Individualized weight management: What can be learned from nutrigenomics and nutrigenetics?

Progress in Molecular Biology and Translational Science

Volumn 108, Issue , 2012, Pages 347-382

  Rudkowska, Iwona ^a   Pérusse, Louis ^a,b  

^a LAVAL UNIVERSITY   (Canada)

^b UNIVERSITÉ LAVAL   (Canada)

Author keywords

Energy intake; Gene expression; Gene nutrient interaction; Genetics; Weight management

Indexed keywords

EID: 84861827080     PISSN: 18771173     EISSN: None     Source Type: Book Series    
DOI: 10.1016/B978-0-12-398397-8.00014-9     Document Type: Chapter

References (112)

1. R.J. Loos Recent progress in the genetics of common obesity Br J Clin Pharmacol 68 2009 811 829
2. E. Meugnier, C. Bossu, M. Oliel, S. Jeanne, A. Michaut, and M. Sothier Changes in gene expression in skeletal muscle in response to fat overfeeding in lean men Obesity (Silver Spring) 15 2007 2583 2594
3. M. Kolehmainen, T. Salopuro, U.S. Schwab, J. Kekalainen, P. Kallio, and D.E. Laaksonen Weight reduction modulates expression of genes involved in extracellular matrix and cell death: the GENOBIN study Int J Obes (Lond) 32 2008 292 303
4. L. Bouchard, R. Rabasa-Lhoret, M. Faraj, M.E. Lavoie, J. Mill, and L. Perusse Differential epigenomic and transcriptomic responses in subcutaneous adipose tissue between low and high responders to caloric restriction Am J Clin Nutr 91 2010 309 320
5. K.R. Ong, A.H. Sims, M. Harvie, M. Chapman, W.B. Dunn, and D. Broadhurst Biomarkers of dietary energy restriction in women at increased risk of breast cancer Cancer Prev Res (Phila) 2 2009 720 731
6. K. Clement, N. Viguerie, C. Poitou, C. Carette, V. Pelloux, and C.A. Curat Weight loss regulates inflammation-related genes in white adipose tissue of obese subjects FASEB J 18 2004 1657 1669
7. A.B. Crujeiras, D. Parra, F.I. Milagro, E. Goyenechea, E. Larrarte, and J. Margareto Differential expression of oxidative stress and inflammation related genes in peripheral blood mononuclear cells in response to a low-calorie diet: a nutrigenomics study OMICS 12 2008 251 261
8. F. Capel, E. Klimcakova, N. Viguerie, B. Roussel, M. Vitkova, and M. Kovacikova Macrophages and adipocytes in human obesity: adipose tissue gene expression and insulin sensitivity during calorie restriction and weight stabilization Diabetes 58 2009 1558 1567
9. F. Capel, N. Viguerie, N. Vega, S. Dejean, P. Arner, and E. Klimcakova Contribution of energy restriction and macronutrient composition to changes in adipose tissue gene expression during dietary weight-loss programs in obese women J Clin Endocrinol Metab 93 2008 4315 4322
10. I. Dahlman, K. Linder, N.E. Arvidsson, I. Andersson, J. Liden, and C. Verdich Changes in adipose tissue gene expression with energy-restricted diets in obese women Am J Clin Nutr 81 2005 1275 1285
11. L.M. Mangravite, K. Dawson, R.R. Davis, J.P. Gregg, and R.M. Krauss Fatty acid desaturase regulation in adipose tissue by dietary composition is independent of weight loss and is correlated with the plasma triacylglycerol response Am J Clin Nutr 86 2007 759 767
12. A. Marquez-Quinones, D.M. Mutch, C. Debard, P. Wang, M. Combes, and B. Roussel Adipose tissue transcriptome reflects variations between subjects with continued weight loss and subjects regaining weight 6 mo after caloric restriction independent of energy intake Am J Clin Nutr 92 2010 975 984
13. L.M. Sparks, H. Xie, R.A. Koza, R. Mynatt, G.A. Bray, and S.R. Smith High-fat/low-carbohydrate diets regulate glucose metabolism via a long-term transcriptional loop Metabolism 55 2006 1457 1463
14. A.E. Thalacker-Mercer, J.C. Fleet, B.A. Craig, and W.W. Campbell The skeletal muscle transcript profile reflects accommodative responses to inadequate protein intake in younger and older males J Nutr Biochem 21 2010 1076 1082
15. M.J. van Erk, W.A. Blom, O.B. van, and H.F. Hendriks High-protein and high-carbohydrate breakfasts differentially change the transcriptome of human blood cells Am J Clin Nutr 84 2006 1233 1241
16. H.R. Brattbakk, I. Arbo, S. Aagaard, I. Lindseth, A.K. de Soysa, and M. Langaas Balanced caloric macronutrient composition downregulates immunological gene expression in human blood cells - adipose tissue diverges OMICS 2011
17. P. Kallio, M. Kolehmainen, D.E. Laaksonen, J. Kekalainen, T. Salopuro, and K. Sivenius Dietary carbohydrate modification induces alterations in gene expression in abdominal subcutaneous adipose tissue in persons with the metabolic syndrome: the FUNGENUT Study Am J Clin Nutr 85 2007 1417 1427
18. S.J. van Dijk, E.J. Feskens, M.B. Bos, D.W. Hoelen, R. Heijligenberg, and M.G. Bromhaar A saturated fatty acid-rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome Am J Clin Nutr 90 2009 1656 1664
19. M. Bouwens, B.M. Grootte, J. Jansen, M. Muller, and L.A. Afman Postprandial dietary lipid-specific effects on human peripheral blood mononuclear cell gene expression profiles Am J Clin Nutr 91 2010 208 217
20. A. Camargo, J. Ruano, J.M. Fernandez, L.D. Parnell, A. Jimenez, and M. Santos-Gonzalez Gene expression changes in mononuclear cells in patients with metabolic syndrome after acute intake of phenol-rich virgin olive oil BMC Genomics 11 2010 253
21. V. Konstantinidou, O. Khymenets, M. Fito, R. De La Torre, R. Anglada, and A. Dopazo Characterization of human gene expression changes after olive oil ingestion: an exploratory approach Folia Biol (Praha) 55 2009 85 91
22. O. Khymenets, M. Fito, M.I. Covas, M. Farre, M.A. Pujadas, and D. Munoz Mononuclear cell transcriptome response after sustained virgin olive oil consumption in humans: an exploratory nutrigenomics study OMICS 13 2009 7 19
23. M. Bouwens, O. van de Rest, N. Dellschaft, M.G. Bromhaar, L.C. de Groot, and J.M. Geleijnse Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells Am J Clin Nutr 90 2009 415 424
24. R. Gorjao, R. Verlengia, T.M. Lima, F.G. Soriano, M.F. Boaventura, and C.C. Kanunfre Effect of docosahexaenoic acid-rich fish oil supplementation on human leukocyte function Clin Nutr 25 2006 923 938
25. I. Rudkowska, A. Ponton, H. Jacques, C. Lavigne, B.J. Holub, and A. Marette Effects of a supplementation of n-3 polyunsaturated fatty acids with or without fish gelatin on gene expression in peripheral blood mononuclear cells in obese, insulin-resistant subjects J Nutrigenet Nutrigenomics 4 2011 192 202
26. S.K. Bohn, M.C. Myhrstad, M. Thoresen, M. Holden, A. Karlsen, and S.H. Tunheim Blood cell gene expression associated with cellular stress defense is modulated by antioxidant-rich food in a randomised controlled clinical trial of male smokers BMC Med 8 2010 54
27. I. Boomgaarden, S. Egert, G. Rimbach, S. Wolffram, M.J. Muller, and F. Doring Quercetin supplementation and its effect on human monocyte gene expression profiles in vivo Br J Nutr 104 2010 336 345
28. V.D. de Mello, M. Kolehmainen, L. Pulkkinen, U. Schwab, U. Mager, and D.E. Laaksonen Downregulation of genes involved in NFkappaB activation in peripheral blood mononuclear cells after weight loss is associated with the improvement of insulin sensitivity in individuals with the metabolic syndrome: the GENOBIN study Diabetologia 51 2008 2060 2067
29. V. Konstantinidou, O. Khymenets, M.I. Covas, R. De La Torre, D. Munoz-Aguayo, and R. Anglada Time course of changes in the expression of insulin sensitivity-related genes after an acute load of virgin olive oil OMICS 13 2009 431 438
30. V. Konstantinidou, M.I. Covas, D. Munoz-Aguayo, O. Khymenets, R. De La Torre, and G. Saez In vivo nutrigenomic effects of virgin olive oil polyphenols within the frame of the Mediterranean diet: a randomized controlled trial FASEB J 24 2010 2546 2557
31. V. Llorente-Cortes, R. Estruch, M.P. Mena, E. Ros, M.A. Gonzalez, and M. Fito Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk Atherosclerosis 208 2010 442 450
32. M. Kabir, G. Skurnik, N. Naour, V. Pechtner, E. Meugnier, and S. Rome Treatment for 2 mo with n 3 polyunsaturated fatty acids reduces adiposity and some atherogenic factors but does not improve insulin sensitivity in women with type 2 diabetes: a randomized controlled study Am J Clin Nutr 86 2007 1670 1679
33. M.L. Dansinger, J.A. Gleason, J.L. Griffith, H.P. Selker, and E.J. Schaefer Comparison of the Atkins, Ornish, Weight Watchers, and Zone diets for weight loss and heart disease risk reduction: a randomized trial JAMA 293 2005 43 53
34. K.B. Adamo, R. Dent, C.D. Langefeld, M. Cox, K. Williams, and K.M. Carrick Peroxisome proliferator-activated receptor gamma 2 and acyl-CoA synthetase 5 polymorphisms influence diet response Obesity (Silver Spring) 15 2007 1068 1075
35. E. Goyenechea, L.J. Collins, D. Parra, I. Abete, A.B. Crujeiras, and S.D. O'Dell The - 11391 G/A polymorphism of the adiponectin gene promoter is associated with metabolic syndrome traits and the outcome of an energy-restricted diet in obese subjects Horm Metab Res 41 2009 55 61
36. K. Tsuzaki, K. Kotani, N. Nagai, K. Saiga, Y. Sano, and T. Hamada Adiponectin gene single-nucleotide polymorphisms and treatment response to obesity J Endocrinol Invest 32 2009 395 400
37. T. Hamada, K. Kotani, N. Nagai, K. Tsuzaki, Y. Sano, and Y. Matsuoka Genetic polymorphisms of the renin-angiotensin system and obesity-related metabolic changes in response to low-energy diets in obese women Nutrition 27 2011 34 39
38. J. Aberle, D. Evans, F.U. Beil, and U. Seedorf A polymorphism in the apolipoprotein A5 gene is associated with weight loss after short-term diet Clin Genet 68 2005 152 154
39. T. Yoshida, N. Sakane, T. Umekawa, M. Sakai, T. Takahashi, and M. Kondo Mutation of beta 3-adrenergic-receptor gene and response to treatment of obesity Lancet 346 1995 1433 1434
40. N. Sakane, T. Yoshida, T. Umekawa, A. Kogure, Y. Takakura, and M. Kondo Effects of Trp64Arg mutation in the beta 3-adrenergic receptor gene on weight loss, body fat distribution, glycemic control, and insulin resistance in obese type 2 diabetic patients Diabetes Care 20 1997 1887 1890
41. A. Kogure, T. Yoshida, N. Sakane, T. Umekawa, Y. Takakura, and M. Kondo Synergic effect of polymorphisms in uncoupling protein 1 and beta3-adrenergic receptor genes on weight loss in obese Japanese Diabetologia 41 1998 1399
42. M. Fogelholm, R. Valve, K. Kukkonen-Harjula, A. Nenonen, V. Hakkarainen, and M. Laakso Additive effects of the mutations in the beta3-adrenergic receptor and uncoupling protein-1 genes on weight loss and weight maintenance in Finnish women J Clin Endocrinol Metab 83 1998 4246 4250
43. H. Benecke, H. Topak, A. von zur Mühlen, and F. Schuppert A study on the genetics of obesity: influence of polymorphisms of the beta-3-adrenergic receptor and insulin receptor substrate 1 in relation to weight loss, waist to hip ratio and frequencies of common cardiovascular risk factors Exp Clin Endocrinol Diabetes 108 2000 86 92
44. W. Xinli, T. Xiaomei, P. Meihua, and L. Song Association of a mutation in the beta3-adrenergic receptor gene with obesity and response to dietary intervention in Chinese children Acta Paediatr 90 2001 1233 1237
45. A. Tchernof, R.D. Starling, A. Turner, A.R. Shuldiner, J.D. Walston, and K. Silver Impaired capacity to lose visceral adipose tissue during weight reduction in obese postmenopausal women with the Trp64Arg beta3-adrenoceptor gene variant Diabetes 49 2000 1709 1713
46. M. Nakamura, M. Tanaka, S. Abe, K. Itoch, K. Imai, and T. Masuda Association between beta-3 adrenergenic receptor polymorphism and lower reduction in the ratio of visceral fat to subcutaneous fat area during weight loss in Japanese obese women Nutr Res 20 2000 25 34
47. O.Y. Kim, E.Y. Cho, H.Y. Park, Y. Jang, and J.H. Lee Additive effect of the mutations in the beta3-adrenoceptor gene and UCP3 gene promoter on body fat distribution and glycemic control after weight reduction in overweight subjects with CAD or metabolic syndrome Int J Obes Relat Metab Disord 28 2004 434 441
48. K. Shiwaku, A. Nogi, E. Anuurad, K. Kitajima, B. Enkhmaa, and K. Shimono Difficulty in losing weight by behavioral intervention for women with Trp64Arg polymorphism of the beta3-adrenergic receptor gene Int J Obes Relat Metab Disord 27 2003 1028 1036
49. N. Sakane, T. Yoshida, T. Umekawa, A. Kogure, and M. Kondo Beta2-adrenoceptor gene polymorphism and obesity Lancet 353 1999 1976
50. K. Masuo, T. Katsuya, H. Kawaguchi, Y. Fu, H. Rakugi, and T. Ogihara Rebound weight gain as associated with high plasma norepinephrine levels that are mediated through polymorphisms in the beta2-adrenoceptor Am J Hypertens 18 2005 1508 1516
51. M. Garaulet, M.D. Corbalan, J.A. Madrid, E. Morales, J.C. Baraza, and Y.C. Lee CLOCK gene is implicated in weight reduction in obese patients participating in a dietary programme based on the Mediterranean diet Int J Obes (Lond) 34 2010 516 523
52. G. Ruano, A. Windemuth, M. Kocherla, T. Holford, M.L. Fernandez, and C.E. Forsythe Physiogenomic analysis of weight loss induced by dietary carbohydrate restriction Nutr Metab (Lond) 3 2006 20
53. D.A. de Luis, S.M. Gonzalez, R. Aller, O. Izaola, and R. Conde Effects of C358A missense polymorphism of the endocannabinoid degrading enzyme fatty acid amide hydrolase on weight loss after a hypocaloric diet Metabolism 60 2011 730 734
54. Y. Takakura, K. Yoshioka, T. Umekawa, A. Kogure, H. Toda, and T. Yoshikawa Thr54 allele of the FABP2 gene affects resting metabolic rate and visceral obesity Diabetes Res Clin Pract 67 2005 36 42
55. D.A. de Luis, R. Aller, O. Izaola, M.G. Sagrado, and R. Conde Influence of Ala54Thr polymorphism of fatty acid-binding protein 2 on weight loss and insulin levels secondary to two hypocaloric diets: a randomized clinical trial Diabetes Res Clin Pract 82 2008 113 118
56. D.A. de Luis, R. Aller, O. Izaola, M.G. Sagrado, and R. Conde Influence of ALA54THR polymorphism of fatty acid binding protein 2 on lifestyle modification response in obese subjects Ann Nutr Metab 50 2006 354 360
57. T. Reinehr, A. Hinney, A.M. Toschke, and J. Hebebrand Aggravating effect of INSIG2 and FTO on overweight reduction in a one-year lifestyle intervention Arch Dis Child 94 2009 965 967
58. K. Grau, T. Hansen, C. Holst, A. Astrup, W.H. Saris, and P. Arner Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans Int J Obes (Lond) 33 2009 1227 1234
59. N. Vogels, E.C. Mariman, F.G. Bouwman, A.D. Kester, K. Diepvens, and M.S. Westerterp-Plantenga Relation of weight maintenance and dietary restraint to peroxisome proliferator-activated receptor gamma2, glucocorticoid receptor, and ciliary neurotrophic factor polymorphisms Am J Clin Nutr 82 2005 740 746
60. U. Mager, T. Degenhardt, L. Pulkkinen, M. Kolehmainen, A.M. Tolppanen, and J. Lindstrom Variations in the ghrelin receptor gene associate with obesity and glucose metabolism in individuals with impaired glucose tolerance PLoS One 3 2008 e2941
61. T. Reinehr, A. Hinney, T.T. Nguyen, and J. Hebebrand Evidence of an influence of a polymorphism near the INSIG2 on weight loss during a lifestyle intervention in obese children and adolescents Diabetes 57 2008 623 626
62. E. Goyenechea, P.M. Dolores, and M.J. Alfredo Weight regain after slimming induced by an energy-restricted diet depends on interleukin-6 and peroxisome-proliferator-activated-receptor-gamma2 gene polymorphisms Br J Nutr 96 2006 965 972
63. O. Mammes, R. Aubert, D. Betoulle, F. Pean, B. Herbeth, and S. Visvikis LEPR gene polymorphisms: associations with overweight, fat mass and response to diet in women Eur J Clin Invest 31 2001 398 404
64. J. Zacharova, J.L. Chiasson, and M. Laakso Leptin receptor gene variation predicts weight change in subjects with impaired glucose tolerance Obes Res 13 2005 501 506
65. I. Abete, E. Goyenechea, A.B. Crujeiras, and J.A. Martinez Inflammatory state and stress condition in weight-lowering Lys109Arg LEPR gene polymorphism carriers Arch Med Res 40 2009 306 310
66. R.D. de Luis, R.A. de la Fuente, M.G. Sagrado, O. Izaola, and R.C. Vicente Leptin receptor Lys656Asn polymorphism is associated with decreased leptin response and weight loss secondary to a lifestyle modification in obese patients Arch Med Res 37 2006 854 859
67. D.A. de Luis, R. Aller, O. Izaola, M.G. Sagrado, and R. Conde Influence of Lys656Asn polymorphism of leptin receptor gene on leptin response secondary to two hypocaloric diets: a randomized clinical trial Ann Nutr Metab 52 2008 209 214
68. J. Spalova, H. Zamrazilova, J. Vcelak, M. Vankova, P. Lukasova, and M. Hill Neuromedin beta: P73T polymorphism in overweight and obese subjects Physiol Res 57 Suppl. 1 2008 S39 S48
69. D. Corella, L. Qi, J.V. Sorli, D. Godoy, O. Portoles, and O. Coltell Obese subjects carrying the 11482G>A polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction J Clin Endocrinol Metab 90 2005 5121 5126
70. S. Deram, C.Y. Nicolau, P. Perez-Martinez, I. Guazzelli, A. Halpern, and B.L. Wajchenberg Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents J Clin Endocrinol Metab 93 2008 4933 4940
71. M.J. Shin, Y. Jang, S.J. Koh, J.S. Chae, O.Y. Kim, and J.E. Lee The association of SNP276G>T at adiponectin gene with circulating adiponectin and insulin resistance in response to mild weight loss Int J Obes (Lond) 30 2006 1702 1708
72. S. Soenen, E.C. Mariman, N. Vogels, F.G. Bouwman, M. den Hoed, and L. Brown Relationship between perilipin gene polymorphisms and body weight and body composition during weight loss and weight maintenance Physiol Behav 96 2009 723 728
73. M. Garaulet, M.D. Corbalan-Tutau, J.A. Madrid, J.C. Baraza, L.D. Parnell, and Y.C. Lee PERIOD2 variants are associated with abdominal obesity, psycho-behavioral factors, and attrition in the dietary treatment of obesity J Am Diet Assoc 110 2010 917 921
74. B.J. Nicklas, E.F. van Rossum, D.M. Berman, A.S. Ryan, K.E. Dennis, and A.R. Shuldiner Genetic variation in the peroxisome proliferator-activated receptor-gamma2 gene (Pro12Ala) affects metabolic responses to weight loss and subsequent weight regain Diabetes 50 2001 2172 2176
75. V.I. Lindi, M.I. Uusitupa, J. Lindstrom, A. Louheranta, J.G. Eriksson, and T.T. Valle Association of the Pro12Ala polymorphism in the PPAR-gamma2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study Diabetes 51 2002 2581 2586
76. T. Matsuo, Y. Nakata, Y. Katayama, M. Iemitsu, S. Maeda, and T. Okura PPARG genotype accounts for part of individual variation in body weight reduction in response to calorie restriction Obesity (Silver Spring) 17 2009 1924 1931
77. A. Haupt, C. Thamer, M. Heni, C. Ketterer, J. Machann, and F. Schick Gene variants of TCF7L2 influence weight loss and body composition during lifestyle intervention in a population at risk for type 2 diabetes Diabetes 59 2010 747 750
78. K. Grau, S. Cauchi, C. Holst, A. Astrup, J.A. Martinez, and W.H. Saris TCF7L2 rs7903146-macronutrient interaction in obese individuals' responses to a 10-wk randomized hypoenergetic diet Am J Clin Nutr 91 2010 472 479
79. F. Fumeron, I. Durack-Bown, D. Betoulle, A.M. Cassard-Doulcier, S. Tuzet, and F. Bouillaud Polymorphisms of uncoupling protein (UCP) and beta 3 adrenoreceptor genes in obese people submitted to a low calorie diet Int J Obes Relat Metab Disord 20 1996 1051 1054
80. J.Y. Kim, and S.S. Lee The effects of uncoupling protein 1 and beta3-adrenergic receptor gene polymorphisms on weight loss and lipid profiles in obese women Int J Vitam Nutr Res 80 2010 87 96
81. N. Nagai, N. Sakane, K. Kotani, T. Hamada, K. Tsuzaki, and T. Moritani Uncoupling protein 1 gene -3826 A/G polymorphism is associated with weight loss on a short-term, controlled-energy diet in young women Nutr Res 31 2011 255 261
82. H.D. Shin, K.S. Kim, M.H. Cha, and Y. Yoon The effects of UCP-1 polymorphisms on obesity phenotypes among Korean female subjects Biochem Biophys Res Commun 335 2005 624 630
83. Y. Yoon, B.L. Park, M.H. Cha, K.S. Kim, H.S. Cheong, and Y.H. Choi Effects of genetic polymorphisms of UCP2 and UCP3 on very low calorie diet-induced body fat reduction in Korean female subjects Biochem Biophys Res Commun 359 2007 451 456
84. D.A. de Luis, R. Aller, O. Izaola, M. Gonzalez Sagrado, and R. Conde Modulation of insulin concentrations and metabolic parameters in obese patients by -55CT polymorphism of the UCP3 gene secondary to two hypocaloric diets Horm Metab Res 41 2009 62 66
85. D.A. de Luis, R. Aller, O. Izaola, M.G. Sagrado, and R. Conde Modulation of adipocytokines response and weight loss secondary to a hypocaloric diet in obese patients by -55CT polymorphism of UCP3 gene Horm Metab Res 40 2008 214 218
86. M.H. Cha, H.D. Shin, K.S. Kim, B.H. Lee, and Y. Yoon The effects of uncoupling protein 3 haplotypes on obesity phenotypes and very low-energy diet-induced changes among overweight Korean female subjects Metabolism 55 2006 578 586
87. D.A. de Luis, S.M. Gonzalez, R. Aller, O. Izaola, and R. Conde Influence of the Trp64Arg polymorphism in the beta 3 adrenoreceptor gene on insulin resistance, adipocytokine response, and weight loss secondary to lifestyle modification in obese patients Eur J Intern Med 18 2007 587 592
88. D.A. de Luis, S.M. Gonzalez, R. Aller, O. Izaola, and R. Conde Influence of Trp64Arg polymorphism of beta 3-adrenoreceptor gene on insulin resistance, adipocytokines and weight loss secondary to two hypocaloric diets Ann Nutr Metab 54 2009 104 110
89. O.Y. Kim, Y.A. Lee, H.J. Ryu, H.Y. Park, Y. Jang, and J.H. Lee Effect of Trp64Arg mutation in the beta-3 adrenergic receptor gene on body fat distribution, glycemic control and lipids in response to hypocaloric diets in men with coronary artery disease Nutr Res 23 2003 1013 1025
90. E.S. Rawson, A. Nolan, K. Silver, A.R. Shuldiner, and E.T. Poehlman No effect of the Trp64Arg beta(3)-adrenoceptor gene variant on weight loss, body composition, or energy expenditure in obese, caucasian postmenopausal women Metabolism 51 2002 801 805
91. C.M. Povel, J.M. Boer, E. Reiling, and E.J. Feskens Genetic variants and the metabolic syndrome: a systematic review Obes Rev 12 2011 952 967
92. C. Li, P.M. Jones, and S.J. Persaud Role of the endocannabinoid system in food intake, energy homeostasis and regulation of the endocrine pancreas Pharmacol Ther 129 2011 307 320
93. D.A. de Luis, M.G. Sagrado, R. Aller, R. Conde, O. Izaola, and B. de la Fuente Role of G1359A polymorphism of the cannabinoid receptor gene on weight loss and adipocytokines levels after two different hypocaloric diets J Nutr Biochem 23 2012 287 291
94. D.A. de Luis, S.M. Gonzalez, R. Aller, R. Conde, O. Izaola, and B. de la Fuente Roles of G1359A polymorphism of the cannabinoid receptor gene (CNR1) on weight loss and adipocytokines after a hypocaloric diet Nutr Hosp 26 2011 317 322
95. D.A. de Luis, M.G. Sagrado, R. Aller, O. Izaola, and R. Conde Effects of C358A missense polymorphism of the degrading enzyme fatty acid amide hydrolase on weight loss, adipocytokines, and insulin resistance after 2 hypocaloric diets Metabolism 59 2010 1387 1392
96. J. Aberle, I. Fedderwitz, N. Klages, E. George, and F.U. Beil Genetic variation in two proteins of the endocannabinoid system and their influence on body mass index and metabolism under low fat diet Horm Metab Res 39 2007 395 397
97. L. Bouchard, V. Drapeau, V. Provencher, S. Lemieux, Y. Chagnon, and T. Rice Neuromedin beta: a strong candidate gene linking eating behaviors and susceptibility to obesity Am J Clin Nutr 80 2004 1478 1486
98. T. Salopuro, L. Pulkkinen, J. Lindstrom, J.G. Eriksson, T.T. Valle, and H. Hamalainen Genetic variation in leptin receptor gene is associated with type 2 diabetes and body weight: the Finnish Diabetes Prevention Study Int J Obes (Lond) 29 2005 1245 1251
99. E. Levy, D. Menard, E. Delvin, S. Stan, G. Mitchell, and M. Lambert The polymorphism at codon 54 of the FABP2 gene increases fat absorption in human intestinal explants J Biol Chem 276 2001 39679 39684
100. Y Jang, OY Kim, JH Lee, SJ Koh, JS Chae, and JY Kim Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss Int J Obes (Lond) 30 11 2006 1601 1608
101. O. Froy Metabolism and circadian rhythms - implications for obesity Endocr Rev 31 2010 1 24
102. S. Yang, A. Liu, A. Weidenhammer, R.C. Cooksey, D. McClain, and M.K. Kim The role of mPer2 clock gene in glucocorticoid and feeding rhythms Endocrinology 150 2009 2153 2160
103. R.J. Loos, and C. Bouchard FTO: the first gene contributing to common forms of human obesity Obes Rev 9 2008 246 250
104. S. Peng, Y. Zhu, F. Xu, X. Ren, X. Li, and M. Lai FTO gene polymorphisms and obesity risk: a meta-analysis BMC Med 9 2011 71
105. D. Dlouha, P. Suchanek, V. Lanskalanskalanska, and J.A. Hubacek Body mass index change in females after short-time life style intervention is not dependent on the FTO polymorphisms Physiol Res 60 2011 199 202
106. A. Haupt, C. Thamer, J. Machann, K. Kirchhoff, N. Stefan, and O. Tschritter Impact of variation in the FTO gene on whole body fat distribution, ectopic fat, and weight loss Obesity (Silver Spring) 16 2008 1969 1972
107. T.J. Lappalainen, A.M. Tolppanen, M. Kolehmainen, U. Schwab, J. Lindstrom, and J. Tuomilehto The common variant in the FTO gene did not modify the effect of lifestyle changes on body weight: the Finnish Diabetes Prevention Study Obesity (Silver Spring) 17 2009 832 836
108. T.D. Muller, A. Hinney, A. Scherag, T.T. Nguyen, F. Schreiner, and H. Schafer 'Fat mass and obesity associated' gene (FTO): no significant association of variant rs9939609 with weight loss in a lifestyle intervention and lipid metabolism markers in German obese children and adolescents BMC Med Genet 9 2008 85
109. S. Cauchi, H. Choquet, R. Gutierrez-Aguilar, F. Capel, K. Grau, and C. Proenca Effects of TCF7L2 polymorphisms on obesity in European populations Obesity (Silver Spring) 16 2008 476 482
110. S.F. Grant, G. Thorleifsson, I. Reynisdottir, R. Benediktsson, A. Manolescu, and J. Sainz Variant of transcription factor 7-like 2 (TCF7L2) gene confers risk of type 2 diabetes Nat Genet 38 2006 320 323
111. T.I. Sorensen, P. Boutin, M.A. Taylor, L.H. Larsen, C. Verdich, and L. Petersen Genetic polymorphisms and weight loss in obesity: a randomised trial of hypo-energetic high- versus low-fat diets PLoS Clin Trials 1 2006 e12
112. J. Wittwer, I. Rubio-Aliaga, B. Hoeft, I. Bendik, P. Weber, and H. Daniel Nutrigenomics in human intervention studies: current status, lessons learned and future perspectives Mol Nutr Food Res 55 2011 341 358