Lifestyle intervention in obese children with variations in the melanocortin 4 receptor gene

Obesity

Volumn 17, Issue 2, 2009, Pages 382-389

  Reinehr, Thomas ^a   Hebebrand, Johannes ^b   Friedel, Susann ^b   Toschke, André M ^c   Brumm, Harald ^d   Biebermann, Heike ^d   Hinney, Anke ^b  

^a UNIVERSITY OF WITTEN HERDECKE   (Germany)

^b UNIVERSITY OF DUISBURG ESSEN   (Germany)

^c KING'S COLLEGE LONDON   (United Kingdom)

^d CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

INSULIN; LEPTIN; MELANOCORTIN 4 RECEPTOR;

ADOLESCENT; ARTICLE; BLOOD; CHILD; COMPARATIVE STUDY; DIET THERAPY; EXERCISE; FEMALE; GENETICS; HUMAN; LIFESTYLE; MALE; MUTATION; OBESITY; PATHOPHYSIOLOGY; PHYSIOLOGY; PRESCHOOL CHILD; WEIGHT REDUCTION;

ADOLESCENT; CHILD; CHILD, PRESCHOOL; EXERCISE; FEMALE; HUMANS; INSULIN; LEPTIN; LIFE STYLE; MALE; MUTATION; NUTRITION THERAPY; OBESITY; RECEPTOR, MELANOCORTIN, TYPE 4; WEIGHT LOSS;

EID: 58849133283     PISSN: 19307381     EISSN: 1930739X     Source Type: Journal    
DOI: 10.1038/oby.2008.422     Document Type: Article

References (38)

1. Ellacott KL, Cone RD. The central melanocortin system and the integration of short- and long-term regulators of energy homeostasis. Recent Prog Horm Res 2004;59:395-408.
2. Lubrano-Berthelier C, Dubern B, Lacorte JM et al. Melanocortin 4 receptor mutations in a large cohort of severely obese adults: prevalence, functional classification, genotype- phenotype relationships, and lack of association with binge eating. J Clin Endocrinol Metab 2006;91:1811-1818.
3. Miraglia Del, Giudice E, Cirillo G, Nigro V et al. Low frequency of melanocortin-4 receptor (MC4R) mutations in a Mediterranean population with early-onset obesity. Int J Obes Relat Metab Disord 2002;26:647-651.
4. Vaisse C, Clement K, Guy-Grand B, Froguel P. A frameshift mutation in human MC4R is associated with a dominant form of obesity. Nat Genet 1998;20:113-114.
5. Farooqi IS, Keogh JM, Yeo GSH et al. Clinical spectrum of obesity and mutations in the melanocortin 4 receptor gene. N Eng J Med 2003;348: 1085-1095.
6. Hinney A, Hohmann S, Geller F et al. Melanocortin-4 receptor gene: case-control study and transmission disequilibrium test confirm that functionally relevant mutations are compatible with a major gene effect for extreme obesity. J Clin Endocrinol Metab 2003;88:4258-4267.
7. Jacobson P, Ukkola O, Rankinen T et al. Melanocortin 4 receptor sequence variations are seldom a cause of human obesity: the Swedish obese subjects, the HERITAGE Family Study, and a Memphis Cohort. J Clin Endocrinol Metab 2002;87:4442-4446.
8. Gotoda T, Scott J, Aitman TJ. Molecular screening of the human melanocortin-4 receptor gene: identification of a missense variant showing no association with obesity, plasma glucose, or insulin. Diabetologia 1997;40:976-979.
9. Tao XY. Molecular mechanisms of the neural melanocortin receptor dysfunction in severe early onset obesity. Mol Cell Endocrinol 2005;239:1-14.
10. Hinney A, Bettecken T, Tarnow P et al. Prevalence, spectrum, and functional characterization of melanocortin-4 receptor gene mutations in a representative population-based sample and obese adults from Germany. J Clin Endocrinol Metab 2006;91:1761-1769.
11. Farooqi IS, Yeo GS, Keogh JM et al. Dominant and recessive inheritance of morbid obesity associated with melanocortin 4 receptor deficiency. J Clin Invest 2000;106:271-279.
12. Dubern B, Clément K, Pelloux V et al. Mutational analysis of melanocortin-4 receptor, agouti-related protein, and (alpha- melanocytestimulating hormone genes in severely obese children. J Pediatr 2001;139:204-209.
13. Dempfle A, Hinney A, Heinzel-Gutenbrunner M et al. Large quantitative effect of melanocortin-4 receptor gene mutations on body mass index. J Med Genet 2004;41:795-800.
14. Geller F, Reichwald K, Dempfle A et al. Melanocortin-4 receptor gene variant I103 is negatively associated with obesity. Am J Hum Genet 2004;74: 572-581.
15. Heid IM, Vollmert C, Hinney A et al. Association of the 103I MC4R allele with decreased body mass in 7937 participants of two population based surveys. J Med Genet 2005;42:e21
16. Stutzmann F, Vatin V, Cauchi S et al. Non-synonymous polymorphisms in melanocortin-4 receptor protect against obesity: the two facets of a Janus obesity gene. Hum Mol Genet 2007;16:1837-1844.
17. Young EH, Wareham NJ, Farooqi S et al. The V103I polymorphism of the MC4R gene and obesity: population based studies and meta-analysis of 29 563 individuals. Int J Obes 2007;31:1437-1441.
18. Xiang Z, Litherland SA, Sorensen NB et al. Pharmacological characterization of 40 human melanocortin-4 receptor polymorphisms with the endogenous proopiomelanocortin-derived agonists and the agouti-related protein (AGRP) antagonist. Biochemistry 2006;13:7277-7288.
19. Lubrano-Berthelier C, Cavazos M, Le Stunff C et al. The human MC4R promoter: characterization and role in obesity. Diabetes 2003;52: 2996-3000.
20. Cole TJ. The LMS method for constructing normalized growth standards. Eur J Clin Nutr 1990;44:45-60.
21. Kromeyer-Hauschild K, Wabitsch M, Geller F et al. Percentiles of body mass index in children and adolescents evaluated from different regional German studies. Monatsschr Kinderheilkd 2001;149:807-818.
22. Cole TJ, Bellizzi MC, Flegal KM, Dietz WH. Establishing a standard definition for child overweight and obesity world-wide: international survey. BMJ 2000;320:1240-1243.
23. National High Blood Pressure Education Program Working Group on High Blood Pressure in Children and Adolescents. The fourth report on the diagnosis, evaluation, and treatment of high blood pressure in children and adolescents. Pediatrics 2004;114(2 Suppl 4th Report):555-576.
24. Slaughter MH, Lohman TG, Boileau RA et al. Skinfold equations for estimation of body fatness in children and youth. Hum Biol 1998;60:709-723.
25. Blum WF, Englaro P, Hanitsch S et al. Plasma leptin levels in healthy children and adolescents: dependence on body mass index, body fat mass, gender, pubertal stage, and testosterone. J Clin Endocrinol Metab 1997;82: 2904-2910.
26. Matthews DR, Hosker JP, Rudenski AS et al. Homeostasis model assessment: insulin resistance and beta-cell function from fasting plasma glucose and insulin concentrations in man. Diabetologia 1985;28: 412-419.
27. Reinehr T, Brylak K, Alexy U, Kersting M, Andler W. Predictors to success in outpatient training in obese children and adolescents. Int J Obes 2003;89: 419-422.
28. Reinehr T, Temmesfeld M, Kersting M, de Sousa G, Toschke AM. Four year follow-up of children and adolescents participating in an obesity intervention program. Int J Obes 2007;31:1074-1077.
29. Reinehr T, de Sousa G, Toschke M, Andler W. Long-term follow-up of cardiovascular risk factors in obese children after intervention. Am J Clin Nutr 2006;84:490-496.
30. Reinehr T, Kersting M, Wollenhaupt A, Alexy U, Kling B, Str̈bele K, Andler W. Evaluation of the training program "OBELDICKS" for obese children and adolescents. Klin Padiatr 2005;217:1-8.
31. Kersting M, Sichert-Hellert W, Lausen B et al. Energy intake of 1 to 18 year old German Children and adolescents. Z Ernahrungswiss 1998;37:47-55.
32. Nijenhuis WA, Garner KM, van Rozen RJ, Adan RA. Poor cell surface expression of human melanocortin-4 receptor mutations associated with obesity. J Biol Chem 2003;278:22939-42295.
33. Tao YX, Segaloff DL. Functional characterization of melanocortin-4 receptor mutations associated with childhood obesity. Endocrinology 2003;144: 4544-4451.
34. Hainerová I, Larsen LH, Holst B et al. Melanocortin 4 receptor mutations in obese Czech children: studies of prevalence, phenotype development, weight reduction response and functional analysis. J Clin Endocrinol Metab 2007;92:3689-3696.
35. Stäubert C, Tarnow P, Brumm H et al. Evolutionary aspects in evaluating mutations in the melanocortin 4 receptor. Endocrinology 2007;148: 4642-4648.
36. Mergen M, Mergen H, Ozata M, Oner R, Oner C. A novel melanocortin 4 receptor (MC4R) gene mutation associated with morbid obesity. J Clin Endocrinol Metab 2001;86:3448.
37. Lubrano-Berthelier C, Le Stunff C, Bougneres P, Vaisse C. A homozygous null mutation delineates the role of the melanocortin-4 receptor in humans. J Clin Endocrinol Metab 2004;89:2028-2032.
38. Valli-Jaakola K, Lipsanen-Nyman M, Oksanen L et al. Identification and characterization of melanocortin-4 receptor gene mutations in morbidly obese finish children and adults. J Clin Endocrinol Metab 2004;89:940-945.