 1667-1675.
31. Inoguchi T, Battan R, Handler E, Sportsman J, Heath W, et al. (1992) Preferential elevation of protein kinase C isoform betaII and diacylglycerol levels in the aorta and heart of diabetic rats: differential reversibility to glycemic control by islet cell transplantation. PNAS 89: 11059-11063.
32. Ishii H, Jirousek MR, Koya D, Takagi C, Xia P, et al. (1996) Amelioration of vascular dysfunctions in diabetic rats by an oral PKC beta inhibitor. Science 272: 728-731.
33. Shiba T, Inoguchi T, Sportsman JR, Heath WF, Bursell S, et al. (1993) Correlation of diacylglycerol level and protein kinase C activity in rat retina to retinal circulation. Am J Physiol 265: E783-793.
34. Crider JY, Yorio T, Sharif NA, Griffin BW, (1997) The effects of elevated glucose on Na,K-ATPase of cultured bovine retinal pigment epithelial cells measured by a new nonradioactive rubidium uptake assay. J Ocul Pharmacol Ther 13: 337-352.
35. Galuska D, Kotova O, Barres R, Chibalina D, Benziane B, et al. (2009) Altered expression and insulin-induced trafficking of Na, K-ATPase in rat skeletal muscle: effects of high fat diet and exercise. Am J Physiol Endocrinol Metab 297: E38-49.
36. Chibalin AV, Kovalenko MV, Ryder JW, Feraille E, Wallberg-Henriksson H, et al. (2001) Insulin- and glucose-induced phosphorylation of the Na, K-adenosine triphosphatase alpha-subunits in rat skeletal muscle. Endocrinology 142: 3474-3482.
37. Al-Khalili L, Chibalin AV, Yu M, Sjödin B, Nylén C, et al. (2004) MEF2 activation in differentiated primary human skeletal muscle cultures requires coordinated involvement of parallel pathways. Am J Physiol Cell Physiol 286: C1410-C1416.