Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents

Journal of Clinical Endocrinology and Metabolism

Volumn 93, Issue 12, 2008, Pages 4933-4940

  Deram, Sophie ^a   Nicolau, Christiane Y ^a   Perez Martinez, Pablo ^b   Guazzelli, Isabel ^a   Halpern, Alfredo ^a   Wajchenberg, Bernardo L ^a   Ordovas, Jose M ^c   Villares, Sandra M ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

^b HOSPITAL UNIVERSITARIO REINA SOFÍA   (Spain)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

LOW DENSITY LIPOPROTEIN CHOLESTEROL; PERILIPIN; TRIACYLGLYCEROL;

ADOLESCENT; ANTHROPOMETRY; ARTICLE; BEHAVIOR THERAPY; BODY MASS; CONTROLLED STUDY; DNA POLYMORPHISM; FEMALE; GENE FREQUENCY; GENE LINKAGE DISEQUILIBRIUM; GENE LOCUS; GENETIC VARIABILITY; GENOTYPE; HAPLOTYPE; HOMEOSTASIS; HUMAN; INSULIN RESISTANCE; MAJOR CLINICAL STUDY; MALE; METABOLIC SYNDROME X; OBESITY; ORAL GLUCOSE TOLERANCE TEST; PRIORITY JOURNAL; RISK ASSESSMENT; SCHOOL CHILD; SINGLE NUCLEOTIDE POLYMORPHISM; WEIGHT REDUCTION;

EID: 57349095232     PISSN: 0021972X     EISSN: 0021972X     Source Type: Journal    
DOI: 10.1210/jc.2008-0947     Document Type: Article

References (30)

1. Kiess W, Reich A, Muller G, Meyer K, Galler A, Bennek J, Kratzsch J 2001 Clinical aspects of obesity in childhood and adolescence: diagnosis, treatment and prevention. Int J Obes Relat Metab Disord 25(Suppl 1):S75-S79
2. Ebbeling CA, Pawlak DB, Ludwig DS 2002 Childhood obesity: public-health crisis, common sense cure. Lancet 360:473-482
3. Gortmaker SL, Must A, Perrin JM, Sobol AM, Dietz WH 1993 Social and economic consequences of overweight in adolescence and young adulthood. N Engl J Med 329:1008-1012
4. Barlow SE, Dietz WH 1998 Obesity evaluation and treatment: Expert Committee recommendations. The Maternal and Child Health Bureau, Health Resources and Services Administration and the Department of Health and Human Sciences. Pediatrics 102:1-11
5. Mutch DM, Clément K 2006 Genetics of human obesity. Best Pract Res Clin Endocrinol Metab 20:647-664
6. Wang Y, Monteiro C, Popkin BM 2002 Trends of obesity and underweight in older children and adolescents in the United States, Brazil, China, and Russia. Am J Clin Nutr 75:971-977
7. IBGE 2006 Consumer Expenditure Survey, 2002-2003: Rio de Janeiro. http://www.ibge.gov.br/home/estatistica/populacao/condicaodevida/pof/ 2003medidas/pof2003medidas.pdf (accessed 20 June 2007)
8. Tai ES, Ordovas JM 2007 The role of perilipin in human obesity and insulin resistance. Curr Opin Lipidol 18:152-156
9. Tansey JT, Sztalryd C, Gruía-Gray J, Roush DL, Zee JV, Gravilova O, Reitman ML, Deng CX, Li C, Kimmel AR, Londos C 2001 Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proc Natl Acad Sci USA 98:6494-6499
10. Mottagui-Tabar S, Ryden M, Lofgren P, Faulds G, Hoffstedt J, Brookes AJ, Andersson I, Arner P 2003 Evidence for an important role of perilipin in the regulation of human adipocyte lipolysis. Diabetologia 46:789-797
11. Qi L, Corella D, Sorli JV, Portoles O, Shen H, Coltell O, Godoy D, Greenberg AS, Ordovas JM 2004 Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in white women. Clin Genet 66:299-310
12. Qi L, Shen H, Larson I, Schaefer EJ, Greenberg AS, Tregouet DA, Corella D, Ordovas JM 2004 Gender-specific association of a perilipin gene haplotype with obesity risk in a white population. Obes Res 12:1758-1765
13. Meirhaeghe A, Thomas S, Ancot F, Cottel D, Arveiler D, Ferrieres J, Amouyel P 2006 Study of the impact of perilipin polymorphisms in a French population. J Negat Results Biomed 5:10
14. Corella D, Qi L, Sorli JV, Godoy D, Portoles O, Coltell O, Greenberg AS, Ordovas JM 2005 Obese subjects carrying the 11482GA polymorphism at the perilipin locus are resistant to weight loss after dietary energy restriction. J Clin Endocrinol Metab 90:5121-5126
15. Kang S, Cha B, Kim H, Kim S, Hur K, Lee H, Shim W, Ahn C, Lee HC 2006 The 11482GA polymorphism in the perilipin gene is associated with weight gain with rosiglitazone treatment in type 2 diabetes. Diabetes Care 29:1320-1324
16. Yan W, Chen S, Huang J, Shen Y, Qiang B, Gu D 2004 Polymorphisms in PLIN and hypertension combined with obesity and lipid profiles in Han Chinese. Obes Res 12:1733-1737
17. Perez-Martinez P, Lopez-Miranda J, Perez-Jimenez F, Ordovas JM 2008 Influence of genetic factors in the modulation of postprandial lipemia. Atheroscler Suppl 9:49-55
18. US Department of Health and Human Services 2000 CDC growth charts: United States. http://www.cdc.gov/growthcharts/
19. Marshall WA, Tanner JM 1969 Variations in the pattern of pubertal changes in girls. Arch Dis Child 44:291-303
20. Marshall WA, Tanner JM 1970 Variations in the pattern of pubertal changes in boys. Arch Dis Child 45:13-23
21. Pecoraro P, Guida B, Caroli M, Trio R, Falconi C, Principato S, Pietrobelli A 2003 Body mass index and skinfold thickness versus bioimpedance analysis: fat mass prediction in children. Acta Diabetol 40(Suppl 1):S278-S281
22. Zimmet P, Alberti G, Kaufman F, Tajima N, Silink M, Arslanian S, Wong G, Bennett P, Shaw J, Caprio S; International Diabetes Federation Task Force on Epidemiology and Prevention of Diabetes 2007 The metabolic syndrome in children and adolescents. Lancet 369: 2059-2061
23. Pimenta JR, Zuccherato LW, Debes AA, Maselli L, Soares RP, Moura-Neto RS, Rocha J, Bydlowski SP, Pena SD 2006 Color and genomic ancestry in Brazilians: a study with forensic microsatellites. Hum Hered 62:190-195
24. Avramoglu RK, Basciano H, Adeli K 2006 Lipid and lipoprotein dysregulation in insulin resistant states. Clin Chim Acta 368:1-19
25. Ten S, Maclaren N 2004 Insulin resistance syndrome in children. J Clin Endocrinol Metab 89:2526-2539
26. Qi L, Tai ES, Tan CE, Shen H, Chew SK, Greenberg AS, Corella D, Ordovas JM 2005 Intragenic linkage disequilibrium structure of the human perilipin gene (PLIN) and haplotype association with increased obesity risk in a multiethnic Asian population. J Mol Med 83: 448-456
27. Jang Y, Kim OY, Lee JH, Koh SJ, Chae JS, Kim JY, Park S, Cho H, Lee JE, Ordovas JM 2006 Genetic variation at the perilipin locus is associated with changes in serum free fatty acids and abdominal fat following mild weight loss. Int J Obes (Lond) 30:1601-1608
28. Suskind RM, Blecker U, Udall Jr JN, Von Almen TK, Schumacher HD, Carlisle L, Sothern MS 2000 Recent advances in the treatment of childhood obesity. Pediatr Diabetes 1:23-33
29. Perez-Martinez P, Yiannakouris N, Lopez-Miranda J, Arnett D, Tsai M, Galan E, Straka R, Delgado-Lista J, Province M, Ruano J, Borecki I, Hixson J, Garcia-Bailo B, Perez-Jimenez F, Ordovas JM 2008 Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations. Am J Clin Nutr Mar 87:744-752
30. Qi L, Zhang C, Greenberg A, Hu FB 2008 Common variation in perilipin gene, central obesity, and risk of type 2 diabetes in US women. Obesity (Silver Spring) 16:1061-1065