메뉴 건너뛰기




Volumn 10, Issue 3, 2015, Pages

Deregulation of DNA double-strand break repair in multiple myeloma: Implications for genome stability

Author keywords

[No Author keywords available]

Indexed keywords

DNA DEPENDENT PROTEIN KINASE; HISTONE H2AX; POLYDEOXYRIBONUCLEOTIDE SYNTHASE; RAD51 PROTEIN; XRCC4 PROTEIN;

EID: 84925400720     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0121581     Document Type: Article
Times cited : (42)

References (57)
  • 1
    • 84860219443 scopus 로고    scopus 로고
    • The genetic architecture of multiple myeloma
    • PMID: 22495321
    • Morgan GJ, Walker BA, Davies FE. The genetic architecture of multiple myeloma. Nat Rev Cancer. 2012; 12: 335-48. doi: 10.1038/nrc3257 PMID: 22495321
    • (2012) Nat Rev Cancer , vol.12 , pp. 335-348
    • Morgan, G.J.1    Walker, B.A.2    Davies, F.E.3
  • 2
    • 70349902608 scopus 로고    scopus 로고
    • Centrosomes and myeloma; aneuploidy and proliferation
    • PMID: 19739237
    • Chng WJ, Fonseca R. Centrosomes and myeloma; aneuploidy and proliferation. Environmental and molecular mutagenesis. 2009; 50: 697-707. doi: 10.1002/em.20528 PMID: 19739237
    • (2009) Environmental and Molecular Mutagenesis , vol.50 , pp. 697-707
    • Chng, W.J.1    Fonseca, R.2
  • 4
    • 77955841541 scopus 로고    scopus 로고
    • Focus on histone variant H2AX: To be or not to be
    • PMID: 20493860
    • Yuan J, Adamski R, Chen J. Focus on histone variant H2AX: To be or not to be. FEBS letters. 2010; 584: 3717-24. doi: 10.1016/j.febslet.2010.05.021 PMID: 20493860
    • (2010) FEBS Letters , vol.584 , pp. 3717-3724
    • Yuan, J.1    Adamski, R.2    Chen, J.3
  • 5
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • PMID: 10959836
    • Paull TT, Rogakou EP, Yamazaki V, Kirchgessner CU, Gellert M, Bonner WM. A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage. Curr Biol. 2000; 10: 886-95. PMID: 10959836
    • (2000) Curr Biol , vol.10 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 7
    • 38049115657 scopus 로고    scopus 로고
    • The mechanism of human nonhomologous DNA end joining
    • PMID: 17999957
    • Lieber MR. The mechanism of human nonhomologous DNA end joining. J Biol Chem. 2008; 283: 1-5. PMID: 17999957
    • (2008) J Biol Chem , vol.283 , pp. 1-5
    • Lieber, M.R.1
  • 8
    • 0042632901 scopus 로고    scopus 로고
    • Pathways of DNA double-strand break repair during the mammalian cell cycle
    • PMID: 12897142
    • Rothkamm K, Kruger I, Thompson LH, Lobrich M. Pathways of DNA double-strand break repair during the mammalian cell cycle. Mol Cell Biol. 2003; 23: 5706-15. PMID: 12897142
    • (2003) Mol Cell Biol , vol.23 , pp. 5706-5715
    • Rothkamm, K.1    Kruger, I.2    Thompson, L.H.3    Lobrich, M.4
  • 9
    • 0035697317 scopus 로고    scopus 로고
    • NHEJ deficiency and disease
    • PMID: 11885597
    • Pierce AJ, Jasin M. NHEJ deficiency and disease. Mol Cell. 2001; 8: 1160-1. PMID: 11885597
    • (2001) Mol Cell , vol.8 , pp. 1160-1161
    • Pierce, A.J.1    Jasin, M.2
  • 10
    • 77953636534 scopus 로고    scopus 로고
    • Homologous recombination in cancer development, treatment and development of drug resistance
    • PMID: 20351092
    • Helleday T. Homologous recombination in cancer development, treatment and development of drug resistance. Carcinogenesis. 2010; 31: 955-60. doi: 10.1093/carcin/bgq064 PMID: 20351092
    • (2010) Carcinogenesis , vol.31 , pp. 955-960
    • Helleday, T.1
  • 11
    • 84863530603 scopus 로고    scopus 로고
    • Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining
    • PMID: 22493298
    • Chakraborty S, Stark JM, Sun CL, Modi H, Chen W, O'Connor TR, et al. Chronic myelogenous leukemia stem and progenitor cells demonstrate chromosomal instability related to repeated breakage-fusion-bridge cycles mediated by increased nonhomologous end joining. Blood. 2012; 119: 6187-97. doi: 10.1182/blood-2011-05-352252 PMID: 22493298
    • (2012) Blood , vol.119 , pp. 6187-6197
    • Chakraborty, S.1    Stark, J.M.2    Sun, C.L.3    Modi, H.4    Chen, W.5    O'Connor, T.R.6
  • 12
    • 0035095972 scopus 로고    scopus 로고
    • Homologous recombination as a mechanism of carcinogenesis
    • PMID: 11250067
    • Bishop AJ, Schiestl RH. Homologous recombination as a mechanism of carcinogenesis. Biochim Biophys Acta. 2001; 1471: M109-21. PMID: 11250067
    • (2001) Biochim Biophys Acta , vol.1471 , pp. M109-M121
    • Bishop, A.J.1    Schiestl, R.H.2
  • 13
    • 79956215808 scopus 로고    scopus 로고
    • Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways
    • PMID: 21329706
    • Mladenov E, Iliakis G. Induction and repair of DNA double strand breaks: The increasing spectrum of non-homologous end joining pathways. Mutation research. 2011; 711: 61-72. doi: 10.1016/j.mrfmmm. 2011.02.005 PMID: 21329706
    • (2011) Mutation Research , vol.711 , pp. 61-72
    • Mladenov, E.1    Iliakis, G.2
  • 14
    • 35348821296 scopus 로고    scopus 로고
    • A backup DNA repair pathway moves to the forefront
    • PMID: 17956720
    • Nussenzweig A, Nussenzweig MC. A backup DNA repair pathway moves to the forefront. Cell. 2007; 131: 223-5. PMID: 17956720
    • (2007) Cell , vol.131 , pp. 223-225
    • Nussenzweig, A.1    Nussenzweig, M.C.2
  • 15
    • 60049083261 scopus 로고    scopus 로고
    • Non-homologous end joining in class switch recombination: The beginning of the end
    • PMID: 19008195
    • Kotnis A, Du L, Liu C, Popov SW, Pan-Hammarstrom Q. Non-homologous end joining in class switch recombination: The beginning of the end. Philos Trans R Soc Lond B Biol Sci. 2009; 364: 653-65. doi: 10.1098/rstb.2008.0196 PMID: 19008195
    • (2009) Philos Trans R Soc Lond B Biol Sci , vol.364 , pp. 653-665
    • Kotnis, A.1    Du, L.2    Liu, C.3    Popov, S.W.4    Pan-Hammarstrom, Q.5
  • 16
    • 34748863465 scopus 로고    scopus 로고
    • IgH class switching and translocations use a robust non-classical end-joining pathway
    • PMID: 17713479
    • Yan CT, Boboila C, Souza EK, Franco S, Hickernell TR, Murphy M, et al. IgH class switching and translocations use a robust non-classical end-joining pathway. Nature. 2007; 449: 478-82. PMID: 17713479
    • (2007) Nature , vol.449 , pp. 478-482
    • Yan, C.T.1    Boboila, C.2    Souza, E.K.3    Franco, S.4    Hickernell, T.R.5    Murphy, M.6
  • 17
    • 34848843525 scopus 로고    scopus 로고
    • Rag mutations reveal robust alternative end joining
    • PMID: 17898768
    • Corneo B, Wendland RL, Deriano L, Cui X, Klein IA, Wong SY, et al. Rag mutations reveal robust alternative end joining. Nature. 2007; 449: 483-6. PMID: 17898768
    • (2007) Nature , vol.449 , pp. 483-486
    • Corneo, B.1    Wendland, R.L.2    Deriano, L.3    Cui, X.4    Klein, I.A.5    Wong, S.Y.6
  • 18
    • 34250654965 scopus 로고    scopus 로고
    • The comet assay: A method to measure DNA damage in individual cells
    • PMID: 17406208
    • Olive PL, Banath JP. The comet assay: A method to measure DNA damage in individual cells. Nat Protoc. 2006; 1: 23-9. PMID: 17406208
    • (2006) Nat Protoc , vol.1 , pp. 23-29
    • Olive, P.L.1    Banath, J.P.2
  • 19
    • 84894859960 scopus 로고    scopus 로고
    • OpenComet: An automated tool for comet assay image analysis
    • PMID: 24624335
    • Gyori BM, Venkatachalam G, Thiagarajan PS, Hsu D, Clement MV. OpenComet: An automated tool for comet assay image analysis. Redox Biol. 2014; 2: 457-65. doi: 10.1016/j.redox.2013.12.020 PMID: 24624335
    • (2014) Redox Biol , vol.2 , pp. 457-465
    • Gyori, B.M.1    Venkatachalam, G.2    Thiagarajan, P.S.3    Hsu, D.4    Clement, M.V.5
  • 21
    • 0033664274 scopus 로고    scopus 로고
    • High-efficiency transient transfection of endothelial cells for functional analysis
    • PMID: 11099466
    • Kovala AT, Harvey KA, McGlynn P, Boguslawski G, Garcia JG, English D. High-efficiency transient transfection of endothelial cells for functional analysis. FASEB J. 2000; 14: 2486-94. PMID: 11099466
    • (2000) FASEB J , vol.14 , pp. 2486-2494
    • Kovala, A.T.1    Harvey, K.A.2    McGlynn, P.3    Boguslawski, G.4    Garcia, J.G.5    English, D.6
  • 22
    • 52049098230 scopus 로고    scopus 로고
    • Comparison of nonhomologous end joining and homologous recombination in human cells
    • PMID: 18675941
    • Mao Z, Bozzella M, Seluanov A, Gorbunova V. Comparison of nonhomologous end joining and homologous recombination in human cells. DNA Repair (Amst). 2008; 7: 1765-71. doi: 10.1016/j.dnarep.2008.06.018 PMID: 18675941
    • (2008) DNA Repair (Amst) , vol.7 , pp. 1765-1771
    • Mao, Z.1    Bozzella, M.2    Seluanov, A.3    Gorbunova, V.4
  • 23
    • 77953166592 scopus 로고    scopus 로고
    • gammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
    • PMID: 20139725
    • Lobrich M, Shibata A, Beucher A, Fisher A, Ensminger M, Goodarzi AA, et al. gammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization. Cell cycle. 2010; 9: 662-9. PMID: 20139725
    • (2010) Cell Cycle , vol.9 , pp. 662-669
    • Lobrich, M.1    Shibata, A.2    Beucher, A.3    Fisher, A.4    Ensminger, M.5    Goodarzi, A.A.6
  • 24
    • 80051785331 scopus 로고    scopus 로고
    • Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX
    • PMID: 21566653
    • Walters DK, Wu X, Tschumper RC, Arendt BK, Huddleston PM, Henderson KJ, et al. Evidence for ongoing DNA damage in multiple myeloma cells as revealed by constitutive phosphorylation of H2AX. Leukemia. 2011; 25: 1344-53. doi: 10.1038/leu.2011.94 PMID: 21566653
    • (2011) Leukemia , vol.25 , pp. 1344-1353
    • Walters, D.K.1    Wu, X.2    Tschumper, R.C.3    Arendt, B.K.4    Huddleston, P.M.5    Henderson, K.J.6
  • 25
    • 4944234150 scopus 로고    scopus 로고
    • Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    • PMID: 15466212
    • Banath JP, Macphail SH, Olive PL. Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines. Cancer Res. 2004; 64: 7144-9. PMID: 15466212
    • (2004) Cancer Res , vol.64 , pp. 7144-7149
    • Banath, J.P.1    Macphail, S.H.2    Olive, P.L.3
  • 26
    • 79960812015 scopus 로고    scopus 로고
    • Understanding the limitations of radiation-induced cell cycle checkpoints
    • PMID: 21524151
    • Deckbar D, Jeggo PA, Lobrich M. Understanding the limitations of radiation-induced cell cycle checkpoints. Critical reviews in biochemistry and molecular biology. 2011; 46: 271-83. doi: 10.3109/10409238.2011.575764 PMID: 21524151
    • (2011) Critical Reviews in Biochemistry and Molecular Biology , vol.46 , pp. 271-283
    • Deckbar, D.1    Jeggo, P.A.2    Lobrich, M.3
  • 27
    • 0034655281 scopus 로고    scopus 로고
    • The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1
    • PMID: 10786669
    • Busby EC, Leistritz DF, Abraham RT, Karnitz LM, Sarkaria JN. The radiosensitizing agent 7-hydroxystaurosporine (UCN-01) inhibits the DNA damage checkpoint kinase hChk1. Cancer research. 2000; 60: 2108-12. PMID: 10786669
    • (2000) Cancer Research , vol.60 , pp. 2108-2112
    • Busby, E.C.1    Leistritz, D.F.2    Abraham, R.T.3    Karnitz, L.M.4    Sarkaria, J.N.5
  • 28
    • 0032189483 scopus 로고    scopus 로고
    • Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin
    • PMID: 9766667
    • Sarkaria JN, Tibbetts RS, Busby EC, Kennedy AP, Hill DE, Abraham RT. Inhibition of phosphoinositide 3-kinase related kinases by the radiosensitizing agent wortmannin. Cancer research. 1998; 58: 4375-82. PMID: 9766667
    • (1998) Cancer Research , vol.58 , pp. 4375-4382
    • Sarkaria, J.N.1    Tibbetts, R.S.2    Busby, E.C.3    Kennedy, A.P.4    Hill, D.E.5    Abraham, R.T.6
  • 29
    • 0036157566 scopus 로고    scopus 로고
    • Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner
    • PMID: 11835680
    • Qi W, Qiao D, Martinez JD. Caffeine induces TP53-independent G(1)-phase arrest and apoptosis in human lung tumor cells in a dose-dependent manner. Radiation research. 2002; 157: 166-74. PMID: 11835680
    • (2002) Radiation Research , vol.157 , pp. 166-174
    • Qi, W.1    Qiao, D.2    Martinez, J.D.3
  • 30
    • 33748087488 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays
    • PMID: 16905207
    • Klokov D, MacPhail SM, Banath JP, Byrne JP, Olive PL. Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays. Radiother Oncol. 2006; 80: 223-9. PMID: 16905207
    • (2006) Radiother Oncol , vol.80 , pp. 223-229
    • Klokov, D.1    MacPhail, S.M.2    Banath, J.P.3    Byrne, J.P.4    Olive, P.L.5
  • 31
    • 76749171245 scopus 로고    scopus 로고
    • Residual gammaH2AX foci as an indication of lethal DNA lesions
    • PMID: 20051134
    • Banath JP, Klokov D, MacPhail SH, Banuelos CA, Olive PL. Residual gammaH2AX foci as an indication of lethal DNA lesions. BMC Cancer. 2010; 10: 4. doi: 10.1186/1471-2407-10-4 PMID: 20051134
    • (2010) BMC Cancer , vol.10 , pp. 4
    • Banath, J.P.1    Klokov, D.2    MacPhail, S.H.3    Banuelos, C.A.4    Olive, P.L.5
  • 32
    • 80655127835 scopus 로고    scopus 로고
    • Retention of gammaH2AX foci as an indication of lethal DNA damage
    • Olive PL. Retention of gammaH2AX foci as an indication of lethal DNA damage. Radiother Oncol. 2010; 101: 18-23.
    • (2010) Radiother Oncol , vol.101 , pp. 18-23
    • Olive, P.L.1
  • 33
    • 51649128895 scopus 로고    scopus 로고
    • Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks
    • PMID: 18524993
    • Sallmyr A, Tomkinson AE, Rassool FV. Up-regulation of WRN and DNA ligase IIIalpha in chronic myeloid leukemia: Consequences for the repair of DNA double-strand breaks. Blood. 2008; 112: 1413-23. doi: 10.1182/blood-2007-07-104257 PMID: 18524993
    • (2008) Blood , vol.112 , pp. 1413-1423
    • Sallmyr, A.1    Tomkinson, A.E.2    Rassool, F.V.3
  • 34
    • 45549094090 scopus 로고    scopus 로고
    • Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks
    • PMID: 18440984
    • Liang L, Deng L, Nguyen SC, Zhao X, Maulion CD, Shao C, et al. Human DNA ligases I and III, but not ligase IV, are required for microhomology-mediated end joining of DNA double-strand breaks. Nucleic Acids Res. 2008; 36: 3297-310. doi: 10.1093/nar/gkn184 PMID: 18440984
    • (2008) Nucleic Acids Res , vol.36 , pp. 3297-3310
    • Liang, L.1    Deng, L.2    Nguyen, S.C.3    Zhao, X.4    Maulion, C.D.5    Shao, C.6
  • 35
    • 11244280890 scopus 로고    scopus 로고
    • Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining
    • PMID: 15498778
    • Audebert M, Salles B, Calsou P. Involvement of poly(ADP-ribose) polymerase-1 and XRCC1/DNA ligase III in an alternative route for DNA double-strand breaks rejoining. J Biol Chem. 2004; 279: 55117-26. PMID: 15498778
    • (2004) J Biol Chem , vol.279 , pp. 55117-55126
    • Audebert, M.1    Salles, B.2    Calsou, P.3
  • 36
    • 20144363082 scopus 로고    scopus 로고
    • DNA ligase III as a candidate component of backup pathways of nonhomologous end joining
    • PMID: 15899791
    • Wang H, Rosidi B, Perrault R, Wang M, Zhang L, Windhofer F, et al. DNA ligase III as a candidate component of backup pathways of nonhomologous end joining. Cancer Res. 2005; 65: 4020-30. PMID: 15899791
    • (2005) Cancer Res , vol.65 , pp. 4020-4030
    • Wang, H.1    Rosidi, B.2    Perrault, R.3    Wang, M.4    Zhang, L.5    Windhofer, F.6
  • 37
    • 79959814259 scopus 로고    scopus 로고
    • DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation
    • PMID: 21655080
    • Simsek D, Brunet E, Wong SY, Katyal S, Gao Y, McKinnon PJ, et al. DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet. 2011; 7: e1002080. doi: 10.1371/journal.pgen.1002080 PMID: 21655080
    • (2011) PLoS Genet , vol.7 , pp. e1002080
    • Simsek, D.1    Brunet, E.2    Wong, S.Y.3    Katyal, S.4    Gao, Y.5    McKinnon, P.J.6
  • 38
    • 38349008365 scopus 로고    scopus 로고
    • A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex
    • PMID: 18176557
    • Dupre A, Boyer-Chatenet L, Sattler RM, Modi AP, Lee JH, Nicolette ML, et al. A forward chemical genetic screen reveals an inhibitor of the Mre11-Rad50-Nbs1 complex. Nat Chem Biol. 2008; 4: 119-125. doi: 10.1038/nchembio.63 PMID: 18176557
    • (2008) Nat Chem Biol , vol.4 , pp. 119-125
    • Dupre, A.1    Boyer-Chatenet, L.2    Sattler, R.M.3    Modi, A.P.4    Lee, J.H.5    Nicolette, M.L.6
  • 39
    • 80053212145 scopus 로고    scopus 로고
    • Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway
    • PMID: 21816818
    • Della-Maria J, Zhou Y, Tsai MS, Kuhnlein J, Carney JP, Paull TT, et al. Human Mre11/human Rad50/Nbs1 and DNA ligase IIIalpha/XRCC1 protein complexes act together in an alternative nonhomologous end joining pathway. J Biol Chem; 286: 33845-53. doi: 10.1074/jbc.M111.274159 PMID: 21816818
    • J Biol Chem , vol.286 , pp. 33845-33853
    • Della-Maria, J.1    Zhou, Y.2    Tsai, M.S.3    Kuhnlein, J.4    Carney, J.P.5    Paull, T.T.6
  • 40
    • 33845657443 scopus 로고    scopus 로고
    • PARP-1 and ku compete for repair of DNA double strand breaks by distinct NHEJ pathways
    • PMID: 17088286
    • Wang M, Wu W, Rosidi B, Zhang L, Wang H, Iliakis G. PARP-1 and ku compete for repair of DNA double strand breaks by distinct NHEJ pathways. Nucleic Acids Res. 2006; 34: 6170-82. PMID: 17088286
    • (2006) Nucleic Acids Res , vol.34 , pp. 6170-6182
    • Wang, M.1    Wu, W.2    Rosidi, B.3    Zhang, L.4    Wang, H.5    Iliakis, G.6
  • 41
    • 84872500010 scopus 로고    scopus 로고
    • Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines
    • PMID: 23286905
    • Magin S, Saha J, Wang M, Mladenova V, Coym N, Iliakis G. Lipofection and nucleofection of substrate plasmid can generate widely different readings of DNA end-joining efficiency in different cell lines. DNA Repair (Amst). 2013; 12: 148-60. doi: 10.1016/j.dnarep.2012.11.008 PMID: 23286905
    • (2013) DNA Repair (Amst) , vol.12 , pp. 148-160
    • Magin, S.1    Saha, J.2    Wang, M.3    Mladenova, V.4    Coym, N.5    Iliakis, G.6
  • 42
    • 36949030242 scopus 로고    scopus 로고
    • DNA double-strand breaks: Their cellular and clinical impact?
    • PMID: 18066083
    • Jeggo PA, Lobrich M. DNA double-strand breaks: Their cellular and clinical impact? Oncogene. 2007; 26: 7717-9. PMID: 18066083
    • (2007) Oncogene , vol.26 , pp. 7717-7719
    • Jeggo, P.A.1    Lobrich, M.2
  • 43
    • 58149470357 scopus 로고    scopus 로고
    • Impaired NHEJ function in multiple myeloma
    • PMID: 19028508
    • Yang C, Betti C, Singh S, Toor A, Vaughan A. Impaired NHEJ function in multiple myeloma. Mutat Res. 2009; 660: 66-73. doi: 10.1016/j.mrfmmm.2008.10.019 PMID: 19028508
    • (2009) Mutat Res , vol.660 , pp. 66-73
    • Yang, C.1    Betti, C.2    Singh, S.3    Toor, A.4    Vaughan, A.5
  • 44
    • 59649124496 scopus 로고    scopus 로고
    • Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break
    • PMID: 19217407
    • Kalocsay M, Hiller NJ, Jentsch S. Chromosome-wide Rad51 spreading and SUMO-H2A.Z-dependent chromosome fixation in response to a persistent DNA double-strand break. Mol Cell. 2009; 33: 335-43. doi: 10.1016/j.molcel.2009.01.016 PMID: 19217407
    • (2009) Mol Cell , vol.33 , pp. 335-343
    • Kalocsay, M.1    Hiller, N.J.2    Jentsch, S.3
  • 45
    • 0036828213 scopus 로고    scopus 로고
    • Ku affects the CHK1-dependent G(2) checkpoint after ionizing radiation
    • PMID: 12414624
    • Wang X, Li GC, Iliakis G, Wang Y. Ku affects the CHK1-dependent G(2) checkpoint after ionizing radiation. Cancer research. 2002; 62: 6031-4. PMID: 12414624
    • (2002) Cancer Research , vol.62 , pp. 6031-6034
    • Wang, X.1    Li, G.C.2    Iliakis, G.3    Wang, Y.4
  • 46
    • 77949817210 scopus 로고    scopus 로고
    • Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma
    • PMID: 20148879
    • Roddam PL, Allan JM, Dring AM, Worrillow LJ, Davies FE, Morgan GJ. Non-homologous end-joining gene profiling reveals distinct expression patterns associated with lymphoma and multiple myeloma. Br J Haematol. 2010; 149: 258-62. doi: 10.1111/j.1365-2141.2010.08088.x PMID: 20148879
    • (2010) Br J Haematol , vol.149 , pp. 258-262
    • Roddam, P.L.1    Allan, J.M.2    Dring, A.M.3    Worrillow, L.J.4    Davies, F.E.5    Morgan, G.J.6
  • 47
    • 52449095058 scopus 로고    scopus 로고
    • DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia
    • PMID: 18559621
    • Willmore E, Elliott SL, Mainou-Fowler T, Summerfield GP, Jackson GH, O'Neill F, et al. DNA-dependent protein kinase is a therapeutic target and an indicator of poor prognosis in B-cell chronic lymphocytic leukemia. Clin Cancer Res. 2008; 14: 3984-92. doi: 10.1158/1078-0432.CCR-07-5158 PMID: 18559621
    • (2008) Clin Cancer Res , vol.14 , pp. 3984-3992
    • Willmore, E.1    Elliott, S.L.2    Mainou-Fowler, T.3    Summerfield, G.P.4    Jackson, G.H.5    O'Neill, F.6
  • 48
    • 0842329805 scopus 로고    scopus 로고
    • Rad51 overexpression promotes alternative doublestrand break repair pathways and genome instability
    • PMID: 14724582
    • Richardson C, Stark JM, Ommundsen M, Jasin M. Rad51 overexpression promotes alternative doublestrand break repair pathways and genome instability. Oncogene. 2004; 23: 546-53. PMID: 14724582
    • (2004) Oncogene , vol.23 , pp. 546-553
    • Richardson, C.1    Stark, J.M.2    Ommundsen, M.3    Jasin, M.4
  • 49
    • 34247626923 scopus 로고    scopus 로고
    • Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements
    • PMID: 17473170
    • Francis R, Richardson C. Multipotent hematopoietic cells susceptible to alternative double-strand break repair pathways that promote genome rearrangements. Genes Dev. 2007; 21: 1064-74. PMID: 17473170
    • (2007) Genes Dev , vol.21 , pp. 1064-1074
    • Francis, R.1    Richardson, C.2
  • 50
    • 30344461008 scopus 로고    scopus 로고
    • BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells
    • PMID: 16297667
    • Slupianek A, Nowicki MO, Koptyra M, Skorski T. BCR/ABL modifies the kinetics and fidelity of DNA double-strand breaks repair in hematopoietic cells. DNA Repair (Amst). 2006; 5: 243-50. PMID: 16297667
    • (2006) DNA Repair (Amst) , vol.5 , pp. 243-250
    • Slupianek, A.1    Nowicki, M.O.2    Koptyra, M.3    Skorski, T.4
  • 51
    • 63849240546 scopus 로고    scopus 로고
    • Dysfunctional homologous recombination mediates genomic instability and progression in myeloma
    • PMID: 19050310
    • Shammas MA, Shmookler Reis RJ, Koley H, Batchu RB, Li C, Munshi NC. Dysfunctional homologous recombination mediates genomic instability and progression in myeloma. Blood. 2009; 113: 2290-7. doi: 10.1182/blood-2007-05-089193 PMID: 19050310
    • (2009) Blood , vol.113 , pp. 2290-2297
    • Shammas, M.A.1    Shmookler Reis, R.J.2    Koley, H.3    Batchu, R.B.4    Li, C.5    Munshi, N.C.6
  • 52
    • 78650047888 scopus 로고    scopus 로고
    • Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: Implications for genomic instability and therapy
    • PMID: 20807885
    • Fan J, Li L, Small D, Rassool F. Cells expressing FLT3/ITD mutations exhibit elevated repair errors generated through alternative NHEJ pathways: Implications for genomic instability and therapy. Blood. 2010; 116: 5298-305. doi: 10.1182/blood-2010-03-272591 PMID: 20807885
    • (2010) Blood , vol.116 , pp. 5298-5305
    • Fan, J.1    Li, L.2    Small, D.3    Rassool, F.4
  • 53
    • 78449286445 scopus 로고    scopus 로고
    • Tumor cell kill by c-MYC depletion: Role of MYC-regulated genes that control DNA double-strand break repair
    • PMID: 20940401
    • Luoto KR, Meng AX, Wasylishen AR, Zhao H, Coackley CL, Penn LZ, et al. Tumor cell kill by c-MYC depletion: Role of MYC-regulated genes that control DNA double-strand break repair. Cancer Res. 2010; 70: 8748-59. doi: 10.1158/0008-5472.CAN-10-0944 PMID: 20940401
    • (2010) Cancer Res , vol.70 , pp. 8748-8759
    • Luoto, K.R.1    Meng, A.X.2    Wasylishen, A.R.3    Zhao, H.4    Coackley, C.L.5    Penn, L.Z.6
  • 54
    • 84855285493 scopus 로고    scopus 로고
    • NF-kappaB regulates DNA doublestrand break repair in conjunction with BRCA1-CtIP complexes
    • PMID: 21908405
    • Volcic M, Karl S, Baumann B, Salles D, Daniel P, Fulda S, et al. NF-kappaB regulates DNA doublestrand break repair in conjunction with BRCA1-CtIP complexes. Nucleic Acids Res. 2012; 40: 181-95. doi: 10.1093/nar/gkr687 PMID: 21908405
    • (2012) Nucleic Acids Res , vol.40 , pp. 181-195
    • Volcic, M.1    Karl, S.2    Baumann, B.3    Salles, D.4    Daniel, P.5    Fulda, S.6
  • 55
    • 84901042047 scopus 로고    scopus 로고
    • Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy
    • PMID: 24505083
    • Hahnel PS, Enders B, Sasca D, Roos WP, Kaina B, Bullinger L, et al. Targeting components of the alternative NHEJ pathway sensitizes KRAS mutant leukemic cells to chemotherapy. Blood. 2014; 123: 2355-66. doi: 10.1182/blood-2013-01-477620 PMID: 24505083
    • (2014) Blood , vol.123 , pp. 2355-2366
    • Hahnel, P.S.1    Enders, B.2    Sasca, D.3    Roos, W.P.4    Kaina, B.5    Bullinger, L.6
  • 56
    • 84876130803 scopus 로고    scopus 로고
    • Targeting abnormal DNA dou-ble- strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias
    • PMID: 22641215
    • Tobin LA, Robert C, Rapoport AP, Gojo I, Baer MR, Tomkinson AE, et al. Targeting abnormal DNA dou-ble- strand break repair in tyrosine kinase inhibitor-resistant chronic myeloid leukemias. Oncogene. 2012; 32: 1784-93. doi: 10.1038/onc.2012.203 PMID: 22641215
    • (2012) Oncogene , vol.32 , pp. 1784-1793
    • Tobin, L.A.1    Robert, C.2    Rapoport, A.P.3    Gojo, I.4    Baer, M.R.5    Tomkinson, A.E.6
  • 57
    • 79955720082 scopus 로고    scopus 로고
    • Anticancer therapy with checkpoint inhibitors: What, where and when?
    • PMID: 21458083
    • Garrett MD, Collins I. Anticancer therapy with checkpoint inhibitors: What, where and when? Trends Pharmacol Sci. 2011; 32: 308-16. doi: 10.1016/j.tips.2011.02.014 PMID: 21458083
    • (2011) Trends Pharmacol Sci , vol.32 , pp. 308-316
    • Garrett, M.D.1    Collins, I.2


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.