메뉴 건너뛰기




Volumn 101, Issue 1, 2011, Pages 18-23

Retention of γh2AX foci as an indication of lethal DNA damage

Author keywords

H2AX; DNA damage; Prediction; Tumour response

Indexed keywords

CISPLATIN; DNA; DOUBLE STRANDED DNA; FORMALDEHYDE; GAMMA HISTONE H2AX; HISTONE H2AX; PARAFFIN; UNCLASSIFIED DRUG;

EID: 80655127835     PISSN: 01678140     EISSN: 18790887     Source Type: Journal    
DOI: 10.1016/j.radonc.2011.05.055     Document Type: Review
Times cited : (67)

References (57)
  • 1
    • 70349574111 scopus 로고    scopus 로고
    • Predicting the response of advanced cervical and ovarian tumors to therapy
    • V.N. Harry, F.J. Gilbert, and D.E. Parkin Predicting the response of advanced cervical and ovarian tumors to therapy Obstet Gynecol Surv 64 2009 548 560
    • (2009) Obstet Gynecol Surv , vol.64 , pp. 548-560
    • Harry, V.N.1    Gilbert, F.J.2    Parkin, D.E.3
  • 3
    • 0018867219 scopus 로고
    • Can tumour response be assessed from a biopsy?
    • K.R. Trott Can tumour response be assessed from a biopsy? Br J Cancer Suppl 4 1980 163 170 (Pubitemid 10047892)
    • (1980) British Journal of Cancer , vol.41 , Issue.SUPPL. 4 , pp. 163-170
    • Trott, K.R.1
  • 4
    • 80655148448 scopus 로고
    • The qualitative and quantitative histological examination of biopsy material from patients treated by radiation for carcinoma of the cervix uteri
    • A. Glucksmann, and F.G. Spear The qualitative and quantitative histological examination of biopsy material from patients treated by radiation for carcinoma of the cervix uteri Br J Radiol 18 1945 313 322
    • (1945) Br J Radiol , vol.18 , pp. 313-322
    • Glucksmann, A.1    Spear, F.G.2
  • 5
    • 49649118620 scopus 로고    scopus 로고
    • Predicting response to clinical radiotherapy: Past, present, and future directions
    • J.F. Torres-Roca, and C.W. Stevens Predicting response to clinical radiotherapy: past, present, and future directions Cancer Control 15 2008 151 156
    • (2008) Cancer Control , vol.15 , pp. 151-156
    • Torres-Roca, J.F.1    Stevens, C.W.2
  • 6
    • 77955709497 scopus 로고    scopus 로고
    • The ESTRO Breur Lecture 2009. from population to voxel-based radiotherapy: Exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer
    • P. Lambin, S.F. Petit, and H.J. Aerts The ESTRO Breur Lecture 2009. From population to voxel-based radiotherapy: exploiting intra-tumour and intra-organ heterogeneity for advanced treatment of non-small cell lung cancer Radiother Oncol 96 2010 145 152
    • (2010) Radiother Oncol , vol.96 , pp. 145-152
    • Lambin, P.1    Petit, S.F.2    Aerts, H.J.3
  • 7
    • 69949115144 scopus 로고    scopus 로고
    • Molecular radiation biology: Perspectives for radiation oncology
    • H.P. Rodemann Molecular radiation biology: perspectives for radiation oncology Radiother Oncol 92 2009 293 298
    • (2009) Radiother Oncol , vol.92 , pp. 293-298
    • Rodemann, H.P.1
  • 8
    • 27844576828 scopus 로고    scopus 로고
    • Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity
    • DOI 10.1080/09553000500140498
    • U. Kasten-Pisula, H. Tastan, and E. Dikomey Huge differences in cellular radiosensitivity due to only very small variations in double-strand break repair capacity Int J Radiat Biol 81 2005 409 419 (Pubitemid 41657557)
    • (2005) International Journal of Radiation Biology , vol.81 , Issue.6 , pp. 409-419
    • Kasten-Pisula, U.1    Tastan, H.2    Dikomey, E.3
  • 9
    • 0031777393 scopus 로고    scopus 로고
    • The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks
    • DOI 10.1016/S0167-8140(97)00200-4, PII S0167814097002004
    • P.K. Zhou, A.R. Sproston, B. Marples, C.M. West, G.P. Margison, and J.H. Hendry The radiosensitivity of human fibroblast cell lines correlates with residual levels of DNA double-strand breaks Radiother Oncol 47 1998 271 276 (Pubitemid 28293648)
    • (1998) Radiotherapy and Oncology , vol.47 , Issue.3 , pp. 271-276
    • Zhou, P.-K.1    Sproston, A.R.M.2    Marples, B.3    West, C.M.L.4    Margison, G.P.5    Hendry, J.H.6
  • 10
    • 0032861343 scopus 로고    scopus 로고
    • Megabase chromatin domains involved in DNA double-strand breaks in vivo
    • E.P. Rogakou, C. Boon, C. Redon, and W.M. Bonner Megabase chromatin domains involved in DNA double-strand breaks In vivo J Cell Biol 146 1999 905 916
    • (1999) J Cell Biol , vol.146 , pp. 905-916
    • Rogakou, E.P.1    Boon, C.2    Redon, C.3    Bonner, W.M.4
  • 12
    • 78649503031 scopus 로고    scopus 로고
    • The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates
    • C.E. Redon, A.J. Nakamura, K. Gouliaeva, A. Rahman, W.F. Blakely, and W.M. Bonner The use of gamma-H2AX as a biodosimeter for total-body radiation exposure in non-human primates PLoS ONE 5 2010 e15544
    • (2010) PLoS ONE , vol.5 , pp. 15544
    • Redon, C.E.1    Nakamura, A.J.2    Gouliaeva, K.3    Rahman, A.4    Blakely, W.F.5    Bonner, W.M.6
  • 14
    • 78649450619 scopus 로고    scopus 로고
    • Assembly and function of DNA double-strand break repair foci in mammalian cells
    • S. Bekker-Jensen, and N. Mailand Assembly and function of DNA double-strand break repair foci in mammalian cells DNA Repair (Amst) 9 2010 1219 1228
    • (2010) DNA Repair (Amst) , vol.9 , pp. 1219-1228
    • Bekker-Jensen, S.1    Mailand, N.2
  • 15
    • 0037981413 scopus 로고    scopus 로고
    • 1-phase cells
    • DOI 10.1667/RR3003
    • S.H. MacPhail, J.P. Banath, Y. Yu, E. Chu, and P.L. Olive Cell cycle-dependent expression of phosphorylated histone H2AX: Reduced expression in unirradiated but not X-Irradiated G(1)-phase cells Radiat Res 159 2003 759 767 (Pubitemid 36676868)
    • (2003) Radiation Research , vol.159 , Issue.6 , pp. 759-767
    • MacPhail, S.H.1    Banath, J.P.2    Yu, Y.3    Chu, E.4    Olive, P.L.5
  • 16
    • 4944234150 scopus 로고    scopus 로고
    • Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines
    • DOI 10.1158/0008-5472.CAN-04-1433
    • J.P. Banath, S.H. MacPhail, and P.L. Olive Radiation sensitivity, H2AX phosphorylation, and kinetics of repair of DNA strand breaks in irradiated cervical cancer cell lines Cancer Res 64 2004 7144 7149 (Pubitemid 39331029)
    • (2004) Cancer Research , vol.64 , Issue.19 , pp. 7144-7149
    • Banath, J.P.1    MacPhail, S.H.2    Olive, P.L.3
  • 17
    • 0033659850 scopus 로고    scopus 로고
    • Computerized video time-lapse analysis of apoptosis of REC:Myc cells X-irradiated in different phases of the cell cycle
    • H.B. Forrester, N. Albright, C.C. Ling, and W.C. Dewey Computerized video time-lapse analysis of apoptosis of REC:Myc cells X-irradiated in different phases of the cell cycle Radiat Res 154 2000 625 639
    • (2000) Radiat Res , vol.154 , pp. 625-639
    • Forrester, H.B.1    Albright, N.2    Ling, C.C.3    Dewey, W.C.4
  • 18
    • 0021249583 scopus 로고
    • Interpretation of the shape of survival curves in terms of induction and repair/misrepair of DNA double-strand breaks
    • D. Frankenberg, M. Frankenberg-Schwager, and R. Harbich Interpretation of the shape of survival curves in terms of induction and repair/misrepair of DNA double-strand breaks Br J Cancer Suppl 6 1984 233 238 (Pubitemid 14132000)
    • (1984) British Journal of Cancer , vol.49 , Issue.SUPPL. 6 , pp. 233-238
    • Frankenberg, D.1    Frankenberg-Schwager, M.2    Harbich, R.3
  • 19
    • 40249086612 scopus 로고    scopus 로고
    • Residual γH2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy
    • DOI 10.1016/j.radonc.2007.09.002, PII S0167814007004550
    • P.L. Olive, J.P. Banath, and M. Keyes Residual gammaH2AX after irradiation of human lymphocytes and monocytes in vitro and its relation to late effects after prostate brachytherapy Radiother Oncol 86 2008 336 346 (Pubitemid 351335443)
    • (2008) Radiotherapy and Oncology , vol.86 , Issue.3 , pp. 336-346
    • Olive, P.L.1    Banath, J.P.2    Keyes, M.3
  • 20
    • 33748087488 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays
    • DOI 10.1016/j.radonc.2006.07.026, PII S0167814006003057, Papers from ICTR 2006. International Conference on Transtational Research and Pre-Clinical Stratigies in Rediation Oncology
    • D. Klokov, S.M. Macphail, J.P. Banath, J.P. Byrne, and P.L. Olive Phosphorylated histone H2AX in relation to cell survival in tumor cells and xenografts exposed to single and fractionated doses of X-rays Radiother Oncol 80 2006 223 229 (Pubitemid 44301540)
    • (2006) Radiotherapy and Oncology , vol.80 , Issue.2 , pp. 223-229
    • Klokov, D.1    MacPhail, S.M.2    Banath, J.P.3    Byrne, J.P.4    Olive, P.L.5
  • 21
    • 66149190689 scopus 로고    scopus 로고
    • {gamma}H2AX expression in tumors exposed to cisplatin and fractionated Irradiation
    • C.A. Banuelos, J.P. Banath, J.Y. Kim, C. Aquino-Parsons, and P.L. Olive {gamma}H2AX expression in tumors exposed to cisplatin and fractionated Irradiation Clin Cancer Res 15 2009 3344 3353
    • (2009) Clin Cancer Res , vol.15 , pp. 3344-3353
    • Banuelos, C.A.1    Banath, J.P.2    Kim, J.Y.3    Aquino-Parsons, C.4    Olive, P.L.5
  • 22
    • 64549100748 scopus 로고    scopus 로고
    • Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis
    • T.A. Kato, R. Okayasu, and J.S. Bedford Signatures of DNA double strand breaks produced in irradiated G1 and G2 cells persist into mitosis J Cell Physiol 219 2009 760 765
    • (2009) J Cell Physiol , vol.219 , pp. 760-765
    • Kato, T.A.1    Okayasu, R.2    Bedford, J.S.3
  • 23
    • 33748472075 scopus 로고    scopus 로고
    • Levels of γ-H2AX foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two AT families and in another apparently normal individual
    • DOI 10.1667/RR3604.1
    • T.A. Kato, H. Nagasawa, M.M. Weil, J.B. Little, and J.S. Bedford Levels of gamma-H2AX Foci after low-dose-rate irradiation reveal a DNA DSB rejoining defect in cells from human ATM heterozygotes in two at families and in another apparently normal individual Radiat Res 166 2006 443 453 (Pubitemid 44353427)
    • (2006) Radiation Research , vol.166 , Issue.3 , pp. 443-453
    • Kato, T.A.1    Nagasawa, H.2    Weil, M.M.3    Little, J.B.4    Bedford, J.S.5
  • 24
    • 1642556817 scopus 로고    scopus 로고
    • A Double-Strand Break Repair Defect in ATM-Deficient Cells Contributes to Radiosensitivity
    • DOI 10.1158/0008-5472.CAN-03-2384
    • M. Kuhne, E. Riballo, N. Rief, K. Rothkamm, P.A. Jeggo, and M. Lobrich A double-strand break repair defect in ATM-deficient cells contributes to radiosensitivity Cancer Res 64 2004 500 508 (Pubitemid 38120888)
    • (2004) Cancer Research , vol.64 , Issue.2 , pp. 500-508
    • Kuhne, M.1    Riballo, E.2    Rief, N.3    Rothkamm, K.4    Jeggo, P.A.5    Lobrich, M.6
  • 25
    • 70350378199 scopus 로고    scopus 로고
    • Variations in radiosensitivity among individuals: A potential impact on risk assessment?
    • T.A. Kato, P.F. Wilson, and H. Nagasaw Variations in radiosensitivity among individuals: a potential impact on risk assessment? Health Phys 97 2009 470 480
    • (2009) Health Phys , vol.97 , pp. 470-480
    • Kato, T.A.1    Wilson, P.F.2    Nagasaw, H.3
  • 26
    • 67349217443 scopus 로고    scopus 로고
    • Two-tier analysis of histone H2AX phosphorylation allows the identification of Ataxia Telangiectasia heterozygotes
    • P. Porcedda, V. Turinetto, and L. Orlando Two-tier analysis of histone H2AX phosphorylation allows the identification of Ataxia Telangiectasia heterozygotes Radiother Oncol 92 2009 133 137
    • (2009) Radiother Oncol , vol.92 , pp. 133-137
    • Porcedda, P.1    Turinetto, V.2    Orlando, L.3
  • 27
    • 77953166592 scopus 로고    scopus 로고
    • GammaH2AX foci analysis for monitoring DNA double-strand break repair: Strengths, limitations and optimization
    • M. Lobrich, A. Shibata, and A. Beucher GammaH2AX foci analysis for monitoring DNA double-strand break repair: strengths, limitations and optimization Cell Cycle 9 2010 662 669
    • (2010) Cell Cycle , vol.9 , pp. 662-669
    • Lobrich, M.1    Shibata, A.2    Beucher, A.3
  • 28
    • 33644547006 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation
    • M. Suzuki, K. Suzuki, S. Kodama, and M. Watanabe Phosphorylated histone H2AX foci persist on rejoined mitotic chromosomes in normal human diploid cells exposed to ionizing radiation Radiat Res 165 2006 269 276
    • (2006) Radiat Res , vol.165 , pp. 269-276
    • Suzuki, M.1    Suzuki, K.2    Kodama, S.3    Watanabe, M.4
  • 29
    • 0019051831 scopus 로고
    • The frequency of micronuclei as a measure of cell survival in irradiated cell populations
    • J. Midander, and L. Revesz The frequency of micronuclei as a measure of cell survival in irradiated cell populations Int J Radiat Biol Relat Stud Phys Chem Med 38 1980 237 242
    • (1980) Int J Radiat Biol Relat Stud Phys Chem Med , vol.38 , pp. 237-242
    • Midander, J.1    Revesz, L.2
  • 30
    • 35548941091 scopus 로고    scopus 로고
    • Phosphorylation of histone H2AX in radiation-induced micronuclei
    • DOI 10.1667/RR0788.1
    • N.G. Medvedeva, I.V. Panyutin, I.G. Panyutin, and R.D. Neumann Phosphorylation of histone H2AX in radiation-induced micronuclei Radiat Res 168 2007 493 498 (Pubitemid 351303177)
    • (2007) Radiation Research , vol.168 , Issue.4 , pp. 493-498
    • Medvedeva, N.G.1    Panyutin, I.V.2    Panyutin, I.G.3    Neumann, R.D.4
  • 31
    • 0034737439 scopus 로고    scopus 로고
    • Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139
    • DOI 10.1074/jbc.275.13.9390
    • E.P. Rogakou, W. Nieves-Neira, C. Boon, Y. Pommier, and W.M. Bonner Initiation of DNA fragmentation during apoptosis induces phosphorylation of H2AX histone at serine 139 J Biol Chem 275 2000 9390 9395 (Pubitemid 30185164)
    • (2000) Journal of Biological Chemistry , vol.275 , Issue.13 , pp. 9390-9395
    • Rogakou, E.P.1    Nieves-Neira, W.2    Boon, C.3    Pommier, Y.4    Bonner, W.M.5
  • 32
    • 1642602686 scopus 로고    scopus 로고
    • Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks
    • DOI 10.1038/ncb1095
    • O.A. Sedelnikova, I. Horikawa, D.B. Zimonjic, N.C. Popescu, W.M. Bonner, and J.C. Barrett Senescing human cells and ageing mice accumulate DNA lesions with unrepairable double-strand breaks Nat Cell Biol 6 2004 168 170 (Pubitemid 38425717)
    • (2004) Nature Cell Biology , vol.6 , Issue.2 , pp. 168-170
    • Sedelnikova, O.A.1    Horikawa, I.2    Zimonjic, D.B.3    Popescu, N.C.4    Bonner, W.M.5    Barrett, J.C.6
  • 34
    • 70449507033 scopus 로고    scopus 로고
    • Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining
    • A. Menegakis, A. Yaromina, and W. Eicheler Prediction of clonogenic cell survival curves based on the number of residual DNA double strand breaks measured by gammaH2AX staining Int J Radiat Biol 85 2009 1032 1041
    • (2009) Int J Radiat Biol , vol.85 , pp. 1032-1041
    • Menegakis, A.1    Yaromina, A.2    Eicheler, W.3
  • 35
    • 59649090207 scopus 로고    scopus 로고
    • The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair
    • U. Kasten-Pisula, A. Menegakis, and I. Brammer The extreme radiosensitivity of the squamous cell carcinoma SKX is due to a defect in double-strand break repair Radiother Oncol 90 2009 257 264
    • (2009) Radiother Oncol , vol.90 , pp. 257-264
    • Kasten-Pisula, U.1    Menegakis, A.2    Brammer, I.3
  • 36
    • 64949127802 scopus 로고    scopus 로고
    • Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities
    • T. Yoshikawa, G. Kashino, K. Ono, and M. Watanabe Phosphorylated H2AX foci in tumor cells have no correlation with their radiation sensitivities J Radiat Res (Tokyo) 50 2009 151 160
    • (2009) J Radiat Res (Tokyo) , vol.50 , pp. 151-160
    • Yoshikawa, T.1    Kashino, G.2    Ono, K.3    Watanabe, M.4
  • 37
    • 30544450198 scopus 로고    scopus 로고
    • Radiation induced DNA damage and damage repair in human tumor and fibroblast cell lines assessed by histone H2AX phosphorylation
    • DOI 10.1016/j.ijrobp.2005.09.037, PII S0360301605027239
    • H. Mahrhofer, S. Burger, U. Oppitz, M. Flentje, and C.S. Djuzenova Radiation induced DNA damage and damage repair in human tumor and fibroblast cell lines assessed by histone H2AX phosphorylation Int J Radiat Oncol Biol Phys 64 2006 573 580 (Pubitemid 43083447)
    • (2006) International Journal of Radiation Oncology Biology Physics , vol.64 , Issue.2 , pp. 573-580
    • Mahrhofer, H.1    Burger, S.2    Oppitz, U.3    Flentje, M.4    Djuzenova, C.S.5
  • 38
    • 17444402057 scopus 로고    scopus 로고
    • Targeting of Rad51-dependent homologous recombination: Implications for the radiation sensitivity of human lung cancer cell lines
    • DOI 10.1038/sj.bjc.6602457
    • A. Sak, G. Stueben, M. Groneberg, W. Bocker, and M. Stuschke Targeting of Rad51-dependent homologous recombination: implications for the radiation sensitivity of human lung cancer cell lines Br J Cancer 92 2005 1089 1097 (Pubitemid 40546674)
    • (2005) British Journal of Cancer , vol.92 , Issue.6 , pp. 1089-1097
    • Sak, A.1    Stueben, G.2    Groneberg, M.3    Bocker, W.4    Stuschke, M.5
  • 41
    • 33746721468 scopus 로고    scopus 로고
    • Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability
    • DOI 10.1016/j.dnarep.2006.05.040, PII S1568786406001790
    • T. Yu, S.H. MacPhail, J.P. Banath, D. Klokov, and P.L. Olive Endogenous expression of phosphorylated histone H2AX in tumors in relation to DNA double-strand breaks and genomic instability DNA Repair (Amst) 5 2006 935 946 (Pubitemid 44160591)
    • (2006) DNA Repair , vol.5 , Issue.8 , pp. 935-946
    • Yu, T.1    MacPhail, S.H.2    Banath, J.P.3    Klokov, D.4    Olive, P.L.5
  • 42
    • 0343280013 scopus 로고    scopus 로고
    • A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage
    • DOI 10.1016/S0960-9822(00)00610-2
    • T.T. Paull, E.P. Rogakou, V. Yamazaki, C.U. Kirchgessner, M. Gellert, and W.M. Bonner A critical role for histone H2AX in recruitment of repair factors to nuclear foci after DNA damage Curr Biol 10 2000 886 895 (Pubitemid 30647617)
    • (2000) Current Biology , vol.10 , Issue.15 , pp. 886-895
    • Paull, T.T.1    Rogakou, E.P.2    Yamazaki, V.3    Kirchgessner, C.U.4    Gellert, M.5    Bonner, W.M.6
  • 43
    • 16844370883 scopus 로고    scopus 로고
    • Melanoma cells express elevated levels of phosphorylated histone H2AX foci
    • DOI 10.1111/j.0022-202X.2005.23674.x
    • R.L. Warters, P.J. Adamson, C.D. Pond, and S.A. Leachman Melanoma cells express elevated levels of phosphorylated histone H2AX foci J Invest Dermatol 124 2005 807 817 (Pubitemid 40489509)
    • (2005) Journal of Investigative Dermatology , vol.124 , Issue.4 , pp. 807-817
    • Warters, R.L.1    Adamson, P.J.2    Pond, C.D.3    Leachman, S.A.4
  • 44
    • 77951976271 scopus 로고    scopus 로고
    • Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells
    • A.J. Nakamura, C.E. Redon, W.M. Bonner, and O.A. Sedelnikova Telomere-dependent and telomere-independent origins of endogenous DNA damage in tumor cells Aging (Albany. NY) 1 2009 212 218
    • (2009) Aging (Albany. NY) , vol.1 , pp. 212-218
    • Nakamura, A.J.1    Redon, C.E.2    Bonner, W.M.3    Sedelnikova, O.A.4
  • 45
    • 77956627442 scopus 로고    scopus 로고
    • Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas
    • J. Bartkova, P. Hamerlik, and M.T. Stockhausen Replication stress and oxidative damage contribute to aberrant constitutive activation of DNA damage signalling in human gliomas Oncogene 29 2010 5095 5102
    • (2010) Oncogene , vol.29 , pp. 5095-5102
    • Bartkova, J.1    Hamerlik, P.2    Stockhausen, M.T.3
  • 46
    • 64349094838 scopus 로고    scopus 로고
    • Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells
    • J.P. Banath, C.A. Banuelos, D. Klokov, S.M. Macphail, P.M. Lansdorp, and P.L. Olive Explanation for excessive DNA single-strand breaks and endogenous repair foci in pluripotent mouse embryonic stem cells Exp Cell Res 315 2009 1505 1520
    • (2009) Exp Cell Res , vol.315 , pp. 1505-1520
    • Banath, J.P.1    Banuelos, C.A.2    Klokov, D.3    MacPhail, S.M.4    Lansdorp, P.M.5    Olive, P.L.6
  • 48
    • 74549209655 scopus 로고    scopus 로고
    • Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix
    • P.L. Olive, C.A. Banuelos, R.E. Durand, J.Y. Kim, and C. Aquino-Parsons Endogenous and radiation-induced expression of gammaH2AX in biopsies from patients treated for carcinoma of the uterine cervix Radiother Oncol 94 2010 82 89
    • (2010) Radiother Oncol , vol.94 , pp. 82-89
    • Olive, P.L.1    Banuelos, C.A.2    Durand, R.E.3    Kim, J.Y.4    Aquino-Parsons, C.5
  • 49
    • 39749114978 scopus 로고    scopus 로고
    • Hypoxia and metabolism: Hypoxia, DNA repair and genetic instability
    • DOI 10.1038/nrc2344, PII NRC2344
    • R.G. Bristow, and R.P. Hill Hypoxia and metabolism. Hypoxia, DNA repair and genetic instability Nat Rev Cancer 8 2008 180 192 (Pubitemid 351301853)
    • (2008) Nature Reviews Cancer , vol.8 , Issue.3 , pp. 180-192
    • Bristow, R.G.1    Hill, R.P.2
  • 50
    • 59349089679 scopus 로고    scopus 로고
    • Phosphorylated H2AX in noninvasive low grade urothelial carcinoma of the bladder: Correlation with tumor recurrence
    • W.L. Cheung, R. Albadine, T. Chan, R. Sharma, and G.J. Netto Phosphorylated H2AX in noninvasive low grade urothelial carcinoma of the bladder: correlation with tumor recurrence J Urol 181 2009 1387 1392
    • (2009) J Urol , vol.181 , pp. 1387-1392
    • Cheung, W.L.1    Albadine, R.2    Chan, T.3    Sharma, R.4    Netto, G.J.5
  • 51
    • 66249084554 scopus 로고    scopus 로고
    • Kinetics of H2AX phosphorylation after exposure to cisplatin
    • P.L. Olive, and J.P. Banath Kinetics of H2AX phosphorylation after exposure to cisplatin Cytometry B Clin Cytom 76 2009 79 90
    • (2009) Cytometry B Clin Cytom , vol.76 , pp. 79-90
    • Olive, P.L.1    Banath, J.P.2
  • 53
    • 0031306970 scopus 로고    scopus 로고
    • DNA damage from oxidants: Influence of lesion complexity and chromatin organization
    • P.L. Olive, and P.J. Johnston DNA damage from oxidants: influence of lesion complexity and chromatin organization Oncol Res 9 1997 287 294 (Pubitemid 127825982)
    • (1997) Oncology Research , vol.9 , Issue.6-7 , pp. 287-294
    • Olive, P.L.1    Johnston, P.J.2
  • 54
    • 3442889371 scopus 로고    scopus 로고
    • Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1,2,4-benzotriazine-1,3-dioxide
    • DOI 10.1158/0008-5472.CAN-04-0729
    • P.L. Olive, J.P. Banath, and L.T. Sinnott Phosphorylated histone H2AX in spheroids, tumors, and tissues of mice exposed to etoposide and 3-amino-1, 2, 4-benzotriazine-1, 3-dioxide Cancer Res 64 2004 5363 5369 (Pubitemid 39006557)
    • (2004) Cancer Research , vol.64 , Issue.15 , pp. 5363-5369
    • Olive, P.L.1    Banath, J.P.2    Sinnott, L.T.3
  • 55
    • 0345835371 scopus 로고    scopus 로고
    • Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks
    • J.P. Banath, and P.L. Olive Expression of phosphorylated histone H2AX as a surrogate of cell killing by drugs that create DNA double-strand breaks Cancer Res 63 2003 4347 4350 (Pubitemid 36951002)
    • (2003) Cancer Research , vol.63 , Issue.15 , pp. 4347-4350
    • Banath, J.P.1    Olive, P.L.2
  • 56
    • 78349238215 scopus 로고    scopus 로고
    • Development of a validated immunofluorescence assay for gammaH2AX as a pharmacodynamic marker of topoisomerase i inhibitor activity
    • R.J. Kinders, M. Hollingshead, and S. Lawrence Development of a validated immunofluorescence assay for gammaH2AX as a pharmacodynamic marker of topoisomerase I inhibitor activity Clin Cancer Res 16 2010 5447 5457
    • (2010) Clin Cancer Res , vol.16 , pp. 5447-5457
    • Kinders, R.J.1    Hollingshead, M.2    Lawrence, S.3
  • 57
    • 0025305031 scopus 로고
    • The ESTRO Regaud lecture. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response
    • L.J. Peters The ESTRO Regaud lecture. Inherent radiosensitivity of tumor and normal tissue cells as a predictor of human tumor response. Radiother Oncol 17 1990 177 190 (Pubitemid 20110265)
    • (1990) Radiotherapy and Oncology , vol.17 , Issue.3 , pp. 177-190
    • Peters, L.J.1


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.