Synthesis and evaluation of multi-target-directed ligands against Alzheimer's disease based on the fusion of donepezil and ebselen

Journal of Medicinal Chemistry

Volumn 56, Issue 22, 2013, Pages 9089-9099

  Luo, Zonghua ^a   Sheng, Jianfei ^a   Sun, Yang ^a   Lu, Chuanjun ^a   Yan, Jun ^a   Liu, Anqiu ^a   Luo, Hai Bin ^a   Huang, Ling ^a   Li, Xingshu ^a  

^a SUN YAT SEN UNIVERSITY   (China)

Author keywords

[No Author keywords available]

Indexed keywords

2 (1 BENZYLPIPERIDIN 4 YL) 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 (1 BENZYLPIPERIDIN 4 YL) 6 CHLOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 (1 BENZYLPIPERIDIN 4 YL) 6 FLUOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 (1 BENZYLPIPERIDIN 4 YL)BENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL] 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL] 6 CHLOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL] 6 FLUOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [(1 BENZYLPIPERIDIN 4 YL)METHYL]BENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3(2H) ONE 1 OXIDE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 6 CHLOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL] 6 FLUOROBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [2 (1 BENZYLPIPERIDIN 4 YL)ETHYL]BENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [3 (1 BENZYLPIPERIDIN 4 YL)PROPYL] 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3 (2H)ONE; 2 [4 (1 BENZYLPIPERIDIN 4 YL)BUTYL] 5,6 DIMETHOXYBENZO[D][1,2]SELENAZOL 3 (2H)ONE; ACETYLCHOLINESTERASE; AMYLOID BETA PROTEIN[1-40]; CHOLINESTERASE INHIBITOR; DONEPEZIL; EBSELEN; GLUTATHIONE PEROXIDASE; HYDROGEN PEROXIDE; LIGAND; PEROXYNITRITE; TACRINE; THIOREDOXIN REDUCTASE; UNCLASSIFIED DRUG;

ACUTE TOXICITY; ALZHEIMER DISEASE; ANIMAL EXPERIMENT; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BLOOD BRAIN BARRIER; CENTRAL NERVOUS SYSTEM; CHOLINESTERASE INHIBITION; CONTROLLED STUDY; DRUG BINDING SITE; DRUG DESIGN; DRUG PENETRATION; DRUG POTENCY; DRUG SAFETY; DRUG SCREENING; DRUG SYNTHESIS; DRUG TARGETING; ELECTROPHORUS; HUMAN; HUMAN CELL; IC 50; IN VITRO STUDY; MOLECULAR DOCKING; MOUSE; NONHUMAN; NUCLEAR MAGNETIC RESONANCE; PROTEIN AGGREGATION; RAT; STRUCTURE ACTIVITY RELATION; TOXICITY TESTING;

ACETYLCHOLINESTERASE; ALZHEIMER DISEASE; AMYLOID BETA-PEPTIDES; ANIMALS; AZOLES; BUTYRYLCHOLINESTERASE; CHEMISTRY TECHNIQUES, SYNTHETIC; CHOLINESTERASE INHIBITORS; ELECTROPHORUS; GLUTATHIONE PEROXIDASE; HUMANS; INDANS; KINETICS; LIGANDS; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR TARGETED THERAPY; ORGANOSELENIUM COMPOUNDS; PEPTIDE FRAGMENTS; PEROXYNITROUS ACID; PIPERIDINES; PROTEIN MULTIMERIZATION; PROTEIN STRUCTURE, SECONDARY; THIOREDOXIN-DISULFIDE REDUCTASE; TOXICITY TESTS, ACUTE;

EID: 84889246292     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm401047q     Document Type: Article

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