-
2
-
-
0000674913
-
The theory of the gene
-
Morgan TH (1917) The theory of the gene. Am Nat 51:513-544
-
(1917)
Am Nat
, vol.51
, pp. 513-544
-
-
Morgan, T.H.1
-
3
-
-
0041892131
-
The analysis of a case of continuous variation in Drosophila by a study of its linkage relations
-
Dexter JS (1914) The analysis of a case of continuous variation in Drosophila by a study of its linkage relations. Am Nat 48:712-758
-
(1914)
Am Nat
, vol.48
, pp. 712-758
-
-
Dexter, J.S.1
-
4
-
-
0001130046
-
Character changes caused by mutation of an entire region of a chromosome in Drosophila
-
Mohr OL (1919) Character changes caused by mutation of an entire region of a chromosome in Drosophila. Genetics 4:275-282
-
(1919)
Genetics
, vol.4
, pp. 275-282
-
-
Mohr, O.L.1
-
6
-
-
0001398372
-
Chromosomal Defi ciencies and the Embryonic Development of Drosophila Melanogaster
-
Poulson DF (1937) Chromosomal Defi ciencies and the Embryonic Development of Drosophila Melanogaster. Proc Natl Acad Sci USA. 23(3):133-7
-
(1937)
Proc Natl Acad Sci USA
, vol.23
, Issue.3
, pp. 133-137
-
-
Poulson, D.F.1
-
8
-
-
0020529437
-
On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster
-
Lehmann R, Jimenez F, Dietrich U, Campos-Ortega JA (1983) On the phenotype and development of mutants of early neurogenesis in Drosophila melanogaster. Rouxs Arch Dev Biol 192:62-74
-
(1983)
Rouxs Arch Dev Biol
, vol.192
, pp. 62-67
-
-
Lehmann, R.1
Jimenez, F.2
Dietrich, U.3
Campos-Ortega, J.A.4
-
10
-
-
0028171718
-
The suppressor of hairless protein participates in notch receptor signaling
-
Fortini ME, Artavanis-Tsakonas S (1994) The suppressor of hairless protein participates in notch receptor signaling. Cell 79:273-282
-
(1994)
Cell
, vol.79
, pp. 273-282
-
-
Fortini, M.E.1
Artavanis-Tsakonas, S.2
-
11
-
-
0025607925
-
The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster
-
Fleming RJ, Scottgale TN, Diederich RJ et al (1990) The gene Serrate encodes a putative EGF-like transmembrane protein essential for proper ectodermal development in Drosophila melanogaster. Genes Dev 4:2188-2201
-
(1990)
Genes Dev
, vol.4
, pp. 2188-2201
-
-
Fleming, R.J.1
Scottgale, T.N.2
Diederich, R.J.3
-
12
-
-
0037517754
-
Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster
-
Artavanis-Tsakonas S, Muskavitch MA, Yedvobnick B (1983) Molecular cloning of Notch, a locus affecting neurogenesis in Drosophila melanogaster. Proc Natl Acad Sci USA 80:1977-1981
-
(1983)
Proc Natl Acad Sci USA
, vol.80
, pp. 1977-1981
-
-
Artavanis-Tsakonas, S.1
Muskavitch, M.A.2
Yedvobnick, B.3
-
13
-
-
0020827989
-
The Notch locus of Drosophila melanogaster
-
Kidd S, Lockett TJ, Young MW (1983) The Notch locus of Drosophila melanogaster. Cell 34:421-433
-
(1983)
Cell
, vol.34
, pp. 421-433
-
-
Kidd, S.1
Lockett, T.J.2
Young, M.W.3
-
14
-
-
0022289842
-
Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats
-
Wharton KA, Johansen KM, Xu T et al (1985) Nucleotide sequence from the neurogenic locus notch implies a gene product that shares homology with proteins containing EGF-like repeats. Cell 43:567-581
-
(1985)
Cell
, vol.43
, pp. 567-581
-
-
Wharton, K.A.1
Johansen, K.M.2
Xu, T.3
-
15
-
-
0022780155
-
Sequence of the notch locus of Drosophila melanogaster: Relationship of the encoded protein to mammalian clotting and growth factors
-
Kidd S, Kelley MR, Young MW (1986) Sequence of the notch locus of Drosophila melanogaster: relationship of the encoded protein to mammalian clotting and growth factors. Mol Cell Biol 6:3094-3108
-
(1986)
Mol Cell Biol
, vol.6
, pp. 3094-3108
-
-
Kidd, S.1
Kelley, M.R.2
Young, M.W.3
-
16
-
-
0023506983
-
The glp-1 locus and cellular interactions in early C. Elegans embryos
-
Priess JR, Schnabel H, Schnabel R (1987) The glp-1 locus and cellular interactions in early C. elegans embryos. Cell 51:601-611
-
(1987)
Cell
, vol.51
, pp. 601-611
-
-
Priess, J.R.1
Schnabel, H.2
Schnabel, R.3
-
17
-
-
0023468962
-
Glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. Elegans
-
Austin J, Kimble J (1987) glp-1 is required in the germ line for regulation of the decision between mitosis and meiosis in C. elegans. Cell 51:589-599
-
(1987)
Cell
, vol.51
, pp. 589-599
-
-
Austin, J.1
Kimble, J.2
-
18
-
-
0023285899
-
The lin-12 locus of Caenorhabditis elegans
-
Greenwald I (1987) The lin-12 locus of Caenorhabditis elegans. Bioessays 6:70-73
-
(1987)
Bioessays
, vol.6
, pp. 70-73
-
-
Greenwald, I.1
-
19
-
-
0025084614
-
Xotch, the Xenopus homolog of Drosophila notch
-
Coffman C, Harris W, Kintner C (1990) Xotch, the Xenopus homolog of Drosophila notch. Science 249:1438-1441
-
(1990)
Science
, vol.249
, pp. 1438-1441
-
-
Coffman, C.1
Harris, W.2
Kintner, C.3
-
20
-
-
0025856717
-
TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms
-
Ellisen LW, Bird J, West DC et al (1991) TAN-1, the human homolog of the Drosophila notch gene, is broken by chromosomal translocations in T lymphoblastic neoplasms. Cell 66:649-661
-
(1991)
Cell
, vol.66
, pp. 649-661
-
-
Ellisen, L.W.1
Bird, J.2
West, D.C.3
-
21
-
-
0026601245
-
Making a difference: The role of cell-cell interactions in establishing separate identities for equivalent cells
-
Greenwald I, Rubin GM (1992) Making a difference: the role of cell-cell interactions in establishing separate identities for equivalent cells. Cell 68:271-281
-
(1992)
Cell
, vol.68
, pp. 271-281
-
-
Greenwald, I.1
Rubin, G.M.2
-
22
-
-
0027738465
-
Notch: Neurogenesis is only part of the picture
-
Fortini ME, Artavanis-Tsakonas S (1993) Notch: neurogenesis is only part of the picture. Cell 75:1245-1247
-
(1993)
Cell
, vol.75
, pp. 1245-1247
-
-
Fortini, M.E.1
Artavanis-Tsakonas, S.2
-
24
-
-
18444417998
-
Aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation
-
Francis R, McGrath G, Zhang J et al (2002) aph-1 and pen-2 are required for Notch pathway signaling, gamma-secretase cleavage of betaAPP, and presenilin protein accumulation. Dev Cell 3:85-97
-
(2002)
Dev Cell
, vol.3
, pp. 85-97
-
-
Francis, R.1
McGrath, G.2
Zhang, J.3
-
25
-
-
0034080403
-
Aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling
-
Goutte C, Hepler W, Mickey KM et al (2000) aph-2 encodes a novel extracellular protein required for GLP-1-mediated signaling. Development 127:2481-2492
-
(2000)
Development
, vol.127
, pp. 2481-2492
-
-
Goutte, C.1
Hepler, W.2
Mickey, K.M.3
-
26
-
-
0037154158
-
APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos
-
Goutte C, Tsunozaki M, Hale VA et al (2002) APH-1 is a multipass membrane protein essential for the Notch signaling pathway in Caenorhabditis elegans embryos. Proc Natl Acad Sci USA 99:775-779
-
(2002)
Proc Natl Acad Sci USA
, vol.99
, pp. 775-779
-
-
Goutte, C.1
Tsunozaki, M.2
Hale, V.A.3
-
27
-
-
0029116848
-
Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene
-
Levitan D, Greenwald I (1995) Facilitation of lin-12-mediated signalling by sel-12, a Caenorhabditis elegans S182 Alzheimer's disease gene. Nature 377:351-354
-
(1995)
Nature
, vol.377
, pp. 351-354
-
-
Levitan, D.1
Greenwald, I.2
-
28
-
-
0027300294
-
Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos
-
Coffman CR, Skoglund P, Harris WA et al (1993) Expression of an extracellular deletion of Xotch diverts cell fate in Xenopus embryos. Cell 73:659-671
-
(1993)
Cell
, vol.73
, pp. 659-671
-
-
Coffman, C.R.1
Skoglund, P.2
Harris, W.A.3
-
29
-
-
0027991383
-
The intracellular domain of mouse Notch: A constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD
-
Kopan R, Nye JS, Weintraub H (1994) The intracellular domain of mouse Notch: a constitutively activated repressor of myogenesis directed at the basic helix-loop-helix region of MyoD. Development 120:2385-2396
-
(1994)
Development
, vol.120
, pp. 2385-2396
-
-
Kopan, R.1
Nye, J.S.2
Weintraub, H.3
-
30
-
-
0027219557
-
Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo
-
Struhl G, Fitzgerald K, Greenwald I (1993) Intrinsic activity of the Lin-12 and Notch intracellular domains in vivo. Cell 74:331-345
-
(1993)
Cell
, vol.74
, pp. 331-345
-
-
Struhl, G.1
Fitzgerald, K.2
Greenwald, I.3
-
31
-
-
0032574993
-
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain
-
Schroeter EH, Kisslinger JA, Kopan R (1998) Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature 393:382-386
-
(1998)
Nature
, vol.393
, pp. 382-386
-
-
Schroeter, E.H.1
Kisslinger, J.A.2
Kopan, R.3
-
32
-
-
0033535504
-
A presenilin-1-dependent gammasecretase-like protease mediates release of Notch intracellular domain
-
De Strooper B, Annaert W, Cupers P et al (1999) A presenilin-1-dependent gammasecretase-like protease mediates release of Notch intracellular domain. Nature 398:518-522
-
(1999)
Nature
, vol.398
, pp. 518-522
-
-
De Strooper, B.1
Annaert, W.2
Cupers, P.3
-
33
-
-
77956300942
-
Mechanistic insights into Notch receptor signaling from structural and biochemical studies
-
Kovall RA, Blacklow SC (2010) Mechanistic insights into Notch receptor signaling from structural and biochemical studies. Curr Top Dev Biol 92:31-71
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 31-71
-
-
Kovall, R.A.1
Blacklow, S.C.2
-
36
-
-
84873185664
-
Stem cells living with a Notch
-
Koch U, Lehal R, Radtke F (2013) Stem cells living with a Notch. Development 140: 689-704
-
(2013)
Development
, vol.140
, pp. 689-704
-
-
Koch, U.1
Lehal, R.2
Radtke, F.3
-
37
-
-
79955040212
-
Not(ch) just development: Notch signalling in the adult brain
-
Ables JL, Breunig JJ, Eisch AJ et al (2011) Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci 12:269-283
-
(2011)
Nat Rev Neurosci
, vol.12
, pp. 269-283
-
-
Ables, J.L.1
Breunig, J.J.2
Eisch, A.J.3
-
38
-
-
79952213043
-
Notch in the vertebrate nervous system: An old dog with new tricks
-
Pierfelice T, Alberi L, Gaiano N (2011) Notch in the vertebrate nervous system: an old dog with new tricks. Neuron 69:840-855
-
(2011)
Neuron
, vol.69
, pp. 840-855
-
-
Pierfelice, T.1
Alberi, L.2
Gaiano, N.3
-
39
-
-
64249172203
-
The canonical Notch signaling pathway: Unfolding the activation mechanism
-
Kopan R, Ilagan MX (2009) The canonical Notch signaling pathway: unfolding the activation mechanism. Cell 137:216-233
-
(2009)
Cell
, vol.137
, pp. 216-233
-
-
Kopan, R.1
Ilagan, M.X.2
-
41
-
-
0000521088
-
Genetic analysis of delta: A neurogenic gene of Drosophila melanogaster
-
Vaessin H, Campos-Ortega JA (1987) Genetic analysis of delta: a neurogenic gene of Drosophila melanogaster. Genetics 116:433-446
-
(1987)
Genetics
, vol.116
, pp. 433-446
-
-
Vaessin, H.1
Campos-Ortega, J.A.2
-
42
-
-
33745232796
-
NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway
-
McDaniell R, Warthen DM, Sanchez-Lara PA et al (2006) NOTCH2 mutations cause Alagille syndrome, a heterogeneous disorder of the notch signaling pathway. Am J Hum Genet 79:169-173
-
(2006)
Am J Hum Genet
, vol.79
, pp. 169-173
-
-
McDaniell, R.1
Warthen, D.M.2
Sanchez-Lara, P.A.3
-
43
-
-
5444242184
-
Haploinsuffi cient lethality and formation of arteriovenous malformations in Notch pathway mutants
-
Krebs LT, Shutter JR, Tanigaki K et al (2004) Haploinsuffi cient lethality and formation of arteriovenous malformations in Notch pathway mutants. Genes Dev 18:2469-2473
-
(2004)
Genes Dev
, vol.18
, pp. 2469-2473
-
-
Krebs, L.T.1
Shutter, J.R.2
Tanigaki, K.3
-
44
-
-
67649304460
-
Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment
-
Demehri S, Turkoz A, Kopan RE (2009) Epidermal Notch1 loss promotes skin tumorigenesis by impacting the stromal microenvironment. Cancer Cell 16:55-66
-
(2009)
Cancer Cell
, vol.16
, pp. 55-66
-
-
Demehri, S.1
Turkoz, A.2
Kopan, R.E.3
-
45
-
-
0037370310
-
Notch1 functions as a tumor suppressor in mouse skin
-
Nicolas M, Wolfer A, Raj K et al (2003) Notch1 functions as a tumor suppressor in mouse skin. Nat Genet 33:416-421
-
(2003)
Nat Genet
, vol.33
, pp. 416-421
-
-
Nicolas, M.1
Wolfer, A.2
Raj, K.3
-
46
-
-
0029942842
-
Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles
-
Pear WS, Aster JC, Scott ML et al (1996) Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles. J Exp Med 183: 2283-2291
-
(1996)
J Exp Med
, vol.183
, pp. 2283-2291
-
-
Pear, W.S.1
Aster, J.C.2
Scott, M.L.3
-
47
-
-
5044225888
-
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia
-
Weng AP, Ferrando AA, Lee W et al (2004) Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science 306:269-271
-
(2004)
Science
, vol.306
, pp. 269-271
-
-
Weng, A.P.1
Ferrando, A.A.2
Lee, W.3
-
48
-
-
59649083306
-
Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells
-
Rosati E, Sabatini R, Rampino G et al (2009) Constitutively activated Notch signaling is involved in survival and apoptosis resistance of B-CLL cells. Blood 113:856-865
-
(2009)
Blood
, vol.113
, pp. 856-865
-
-
Rosati, E.1
Sabatini, R.2
Rampino, G.3
-
49
-
-
80052177544
-
Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1
-
Agrawal N, Frederick MJ, Pickering CR et al (2011) Exome sequencing of head and neck squamous cell carcinoma reveals inactivating mutations in NOTCH1. Science 333: 1154-1157
-
(2011)
Science
, vol.333
, pp. 1154-1157
-
-
Agrawal, N.1
Frederick, M.J.2
Pickering, C.R.3
-
50
-
-
80055092549
-
Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma
-
Wang NJ, Sanborn Z, Arnett KL et al (2011) Loss-of-function mutations in Notch receptors in cutaneous and lung squamous cell carcinoma. Proc Natl Acad Sci USA 108: 17761-17766
-
(2011)
Proc Natl Acad Sci USA
, vol.108
, pp. 17761-17766
-
-
Wang, N.J.1
Sanborn, Z.2
Arnett, K.L.3
-
51
-
-
80052158097
-
The mutational landscape of head and neck squamous cell carcinoma
-
Stransky N, Egloff AM, Tward AD et al (2011) The mutational landscape of head and neck squamous cell carcinoma. Science 333:1157-1160
-
(2011)
Science
, vol.333
, pp. 1157-1160
-
-
Stransky, N.1
Egloff, A.M.2
Tward, A.D.3
-
52
-
-
33747623018
-
Notch signalling: A simple pathway becomes complex
-
Bray SJ (2006) Notch signalling: a simple pathway becomes complex. Nat Rev Mol Cell Biol 7:678-689
-
(2006)
Nat Rev Mol Cell Biol
, vol.7
, pp. 678-689
-
-
Bray, S.J.1
-
53
-
-
70350652153
-
Notch signaling is required for activitydependent synaptic plasticity at the Drosophila neuromuscular junction
-
de Bivort BL, Guo HF, Zhong Y (2009) Notch signaling is required for activitydependent synaptic plasticity at the Drosophila neuromuscular junction. J Neurogenet 23: 395-404
-
(2009)
J Neurogenet
, vol.23
, pp. 395-404
-
-
De Bivort, B.L.1
Guo, H.F.2
Zhong, Y.3
-
54
-
-
70350643872
-
Suppressor of hairless is required for longterm memory formation in Drosophila
-
Song Q, Sun K, Shuai Y et al (2009) Suppressor of hairless is required for longterm memory formation in Drosophila. J Neurogenet 23:405-411
-
(2009)
J Neurogenet
, vol.23
, pp. 405-411
-
-
Song, Q.1
Sun, K.2
Shuai, Y.3
-
55
-
-
3042796016
-
Notch signaling in Drosophila long-term memory formation
-
Ge X, Hannan F, Xie Z et al (2004) Notch signaling in Drosophila long-term memory formation. Proc Natl Acad Sci USA 101:10172-10176
-
(2004)
Proc Natl Acad Sci USA
, vol.101
, pp. 10172-10176
-
-
Ge, X.1
Hannan, F.2
Xie, Z.3
-
57
-
-
79551656505
-
DSLNotch signaling in the Drosophila brain in response to olfactory stimulation
-
Lieber T, Kidd S, Struhl G (2011) DSLNotch signaling in the Drosophila brain in response to olfactory stimulation. Neuron 69:468-481
-
(2011)
Neuron
, vol.69
, pp. 468-481
-
-
Lieber, T.1
Kidd, S.2
Struhl, G.3
-
58
-
-
0041700113
-
Learning and memory defi cits in Notch mutant mice
-
Costa RM, Honjo T, Silva AJ (2003) Learning and memory defi cits in Notch mutant mice. Curr Biol 13:1348-1354
-
(2003)
Curr Biol
, vol.13
, pp. 1348-2135
-
-
Costa, R.M.1
Honjo, T.2
Silva, A.J.3
-
59
-
-
79551663694
-
Activityinduced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks
-
Alberi L, Liu S, Wang Y et al (2011) Activityinduced Notch signaling in neurons requires Arc/Arg3.1 and is essential for synaptic plasticity in hippocampal networks. Neuron 69:437-444
-
(2011)
Neuron
, vol.69
, pp. 437-444
-
-
Alberi, L.1
Liu, S.2
Wang, Y.3
-
60
-
-
34548215222
-
Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats
-
Conboy L, Seymour CM, Monopoli MP et al (2007) Notch signalling becomes transiently attenuated during long-term memory consolidation in adult Wistar rats. Neurobiol Learn Mem 88:342-351
-
(2007)
Neurobiol Learn Mem
, vol.88
, pp. 342-351
-
-
Conboy, L.1
Seymour, C.M.2
Monopoli, M.P.3
-
61
-
-
80051531363
-
Notch signaling: Simplicity in design, versatility in function
-
Andersson ER, Sandberg R, Lendahl U (2011) Notch signaling: simplicity in design, versatility in function. Development 138:3593-3612
-
(2011)
Development
, vol.138
, pp. 3593-3612
-
-
Andersson, E.R.1
Sandberg, R.2
Lendahl, U.3
-
62
-
-
33947241465
-
Snap Shot: Notch signaling pathway
-
Ilagan MX, Kopan R (2007) SnapShot: notch signaling pathway. Cell 128:1246
-
(2007)
Cell
, vol.128
, pp. 1246
-
-
Ilagan, M.X.1
Kopan, R.2
-
63
-
-
77956328365
-
Biodiversity and noncanonical Notch signaling
-
Heitzler P (2010) Biodiversity and noncanonical Notch signaling. Curr Top Dev Biol 92:457-481
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 457-481
-
-
Heitzler, P.1
-
64
-
-
80053570445
-
Fringe benefi ts: Functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors
-
Rana NA, Haltiwanger RS (2011) Fringe benefi ts: functional and structural impacts of O-glycosylation on the extracellular domain of Notch receptors. Curr Opin Struct Biol 21:583-589
-
(2011)
Curr Opin Struct Biol
, vol.21
, pp. 583-589
-
-
Rana, N.A.1
Haltiwanger, R.S.2
-
65
-
-
0034644110
-
The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD
-
Munro S, Freeman M (2000) The notch signalling regulator fringe acts in the Golgi apparatus and requires the glycosyltransferase signature motif DXD. Curr Biol 10:813-820
-
(2000)
Curr Biol
, vol.10
, pp. 813-820
-
-
Munro, S.1
Freeman, M.2
-
66
-
-
0001395691
-
Fringe is a glycosyltransferase that modifi es Notch
-
Moloney DJ, Panin VM, Johnston SH et al (2000) Fringe is a glycosyltransferase that modifi es Notch. Nature 406:369-375
-
(2000)
Nature
, vol.406
, pp. 369-375
-
-
Moloney, D.J.1
Panin, V.M.2
Johnston, S.H.3
-
67
-
-
0242593940
-
Glycosyltransferase activity of Fringe modulates Notch-Delta interactions
-
Bruckner K, Perez L, Clausen H et al (2000) Glycosyltransferase activity of Fringe modulates Notch-Delta interactions. Nature 406:411-415
-
(2000)
Nature
, vol.406
, pp. 411-415
-
-
Bruckner, K.1
Perez, L.2
Clausen, H.3
-
68
-
-
38649125625
-
Rumi is a CAP10 domain glycosyltransferase that modifi es Notch and is required for Notch signaling
-
Acar M, Jafar-Nejad H, Takeuchi H et al (2008) Rumi is a CAP10 domain glycosyltransferase that modifi es Notch and is required for Notch signaling. Cell 132:247-258
-
(2008)
Cell
, vol.132
, pp. 247-258
-
-
Acar, M.1
Jafar-Nejad, H.2
Takeuchi, H.3
-
69
-
-
84879660816
-
Negative regulation of notch signaling by xylose
-
Lee TV, Sethi MK, Leonardi J et al (2013) Negative regulation of notch signaling by xylose. PLoS Genet 9:e1003547
-
(2013)
PLoS Genet
, vol.9
-
-
Lee, T.V.1
Sethi, M.K.2
Leonardi, J.3
-
70
-
-
0032493302
-
The Notch1 receptor is cleaved constitutively by a furin-like convertase
-
Logeat F, Bessia C, Brou C et al (1998) The Notch1 receptor is cleaved constitutively by a furin-like convertase. Proc Natl Acad Sci USA 95:8108-8112
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 8108-8112
-
-
Logeat, F.1
Bessia, C.2
Brou, C.3
-
71
-
-
69249209928
-
In vivo analysis of the Notch receptor S1 cleavage
-
Lake RJ, Grimm LM, Veraksa A et al (2009) In vivo analysis of the Notch receptor S1 cleavage. PLoS One 4:e6728
-
(2009)
PLoS One
, vol.4
-
-
Lake, R.J.1
Grimm, L.M.2
Veraksa, A.3
-
72
-
-
70049114590
-
Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2
-
Gordon WR, Vardar-Ulu D, L'Heureux S et al (2009) Effects of S1 cleavage on the structure, surface export, and signaling activity of human Notch1 and Notch2. PLoS One 4:e6613
-
(2009)
PLoS One
, vol.4
-
-
Gordon, W.R.1
Vardar-Ulu, D.2
L'Heureux, S.3
-
73
-
-
0030938788
-
The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos
-
Jen WC, Wettstein D, Turner D et al (1997) The Notch ligand, X-Delta-2, mediates segmentation of the paraxial mesoderm in Xenopus embryos. Development 124:1169-1178
-
(1997)
Development
, vol.124
, pp. 1169-1178
-
-
Jen, W.C.1
Wettstein, D.2
Turner, D.3
-
74
-
-
84893801398
-
Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11
-
Charng WL, Yamamoto S, Jaiswal M et al (2014) Drosophila Tempura, a novel protein prenyltransferase α subunit, regulates notch signaling via Rab1 and Rab11. PLoS Biol 12(1):e1001777
-
(2014)
PLoS Biol
, vol.12
, Issue.1
-
-
Charng, W.L.1
Yamamoto, S.2
Jaiswal, M.3
-
75
-
-
84863052624
-
DEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions
-
Giagtzoglou N, Yamamoto S, Zitserman D et al (2012) dEHBP1 controls exocytosis and recycling of Delta during asymmetric divisions. J Cell Biol 196:65-83
-
(2012)
J Cell Biol
, vol.196
, pp. 65-83
-
-
Giagtzoglou, N.1
Yamamoto, S.2
Zitserman, D.3
-
76
-
-
77956309044
-
Endocytosis and intracellular traffi cking of Notch and its ligands
-
Yamamoto S, Charng WL, Bellen HJ (2010) Endocytosis and intracellular traffi cking of Notch and its ligands. Curr Top Dev Biol 92:165-200
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 165-200
-
-
Yamamoto, S.1
Charng, W.L.2
Bellen, H.J.3
-
77
-
-
79960205452
-
Notch ligand ubiquitylation: What is it good for?
-
Weinmaster G, Fischer JA (2011) Notch ligand ubiquitylation: what is it good for? Dev Cell 21:134-144
-
(2011)
Dev Cell
, vol.21
, pp. 134-144
-
-
Weinmaster, G.1
Fischer, J.A.2
-
78
-
-
77956315469
-
Gammasecretase and the intramembrane proteolysis of Notch
-
Jorissen E, De Strooper B (2010) Gammasecretase and the intramembrane proteolysis of Notch. Curr Top Dev Biol 92:201-230
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 201-230
-
-
Jorissen, E.1
De Strooper, B.2
-
79
-
-
77956643127
-
Notch1 signaling is mediated by importins alpha 3 4, and 7
-
Huenniger K, Kramer A, Soom M et al (2010) Notch1 signaling is mediated by importins alpha 3, 4, and 7. Cell Mol Life Sci 67:3187-3196
-
(2010)
Cell Mol Life Sci
, vol.67
, pp. 3187-3196
-
-
Huenniger, K.1
Kramer, A.2
Soom, M.3
-
80
-
-
0021926007
-
Opa: A novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. Melanogaster
-
Wharton KA, Yedvobnick B, Finnerty VG et al (1985) opa: a novel family of transcribed repeats shared by the Notch locus and other developmentally regulated loci in D. melanogaster. Cell 40:55-62
-
(1985)
Cell
, vol.40
, pp. 55-62
-
-
Wharton, K.A.1
Yedvobnick, B.2
Finnerty, V.G.3
-
81
-
-
0035856467
-
Novel Notch alleles reveal a Deltexdependent pathway repressing neural fate
-
Ramain P, Khechumian K, Seugnet L et al (2001) Novel Notch alleles reveal a Deltexdependent pathway repressing neural fate. Curr Biol 11:1729-1738
-
(2001)
Curr Biol
, vol.11
, pp. 1729-1738
-
-
Ramain, P.1
Khechumian, K.2
Seugnet, L.3
-
82
-
-
8844229536
-
Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover
-
Fryer CJ, White JB, Jones KA (2004) Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover. Mol Cell 16:509-520
-
(2004)
Mol Cell
, vol.16
, pp. 509-520
-
-
Fryer, C.J.1
White, J.B.2
Jones, K.A.3
-
83
-
-
84856101707
-
Fine-tuning of the intracellular canonical Notch signaling pathway
-
Borggrefe T, Liefke R (2012) Fine-tuning of the intracellular canonical Notch signaling pathway. Cell Cycle 11:264-276
-
(2012)
Cell Cycle
, vol.11
, pp. 264-276
-
-
Borggrefe, T.1
Liefke, R.2
-
84
-
-
77956316745
-
Two opposing roles of RBP-J in Notch signaling
-
Tanigaki K, Honjo T (2010) Two opposing roles of RBP-J in Notch signaling. Curr Top Dev Biol 92:231-252
-
(2010)
Curr Top Dev Biol
, vol.92
, pp. 231-252
-
-
Tanigaki, K.1
Honjo, T.2
-
85
-
-
0035177388
-
A model Notch response element detects suppressor of hairless-dependent molecular switch
-
Furriols M, Bray S (2001) A model Notch response element detects suppressor of hairless-dependent molecular switch. Curr Biol 11:60-64
-
(2001)
Curr Biol
, vol.11
, pp. 60-64
-
-
Furriols, M.1
Bray, S.2
-
86
-
-
27944445286
-
Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors
-
Nagel AC, Krejci A, Tenin G et al (2005) Hairless-mediated repression of notch target genes requires the combined activity of Groucho and CtBP corepressors. Mol Cell Biol 25:10433-10441
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10433-10441
-
-
Nagel, A.C.1
Krejci, A.2
Tenin, G.3
-
87
-
-
0035873851
-
Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila
-
Morel V, Lecourtois M, Massiani O et al (2001) Transcriptional repression by suppressor of hairless involves the binding of a hairless-dCtBP complex in Drosophila. Curr Biol 11:789-792
-
(2001)
Curr Biol
, vol.11
, pp. 789-792
-
-
Morel, V.1
Lecourtois, M.2
Massiani, O.3
-
88
-
-
0032145527
-
A histone deacetylase corepressor complex regulates the Notch signal transduction pathway
-
Kao HY, Ordentlich P, Koyano-Nakagawa N et al (1998) A histone deacetylase corepressor complex regulates the Notch signal transduction pathway. Genes Dev 12:2269-2277
-
(1998)
Genes Dev
, vol.12
, pp. 2269-2277
-
-
Kao, H.Y.1
Ordentlich, P.2
Koyano-Nakagawa, N.3
-
89
-
-
27944491856
-
RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes
-
Oswald F, Winkler M, Cao Y et al (2005) RBP-Jkappa/SHARP recruits CtIP/CtBP corepressors to silence Notch target genes. Mol Cell Biol 25:10379-10390
-
(2005)
Mol Cell Biol
, vol.25
, pp. 10379-10390
-
-
Oswald, F.1
Winkler, M.2
Cao, Y.3
-
90
-
-
0028345891
-
The recombination signal sequence-binding protein RBP-2 N functions as a transcriptional repressor
-
Dou S, Zeng X, Cortes P et al (1994) The recombination signal sequence-binding protein RBP-2 N functions as a transcriptional repressor. Mol Cell Biol 14:3310-3319
-
(1994)
Mol Cell Biol
, vol.14
, pp. 3310-3319
-
-
Dou, S.1
Zeng, X.2
Cortes, P.3
-
91
-
-
0034142323
-
Repression by suppressor of hairless and activation by Notch are required to defi ne a single row of single-minded expressing cells in the Drosophila embryo
-
Morel V, Schweisguth F (2000) Repression by suppressor of hairless and activation by Notch are required to defi ne a single row of single-minded expressing cells in the Drosophila embryo. Genes Dev 14:377-388
-
(2000)
Genes Dev
, vol.14
, pp. 377-388
-
-
Morel, V.1
Schweisguth, F.2
-
92
-
-
0036682974
-
Default repression and Notch signaling: Hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to suppressor of hairless
-
Barolo S, Stone T, Bang AG et al (2002) Default repression and Notch signaling: hairless acts as an adaptor to recruit the corepressors Groucho and dCtBP to suppressor of hairless. Genes Dev 16:1964-1976
-
(2002)
Genes Dev
, vol.16
, pp. 1964-1976
-
-
Barolo, S.1
Stone, T.2
Bang, A.G.3
-
93
-
-
0035916817
-
Notch pathway: Making sense of suppressor of hairless
-
Bray S, Furriols M (2001) Notch pathway: making sense of suppressor of hairless. Curr Biol 11:R217-R221
-
(2001)
Curr Biol
, vol.11
-
-
Bray, S.1
Furriols, M.2
-
94
-
-
0034595665
-
Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5
-
Kurooka H, Honjo T (2000) Functional interaction between the mouse notch1 intracellular region and histone acetyltransferases PCAF and GCN5. J Biol Chem 275:17211-17220
-
(2000)
J Biol Chem
, vol.275
, pp. 17211-17220
-
-
Kurooka, H.1
Honjo, T.2
-
95
-
-
0036840497
-
P300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro
-
Wallberg AE, Pedersen K, Lendahl U et al (2002) p300 and PCAF act cooperatively to mediate transcriptional activation from chromatin templates by notch intracellular domains in vitro. Mol Cell Biol 22:7812-7819
-
(2002)
Mol Cell Biol
, vol.22
, pp. 7812-7819
-
-
Wallberg, A.E.1
Pedersen, K.2
Lendahl, U.3
-
96
-
-
0034775446
-
P300 acts as a transcriptional coactivator for mammalian Notch-1
-
Oswald F, Tauber B, Dobner T et al (2001) p300 acts as a transcriptional coactivator for mammalian Notch-1. Mol Cell Biol 21: 7761-7774
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7761-7774
-
-
Oswald, F.1
Tauber, B.2
Dobner, T.3
-
97
-
-
0036606776
-
Mastermind mediates chromatin-specifi c transcription and turnover of the Notch enhancer complex
-
Fryer CJ, Lamar E, Turbachova I et al (2002) Mastermind mediates chromatin-specifi c transcription and turnover of the Notch enhancer complex. Genes Dev 16:1397-1411
-
(2002)
Genes Dev
, vol.16
, pp. 1397-1411
-
-
Fryer, C.J.1
Lamar, E.2
Turbachova, I.3
-
98
-
-
0030659821
-
Sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins
-
Hubbard EJ, Wu G, Kitajewski J et al (1997) sel-10, a negative regulator of lin-12 activity in Caenorhabditis elegans, encodes a member of the CDC4 family of proteins. Genes Dev 11:3182-3193
-
(1997)
Genes Dev
, vol.11
, pp. 3182-3193
-
-
Hubbard, E.J.1
Wu, G.2
Kitajewski, J.3
-
99
-
-
0035929669
-
The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog
-
Oberg C, Li J, Pauley A et al (2001) The Notch intracellular domain is ubiquitinated and negatively regulated by the mammalian Sel-10 homolog. J Biol Chem 276:35847-35853
-
(2001)
J Biol Chem
, vol.276
, pp. 35847-35853
-
-
Oberg, C.1
Li, J.2
Pauley, A.3
-
100
-
-
0034791336
-
SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation
-
Wu G, Lyapina S, Das I et al (2001) SEL-10 is an inhibitor of notch signaling that targets notch for ubiquitin-mediated protein degradation. Mol Cell Biol 21:7403-7415
-
(2001)
Mol Cell Biol
, vol.21
, pp. 7403-7415
-
-
Wu, G.1
Lyapina, S.2
Das, I.3
-
101
-
-
0035860804
-
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor
-
Gupta-Rossi N, Le Bail O, Gonen H et al (2001) Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem 276:34371-34378
-
(2001)
J Biol Chem
, vol.276
, pp. 34371-34378
-
-
Gupta-Rossi, N.1
Le Bail, O.2
Gonen, H.3
-
102
-
-
79251523519
-
Mechanism and signifi cance of cisinhibition in Notch signalling
-
del Alamo D, Rouault H, Schweisguth F (2011) Mechanism and signifi cance of cisinhibition in Notch signalling. Curr Biol 21:R40-R47
-
(2011)
Curr Biol
, vol.21
-
-
Del Alamo, D.1
Rouault, H.2
Schweisguth, F.3
-
103
-
-
77949484882
-
A role of receptor Notch in ligand cis-inhibition in Drosophila
-
Becam I, Fiuza UM, Arias AM et al (2010) A role of receptor Notch in ligand cis-inhibition in Drosophila. Curr Biol 20:554-560
-
(2010)
Curr Biol
, vol.20
, pp. 554-560
-
-
Becam, I.1
Fiuza, U.M.2
Arias, A.M.3
-
104
-
-
77952092577
-
Cis-interactions between Notch and Delta generate mutually exclusive signalling states
-
Sprinzak D, Lakhanpal A, Lebon L et al (2011) Cis-interactions between Notch and Delta generate mutually exclusive signalling states. Nature 465:86-90
-
(2011)
Nature
, vol.465
, pp. 86-90
-
-
Sprinzak, D.1
Lakhanpal, A.2
Lebon, L.3
-
105
-
-
84870224298
-
A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands
-
Yamamoto S, Charng WL, Rana NA et al (2012) A mutation in EGF repeat-8 of Notch discriminates between Serrate/Jagged and Delta family ligands. Science 338: 1229-1232
-
(2012)
Science
, vol.338
, pp. 1229-1232
-
-
Yamamoto, S.1
Charng, W.L.2
Rana, N.A.3
-
106
-
-
0033551101
-
The folding and structural integrity of the fi rst LIN-12 module of human Notch1 are calcium-dependent
-
Aster JC, Simms WB, Zavala-Ruiz Z et al (1999) The folding and structural integrity of the fi rst LIN-12 module of human Notch1 are calcium-dependent. Biochemistry 38:4736-4742
-
(1999)
Biochemistry
, vol.38
, pp. 4736-4742
-
-
Aster, J.C.1
Simms, W.B.2
Zavala-Ruiz, Z.3
-
107
-
-
0033974972
-
Calcium depletion dissociates and activates heterodimeric notch receptors
-
Rand MD, Grimm LM, Artavanis-Tsakonas S et al (2000) Calcium depletion dissociates and activates heterodimeric notch receptors. Mol Cell Biol 20:1825-1835
-
(2000)
Mol Cell Biol
, vol.20
, pp. 1825-1835
-
-
Rand, M.D.1
Grimm, L.M.2
Artavanis-Tsakonas, S.3
-
108
-
-
84873152689
-
Regulation of ligand-independent Notch signal through intracellular traffi cking
-
Hori K, Sen A, Kirchhausen T et al (2012) Regulation of ligand-independent Notch signal through intracellular traffi cking. Commun Integr Biol 5:374-376
-
(2012)
Commun Integr Biol
, vol.5
, pp. 374-376
-
-
Hori, K.1
Sen, A.2
Kirchhausen, T.3
-
109
-
-
67949120665
-
Endocytic regulation of Notch signaling
-
Fortini ME, Bilder D (2009) Endocytic regulation of Notch signaling. Curr Opin Genet Dev 19:323-328
-
(2009)
Curr Opin Genet Dev
, vol.19
, pp. 323-322
-
-
Fortini, M.E.1
Bilder, D.2
-
111
-
-
66149151737
-
Structure of the Notch1-negative regulatory region: Implications for normal activation and pathogenic signaling in T-ALL
-
Gordon WR, Roy M, Vardar-Ulu D et al (2009) Structure of the Notch1-negative regulatory region: implications for normal activation and pathogenic signaling in T-ALL. Blood 113:4381-4390
-
(2009)
Blood
, vol.113
, pp. 4381-4390
-
-
Gordon, W.R.1
Roy, M.2
Vardar-Ulu, D.3
-
112
-
-
77949831756
-
Structural variation in the human genome and its role in disease
-
Stankiewicz P, Lupski JR (2010) Structural variation in the human genome and its role in disease. Annu Rev Med 61:437-455
-
(2010)
Annu Rev Med
, vol.61
, pp. 437-455
-
-
Stankiewicz, P.1
Lupski, J.R.2
-
113
-
-
80053549439
-
Clan genomics and the complex architecture of human disease
-
Lupski JR, Belmont JW, Boerwinkle E et al (2013) Clan genomics and the complex architecture of human disease. Cell 147:32-43
-
(2013)
Cell
, vol.147
, pp. 32-43
-
-
Lupski, J.R.1
Belmont, J.W.2
Boerwinkle, E.3
|