Design, synthesis, and biological evaluation of coumarin derivatives tethered to an edrophonium-like fragment as highly potent and selective dual binding site acetylcholinesterase inhibitors

ChemMedChem

Volumn 5, Issue 9, 2010, Pages 1616-1630

  Pisani, Leonardo ^a   Catto, Marco ^a   Giangreco, Ilenia ^a   Leonetti, Francesco ^a   Nicolotti, Orazio ^a   Stefanachi, Angela ^a   Cellamare, Saverio ^a   Carotti, Angelo ^a  

^a UNIVERSITY OF BARI   (Italy)

Author keywords

Acetylcholinesterase; Alzheimer's disease; Coumarin derivatives; Glaucoma; Inhibitors

Indexed keywords

3 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; 3 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 6,7 DIMETHOXY 2H CHROMEN 2 ONE; 3 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 6H BENZO[C]CHROMEN 6 ONE; 3 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 7,8,9,10 TETRAHYDRO 6H BENZO[C]CHROMEN 6 ONE; 3 CHLORO 7 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 3 CHLORO 7 [[3 [[3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]METHYL] BENZYL]OXY] 4 METHYL 2H CHROMEN 2 ONE; 3 CHLORO 7 [[5 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]PENTYL] OXY] 4 METHYL 2H CHROMEN 2 ONE; 4 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; 5 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; 6 (2 BROMOETHOXY) 2H CHROMEN 2 ONE; 6 [2 [2 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]ETHYL] (METHYL)AMINO]ETHOXY] 2H CHROMEN 2 ONE; 6 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; 6 [[ 4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUT 2 EN 1 YL]OXY] 2H CHROMEN 2 ONE; 6 [[5 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]PENTYL]OXY] 2H CHROMEN 2 ONE; 7 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; 7 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 3 METHYL 2H CHROMEN 2 ONE; 7 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 4 (TRIFLUOROMETHYL) 2H CHROMEN 2 ONE; 7 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 4 METHYL 2H CHROMEN 2 ONE; 8 [4 [3 (DIMETHYLAMINO) 5 HYDROXYPHENOXY]BUTOXY] 2H CHROMEN 2 ONE; CHOLINESTERASE INHIBITOR; COUMARIN DERIVATIVE; DONEPEZIL; GALANTAMINE; MEMANTINE; RIVASTIGMINE; TACRINE; UNCLASSIFIED DRUG;

ALZHEIMER DISEASE; ARTICLE; BINDING SITE; DRUG BINDING; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; PRIORITY JOURNAL; STRUCTURE ACTIVITY RELATION;

ACETYLCHOLINESTERASE; BINDING SITES; CHOLINESTERASE INHIBITORS; COMPUTER SIMULATION; COUMARINS; DRUG DESIGN; EDROPHONIUM; HUMANS; PROTEIN STRUCTURE, TERTIARY; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 77956413632     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.201000210     Document Type: Article

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