Synthesis, biological assessment and molecular modeling of new multipotent MAO and cholinesterase inhibitors as potential drugs for the treatment of Alzheimer's disease

European Journal of Medicinal Chemistry

Volumn 46, Issue 9, 2011, Pages 4665-4668

  Samadi, Abdelouahid ^a   Chioua, Mourad ^a   Bolea, Irene ^b   De Los Ríos, Cristóbal ^c,d   Iriepa, Isabel ^d   Moraleda, Ignacio ^c,d   Bastida, Agatha ^a   Esteban, Gerard ^b   Unzeta, Mercedes ^b   Gálvez, Enrique ^d   Marco Contelles, José ^a  

^a INSTITUTO DE QUÍMICA ORGÁNICA GENERAL   (Spain)

^b UNIVERSITAT AUTÒNOMA DE BARCELONA   (Spain)

^c HOSPITAL UNIVERSITARIO DE LA PRINCESA   (Spain)

^d UNIVERSITY OF ALCALÁ   (Spain)

Author keywords

AChE; Alzheimer's disease; BuChE; Inhibition mechanism; Kinetic analysis; MAO A; MAO B; Molecular modeling; Multipotent molecules; Naphthyridines; Pyridines

Indexed keywords

ACETYLCHOLINESTERASE; AMINE; AMINE OXIDASE (FLAVIN CONTAINING); CHOLINESTERASE; CHOLINESTERASE INHIBITOR; MONOAMINE OXIDASE INHIBITOR; PYRIDINE DERIVATIVE;

ALZHEIMER DISEASE; ARTICLE; DRUG SELECTIVITY; DRUG STRUCTURE; DRUG SYNTHESIS; ENZYME ACTIVE SITE; ENZYME INHIBITION; EVALUATION; IC 50; MOLECULAR MODEL;

ALZHEIMER DISEASE; CHOLINESTERASE INHIBITORS; HUMANS; MODELS, MOLECULAR; MONOAMINE OXIDASE INHIBITORS;

EID: 80052925179     PISSN: 02235234     EISSN: 17683254     Source Type: Journal    
DOI: 10.1016/j.ejmech.2011.05.048     Document Type: Article

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