SDCCAG8 obesity alleles and reduced weight loss after a lifestyle intervention in overweight children and adolescents

Obesity

Volumn 20, Issue 2, 2012, Pages 466-470

  Scherag, André ^a   Kleber, Michaela ^b   Boes, Tanja ^a   Kolbe, Andreea Liliana ^a   Ruth, Anne ^a   Grallert, Harald ^c   Illig, Thomas ^c   Heid, Iris M ^c,d   Toschke, André M ^e   Grau, Katrine ^f   Sørensen, Thorkild I A ^f   Hebebrand, Johannes ^a   Hinney, Anke ^a   Reinehr, Thomas ^b  

^a UNIVERSITY OF DUISBURG ESSEN   (Germany)

^b UNIVERSITY OF WITTEN HERDECKE   (Germany)

^c INSTITUTE OF EPIDEMIOLOGY   (Germany)

^d UNIVERSITY OF REGENSBURG   (Germany)

^e UNIVERSITY OF MUNICH   (Germany)

^f The Capital Region   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

ADOLESCENT; ARTICLE; BODY MASS; CARDIOMETABOLIC RISK; CHILD; FEMALE; GENE; GENOTYPE; HUMAN; INTRON; LIFESTYLE MODIFICATION; LOW CALORY DIET; MAJOR CLINICAL STUDY; MALE; OBESITY; RISK; SCHOOL CHILD; SDCCAG8 GENE; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT REDUCTION;

ADOLESCENT; ALLELES; AUTOANTIGENS; BODY MASS INDEX; CHILD; FEMALE; GENETIC PREDISPOSITION TO DISEASE; GENOME-WIDE ASSOCIATION STUDY; GERMANY; HUMANS; MALE; NEOPLASM PROTEINS; OBESITY; POLYMORPHISM, SINGLE NUCLEOTIDE;

EID: 84856266788     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2011.339     Document Type: Article

References (18)

1. Hebebrand J, Volckmar AL, Knoll N, Hinney A. Chipping away the 'missing heritability': GIANT steps forward in the molecular elucidation of obesity-but still lots to go. Obes Facts 2010;3:294-303.
2. Speliotes EK, Willer CJ, Berndt SI et al.; MAGIC; Procardis Consortium. Association analyses of 249,796 individuals reveal 18 new loci associated with body mass index. Nat Genet 2010;42:937-948.
3. Meyre D, Delplanque J, Chèvre JC et al. Genome-wide association study for early-onset and morbid adult obesity identifies three new risk loci in European populations. Nat Genet 2009;41:157-159.
4. Scherag A, Dina C, Hinney A et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet 2010;6:e1000916.
5. Müller TD, Hinney A, Scherag A et al. Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents. BMC Med Genet 2008;9:85.
6. Sørensen TI, Boutin P, Taylor MA et al.; NUGENOB Consortium. Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high-versus low-fat diets. PLoS Clin Trials 2006;1:e12.
7. Vogel CI, Boes T, Reinehr T et al. Common variants near MC4R: exploring gender effects in overweight and obese children and adolescents participating in a lifestyle intervention. Obes Facts 2011;4:67-75.
8. Janssen S, Ramaswami G, Davis EE et al. Mutation analysis in Bardet-Biedl syndrome by DNA pooling and massively parallel resequencing in 105 individuals. Hum Genet 2011;129:79-90.
9. Otto EA, Hurd TW, Airik R et al. Candidate exome capture identifies mutation of SDCCAG8 as the cause of a retinal-renal ciliopathy. Nat Genet 2010;42:840-850.
10. McCarthy MI. Genomics, type 2 diabetes, and obesity. N Engl J Med 2010;363:2339-2350.
11. Reinehr T, Hebebrand J, Friedel S et al. Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene. Obesity (Silver Spring) 2009;17:382-389.
12. Reinehr T, de Sousa G, Toschke AM, Andler W. Long-term follow-up of cardiovascular disease risk factors in children after an obesity intervention. Am J Clin Nutr 2006;84:490-496. (Pubitemid 44713397)
13. Reinehr T, Temmesfeld M, Kersting M, de Sousa G, Toschke AM. Four-year follow-up of children and adolescents participating in an obesity intervention program. Int J Obes (Lond) 2007;31:1074-1077. (Pubitemid 46987777)
14. Grau K, Hansen T, Holst C et al. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. Int J Obes (Lond) 2009;33:1227-1234.
15. Grau K, Cauchi S, Holst C et al. TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet. Am J Clin Nutr 2010;91:472-479.
16. Kromeyer-Hauschild K, Wabitsch M, Kunze D et al. Perzentilen für den Body Mass Index für das Kinder-und Jugendalter unter Heranziehung verschiedener deutscher Stichproben. Monatsschr Kinderheilkd 2001;149:807-818. (Pubitemid 32830649)
17. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2000;320:1240-1243. (Pubitemid 30240471)
18. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28:412-419. (Pubitemid 15018832)