Oxidative stress induces senescence in human mesenchymal stem cells

Experimental Cell Research

Volumn 317, Issue 11, 2011, Pages 1541-1547

  Brandl, Anita ^a   Meyer, Matthias ^a   Bechmann, Volker ^a   Nerlich, Michael ^a   Angele, Peter ^a  

^a UNIVERSITY HOSPITAL REGENSBURG   (Germany)

Author keywords

Cellular senescence; DNA damage; Human mesenchymal stem cells; Oxidative stress; Telomeres

Indexed keywords

DNA; HYDROGEN PEROXIDE;

AGED; ARTICLE; CARTILAGE CELL; CELL PROLIFERATION; CONTROLLED STUDY; DNA DAMAGE; FIBROBLAST; GENE EXPRESSION; HUMAN; MESENCHYMAL STEM CELL; MORPHOLOGY; OXIDATIVE STRESS; PRIORITY JOURNAL; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SENESCENCE; STEM CELL; TELOMERE; TISSUE REPAIR; UPREGULATION;

EID: 79956293260     PISSN: 00144827     EISSN: 10902422     Source Type: Journal    
DOI: 10.1016/j.yexcr.2011.02.015     Document Type: Article

References (33)

1. Pittenger M.F., Mackay A.M., Beck S.C., Jaiswal R.K., Douglas R., Mosca J.D., Moorman M.A., Simonetti D.W., Craig S., Marshak D.R. Multilineage potential of adult human mesenchymal stem cells. Science 1999, 284:143-147.
2. Blackburn E.H. Telomere states and cell fates. Nature 2000, 408:53-56.
3. Xin H., Liu D., Songyang Z. The telosome/shelterin complex and its functions. Genome Biol. 2008, 9:232.
4. Palm W., de Lange T. How shelterin protects mammalian telomeres. Annu. Rev. Genet. 2008, 42:301-334.
5. Thacker J., Zdzienicka M.Z. The mammalian XRCC genes: their roles in DNA repair and genetic stability. DNA Repair (Amst) 2003, 2:655-672.
6. Thacker J., Zdzienicka M.Z. The XRCC genes: expanding roles in DNA double-strand break repair. DNA Repair (Amst) 2004, 3:1081-1090.
7. Guarente L. Diverse and dynamic functions of the Sir silencing complex. Nat. Genet. 1999, 23:281-285.
8. Herbig U., Jobling W.A., Chen B.P., Chen D.J., Sedivy J.M. Telomere shortening triggers senescence of human cells through a pathway involving ATM, p53, and p21(CIP1), but not p16(INK4a). Mol. Cell 2004, 14:501-513.
9. Ben-Porath I., Weinberg R.A. The signals and pathways activating cellular senescence. Int. J. Biochem. Cell Biol. 2005, 37:961-976.
10. Samani N.J., Boultby R., Butler R., Thompson J.R., Goodall A.H. Telomere shortening in atherosclerosis. Lancet 2001, 358:472-473.
11. Brouilette S., Singh R.K., Thompson J.R., Goodall A.H., Samani N.J. White cell telomere length and risk of premature myocardial infarction. Arterioscler. Thromb. Vasc. Biol. 2003, 23:842-846.
12. von Zglinicki T. Oxidative stress shortens telomeres. Trends Biochem. Sci. 2002, 27:339-344.
13. Tchirkov A., Lansdorp P.M. Role of oxidative stress in telomere shortening in cultured fibroblasts from normal individuals and patients with ataxia-telangiectasia. Hum. Mol. Genet. 2003, 12:227-232.
14. Dimri G.P., Lee X., Basile G., Acosta M., Scott G., Roskelley C., Medrano E.E., Linskens M., Rubelj I., Pereira-Smith O., et al. A biomarker that identifies senescent human cells in culture and in aging skin in vivo. Proc. Natl. Acad. Sci. USA 1995, 92:9363-9367.
15. Duan J., Zhang Z., Tong T. Irreversible cellular senescence induced by prolonged exposure to H2O2 involves DNA-damage-and-repair genes and telomere shortening. Int. J. Biochem. Cell Biol. 2005, 37:1407-1420.
16. Toussaint O., Medrano E.E., von Zglinicki T. Cellular and molecular mechanisms of stress-induced premature senescence (SIPS) of human diploid fibroblasts and melanocytes. Exp. Gerontol. 2000, 35:927-945.
17. Frippiat C., Chen Q.M., Zdanov S., Magalhaes J.P., Remacle J., Toussaint O. Subcytotoxic H2O2 stress triggers a release of transforming growth factor-beta 1, which induces biomarkers of cellular senescence of human diploid fibroblasts. J. Biol. Chem. 2001, 276:2531-2537.
18. Brandl A., Hartmann A., Bechmann V., Graf B., Nerlich M., Angele P. Oxidative stress induces senescence in chondrocytes. J. Orthop. Res. 2011.
19. Sklavounou E., Hay A., Ashraf N., Lamb K., Brown E., Mac Intyre A., George W.D., Hartley R.C., Shiels P.G. The use of telomere biology to identify and develop superior nitrone based anti-oxidants. Biochem. Biophys. Res. Commun. 2006, 347:420-427.
20. Chen Q.M., Prowse K.R., Tu V.C., Purdom S., Linskens M.H. Uncoupling the senescent phenotype from telomere shortening in hydrogen peroxide-treated fibroblasts. Exp. Cell Res. 2001, 265:294-303.
21. Rubio M.A., Davalos A.R., Campisi J. Telomere length mediates the effects of telomerase on the cellular response to genotoxic stress. Exp. Cell Res. 2004, 298:17-27.
22. Opresko P.L., Fan J., Danzy S., Wilson D.M., Bohr V.A. Oxidative damage in telomeric DNA disrupts recognition by TRF1 and TRF2. Nucleic Acids Res. 2005, 33:1230-1239.
23. d'Adda di Fagagna F., Reaper P.M., Clay-Farrace L., Fiegler H., Carr P., Von Zglinicki T., Saretzki G., Carter N.P., Jackson S.P. A DNA damage checkpoint response in telomere-initiated senescence. Nature 2003, 426:194-198.
24. Hayflick L. The illusion of cell immortality. Br. J. Cancer 2000, 83:841-846.
25. Brandl A., Angele P., Roll C., Prantl L., Kujat R., Kinner B. Influence of the growth factors PDGF-BB, TGF-beta1 and bFGF on the replicative aging of human articular chondrocytes during in vitro expansion. J. Orthop. Res. 2010, 28:354-360.
26. Saretzki G., Von Zglinicki T. Replicative aging, telomeres, and oxidative stress. Ann. NY Acad. Sci. 2002, 959:24-29.
27. Saretzki G., von Zglinicki T. Replicative senescence as a model of aging: the role of oxidative stress and telomere shortening - an overview. Z. Gerontol. Geriatr. 1999, 32:69-75.
28. von Zglinicki T. Role of oxidative stress in telomere length regulation and replicative senescence. Ann. NY Acad. Sci. 2000, 908:99-110.
29. von Zglinicki T., Petrie J., Kirkwood T.B. Telomere-driven replicative senescence is a stress response. Nat. Biotechnol. 2003, 21:229-230.
30. Oh H., Wang S.C., Prahash A., Sano M., Moravec C.S., Taffet G.E., Michael L.H., Youker K.A., Entman M.L., Schneider M.D. Telomere attrition and Chk2 activation in human heart failure. Proc. Natl. Acad. Sci. USA 2003, 100:5378-5383.
31. Zhang Y., Cao E.H., Qin J.F. Up-regulation of telomere-binding TRF1, TRF2 related to reactive oxygen species induced by As(2)O(3) in MGC-803 cells. Eur. J. Pharmacol. 2005, 516:1-9.
32. Vaziri H., Dessain S.K., Ng Eaton E., Imai S.I., Frye R.A., Pandita T.K., Guarente L., Weinberg R.A. hSIR2(SIRT1) functions as an NAD-dependent p53 deacetylase. Cell 2001, 107:149-159.
33. Shackelford D.A., Tobaru T., Zhang S., Zivin J.A. Changes in expression of the DNA repair protein complex DNA-dependent protein kinase after ischemia and reperfusion. J. Neurosci. 1999, 19:4727-4738.