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Volumn 95, Issue , 2015, Pages 153-165
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Multi-target tacrine-coumarin hybrids: Cholinesterase and monoamine oxidase B inhibition properties against Alzheimer's disease
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Author keywords
Alzheimer's disease; Cholinesterase; Coumarin; Docking; Monoamine oxidase; Tacrine
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Indexed keywords
3 CHLORO 4 METHYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
3 METHYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
3 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 7,8,9,10 TETRAHYDRO 6H BENZO[C]CHROMEN 6 ONE;
3,4 DIMETHYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
4 AMINO 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
4 ETHOXY 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
4 METHOXY 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
4 METHYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
4 PHENYL 7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
7 [2 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 2H CHROMEN 2 ONE;
7 [2 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]ETHOXY] 4 (TRIFLUOROMETHYL) 2H CHROMEN 2 ONE;
7 [3 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]PROPOXY] 2H CHROMEN 2 ONE;
7 [3 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PROPOXY] 2H CHROMEN 2 ONE;
7 [4 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]BUTOXY] 2H CHROMEN 2 ONE;
7 [4 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]BUTOXY] 2H CHROMEN 2 ONE;
7 [[5 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]PENTYL]OXY] 2H CHROMEN 2 ONE;
7 [[5 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]PENTYL]OXY] 2H CHROMEN 2 ONE;
7 [[6 [4 [2 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]ETHYL]PIPERAZIN 1 YL]HEXYL]OXY] 2H CHROMEN 2 ONE;
7 [[6 [4 [3 [(1,2,3,4 TETRAHYDROACRIDIN 9 YL)AMINO]PROPYL]PIPERAZIN 1 YL]HEXYL]OXY] 2H CHROMEN 2 ONE;
ACETYLCHOLINESTERASE;
AMINE OXIDASE (FLAVIN CONTAINING) ISOENZYME B;
CHOLINESTERASE INHIBITOR;
COUMARIN DERIVATIVE;
IPRONIAZID;
MONOAMINE OXIDASE INHIBITOR;
NOOTROPIC AGENT;
TACRINE DERIVATIVE;
UNCLASSIFIED DRUG;
3,4-DIMETHYL-7-(2-(4-(3-((1,2,3,4-TETRAHYDROACRIDIN-9-YL)AMINO)PROPYL)PIPERAZIN-1-YL)ETHOXY)-2H-CHROMEN-2-ONE;
AMINE OXIDASE (FLAVIN CONTAINING);
BENZOPYRAN DERIVATIVE;
COUMARIN;
PIPERAZINE DERIVATIVE;
TACRINE;
ALKYLATION;
ALZHEIMER DISEASE;
ARTICLE;
BIOASSAY;
BLOOD BRAIN BARRIER;
CATALYSIS;
CELL VIABILITY;
CHOLINESTERASE INHIBITION;
CRYSTAL STRUCTURE;
CYTOTOXICITY;
DRUG DESIGN;
DRUG PENETRATION;
DRUG SCREENING;
DRUG SYNTHESIS;
ENZYME INHIBITION;
HUMAN;
HUMAN CELL;
HYDROGEN BOND;
IC50;
IN VITRO STUDY;
LIPOPHILICITY;
MOLECULAR DOCKING;
MOLECULAR DYNAMICS;
MOLECULAR MODEL;
STEREOSPECIFICITY;
BRAIN;
CELL CULTURE;
CELL SURVIVAL;
CHEMICAL STRUCTURE;
CHEMISTRY;
CYTOLOGY;
DRUG EFFECTS;
ENZYMOLOGY;
ERYTHROCYTE;
KINETICS;
NEUROBLASTOMA;
PATHOLOGY;
ACETYLCHOLINESTERASE;
ALZHEIMER DISEASE;
BENZOPYRANS;
BLOOD-BRAIN BARRIER;
BRAIN;
CELL SURVIVAL;
CELLS, CULTURED;
CHOLINESTERASE INHIBITORS;
COUMARINS;
DRUG DESIGN;
ERYTHROCYTES;
HUMANS;
KINETICS;
MODELS, MOLECULAR;
MOLECULAR DOCKING SIMULATION;
MONOAMINE OXIDASE;
MONOAMINE OXIDASE INHIBITORS;
NEUROBLASTOMA;
PIPERAZINES;
TACRINE;
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EID: 84925444000
PISSN: 02235234
EISSN: 17683254
Source Type: Journal
DOI: 10.1016/j.ejmech.2015.03.040 Document Type: Article |
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Times cited : (163)
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References (54)
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