Persistent DNA damage-induced premature senescence alters the functional features of human bone marrow mesenchymal stem cells

Journal of Cellular and Molecular Medicine

Volumn 19, Issue 4, 2015, Pages 734-743

  Minieri, Valentina ^a   Saviozzi, Silvia ^a   Gambarotta, Giovanna ^a   Lo Iacono, Marco ^b   Accomasso, Lisa ^a   Cibrario Rocchietti, Elisa ^a   Gallina, Clara ^a   Turinetto, Valentina ^a   Giachino, Claudia ^a  

^a UNIVERSITY OF TURIN   (Italy)

^b UNIVERSITY OF TURIN   (Italy)

Author keywords

Actinomycin D; DNA damage; Mesenchymal stem cell; Senescence associated secretory phenotype; Stress induced premature senescence

Indexed keywords

ANTINEOPLASTIC ANTIBIOTIC; BETA GALACTOSIDASE; CDKN1A PROTEIN, HUMAN; CYCLIN DEPENDENT KINASE INHIBITOR 1A; CYCLIN DEPENDENT KINASE INHIBITOR 2A; DACTINOMYCIN; DNA; H2AFX PROTEIN, HUMAN; HISTONE; INTERLEUKIN 6; INTERLEUKIN 8; SIGNAL PEPTIDE; TP53BP1 PROTEIN, HUMAN; TUMOR SUPPRESSOR P53 BINDING PROTEIN 1;

CELL AGING; CELL CULTURE; CELL DIFFERENTIATION; CELL SURVIVAL; CONFOCAL MICROSCOPY; DNA DAMAGE; DRUG EFFECTS; GENE EXPRESSION; GENETICS; HUMAN; IMMUNOBLOTTING; MESENCHYMAL STROMA CELL; METABOLISM; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TUMOR CELL LINE;

ANTIBIOTICS, ANTINEOPLASTIC; BETA-GALACTOSIDASE; CELL AGING; CELL DIFFERENTIATION; CELL LINE, TUMOR; CELL SURVIVAL; CELLS, CULTURED; CYCLIN-DEPENDENT KINASE INHIBITOR P16; CYCLIN-DEPENDENT KINASE INHIBITOR P21; DACTINOMYCIN; DNA; DNA DAMAGE; GENE EXPRESSION; HISTONES; HUMANS; IMMUNOBLOTTING; INTERLEUKIN-6; INTERLEUKIN-8; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MESENCHYMAL STROMAL CELLS; MICROSCOPY, CONFOCAL; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TUMOR SUPPRESSOR P53-BINDING PROTEIN 1;

EID: 84925956501     PISSN: 15821838     EISSN: None     Source Type: Journal    
DOI: 10.1111/jcmm.12387     Document Type: Article

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