Common polymorphisms in the genes regulating the early insulin signalling pathway: Effects on weight and the conversion from impaired glucose tolerance to Type 2 diabetes. The finnish diabetes prevention study

Diabetologia

Volumn 47, Issue 5, 2004, Pages 871-877

  Laukkanen, O ^a   Pihlajamaki J ^a   Lindstrom J ^b   Eriksson, J ^b   Valle, T T ^b   Hamalainen H ^c   Ilanne Parikka, P ^d   Keinanen Kiukaanniemi S ^e,f   Tuomilehto, J ^b,g   Uusitupa, M ^a   Laakso, M ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b NATIONAL PUBLIC HEALTH INSTITUTE   (Finland)

^c SOCIAL INSURANCE INSTITUTION   (Finland)

^d TAMPERE UNIVERSITY HOSPITAL   (Finland)

^e UNIVERSITY OF OULU   (Finland)

^f OULU DEACONESS INSTITUTE   (Finland)

^g UNIVERSITY OF HELSINKI   (Finland)

Author keywords

Genes; Impaired glucose tolerance; Insulin; Insulin signalling; Prevention; Type 2 diabetes; Weight change

Indexed keywords

GLYCOPROTEIN; INSULIN; INSULIN RECEPTOR; PHOSPHATIDYLINOSITOL 3 KINASE; SOMATOMEDIN C RECEPTOR;

ADULT; AGED; ARTICLE; CONTROLLED STUDY; DIET SUPPLEMENTATION; DNA DETERMINATION; EXERCISE; FEMALE; GENE CONTROL; GENETIC POLYMORPHISM; GENOTYPE; HUMAN; IMPAIRED GLUCOSE TOLERANCE; LIFESTYLE; MAJOR CLINICAL STUDY; MALE; NON INSULIN DEPENDENT DIABETES MELLITUS; PRIORITY JOURNAL; RANDOMIZATION; SIGNAL TRANSDUCTION; STATISTICAL ANALYSIS; WEIGHT REDUCTION;

BODY MASS INDEX; BODY WEIGHT; DIABETES MELLITUS, TYPE 2; FINLAND; GENE FREQUENCY; GLUCOSE INTOLERANCE; HUMANS; INSULIN; LIFE STYLE; MINISATELLITE REPEATS; OBESITY; POLYMORPHISM, GENETIC; SIGNAL TRANSDUCTION;

EID: 2942538530     PISSN: 0012186X     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00125-004-1395-6     Document Type: Article

References (38)

1. Groop LC (1997) The molecular genetics of non-insulin-dependent diabetes mellitus. J Intern Med 241:95-101
2. Knowler WC, Barrett-Connor E, Fowler SE et al. (2002) Reduction in the incidence of type 2 diabetes with lifestyle intervention or metformin. N Engl J Med 346:393-403
3. Pan XR, Li GW, Hu YH et al. (1997) Effects of diet and exercise in preventing NIDDM in people with impaired glucose tolerance. The Da Qing IGT and Diabetes Study. Diabetes Care 20:537-544
4. Weedon MN, Schwarz PE, Horikawa Y et al. (2003) Meta-analysis and a large association study confirm a role for calpain-10 variation in type 2 diabetes susceptibility. Am J Hum Genet 73:1208-1212
5. Altshuler D, Hirschorn JN, Klannemark M et al. (2000) The common PPARgamma Pro12Ala polymorphism is associated with decreased risk of type 2 diabetes. Nat Genet 26:76-80
6. Gloyn AL, Weedon MN, Owen KR et al. (2003) Large-scale association studies of variants in genes encoding the pancreatic beta-cell KATP channel subunits Kir6.2 (KCNJ11) and SUR1 (ABCC8) confirm that the KCNJ11 E23K variant is associated with type 2 diabetes. Diabetes 52:568-572
7. Saltiel AR, Pessin JE (2002) Insulin signaling pathways in time and space. Trends Cell Biol 12:65-71
8. Ong KK, Phillips DI, Fall C et al. (1999) The insulin gene VNTR, type 2 diabetes and birth weight. Nat Genet 21:262-263
9. Le Stunff C, Fallin D, Schork NJ, Bougnères P (2000) The insulin gene VNTR is associated with fasting insulin levels and development of juvenile obesity. Nat Genet 26:444-446
10. Maddux BA, Goldfine ID (2000) Membrane glycoprotein PC-1 inhibition of insulin receptor function occurs via direct interaction with the receptor alpha-subunit. Diabetes 49:13-19
11. Frittitta L, Baratta R, Spampinato D et al. (2001) The Q121 PC-1 variant and obesity have additive and independent effects in causing insulin resistance. J Clin Endocrinol Metab 86:5888-5891
12. Pizzuti A, Frittitta L, Argiolas A et al. (1999) A polymorphism (K121Q) of the human glycoprotein PC-1 gene coding region is strongly associated with insulin resistance. Diabetes 48:1881-1884
13. Burks DJ, White MF (2001) IRS proteins and beta-cell function. Diabetes 50 [Suppl 1]:S140-S145
14. Withers DJ, Gutierrez JS, Towery H et al. (1998) Disruption of IRS-2 causes type 2 diabetes in mice. Nature 391:900-904
15. Almind K, Frederiksen SK, Bernal D et al. (1999) Search for variants of the gene-promoter and the potential phosphotyrosine encoding sequence of the insulin receptor substrate-2 gene: evaluation of their relation with alterations in insulin secretion and insulin sensitivity. Diabetologia 42:1244-1249
16. Mammarella S, Romano F, Di Valerio A et al. (2000) Interaction between the G1057D variant of IRS-2 and overweight in the pathogenesis of type 2 diabetes. Hum Mol Genet 9:2517-2521
17. Fritsche A, Madaus A, Renn W et al. (2001) The prevalent Gly1057Asp polymorphism in the insulin receptor substrate-2 gene is not associated with impaired insulin secretion. J Clin Endocrinol Metab 86:4822-4825
18. Stefan N, Kovacs P, Stumvoll M et al. (2003) Metabolic effects of the Gly1057Asp polymorphism in IRS-2 and interactions with obesity. Diabetes 52:1544-1550
19. Almind K, Bjørbaek C, Vestergaard H, Hansen T, Echwald S, Pedersen O (1993) Amino acid polymorphisms of insulin receptor substrate-1 in non-insulin-dependent diabetes mellitus. Lancet 342:828-832
20. Sigal RJ, Doria A, Warram JH, Krolewski AS (1996) Codon 972 polymorphism in the insulin receptor substrate-1 gene, obesity, and risk of noninsulin-dependent diabetes mellitus. J Clin Endocrinol Metab 81:1657-1659
21. Almind K, Inoue G, Pedersen O, Kahn CR (1996) A common amino acid polymorphism in insulin receptor substrate-1 causes impaired insulin signaling. Evidence from transfection studies. J Clin Invest 97:2569-2575
22. Porzio O, Federici M, Hribal ML et al. (1999) The Gly 972→Arg amino acid polymorphism in IRS-1 impairs insulin secretion in pancreatic beta cells. J Clin Invest 104:357-364
23. Marchetti P, Lupi R, Federici M et al. (2002) Insulin secretory function is impaired in isolated human islets carrying the Gly(972)-→Arg IRS-1 polymorphism. Diabetes 51:1419-1424
24. Xuan S, Kitamura T, Nakae J et al. (2002) Defective insulin secretion in pancreatic beta cells lacking type 1 IGF receptor. J Clin Invest 110:1011-1019
25. Férnandez AM, Kim JK, Yakar S et al. (2001) Functional inactivation of the IGF-I and insulin receptors in skeletal muscle causes type 2 diabetes. Genes Dev 15:1926-1934
26. Dey BR, Furlanetto RW, Nissley SP (1998) Cloning of human p55 gamma, a regulatory subunit of phosphatidylinositol 3-kinase, by a yeast two-hybrid library screen with the insulin-like growth factor-I receptor. Gene 209:175-183
27. Shepherd PR, Kahn BB (1999) Glucose transporters and insulin action - implications for insulin resistance and diabetes mellitus. N Engl J Med 341:248-257
28. Terauchi Y, Tsuji Y, Satoh S et al. (1999) Increased insulin sensitivity and hypoglycaemia in mice lacking the p85 alpha subunit of phosphoinositide 3-kinase. Nat Genet 21:230-235
29. Baier LJ, Wiedrich C, Hanson RL, Bogardus C (1998) Variant in the regulatory subunit of phosphatidylinositol 3-kinase (p85alpha): preliminary evidence indicates a potential role of this variant in the acute insulin response and type 2 diabetes in Pima women. Diabetes 47:973-975
30. Hansen T, Andersen CB, Echwald SM et al. (1997) Identification of a common amino acid polymorphism in the p85alpha regulatory subunit of phosphatidylinositol 3-kinase: effects on glucose disappearance constant, glucose effectiveness, and the insulin sensitivity index. Diabetes 46:494-501
31. Hansen L, Zethelius B, Berglund L et al. (2001) In vitro and in vivo studies of a naturally occurring variant of the human p85alpha regulatory subunit of the phosphoinositide 3-kinase: inhibition of protein kinase B and relationships with type 2 diabetes, insulin secretion, glucose disappearance constant, and insulin sensitivity. Diabetes 50:690-693
32. Tuomilehto J, Lindström J, Eriksson JG et al. (2001) Prevention of type 2 diabetes mellitus by changes in lifestyle among subjects with impaired glucose tolerance. N Engl J Med 344:1343-1350
33. Eriksson J, Lindström J, Valle T et al. (1999) Prevention of Type II diabetes in subjects with impaired glucose tolerance: the Diabetes Prevention Study (DPS) in Finland. Study design and 1-year interim report on the feasibility of the lifestyle intervention programme. Diabetologia 42:793-801
34. World Health Organization (1985) Diabetes mellitus. Report of a WHO Study Group. World Health Organ Tech Rep Ser 727:1-113
35. Laakso M, Malkki M, Kekäläinen P, Kuusisto J, Deeb SS (1994) Insulin receptor substrate-1 variants in non-insulin-dependent diabetes. J Clin Invest 94:1141-1146
36. Goldstein BJ (2002) Insulin resistance as the core defect in type 2 diabetes mellitus. Am J Cardiol 90:3G-10G
37. Lindi V, Uusitupa M, Lindström J et al.(2002) Association of the Pro12Ala polymorphism in the PPAR-gamma 2 gene with 3-year incidence of type 2 diabetes and body weight change in the Finnish Diabetes Prevention Study. Diabetes 51:2581-2586
38. Rasmussen SK, Lautier C, Hansen L et al. (2000) Studies of the variability of the genes encoding the insulin-like growth factor I receptor and its ligand in relation to type 2 diabetes mellitus. J Clin Endocrinol Metab 85:1606-1610