Genetics of weight loss: A basis for personalized obesity management

Trends in Food Science and Technology

Volumn 42, Issue 2, 2015, Pages 97-115

  Martínez, J Alfredo ^a,b   Milagro, Fermin I ^a,b  

^a UNIVERSITY OF NAVARRA   (Spain)

^b INSTITUTO DE SALUD CARLOS III   (Spain)

Author keywords

[No Author keywords available]

Indexed keywords

BIOTECHNOLOGY; FOOD TECHNOLOGY;

BODY WEIGHT; GENETIC MAKE-UP; GENOME-WIDE ASSOCIATION; PHENOTYPIC TRAITS; SINGLE NUCLEOTIDE POLYMORPHISMS; SYSTEMATIC REVIEW; WEIGHT LOSS;

NUTRITION;

EID: 84925343385     PISSN: 09242244     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tifs.2014.12.007     Document Type: Review

References (136)

1. Aberle J., Evans D., Beil F.U., Seedorf U. A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet. Clinical Genetics 2005, 68:152-154.
2. Aberle J., Flitsch J., Beck N.A., Mann O., Busch P., Peitsmeier P., et al. Genetic variation may influence obesity only under conditions of diet: analysis of three candidate genes. Molecular Genetics and Metabolism 2008, 95:188-191.
3. Abete I., Goyenechea E., Crujeiras A.B., Martínez J.A. Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers. Archives of Medical Research 2009, 40:306-310.
4. Abete I., Goyenechea E., Zulet M.A., Martínez J.A. Obesity and metabolic syndrome: potential benefit from specific nutritional components. Nutrition, Metabolism & Cardiovascular Diseases 2011, 21:B1-B15.
5. Abete I., Navas-Carretero S., Marti A., Martinez J.A. Nutrigenetics and nutrigenomics of caloric restriction. Progress in Molecular Biology and Translational Science 2012, 108:323-346.
6. Adamo K.B., Dent R., Langefeld C.D., Cox M., Williams K., Carrick K.M., et al. Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response. Obesity 2007, 15:1068-1075.
7. Arkadianos I., Valdes A.M., Marinos E., Florou A., Gill R.D., Grimaldi K.A. Improved weight management using genetic information to personalize a calorie controlled diet. Nutrition Journal 2007, 6:29.
8. Bell C.G., Walley A.J., Froguel P. The genetics of human obesity. Nature Reviews Genetics 2005, 6:221-234.
9. Belsky D.W., Moffitt T.E., Sugden K., Williams B., Houts R., McCarthy J., et al. Development and evaluation of a genetic risk score for obesity. Biodemography and Social Biology 2013, 59:85-100.
10. Benecke H., Topak H., von zur Mühle A., Schuppert F. A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors. Experimental and Clinical Endocrinology & Diabetes 2000, 108:86-92.
11. Bloss C.S., Schork N.J., Topol E.J. Effect of direct-to-consumer genome-wide profiling to assess disease risk. New England Journal of Medicine 2011, 364:524-534.
12. Bouchard C., Ordovas J.M. Fundamentals of nutrigenetics and nutrigenomics. Progress in Molecular Biology and Translational Science 2012, 108:1-15.
13. Cameron J.D., Riou M. È., Tesson F., Goldfield G.S., Rabasa-Lhoret R., Brochu M., et al. The TaqIA RFLP is associated with attenuated intervention-induced body weight loss and increased carbohydrate intake in post-menopausal obese women. Appetite 2013, 60:111-116.
14. Cha M.H., Shin H.D., Kim K.S., Lee B.H., Yoon Y. The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects. Metabolism 2006, 55:578-586.
15. Corella D., Qi L., Sorlí J.V., Godoy D., Portolés O., Coltell O., et al. Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. Journal of Clinical Endocrinology and Metabolism 2005, 90:5121-5126.
16. Curti M.L., Rogero M.M., Baltar V.T., Barros C.R., Siqueira-Catania A., Ferreira S.R. FTO T/A and peroxisome proliferator-activated receptor-γ Pro12Ala polymorphisms but not ApoA1-75 are associated with better response to lifestyle intervention in Brazilians at high cardiometabolic risk. Metabolic Syndrome and Related Disorders 2013, 11:169-176.
17. Dauncey M.J. Recent advances in nutrition, genes and brain health. Proceedings of the Nutrition Society 2012, 71:581-591.
18. De Caterina R. Opportunities and challenges in nutrigenetics/nutrigenomics and health. World Review of Nutrition and Dietetics 2010, 101:1-7.
19. De Luis D.A., Aller R., Conde R., Izaola O., Sagrado M.G., Castrodeza Sanz J. The rs9939609 gene variant in FTO modified the metabolic response of weight loss after a 3-month intervention with a hypocaloric diet. Journal of Investigative Medicine 2013, 61:22-26.
20. De Luis D., Aller R., Izaola O., Conde R., de la Fuente B., Sagrado M.G. Genetic variation in the endocannabinoid degrading enzyme fatty acid amide hydrolase (FAAH) and their influence on weight loss and insulin resistance under a high monounsaturated fat hypocaloric diet. Journal of Diabetes and its Complications 2013, 27:235-239.
21. De Luis D.A., Aller R., Izaola O., Sagrado M.G., Conde R. Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial. Annals of Nutrition and Metabolism 2008, 52:209-214.
22. De Luis D.A., Aller R., Izaola O., Sagrado M.G., Conde R. Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene. Hormone and Metabolic Research 2008, 40:214-218.
23. De Luis D., Aller R., Izaola O., Sagrado M.G., de la Fuente B., Conde R., et al. Effect of fatty acid-binding protein 2 Ala54Thr genotype on weight loss and cardiovascular risk factors after a high-polyunsaturated fat diet in obese patients. Journal of Investigative Medicine 2012, 60:1194-1198.
24. De Luis D.A., Aller R., Sagrado M.G., Conde R., Izaola O., De la Fuente B. Genetic variation in the cannabinoid receptor gene (CNR1) (G1359A polymorphism) and their influence on anthropometric parameters and metabolic parameters under a high monounsaturated vs. high polyunsaturated fat hypocaloric diets. Journal of Nutritional Biochemistry 2013, 24:1431-1435.
25. De Luis D.A., González Sagrado M., Aller R., Izaola O., Conde R. Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets. Annals of Nutrition and Metabolism 2009, 54:104-110.
26. De Luis D.A., Gonzalez Sagrado M., Aller R., Izaola O., Conde R. Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amidehydrolase on weight loss after a hypocaloric diet. Metabolism 2011, 60:730-734.
27. De Roos B. Personalised nutrition: ready for practice?. Proceedings of the Nutrition Society 2013, 72:48-52.
28. Delahanty L.M., Peyrot M., Shrader P.J., Williamson D.A., Meigs J.B., Nathan D.M., et al. Pretreatment, psychological, and behavioral predictors of weight outcomes among lifestyle intervention participants in the Diabetes Prevention Program (DPP). Diabetes Care 2013, 36:34-40.
29. Deram S., Nicolau C.Y., Perez-Martinez P., Guazzelli I., Halpern A., Wajchenberg B.L., et al. Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents. Journal of Clinical Endocrinology and Metabolism 2008, 93:4933-4940.
30. Dlouhá D., Suchánek P., Lánská V., Hubáček J.A. Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms. Physiological Research 2011, 60:199-202.
31. Doche M.E., Bochukova E.G., Su H.W., Pearce L.R., Keogh J.M., Henning E., et al. Human SH2B1 mutations are associated with maladaptive behaviors and obesity. Journal of Clinical Investigation 2012, 122:4732-4736.
32. El-Sayed Moustafa J.S., Froguel P. From obesity genetics to the future of personalized obesity therapy. Nature Reviews Endocrinology 2013, 9:402-413.
33. Fenech M., El-Sohemy A., Cahill L., Ferguson L.R., French T.A., Tai E.S., et al. Nutrigenetics and nutrigenomics: viewpoints on the current status and applications in nutrition research and practice. Journal of Nutrigenetics and Nutrigenomics 2011, 4:69-89.
34. Fogelholm M., Anderssen S., Gunnarsdottir I., Lahti-Koski M. Dietary macronutrients and food consumption as determinants of long-term weight change in adult populations: a systematic literature review. Food & Nutrition Research 2012, 2012:56.
35. Fogelholm M., Valve R., Kukkonen-Hara K., Nenonen A., Hakkarainen V., Laakso M., et al. Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women. Journal of Clinical Endocrinology and Metabolism 1998, 83:4246-4250.
36. Franks P.W., Jablonski K.A., Delahanty L., Hanson R.L., Kahn S.E., Altshuler D., et al. The Pro12Ala variant at the peroxisome proliferator-activated receptor gamma gene and change in obesity-related traits in the Diabetes Prevention Program. Diabetologia 2007, 50:2451-2460.
37. Frey U.H., Michalsen A., Merse S., Dobos G.J., Siffert W. A functional GNAS promoter polymorphism is associated with altered weight loss during short-term fasting. European Journal of Medical Research 2008, 13:576-578.
38. Fumeron F., Durack-Bown I., Betoulle D., Cassard-Doulcier A.M., Tuzet S., Bouillaud F., et al. Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet. International Journal of Obesity 1996, 20:1051-1054.
39. Garaulet M., Corbalán M.D., Madrid J.A., Morales E., Baraza J.C., Lee Y.C., et al. CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet. International Journal of Obesity 2010, 34:516-523.
40. Garaulet M., Esteban Tardido A., Lee Y.C., Smith C.E., Parnell L.D., Ordovás J.M. SIRT1 and CLOCK 3111T> C combined genotype is associated with evening preference and weight loss resistance in a behavioral therapy treatment for obesity. International Journal of Obesity 2012, 36:1436-1441.
41. Garaulet M., Smith C.E., Hernández-González T., Lee Y.C., Ordovás J.M. PPARγ Pro12Ala interacts with fat intake for obesity and weight loss in a behavioural treatment based on the Mediterranean diet. Molecular Nutrition & Food Research 2011, 55:1771-1779.
42. Goyenechea E., Collins L.J., Parra D., Abete I., Crujeiras A.B., O'Dell S.D., et al. The -11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the outcome of an energy-restricted diet in obese subjects. Hormone and Metabolic Research 2009, 41:55-61.
43. Goyenechea E., Parra D., Martínez J.A. Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-gamma2 gene polymorphisms. British Journal of Nutrition 2006, 96:965-972.
44. Grau K., Cauchi S., Holst C., Astrup A., Martinez J.A., Saris W.H., et al. TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. American Journal of Clinical Nutrition 2010, 91:472-479.
45. Grau K., Hansen T., Holst C., Astrup A., Saris W.H., Arner P., et al. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. International Journal of Obesity 2009, 33:1227-1234.
46. Hainerová I., Larsen L.H., Holst B., Finková M., Hainer V., Lebl J., et al. Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response, and functional analysis. Journal of Clinical Endocrinology and Metabolism 2007, 92:3689-3696.
47. Hamada T., Kotani K., Nagai N., Tsuzaki K., Sano Y., Matsuoka Y., et al. Genetic polymorphisms of the renin-angiotensin system and obesity-related metabolic changes in response to low-energy diets in obese women. Nutrition 2011, 27:34-39.
48. Haupt A., Thamer C., Heni M., Ketterer C., Machann J., Schick F., et al. Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes. Diabetes 2010, 59:747-750.
49. Haupt A., Thamer C., Heni M., Tschritter O., Machann J., Schick F., et al. Impact of variation near MC4R on whole-body fat distribution, liver fat, and weight loss. Obesity 2009, 17:1942-1945.
50. Haupt A., Thamer C., Machann J., Kirchhoff K., Stefan N., Tschritter O., et al. Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss. Obesity 2008, 16:1969-1972.
51. Heilbronn L.K., Noakes M., Morris A.M., Kind K.L., Clifton P.M. 360His polymorphism of the apolipoprotein A-IV gene and plasma lipid response to energy restricted diets in overweight subjects. Atherosclerosis 2000, 150:187-192.
52. Hendriks H.F. Use of nutrigenomics endpoints in dietary interventions. Proceedings of the Nutrition Society 2013, 28:1-4.
53. Heni M., Herzberg-Schäfer S., Machicao F., Häring H.U., Fritsche A. Dietary fiber intake modulates the association between variants in TCF7L2 and weight loss during a lifestyle intervention. Diabetes Care 2012, 35:e24.
54. Hernell O., West C. Do we need personalized recommendations for infants at risk of developing disease?. Nestlé Nutrition Institute Workshop Series in Pediatric, Clinical, Adult and Sports Nutrition 2008, 6:239-249.
55. Herring M.P., Sailors M.H., Bray M.S. Genetic factors in exercise adoption, adherence and obesity. Obesity Reviews 2014, 15:29-39.
56. Hinney A., Wolters B., Pütter C., Grallert H., Illig T., Hebebrand J., et al. No impact of obesity susceptibility loci on weight regain after a lifestyle intervention in overweight children. Journal of Pediatric Endocrinology and Metabolism 2013, 10:1-5.
57. Huang T., Qi Q., Li Y., Hu F.B., Bray G.A., Sacks F.M., et al. FTO genotype, dietary protein, and change in appetite: the preventing overweight using novel dietary strategies trial. American Journal of Clinical Nutrition 2014, 99:1126-1130.
58. Imai K., Kricka L.J., Fortina P. Concordance study of 3 direct-to-consumer genetic-testing services. Clinical Chemistry 2011, 57:518-521.
59. Jenab M., Slimani N., Bictash M., Ferrari P., Bingham S.A. Biomarkers in nutritional epidemiology: applications, needs and new horizons. Human Genetics 2009, 125:507-525.
60. Kang J.X. Identification of metabolic biomarkers for personalized nutrition. Journal of Nutrigenetics and Nutrigenomics 2012, 5:I-II.
61. Kang J.X. The coming of age of nutrigenetics and nutrigenomics. Journal of Nutrigenetics and Nutrigenomics 2012, 5:I-II.
62. Kim O.Y., Cho E.Y., Park H.Y., Lee J.H. Additive effect of the mutations in the beta3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome. International Journal of Obesity 2004, 28:434-441.
63. Knoll N., Volckmar A.L., Pütter C., Scherag A., Kleber M., Hebebrand J., et al. The fatty acid amide hydrolase (FAAH) gene variant rs324420 AA/AC is not associated with weight loss in a 1-year lifestyle intervention for obese children and adolescents. Hormone and Metabolic Research 2012, 44:75-77.
64. Kostis J.B., Wilson A.C., Hooper W.C., Harrison K.W., Philipp C.S., Appel L.J., et al. Association of angiotensin-converting enzyme DD genotype with blood pressure sensitivity to weight loss. American Heart Journal 2002, 144:625-629.
65. Lappalainen T.J., Tolppanen A.M., Kolehmainen M., Schwab U., Lindström J., Tuomilehto J., et al. The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish diabetes prevention study. Obesity 2009, 17:832-836.
66. Laukkanen O., Pihlajamäki J., Lindström J., Eriksson J., Valle T.T., Hämäläinen H., et al. Common polymorphisms in the genes regulating the early insulin signalling pathway: effects on weight change and the conversion from impaired glucose tolerance to type 2 diabetes. Diabetologia 2004, 47:871-877.
67. Lee J.S., Kawakubo K., Inoue S., Akabayashi A. Effect of β-adrenergic receptor gene polymorphism on body weight change in middle-aged, overweight women. Environmental Health and Preventive Medicine 2006, 11:69-74.
68. Lindi V.I., Uusitupa M.I., Lindström J., Louheranta A., Eriksson J.G., Valle T.T., et al. Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 2002, 51:2581-2586.
69. Lippi G., Favaloro E.J., Plebani M. Direct-to-consumer testing: more risks than opportunities. International Journal of Clinical Practice 2011, 65. 1221-1219.
70. Mammès O., Betoulle D., Aubert R., Giraud V., Tuzet S., Petiet A., et al. Polymorphisms in the 5' region of the LEP gene: association with leptin levels and response to low-calorie diet in human obesity. Diabetes 1998, 47:487-489.
71. Martínez J.A. Perspectives on personalized nutrition for obesity. Journal of Nutrigenetics and Nutrigenomics 2014, 10.1159/000365158.
72. Martínez J.A., Cordero P., Campión J., Milagro F.I. Interplay of early-life nutritional programming on obesity, inflammation and epigenetic outcomes. Proceedings of the Nutrition Society 2012, 71:276-283.
73. Martínez J.A., Enríquez L., Moreno-Aliaga M.J., Marti A. Genetics of obesity. Public Health Nutrition 2007, 10:1138-1144.
74. Martinez J.A., Navas-Carretero S., Saris W.H., Astrup A. Personalized weight loss strategies-the role of macronutrient distribution. Nature Reviews Endocrinology 2014, 10:749-760.
75. Martinez J.A., Parra M.D., Santos J.L., Moreno-Aliaga M.J., Marti A., Martinez-Gonzalez M.A. Genotype-dependent response to energy-restricted diets in obese subjects: towards personalized nutrition. Asia Pacific Journal of Clinical Nutrition 2008, 17:119-122.
76. Martinez-Lopez E., Garcia-Garcia M.R., Gonzalez-Avalos J.M., Maldonado-Gonzalez M., Ruiz-Madrigal B., Vizmanos B., et al. Effect of Ala54Thr polymorphism of FABP2 on anthropometric and biochemical variables in response to a moderate-fat diet. Nutrition 2013, 29:46-51.
77. Matsuo T., Nakata Y., Katayama Y., Iemitsu M., Maeda S., Okura T., et al. PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction. Obesity 2009, 17:1924-1931.
78. Matsuo T., Nakata Y., Murotake Y., Hotta K., Tanaka K. Effects of FTO genotype on weight loss and metabolic risk factors in response to calorie restriction among Japanese women. Obesity 2012, 20:1122-11216.
79. Mattei J., Qi Q., Hu F.B., Sacks F., Qi L. TCF7L2 genetic variants modulate the effect of dietary fat intake on changes in body composition during a weight-loss intervention. American Journal of Clinical Nutrition 2012, 96:1129-1136.
80. McCabe-Sellers B., Lovera D., Nuss H., Wise C., Ning B., Teitel C., et al. Personalizing nutrigenomics research through community based participatory research and omics technologies. OMICS 2008, 12:263-272.
81. McCaffery J.M., Jablonski K.A., Franks P.W., Dagogo-Jack S., Wing R.R., Knowler W.C., et al. TCF7L2 polymorphism, weight loss and proinsulin: insulin ratio in the diabetes prevention program. PLoS One 2011, 6:e21518.
82. McCaffery J.M., Papandonatos G.D., Huggins G.S., Peter I., Kahn S.E., Knowler W.C., et al. FTO predicts weight regain in the look AHEAD clinical trial. International Journal of Obesity 2013, 37:1545-1552.
83. Moleres A., Rendo-Urteaga T., Zulet M.A., Marcos A., Campoy C., Garagorri J.M., et al. Obesity susceptibility loci on body mass index and weight loss in Spanish adolescents after a lifestyle intervention. Journal of Pediatrics 2012, 161:466-470.
84. Müller T.D., Hinney A., Scherag A., Nguyen T.T., Schreiner F., Schäfer H., et al. 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Medical Genetics 2008, 9:85.
85. Mutombo P.B., Yamasaki M., Shiwaku K. UCP2 I/D modulated change in BMI during a lifestyle modification intervention study in Japanese subjects. Genetic Testing and Molecular Biomarkers 2013, 17:16-20.
86. Nagai N., Sakane N., Kotani K., Hamada T., Tsuzaki K., Moritani T. Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women. Nutrition Research 2011, 31:255-261.
87. Nakamura M., Tanaka M., Abe S., Itoh K., Imai K., Masuda T., et al. Association between beta 3-adrenergic receptor polymorphism and a lower reduction in the ratio of visceral fat to subcutaneous fat area during weight loss in Japanese obese women. Nutrition Research 2000, 20:25-34.
88. Nieminen T., Matinheikki J., Nenonen A., Kukkonen-Harjula K., Lindi V., Hämelahti P., et al. The relationship of sterol regulatory element-binding protein cleavage-activation protein and apolipoprotein E gene polymorphisms with metabolic changes during weight reduction. Metabolism 2007, 56:876-880.
89. Pan Q., Delahanty L.M., Jablonski K.A., Knowler W.C., Kahn S.E., Florez J.C., et al. Variation at the melanocortin 4 receptor gene and response to weight-loss interventions in the diabetes prevention program. Obesity 2013, 21:E520-E526.
90. Papazoglou D., Papathanasiou P., Papanas N., Papatheodorou K., Chatziangeli E., Nikitidis I., et al. Uncoupling protein-2 45-base pair insertion/deletion polymorphism: is there an association with severe obesity and weight loss in morbidly obese subjects?. Metabolic Syndrome and Related Disorders 2012, 10:307-311.
91. Peter I., McCaffery J.M., Kelley-Hedgepeth A., Hakonarson H., Reis S., Wagenknecht L.E., et al. Association of type 2 diabetes susceptibility loci with one-year weight loss in the look AHEAD clinical trial. Obesity 2012, 20:1675-1682.
92. Pooley E.C., Fairburn C.G., Cooper Z., Sodhi M.S., Cowen P.J., Harrison P.J. A 5-HT2C receptor promoter polymorphism (HTR2C - 759C/T) is associated with obesity in women, and with resistance to weight loss in heterozygotes. American Journal of Medical Genetics Part B Neuropsychiatric Genetics 2004, 126B:124-127.
93. Qi L. Gene-diet interaction and weight loss. Current Opinion in Lipidology 2014, 25:27-34.
94. Qi Q., Bray G.A., Hu F.B., Sacks F.M., Qi L. Glucose-dependent insulinotropic polypeptide receptor rs2287019 genotype effects on changes in body weight, fasting glucose, and insulin resistance: the preventing overweight using novel dietary strategies trial. American Journal of Clinical Nutrition 2012, 95:506-513.
95. Qi Q., Chu A.Y., Kang J.H., Jensen M.K., Curhan G.C., Pasquale L.R., et al. Sugar-sweetened beverages and genetic risk of obesity. New England Journal of Medicine 2012, 367:1387-1396.
96. Rankinen T., Zuberi A., Chagnon Y.C., Weisnagel S.J., Argyropoulos G., Walts B., et al. The human obesity gene map: the 2005 update. Obesity 2006, 14:529-644.
97. Rauhio A., Uusi-Rasi K., Nikkari S.T., Kannus P., Sievänen H., Kunnas T. Association of the FTO and ADRB2 genes with body composition and fat distribution in obese women. Maturitas 2013, 76:165-171.
98. Razquin C., Marti A., Martinez J.A. Evidences on three relevant obesogenes: MC4R, FTO and PPARγ. Approaches for personalized nutrition. Molecular Nutrition & Food Research 2011, 55:136-149.
99. Reinehr T., Friedel S., Mueller T.D., Toschke A.M., Hebebrand J., Hinney A. Evidence for an influence of TCF7L2 polymorphism rs7903146 on insulin resistance and sensitivity indices in overweight children and adolescents during a lifestyleintervention. International Journal of Obesity 2008, 32:1521-1524.
100. Reinehr T., Hebebrand J., Friedel S., Toschke A.M., Brumm H., Biebermann H., et al. Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity 2009, 17:382-389.
101. Reinehr T., Hinney A., Nguyen T.T., Hebebrand J. Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents. Diabetes 2008, 57:623-626.
102. Reinehr T., Hinney A., Toschke A.M., Hebebrand J. Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention. Archives of Disease in Childhood 2009, 94:965-967.
103. Rimbach G., Minihane A.M. Nutrigenetics and personalised nutrition: how far have we progressed and are we likely to get there?. Proceedings of the Nutrition Society 2009, 68:162-172.
104. Rosado E.L., Bressan J., Hernández J.A., Martins M.F., Cecon P.R. Effect of diet and PPARgamma2 and beta2-adrenergic receptor genes on energy metabolism and body composition in obese women. Nutrición Hospitalaria 2006, 21:317-331.
105. Rubio-Aliaga I., Kochhar S., Silva-Zolezzi I. Biomarkers of nutrient bioactivity and efficacy: a route toward personalized nutrition. Journal of Clinical Gastroenterology 2012, 46:545-554.
106. Rudkowska I., Pérusse L. Individualized weight management: what can be learned from nutrigenomics and nutrigenetics?. Progress in Molecular Biology and Translational Science 2012, 108:347-382.
107. Ruiz J.R., Larrarte E., Margareto J., Ares R., Alkorta P., Labayen I. Preliminary findings on the role of PLIN1 polymorphisms on body composition and energy metabolism response to energy restriction in obese women. British Journal of Nutrition 2011, 106:486-490.
108. Sakane N., Yoshida T., Umekawa T., Kogure A., Kondo M. Beta2-adrenoceptor genepolymorphism and obesity. Lancet 1999, 353:1976.
109. Sakane N., Yoshida T., Umekawa T., Kogure A., Takakura Y., Kondo M. Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients. Diabetes Care 1997, 20:1887-1890.
110. San Cristobal R., Milagro F.I., Martinez J.A. Future challenges and present ethical considerations in the use of personalized nutrition based on genetic advice. Journal of the Academy of Nutrition and Dietetics 2013, 113:1447-1454.
111. Santoro N., Perrone L., Cirillo G., Raimondo P., Amato A., Brienza C., et al. Effect of the melanocortin-3 receptor C17A and G241A variants on weight loss in childhood obesity. American Journal of Clinical Nutrition 2007, 85:950-953.
112. Santoro N., Perrone L., Cirillo G., Raimondo P., Amato A., Coppola F., et al. Weight loss in obese children carrying the proopiomelanocortin R236G variant. Journal of Endocrinological Investigation 2006, 29:226-230.
113. Santos J.L., De la Cruz R., Holst C., Grau K., Naranjo C., Maiz A., et al. Allelic variants of melanocortin 3 receptor gene (MC3R) and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS One 2011, 6:e19934.
114. Scherag A., Dina C., Hinney A., Vatin V., Scherag S., Vogel C.I., et al. Two new loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and German study groups. PLoS Genetics 2010, 6:e1000916.
115. Scherag A., Kleber M., Boes T., Kolbe A.L., Ruth A., Grallert H., et al. SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents. Obesity 2012, 20:466-470.
116. Shapira N. Women's higher health risks in the obesogenic environment: a gender nutrition approach to metabolic dimorphism with predictive, preventive, and personalised medicine. EPMA Journal 2013, 4:1.
117. Shin M.J., Jang Y., Koh S.J., Chae J.S., Kim O.Y., Lee J.E., et al. The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss. International Journal of Obesity 2006, 30:1702-1708.
118. Shiwaku K., Nogi A., Anuurad E., Kitajima K., Enkhmaa B., Shimono K., et al. Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene. International Journal of Obesity 2003, 27:1028-1036.
119. Simopoulos A.P. Nutrigenetics/Nutrigenomics. Annual Review of Public Health 2010, 31:53-68.
120. Soenen S., Mariman E.C., Vogels N., Bouwman F.G., den Hoed M., Brown L., et al. Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance. Physiology & Behavior 2009, 96:723-728.
121. Sørensen T.I., Boutin P., Taylor M.A., Larsen L.H., Verdich C., Petersen L., et al. Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets. PLoS Clinical Trials 2006, 1:e12.
122. Stocks T., Angquist L., Banasik K., Harder M.N., Taylor M.A., Hager J., et al. TFAP2B influences the effect of dietary fat on weight loss under energy restriction. PLoS One 2012, 7:e43212.
123. Stover P.J., Caudill M.A. Genetic and epigenetic contributions to human nutrition and health: managing genome-diet interactions. Journal of the American Dietetic Association 2008, 108:1480-1487.
124. Subbiah M.T. Nutrigenetics and nutraceuticals: the next wave riding on personalized medicine. Translational Research 2007, 149:55-61.
125. Tchernof A., Starling R.D., Turner A., Shuldiner A.R., Walston J.D., Silver K., et al. Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant. Diabetes 2000, 49:1709-1713.
126. Teng A.C., Adamo K., Tesson F., Stewart A.F. Functional characterization of a promoter polymorphism that drives ACSL5 gene expression in skeletal muscle andassociates with diet-induced weight loss. FASEB Journal 2009, 23:1705-1709.
127. Tussing-Humphreys L.M., Fitzgibbon M.L., Kong A., Odoms-Young A. Weight loss maintenance in African American women: a systematic review of the behavioral lifestyle intervention literature. Journal of Obesity 2013, 2013:437369.
128. Verhoef S.P., Camps S.G., Bouwman F.G., Mariman E.C., Westerterp K.R. Genetic predisposition, dietary restraint and disinhibition in relation to short and long-term weight loss. Physiology & Behavior 2014, 10.1016/j.physbeh.2014.02.004.
129. Volckmar A.L., Pütter C., Song J.Y., Graniger J., Knoll N., Wolters B., et al. Analyses of non-synonymous obesity risk alleles in SH2B1 (rs7498665) and APOB48R (rs180743) in obese children and adolescents undergoing a 1-year lifestyle intervention. Experimental and Clinical Endocrinology & Diabetes 2013, 121:334-337.
130. Woehning A., Schultz J.H., Roeder E., Moeltner A., Isermann B., Nawroth P.P., et al. The A-allele of the common FTO gene variant rs9939609 complicates weight maintenance in severe obese patients. International Journal of Obesity 2013, 37:135-139.
131. Yamakita M., Ando D., Tang S., Yamagata Z. The Trp64Arg polymorphism of the beta3-adrenergic receptor gene is associated with weight changes in obese Japanese men: a 4-year follow-up study. Journal of Physiological Anthropology 2010, 29:133-139.
132. Yang Y., Kim O.Y., Lee J.H., Koh S.J., Chae J.S., Kim J.Y., et al. Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. International Journal of Obesity 2006, 30:1601-1608.
133. Yoon Y., Park B.L., Cha M.H., Kim K.S., Cheong H.S., Choi Y.H., et al. Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects. Biochemical and Biophysical Research Communications 2007, 359:451-456.
134. Zacharova J., Chiasson J.L., Laakso M. Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance. Obesity Research 2005, 13:501-506.
135. Zhang X., Qi Q., Zhang C., Smith S.R., Hu F.B., Sacks F.M., et al. FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST trial. Diabetes 2012, 61:3005-3011.
136. Zlatohlavek L., Vrablik M., Motykova E., Ceska R., Vasickova L., Dlouha D., et al. FTO and MC4R gene variants determine BMI changes in children after intensive lifestyle intervention. Clinical Biochemistry 2013, 46:313-316.