New Insights into the Role ofFicolins in the Lectin Pathway of Innate Immunity

International Review of Cell and Molecular Biology

Volumn 316, Issue , 2015, Pages 49-110

  Endo, Yuichi ^a   Matsushita, Misao ^b   Fujita, Teizo ^a,c  

^a FUKUSHIMA MEDICAL UNIVERSITY   (Japan)

^b TOKAI UNIVERSITY   (Japan)

^c Fukushima Prefectural General Hygiene Institute   (Japan)

Author keywords

Complement system; Ficolin; Host defense; Innate immunity; Lectin; Lectin pathway

Indexed keywords

CARBOHYDRATE; COMPLEMENT; FICOLIN; MANNOSE BINDING LECTIN ASSOCIATED SERINE PROTEASE; N ACETYLGLUCOSAMINE; SERINE PROTEINASE; SUGAR; UNCLASSIFIED DRUG; COLLAGEN; CYTOKINE; FIBRINOGEN; LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MANNOSE BINDING LECTIN;

APOPTOSIS; ARTICLE; CELL DEATH; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CYTOKINE PRODUCTION; DISEASE ASSOCIATION; DNA POLYMORPHISM; EVOLUTION; GENE LOCUS; HOMEOSTASIS; HOST RESISTANCE; HUMAN; IMMUNE RESPONSE; INFECTION; INFECTION PREVENTION; INNATE IMMUNITY; INVERTEBRATE; MAMMAL; MICROORGANISM; MOLECULAR INTERACTION; MOLECULE; NONHUMAN; OPSONIZATION; PATHOGENESIS; PHENOTYPE; PHYLOGENY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN DEFICIENCY; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; AMINO ACID SEQUENCE; ANIMAL; CHEMISTRY; IMMUNE SYSTEM; METABOLISM; MOLECULAR GENETICS; MOUSE; PH; PHAGOCYTOSIS; PHYSIOLOGY; PROTEIN TERTIARY STRUCTURE; SEQUENCE HOMOLOGY;

ANIMALIA; INVERTEBRATA; MAMMALIA;

ACETYLGLUCOSAMINE; AMINO ACID SEQUENCE; ANIMALS; CARBOHYDRATES; COLLAGEN; CYTOKINES; FIBRINOGEN; HOMEOSTASIS; HUMANS; HYDROGEN-ION CONCENTRATION; IMMUNE SYSTEM; IMMUNITY, INNATE; LECTINS; MANNOSE-BINDING LECTIN; MANNOSE-BINDING PROTEIN-ASSOCIATED SERINE PROTEASES; MICE; MOLECULAR SEQUENCE DATA; PHAGOCYTOSIS; PROTEIN STRUCTURE, TERTIARY; SEQUENCE HOMOLOGY, AMINO ACID;

EID: 84925260909     PISSN: 19376448     EISSN: None     Source Type: Book Series    
DOI: 10.1016/bs.ircmb.2015.01.003     Document Type: Article

References (216)

1. Akaiwa M., Yae Y., Sugimoto R., Suzuki S.O., Iwaki T., Izuhara K., Hamasaki N. Hakata antigen, a new member of the ficolin/opsonin p35 family, is a novel human lectin secreted into bronchus/alveolus and bile. J. Histochem. Cytochem. 1999, 47:777-786.
2. Ali Y.M., Lynch N.J., Haleem K.S., Fujita T., Endo Y., Hansen S., Holmskov U., Takahashi K., Stahl G.L., Dudler T., Girija U.V., Wallis R., Kadioglu A., Stover C.M., Andrew P.W., Schwaeble W.J. The lectin pathway of complement activation is a critical component of the innate immune response to pneumococcal infection. PLoS Pathog. 2012, 8:e1002793.
3. Ameye L., Paesmans M., Thiel S., Jensenius J.C., Aoun M. M-ficolin levels are associated with the occurrence of severe infections in patients with haematological cancer undergoing chemotherapy. Clin. Exp. Immunol. 2012, 167:303-308.
4. Ammitzboll C.G., Kjaer T.R., Steffensen R., Stengaard-Pedersen K., Nielsen H.J., Thiel S., Bogsted M., Jensenius J.C. Non-synonymous polymorphisms in the FCN1 gene determine ligand-binding ability and serum levels of M-ficolin. PLoS One 2012, 7:e50585.
5. Ammitzboll C.G., Thiel S., Ellingsen T., Deleuran B., Jorgensen A., Jensenius J.C., Stengaard-Pedersen K. Levels of lectin pathway proteins in plasma and synovial fluid of rheumatoid arthritis and osteoarthritis. Rheumatol. Int. 2012, 32:1457-1463.
6. Ammitzboll C.G., Thiel S., Jensenius J.C., Ellingsen T., Horslev-Petersen K., Hetland M.L., Junker P., Krogh N.S., Ostergaard M., Stengaard-Pedersen K. M-ficolin levels reflect disease activity and predict remission in early rheumatoid arthritis. Arthritis Rheum. 2013, 65:3045-3050.
7. Andersen J.D., Boylan K.L., Xue F.S., Anderson L.B., Witthuhn B.A., Markowski T.W., Higgins L., Skubitz A.P. Identification of candidate biomarkers in ovarian cancer serum by depletion of highly abundant proteins and differential in-gel electrophoresis. Electrophoresis 2010, 31:599-610.
8. Andersen T., Munthe-Fog L., Garred P., Jacobsen S. Serum levels of ficolin-3 (Hakata antigen) in patients with systemic lupus erythematosus. J. Rheumatol. 2009, 36:757-759.
9. Aoyagi Y., Adderson E.E., Min J.G., Matsushita M., Fujita T., Takahashi S., Okuwaki Y., Bohnsack J.F. Role of L-ficolin/mannose-binding lectin-associated serine protease complexes in the opsonophagocytosis of type III group B streptococci. J. Immunol. 2005, 174:418-425.
10. Aoyagi Y., Adderson E.E., Rubens C.E., Bohnsack J.F., Min J.G., Matsushita M., Fujita T., Okuwaki Y., Takahashi S. L-Ficolin/mannose-binding lectin-associated serine protease complexes bind to group B streptococci primarily through N-acetylneuraminic acid of capsular polysaccharide and activate the complement pathway. Infect. Immun. 2008, 76:179-188.
11. Assaf A., Hoang T.V., Faik I., Aebischer T., Kremsner P.G., Kun J.F., Velavan T.P. Genetic evidence of functional ficolin-2 haplotype as susceptibility factor in cutaneous leishmaniasis. PLoS One 2012, 7:e34113.
12. Atkinson A.P., Cedzynski M., Szemraj J., St Swierzko A., Bak-Romaniszyn L., Banasik M., Zeman K., Matsushita M., Turner M.L., Kilpatrick D.C. L-ficolin in children with recurrent respiratory infections. Clin. Exp. Immunol. 2004, 138:517-520.
13. Bidula S., Kenawy H., Ali Y.M., Sexton D., Schwaeble W.J., Schelenz S. Role of ficolin-A and lectin complement pathway in the innate defense against pathogenic Aspergillus species. Infect. Immun. 2013, 81:1730-1740.
14. Boldt A.B., Sanchez M.I., Stahlke E.R., Steffensen R., Thiel S., Jensenius J.C., Prevedello F.C., Mira M.T., Kun J.F., Messias-Reason I.J. Susceptibility to leprosy is associated with M-ficolin polymorphisms. J. Clin. Immunol. 2013, 33:210-219.
15. Bottazzi B., Vouret-Craviari V., Bastone A., De Gioia L., Matteucci C., Peri G., Spreafico F., Pausa M., D'Ettorre C., Gianazza E., Tagliabue A., Salmona M., Tedesco F., Introna M., Mantovani A. Multimer formation and ligand recognition by the long pentraxin PTX3. Similarities and differences with the short pentraxins C-reactive protein and serum amyloid P component. J. Biol. Chem. 1997, 272:32817-32823.
16. Bottcher A., Ostwald J., Koczan D., Knecht R., Kramp B., Dommerich S. Gene expression profiling of circulating natural killer cells in head and neck squamous cell carcinoma. Cancer Genomics Proteomics 2013, 10:197-207.
17. Brinkmann C.R., Jensen L., Dagnaes-Hansen F., Holm I.E., Endo Y., Fujita T., Thiel S., Jensenius J.C., Degn S.E. Mitochondria and the lectin pathway of complement. J. Biol. Chem. 2013, 288:8016-8027.
18. Brooks A.S., DeLay J.P., Hayes M.A. Characterization of porcine plasma ficolins that bind Actinobacillus pleuropneumoniae serotype 5B. Immunobiology 2003, 207:327-337.
19. Carroll M.V., Lack N., Sim E., Krarup A., Sim R.B. Multiple routes of complement activation by Mycobacterium bovis BCG. Mol. Immunol. 2009, 46:3367-3378.
20. Cedzynski M., Atkinson A.P., St Swierzko A., MacDonald S.L., Szala A., Zeman K., Buczylko K., Bak-Romaniszyn L., Wiszniewska M., Matsushita M., Szemraj J., Banasik M., Turner M.L., Kilpatrick D.C. L-ficolin (ficolin-2) insufficiency is associated with combined allergic and infectious respiratory disease in children. Mol. Immunol. 2009, 47:415-419.
21. Cedzynski M., Nuytinck L., Atkinson A.P., St Swierzko A., Zeman K., Szemraj J., Szala A., Turner M.L., Kilpatrick D.C. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. Clin. Exp. Immunol. 2007, 150:99-104.
22. Cestari I., Ramirez M.I. Inefficient complement system clearance of Trypanosoma cruzi metacyclic trypomastigotes enables resistant strains to invade eukaryotic cells. PLoS One 2010, 5:e9721.
23. Cestari Idos S., Krarup A., Sim R.B., Inal J.M., Ramirez M.I. Role of early lectin pathway activation in the complement-mediated killing of Trypanosoma cruzi. Mol. Immunol. 2009, 47:426-437.
24. Chapman S.J., Vannberg F.O., Khor C.C., Segal S., Moore C.E., Knox K., Day N.P., Davies R.J., Crook D.W., Hill A.V. Functional polymorphisms in the FCN2 gene are not associated with invasive pneumococcal disease. Mol. Immunol. 2007, 44:3267-3270.
25. Chen F., Liu Q., Xue Y., Huang Y., Huang F., Lin Y., Tan G., Zhou J. Ficolin-a enhances inhibition of the C-terminal 19kDa region of merozoite surface protein-1 of plasmodium berghei using test in vivo. Iran. J. Parasitol. 2013, 8:33-39.
26. Chen H., Lu J., Chen X., Yu H., Zhang L., Bao Y., Lu F., Tang J., Gu C., Jia W. Low serum levels of the innate immune component ficolin-3 is associated with insulin resistance and predicts the development of type 2 diabetes. J. Mol. Cell. Biol. 2012, 4:256-257.
27. Chen X., Katoh Y., Nakamura K., Oyama N., Kaneko F., Endo Y., Fujita T., Nishida T., Mizuki N. Single nucleotide polymorphisms of Ficolin 2 gene in Behcet's disease. J. Dermatol. Sci. 2006, 43:201-205.
28. Cseh S., Vera L., Matsushita M., Fujita T., Arlaud G.J., Thielens N.M. Characterization of the interaction between L-ficolin/p35 and mannan-binding lectin-associated serine proteases-1 and -2. J. Immunol. 2002, 169:5735-5743.
29. Csuka D., Munthe-Fog L., Skjoedt M.O., Kocsis A., Zotter Z., Gal P., Varga L., Farkas H., Fust G., Garred P. The role of ficolins and MASPs in hereditary angioedema due to C1-inhibitor deficiency. Mol. Immunol. 2013, 54:271-277.
30. Dahl M.R., Thiel S., Matsushita M., Fujita T., Willis A.C., Christensen T., Vorup-Jensen T., Jensenius J.C. MASP-3 and its association with distinct complexes of the mannan-binding lectin complement activation pathway. Immunity 2001, 15:127-135.
31. Dai S., Rajaram M.V., Curry H.M., Leander R., Schlesinger L.S. Fine tuning inflammation at the front door: macrophage complement receptor 3-mediates phagocytosis and immune suppression for Francisella tularensis. PLoS Pathog. 2013, 9:e1003114.
32. de Messias-Reason I., Kremsner P.G., Kun J.F. Functional haplotypes that produce normal ficolin-2 levels protect against clinical leprosy. J. Infect. Dis. 2009, 199:801-804.
33. de Rooij B.J., van der Beek M.T., van Hoek B., Vossen A.C., Rogier Ten Hove W., Roos A., Schaapherder A.F., Porte R.J., van der Reijden J.J., Coenraad M.J., Hommes D.W., Verspaget H.W. Mannose-binding lectin and ficolin-2 gene polymorphisms predispose to cytomegalovirus (re)infection after orthotopic liver transplantation. J. Hepatol. 2011, 55:800-807.
34. Degn S.E., Hansen A.G., Steffensen R., Jacobsen C., Jensenius J.C., Thiel S. MAp44, a human protein associated with pattern recognition molecules of the complement system and regulating the lectin pathway of complement activation. J. Immunol. 2009, 183:7371-7378.
35. Duus K., Thielens N.M., Lacroix M., Tacnet P., Frachet P., Holmskov U., Houen G. CD91 interacts with mannan-binding lectin (MBL) through the MBL-associated serine protease-binding site. FEBS J. 2010, 277:4956-4964.
36. Edgar P.F. Hucolin, a new corticosteroid-binding protein from human plasma with structural similarities to ficolins, transforming growth factor-beta 1-binding proteins. FEBS Lett. 1995, 375:159-161.
37. Eikmans M., de Canck I., van der Pol P., Baan C.C., Haasnoot G.W., Mallat M.J., Vergunst M., de Meester E., Roodnat J.I., Anholts J.D., van Thielen M., Doxiadis, de Fijter J.W., van der Linden P.J., van Beelen E., van Kooten C., Kal-van Gestel J.A., Peeters A.M., Weimar W., Roelen D.L., Rossau R., Claas F.H. The functional polymorphism Ala258Ser in the innate receptor gene ficolin-2 in the donor predicts improved renal transplant outcome. Transplantation 2012, 94:478-485.
38. Endo Y., Iwaki D., Ishida Y., Takahashi M., Matsushita M., Fujita T. Mouse ficolin B has an ability to form complexes with mannose-binding lectin-associated serine proteases and activate complement through the lectin pathway. J. Biomed. Biotechnol. 2012, 2012:105891.
39. Endo Y., Liu Y., Fujita T. Structure and function of ficolins. Adv. Exp. Med. Biol. 2006, 586:265-279.
40. Endo Y., Liu Y., Kanno K., Takahashi M., Matsushita M., Fujita T. Identification of the mouse H-ficolin gene as a pseudogene and orthology between mouse ficolins A/B and human L-/M-ficolins. Genomics 2004, 84:737-744.
41. Endo Y., Matsushita M., Fujita T. Role of ficolin in innate immunity and its molecular basis. Immunobiology 2007, 212:371-379.
42. Endo Y., Nakazawa N., Iwaki D., Takahashi M., Matsushita M., Fujita T. Interactions of ficolin and mannose-binding lectin with fibrinogen/fibrin augment the lectin complement pathway. J. Innate Immun. 2010, 2:33-42.
43. Endo Y., Nakazawa N., Liu Y., Iwaki D., Takahashi M., Fujita T., Nakata M., Matsushita M. Carbohydrate-binding specificities of mouse ficolin A, a splicing variant of ficolin A and ficolin B and their complex formation with MASP-2 and sMAP. Immunogenetics 2005, 57:837-844.
44. Endo Y., Nonaka M., Saiga H., Kakinuma Y., Matsushita A., Takahashi M., Matsushita M., Fujita T. Origin of mannose-binding lectin-associated serine protease (MASP)-1 and MASP-3 involved in the lectin complement pathway traced back to the invertebrate, amphioxus. J. Immunol. 2003, 170:4701-4707.
45. Endo Y., Sato Y., Matsushita M., Fujita T. Cloning and characterization of the human lectin P35 gene and its related gene. Genomics 1996, 36:515-521.
46. Endo Y., Takahashi M., Iwaki D., Ishida Y., Nakazawa N., Kodama T., Matsuzaka T., Kanno K., Liu Y., Tsuchiya K., Kawamura I., Ikawa M., Waguri S., Wada I., Matsushita M., Schwaeble W.J., Fujita T. Mice deficient in ficolin, a lectin complement pathway recognition molecule, are susceptible to Streptococcus pneumoniae infection. J. Immunol. 2012, 189:5860-5866.
47. Endo Y., Takahashi M., Nakao M., Saiga H., Sekine H., Matsushita M., Nonaka M., Fujita T. Two lineages of mannose-binding lectin-associated serine protease (MASP) in vertebrates. J. Immunol. 1998, 161:4924-4930.
48. Evans-Osses I., Ansa-Addo E.A., Inal J.M., Ramirez M.I. Involvement of lectin pathway activation in the complement killing of Giardia intestinalis. Biochem. Biophys. Res. Commun. 2010, 395:382-386.
49. Faik I., Oyedeji S.I., Idris Z., de Messias-Reason I.J., Lell B., Kremsner P.G., Kun J.F. Ficolin-2 levels and genetic polymorphisms of FCN2 in malaria. Hum. Immunol. 2011, 72:74-79.
50. Faro J., Chen Y., Jhaveri P., Oza P., Spear G.T., Lint T.F., Gewurz H. L-ficolin binding and lectin pathway activation by acetylated low-density lipoprotein. Clin. Exp. Immunol. 2008, 151:275-283.
51. Feinberg H., Uitdehaag J.C., Davies J.M., Wallis R., Drickamer K., Weis W.I. Crystal structure of the CUB1-EGF-CUB2 region of mannose-binding protein associated serine protease-2. EMBO J. 2003, 22:2348-2359.
52. Ferrin G., Ranchal I., Llamoza C., Rodriguez-Peralvarez M.L., Romero-Ruiz A., Aguilar-Melero P., Lopez-Cillero P., Briceno J., Muntane J., Montero-Alvarez J.L., De la Mata M. Identification of candidate biomarkers for hepatocellular carcinoma in plasma of HCV-infected cirrhotic patients by 2-D DIGE. Liver Int. 2014, 34:438-446.
53. Fu H., Liu B., Frost J.L., Hong S., Jin M., Ostaszewski B., Shankar G.M., Costantino I.M., Carroll M.C., Mayadas T.N., Lemere C.A. Complement component C3 and complement receptor type 3 contribute to the phagocytosis and clearance of fibrillar Abeta by microglia. Glia 2012, 60:993-1003.
54. Fujieda M., Aoyagi Y., Matsubara K., Takeuchi Y., Fujimaki W., Matsushita M., Bohnsack J.F., Takahashi S. L-ficolin and capsular polysaccharide-specific IgG in cord serum contribute synergistically to opsonophagocytic killing of serotype III and V group B streptococci. Infect. Immun. 2012, 80:2053-2060.
55. Fujimori Y., Harumiya S., Fukumoto Y., Miura Y., Yagasaki K., Tachikawa H., Fujimoto D. Molecular cloning and characterization of mouse ficolin-A. Biochem. Biophys. Res. Commun. 1998, 244:796-800.
56. Fujita T. Evolution of the lectin-complement pathway and its role in innate immunity. Nat. Rev. Immunol. 2002, 2:346-353.
57. Fujita T., Matsushita M., Endo Y. The lectin-complement pathway-its role in innate immunity and evolution. Immunol. Rev. 2004, 198:185-202.
58. Fujito N.T., Sugimoto S., Nonaka M. Evolution of thioester-containing proteins revealed by cloning and characterization of their genes from a cnidarian sea anemone, Haliplanella lineate. Dev. Comp. Immunol. 2010, 34:775-784.
59. Gardai S.J., McPhillips K.A., Frasch S.C., Janssen W.J., Starefeldt A., Murphy-Ullrich J.E., Bratton D.L., Oldenborg P.A., Michalak M., Henson P.M. Cell-surface calreticulin initiates clearance of viable or apoptotic cells through trans-activation of LRP on the phagocyte. Cell 2005, 123:321-334.
60. Garlatti V., Belloy N., Martin L., Lacroix M., Matsushita M., Endo Y., Fujita T., Fontecilla-Camps J.C., Arlaud G.J., Thielens N.M., Gaboriaud C. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J. 2007, 26:623-633.
61. Garlatti V., Martin L., Gout E., Reiser J.B., Fujita T., Arlaud G.J., Thielens N.M., Gaboriaud C. Structural basis for innate immune sensing by M-ficolin and its control by a pH-dependent conformational switch. J. Biol. Chem. 2007, 282:35814-35820.
62. Garlatti V., Martin L., Lacroix M., Gout E., Arlaud G.J., Thielens N.M., Gaboriaud C. Structural insights into the recognition properties of human ficolins. J. Innate Immun. 2010, 2:17-23.
63. Garred P., Honore C., Ma Y.J., Rorvig S., Cowland J., Borregaard N., Hummelshoj T. The genetics of ficolins. J. Innate Immun. 2010, 2:3-16.
64. Girija U.V., Dodds A.W., Roscher S., Reid K.B., Wallis R. Localization and characterization of the mannose-binding lectin (MBL)-associated-serine protease-2 binding site in rat ficolin-A: equivalent binding sites within the collagenous domains of MBLs and ficolins. J. Immunol. 2007, 179:455-462.
65. Gokudan S., Muta T., Tsuda R., Koori K., Kawahara T., Seki N., Mizunoe Y., Wai S.N., Iwanaga S., Kawabata S. Horseshoe crab acetyl group-recognizing lectins involved in innate immunity are structurally related to fibrinogen. Proc. Natl. Acad. Sci. U.S.A. 1999, 96:10086-10091.
66. Gorovoy M., Gaultier A., Campana W.M., Firestein G.S., Gonias S.L. Inflammatory mediators promote production of shed LRP1/CD91, which regulates cell signaling and cytokine expression by macrophages. J. Leukoc. Biol. 2010, 88:769-778.
67. Gout E., Garlatti V., Smith D.F., Lacroix M., Dumestre-Perard C., Lunardi T., Martin L., Cesbron J.Y., Arlaud G.J., Gaboriaud C., Thielens N.M. Carbohydrate recognition properties of human ficolins: glycan array screening reveals the sialic acid binding specificity of M-ficolin. J. Biol. Chem. 2010, 285:6612-6622.
68. Gout E., Moriscot C., Doni A., Dumestre-Perard C., Lacroix M., Perard J., Schoehn G., Mantovani A., Arlaud G.J., Thielens N.M. M-ficolin interacts with the long pentraxin PTX3: a novel case of cross-talk between soluble pattern-recognition molecules. J. Immunol. 2011, 186:5815-5822.
69. Gregory L.A., Thielens N.M., Matsushita M., Sorensen R., Arlaud G.J., Fontecilla-Camps J.C., Gaboriaud C. The X-ray structure of human mannan-binding lectin-associated protein 19 (MAp19) and its interaction site with mannan-binding lectin and L-ficolin. J. Biol. Chem. 2004, 279:29391-29397.
70. Guo C.J., Atochina-Vasserman E.N., Abramova E., Foley J.P., Zaman A., Crouch E., Beers M.F., Savani R.C., Gow A.J. S-nitrosylation of surfactant protein-D controls inflammatory function. PLoS Biol. 2008, 6:e266.
71. Haerynck F., Van Steen K., Cattaert T., Loeys B., Van Daele S., Schelstraete P., Claes K., Van Thielen M., De Canck I., Mahachie John J.M., De Baets F. Polymorphisms in the lectin pathway genes as a possible cause of early chronic Pseudomonas aeruginosa colonization in cystic fibrosis patients. Hum. Immunol. 2012, 73:1175-1183.
72. Hajela K., Kojima M., Ambrus G., Wong K.H., Moffatt B.E., Ferluga J., Hajela S., Gal P., Sim R.B. The biological functions of MBL-associated serine proteases (MASPs). Immunobiology 2002, 205:467-475.
73. Halmos A., Rigo J., Szijarto J., Fust G., Prohaszka Z., Molvarec A. Circulating ficolin-2 and ficolin-3 in normal pregnancy and pre-eclampsia. Clin. Exp. Immunol. 2012, 169:49-56.
74. Hansen S., Selman L., Palaniyar N., Ziegler K., Brandt J., Kliem A., Jonasson M., Skjoedt M.O., Nielsen O., Hartshorn K., Jorgensen T.J., Skjodt K., Holmskov U. Collectin 11 (CL-11, CL-K1) is a MASP-1/3-associated plasma collectin with microbial-binding activity. J. Immunol. 2010, 185:6096-6104.
75. Harumiya S., Omori A., Sugiura T., Fukumoto Y., Tachikawa H., Fujimoto D. EBP-37, a new elastin-binding protein in human plasma: structural similarity to ficolins, transforming growth factor-beta 1-binding proteins. J. Biochem. 1995, 117:1029-1035.
76. Harumiya S., Takeda K., Sugiura T., Fukumoto Y., Tachikawa H., Miyazono K., Fujimoto D., Ichijo H. Characterization of ficolins as novel elastin-binding proteins and molecular cloning of human ficolin-1. J. Biochem. 1996, 120:745-751.
77. Helmy K.Y., Katschke K.J., Gorgani N.N., Kljavin N.M., Elliott J.M., Diehl L., Scales S.J., Ghilardi N., van Lookeren Campagne M. CRIg: a macrophage complement receptor required for phagocytosis of circulating pathogens. Cell 2006, 124:915-927.
78. Henriksen M.L., Brandt J., Andrieu J.P., Nielsen C., Jensen P.H., Holmskov U., Jorgensen T.J., Palarasah Y., Thielens N.M., Hansen S. Heteromeric complexes of native collectin kidney 1 and collectin liver 1 are found in the circulation with MASPs and activate the complement system. J. Immunol. 2013, 191:6117-6127.
79. Herpers B.L., Immink M.M., de Jong B.A., van Velzen-Blad H., de Jongh B.M., van Hannen E.J. Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors. Mol. Immunol. 2006, 43:851-855.
80. Hoang T.V., Toan N.L., Song le H., Ouf E.A., Bock C.T., Kremsner P.G., Kun J.F., Velavan T.P. Ficolin-2 levels and FCN2 haplotypes influence hepatitis B infection outcome in Vietnamese patients. PLoS One 2011, 6:e28113.
81. Honore C., Hummelshoj T., Hansen B.E., Madsen H.O., Eggleton P., Garred P. The innate immune component ficolin 3 (Hakata antigen) mediates the clearance of late apoptotic cells. Arthritis Rheum. 2007, 56:1598-1607.
82. Honore C., Rorvig S., Munthe-Fog L., Hummelshoj T., Madsen H.O., Borregaard N., Garred P. The innate pattern recognition molecule Ficolin-1 is secreted by monocytes/macrophages and is circulating in human plasma. Mol. Immunol. 2008, 45:2782-2789.
83. Hu Y.L., Luo F.L., Fu J.L., Chen T.L., Wu S.M., Zhou Y.D., Zhang X.L. Early increased ficolin-2 concentrations are associated with severity of liver inflammation andefficacy of anti-viral therapy in chronic hepatitis C patients. Scand. J. Immunol. 2013, 77:144-150.
84. Huang H., Huang S., Yu Y., Yuan S., Li R., Wang X., Zhao H., Yu Y., Li J., Yang M., Xu L., Chen S., Xu A. Functional characterization of a ficolin-mediated complement pathway in amphioxus. J. Biol. Chem. 2011, 286:36739-36748.
85. Hummelshoj T., Ma Y.J., Munthe-Fog L., Bjarnsholt T., Moser C., Skjoedt M.O., Romani L., Fujita T., Endo Y., Garred P. The interaction pattern of murine serum ficolin-A with microorganisms. PLoS One 2012, 7:e38196.
86. Hummelshoj T., Munthe-Fog L., Madsen H.O., Fujita T., Matsushita M., Garred P. Polymorphisms in the FCN2 gene determine serum variation and function of Ficolin-2. Hum. Mol. Genet. 2005, 14:1651-1658.
87. Hummelshoj T., Munthe-Fog L., Madsen H.O., Garred P. Functional SNPs in the human ficolin (FCN) genes reveal distinct geographical patterns. Mol. Immunol. 2008, 45:2508-2520.
88. Hummelshoj T., Thielens N.M., Madsen H.O., Arlaud G.J., Sim R.B., Garred P. Molecular organization of human Ficolin-2. Mol. Immunol. 2007, 44:401-411.
89. Ichijo H., Hellman U., Wernstedt C., Gonez L.J., Claesson-Welsh L., Heldin C.H., Miyazono K. Molecular cloning and characterization of ficolin, a multimeric protein with fibrinogen- and collagen-like domains. J. Biol. Chem. 1993, 268:14505-14513.
90. Inaba S., Okochi K., Yae Y., Niklasson F., de Verder C.H. Serological studies of an SLE-associated antigen-antibody system discovered as a precipitation reaction in agarose gel: the HAKATA antigen-antibody system. Fukuoka Igaku Zasshi 1990, 81:284-291.
91. Iwaki D., Kanno K., Takahashi M., Endo Y., Lynch N.J., Schwaeble W.J., Matsushita M., Okabe M., Fujita T. Small mannose-binding lectin-associated protein plays a regulatory role in the lectin complement pathway. J. Immunol. 2006, 177:8626-8632.
92. Iwaki D., Kanno K., Takahashi M., Endo Y., Matsushita M., Fujita T. The role of mannose-binding lectin-associated serine protease-3 in activation of the alternative complement pathway. J. Immunol. 2011, 187:3751-3758.
93. Jeannin P., Jaillon S., Delneste Y. Pattern recognition receptors in the immune response against dying cells. Curr. Opin. Immunol. 2008, 20:530-537.
94. Jensen M.L., Honore C., Hummelshoj T., Hansen B.E., Madsen H.O., Garred P. Ficolin-2 recognizes DNA and participates in the clearance of dying host cells. Mol. Immunol. 2007, 44:856-865.
95. Ji X., Azumi K., Sasaki M., Nonaka M. Ancient origin of the complement lectin pathway revealed by molecular cloning of mannan binding protein-associated serine protease from a urochordate, the Japanese ascidian, Halocynthia roretzi. Proc. Natl. Acad. Sci. U.S.A. 1997, 94:6340-6345.
96. Kairies N., Beisel H.G., Fuentes-Prior P., Tsuda R., Muta T., Iwanaga S., Bode W., Huber R., Kawabata S. The 2.0-A crystal structure of tachylectin 5A provides evidence for the common origin of the innate immunity and the blood coagulation systems. Proc. Natl. Acad. Sci. U.S.A. 2001, 98:13519-13524.
97. Kakinuma Y., Endo Y., Takahashi M., Nakata M., Matsushita M., Takenoshita S., Fujita T. Molecular cloning and characterization of novel ficolins from Xenopus laevis. Immunogenetics 2003, 55:29-37.
98. Kawasaki T., Etoh R., Yamashina I. Isolation and characterization of a mannan-binding protein from rabbit liver. Biochem. Biophys. Res. Commun. 1978, 81:1018-1024.
99. Keirstead N.D., Lee C., Yoo D., Brooks A.S., Hayes M.A. Porcine plasma ficolin binds and reduces infectivity of porcine reproductive and respiratory syndrome virus (PRRSV) in vitro. Antivir. Res. 2008, 77:28-38.
100. Kenjo A., Takahashi M., Matsushita M., Endo Y., Nakata M., Mizuochi T., Fujita T. Cloning and characterization of novel ficolins from the solitary ascidian, Halocynthia roretzi. J. Biol. Chem. 2001, 276:19959-19965.
101. Keshi H., Sakamoto T., Kawai T., Ohtani K., Katoh T., Jang S.J., Motomura W., Yoshizaki T., Fukuda M., Koyama S., Fukuzawa J., Fukuoh A., Yoshida I., Suzuki Y., Wakamiya N. Identification and characterization of a novel human collectin CL-K1. Microbiol. Immunol. 2006, 50:1001-1013.
102. Kilpatrick D.C., Chalmers J.D., MacDonald S.L., Murray M., Mohammed A., Hart S.P., Matsushita M., Hill A. Stable bronchiectasis is associated with low serum L-ficolin concentrations. Clin. Respir. J. 2009, 3:29-33.
103. Kilpatrick D.C., Fujita T., Matsushita M. P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Immunol. Lett. 1999, 67:109-112.
104. Kilpatrick D.C., St Swierzko A., Matsushita M., Domzalska-Popadiuk I., Borkowska-Klos M., Szczapa J., Cedzynski M. The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates. Hum. Immunol. 2013, 74:867-871.
105. Kimura A., Sakaguchi E., Nonaka M. Multi-component complement system of Cnidaria: C3, Bf, and MASP genes expressed in the endodermal tissues of a sea anemone, Nematostella vectensis. Immunobiology 2009, 214:165-178.
106. Kjaer T.R., Hansen A.G., Sorensen U.B., Holm A.T., Sorensen G.L., Jensenius J.C., Thiel S. M-ficolin binds selectively to the capsular polysaccharides of Streptococcus pneumoniae serotypes 19B and 19C and of a Streptococcus mitis strain. Infect. Immun. 2013, 81:452-459.
107. Kjaer T.R., Hansen A.G., Sorensen U.B., Nielsen O., Thiel S., Jensenius J.C. Investigations on the pattern recognition molecule M-ficolin: quantitative aspects of bacterial binding and leukocyte association. J. Leukoc. Biol. 2011, 90:425-437.
108. Krarup A., Gulla K.C., Gal P., Hajela K., Sim R.B. The action of MBL-associated serine protease 1 (MASP1) on factor XIII and fibrinogen. Biochim. Biophys. Acta 2008, 1784:1294-1300.
109. Krarup A., Sorensen U.B., Matsushita M., Jensenius J.C., Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect. Immun. 2005, 73:1052-1060.
110. Krarup A., Wallis R., Presanis J.S., Gal P., Sim R.B. Simultaneous activation of complement and coagulation by MBL-associated serine protease 2. PLoS One 2007, 2:e623.
111. Kuraya M., Ming Z., Liu X., Matsushita M., Fujita T. Specific binding of L-ficolin and H-ficolin to apoptotic cells leads to complement activation. Immunobiology 2005, 209:689-697.
112. Lacroix M., Dumestre-Perard C., Schoehn G., Houen G., Cesbron J.Y., Arlaud G.J., Thielens N.M. Residue Lys57 in the collagen-like region of human L-ficolin and its counterpart Lys47 in H-ficolin play a key role in the interaction with the mannan-binding lectin-associated serine proteases and the collectin receptor calreticulin. J. Immunol. 2009, 182:456-465.
113. Le Y., Lee S.H., Kon O.L., Lu J. Human L-ficolin: plasma levels, sugar specificity, and assignment of its lectin activity to the fibrinogen-like (FBG) domain. FEBS Lett. 1998, 425:367-370.
114. Li R.X., Chen H.B., Tu K., Zhao S.L., Zhou H., Li S.J., Dai J., Li Q.R., Nie S., Li Y.X., Jia W.P., Zeng R., Wu J.R. Localized-statistical quantification of human serum proteome associated with type 2 diabetes. PLoS One 2008, 3:e3224.
115. Liu J., Ali M.A., Shi Y., Zhao Y., Luo F., Yu J., Xiang T., Tang J., Li D., Hu Q., Ho W., Zhang X. Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation. Cell. Mol. Immunol. 2009, 6:235-244.
116. Liu Y., Endo Y., Homma S., Kanno K., Yaginuma H., Fujita T. Ficolin A and ficolin B are expressed in distinct ontogenic patterns and cell types in the mouse. Mol. Immunol. 2005, 42:1265-1273.
117. Liu Y., Endo Y., Iwaki D., Nakata M., Matsushita M., Wada I., Inoue K., Munakata M., Fujita T. Human M-ficolin is a secretory protein that activates the lectin complement pathway. J. Immunol. 2005, 175:3150-3156.
118. Low D.H., Ang Z., Yuan Q., Frecer V., Ho B., Chen J., Ding J.L. A novel human tectonin protein with multivalent beta-propeller folds interacts with ficolin and binds bacterial LPS. PLoS One 2009, 4:e6260.
119. Lu J., Le Y. Ficolins and the fibrinogen-like domain. Immunobiology 1998, 199:190-199.
120. Lu J., Le Y., Kon O.L., Chan J., Lee S.H. Biosynthesis of human ficolin, an Escherichia coli-binding protein, by monocytes: comparison with the synthesis of twomacrophage-specific proteins, C1q and the mannose receptor. Immunology 1996, 89:289-294.
121. Lu J., Li M., Zhang R., Hu C., Wang C., Jiang F., Yu W., Qin W., Tang S., Jia W. A common genetic variant of FCN3/CD164L2 is associated with essential hypertension in a Chinese population. Clin. Exp. Hypertens. 2012, 34:377-382.
122. Lu J., Tay P.N., Kon O.L., Reid K.B. Human ficolin: cDNA cloning, demonstration of peripheral blood leucocytes as the major site of synthesis and assignment of the gene to chromosome 9. Biochem. J. 1996, 313(Pt 2):473-478.
123. Luo F., Sun X., Wang Y., Wang Q., Wu Y., Pan Q., Fang C., Zhang X.L. Ficolin-2 defends against virulent Mycobacteria tuberculosis infection in vivo, and its insufficiency is associated with infection in humans. PLoS One 2013, 8:e73859.
124. Luo J.H., Ren B., Keryanov S., Tseng G.C., Rao U.N., Monga S.P., Strom S., Demetris A.J., Nalesnik M., Yu Y.P., Ranganathan S., Michalopoulos G.K. Transcriptomic and genomic analysis of human hepatocellular carcinomas and hepatoblastomas. Hepatology 2006, 44:1012-1024.
125. Luz P.R., Boldt A.B., Grisbach C., Kun J.F., Velavan T.P., Messias-Reason I.J. Association of L-ficolin levels and FCN2 genotypes with chronic Chagas disease. PLoS One 2013, 8:e60237.
126. Lynch N.J., Roscher S., Hartung T., Morath S., Matsushita M., Maennel D.N., Kuraya M., Fujita T., Schwaeble W.J. L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of gram-positive bacteria, and activates the lectin pathway of complement. J. Immunol. 2004, 172:1198-1202.
127. Ma Y.J., Doni A., Hummelshoj T., Honore C., Bastone A., Mantovani A., Thielens N.M., Garred P. Synergy between ficolin-2 and pentraxin 3 boostsinnate immune recognition and complement deposition. J. Biol. Chem. 2009, 284:28263-28275.
128. Ma Y.J., Doni A., Romani L., Jurgensen H.J., Behrendt N., Mantovani A., Garred P. Ficolin-1-PTX3 complex formation promotes clearance of altered self-cells and modulates IL-8 production. J. Immunol. 2013, 191:1324-1333.
129. Ma Y.J., Skjoedt M.O., Garred P. Collectin-11/MASP complex formation triggers activation of the lectin complement pathway-the fifth lectin pathway initiation complex. J. Innate Immun. 2013, 5:242-250.
130. Matsushita M., Endo Y., Fujita T. Cutting edge: complement-activating complex of ficolin and mannose-binding lectin-associated serine protease. J. Immunol. 2000, 164:2281-2284.
131. Matsushita M., Endo Y., Fujita T. Structural and functional overview of the lectin complement pathway: its molecular basis and physiological implication. Arch. Immunol. Ther. Exp. Warsz. 2013, 61:273-283.
132. Matsushita M., Endo Y., Hamasaki N., Fujita T. Activation of the lectin complement pathway by ficolins. Int. Immunopharmacol. 2001, 1:359-363.
133. Matsushita M., Endo Y., Taira S., Sato Y., Fujita T., Ichikawa N., Nakata M., Mizuochi T. A novel human serum lectin with collagen- and fibrinogen-like domains that functions as an opsonin. J. Biol. Chem. 1996, 271:2448-2454.
134. Matsushita M., Fujita T. Activation of the classical complement pathway by mannose-binding protein in association with a novel C1s-like serine protease. J. Exp. Med. 1992, 176:1497-1502.
135. Matsushita M., Kuraya M., Hamasaki N., Tsujimura M., Shiraki H., Fujita T. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J.Immunol. 2002, 168:3502-3506.
136. Matsushita M., Matsushita A., Endo Y., Nakata M., Kojima N., Mizuochi T., Fujita T. Origin of the classical complement pathway: lamprey orthologue of mammalian C1q acts as a lectin. Proc. Natl. Acad. Sci. U.S.A. 2004, 101:10127-10131.
137. Matsushita M., Thiel S., Jensenius J.C., Terai I., Fujita T. Proteolytic activities oftwo types of mannose-binding lectin-associated serine protease. J. Immunol. 2000, 165:2637-2642.
138. Meijvis S.C., Herpers B.L., Endeman H., de Jong B., van Hannen E., van Velzen-Blad H., Krediet R.T., Struijk D.G., Biesma D.H., Bos W.J. Mannose-binding lectin (MBL2) and ficolin-2 (FCN2) polymorphisms in patients on peritonealdialysis with staphylococcal peritonitis. Nephrol. Dial. Transplant. 2011, 26:1042-1045.
139. Messias-Reason I.J., Schafranski M.D., Kremsner P.G., Kun J.F. Ficolin 2 (FCN2) functional polymorphisms and the risk of rheumatic fever and rheumatic heart disease. Clin. Exp. Immunol. 2009, 157:395-399.
140. Michalski M., Szala A., St Swierzko A., Lukasiewicz J., Maciejewska A., Kilpatrick D.C., Matsushita M., Domzalska-Popadiuk I., Borkowska-Klos M., Sokolowska A., Szczapa J., Lugowski C., Cedzynski M. H-ficolin (ficolin-3) concentrations and FCN3 gene polymorphism in neonates. Immunobiology 2012, 217:730-737.
141. Moreno-Amaral A.N., Gout E., Danella-Polli C., Tabarin F., Lesavre P., Pereira-da-Silva G., Thielens N.M., Halbwachs-Mecarelli L. M-ficolin and leukosialin (CD43): new partners in neutrophil adhesion. J. Leukoc. Biol. 2012, 91:469-474.
142. Munthe-Fog L., Hummelshoj T., Hansen B.E., Koch C., Madsen H.O., Skjodt K., Garred P. The impact of FCN2 polymorphisms and haplotypes on the Ficolin-2 serum levels. Scand. J. Immunol. 2007, 65:383-392.
143. Munthe-Fog L., Hummelshoj T., Honore C., Madsen H.O., Permin H., Garred P. Immunodeficiency associated with FCN3 mutation and ficolin-3 deficiency. N. Engl. J. Med. 2009, 360:2637-2644.
144. Munthe-Fog L., Hummelshoj T., Honore C., Moller M.E., Skjoedt M.O., Palsgaard I., Borregaard N., Madsen H.O., Garred P. Variation in FCN1 affects biosynthesis of ficolin-1 and is associated with outcome of systemic inflammation. Genes. Immun. 2012, 13:515-522.
145. Muso E., Okuzaki D., Kobayashi S., Iwasaki Y., Sakurai M.A., Ito A., Nojima H. Ficolin-1 is up-regulated in leukocytes and glomeruli from microscopic polyangiitis patients. Autoimmunity 2013, 46:513-524.
146. Nahid A.M., Sugii S. Binding of porcine ficolin-alpha to lipopolysaccharides from gram-negative bacteria and lipoteichoic acids from gram-positive bacteria. Dev. Comp. Immunol. 2006, 30:335-343.
147. Naito A.T., Sumida T., Nomura S., Liu M.L., Higo T., Nakagawa A., Okada K., Sakai T., Hashimoto A., Hara Y., Shimizu I., Zhu W., Toko H., Katada A., Akazawa H., Oka T., Lee J.K., Minamino T., Nagai T., Walsh K., Kikuchi A., Matsumoto M., Botto M., Shiojima I., Komuro I. Complement C1q activates canonical Wnt signaling and promotes aging-related phenotypes. Cell 2012, 149:1298-1313.
148. Nauta A.J., Bottazzi B., Mantovani A., Salvatori G., Kishore U., Schwaeble W.J., Gingras A.R., Tzima S., Vivanco F., Egido J., Tijsma O., Hack E.C., Daha M.R., Roos A. Biochemical and functional characterization of the interaction between pentraxin 3 and C1q. Eur. J. Immunol. 2003, 33:465-473.
149. Ogden C.A., deCathelineau A., Hoffmann P.R., Bratton D., Ghebrehiwet B., Fadok V.A., Henson P.M. C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells. J. Exp. Med. 2001, 194:781-795.
150. Ohashi T., Erickson H.P. Oligomeric structure and tissue distribution of ficolins from mouse, pig and human. Arch. Biochem. Biophys. 1998, 360:223-232.
151. Ohashi T., Erickson H.P. The disulfide bonding pattern in ficolin multimers. J. Biol. Chem. 2004, 279:6534-6539.
152. Ojurongbe O., Ouf E.A., Van Tong H., Toan N.L., Song le H., Luz P.R., Messias-Reason I.J., Nurjadi D., Zanger P., Kun J.F., Kremsner P.G., Velavan T.P. Reliable and rapid characterization of functional FCN2 gene variants reveals diverse geographical patterns. BMC Med. Genet. 2012, 13:37.
153. Omori-Satoh T., Yamakawa Y., Mebs D. The antihemorrhagic factor, erinacin, from the European hedgehog (Erinaceus europaeus), a metalloprotease inhibitor of largemolecular size possessing ficolin/opsonin P35 lectin domains. Toxicon 2000, 38:1561-1580.
154. OmPraba G., Chapeaurouge A., Doley R., Devi K.R., Padmanaban P., Venkatraman C., Velmurugan D., Lin Q., Kini R.M. Identification of a novel family of snake venom proteins Veficolins from Cerberus rynchops using a venom gland transcriptomics and proteomics approach. J. Proteome Res. 2010, 9:1882-1893.
155. Opas M., Dziak E., Fliegel L., Michalak M. Regulation of expression and intracellular distribution of calreticulin, a major calcium binding protein of nonmuscle cells. J.Cell. Physiol. 1991, 149:160-171.
156. Ostergaard O., Nielsen C.T., Iversen L.V., Tanassi J.T., Knudsen S., Jacobsen S., Heegaard N.H. Unique protein signature of circulating microparticles in systemic lupus erythematosus. Arthritis Rheum. 2013, 65:2680-2690.
157. Ouf E.A., Ojurongbe O., Akindele A.A., Sina-Agbaje O.R., Van Tong H., Adeyeba A.O., Kremsner P.G., Kun J.F., Velavan T. Ficolin-2 levels and FCN2 genetic polymorphisms as a susceptibility factor in schistosomiasis. J. Infect. Dis. 2012, 206:562-570.
158. Pagh R., Duus K., Laursen I., Hansen P.R., Mangor J., Thielens N., Arlaud G.J., Kongerslev L., Hojrup P., Houen G. The chaperone and potential mannan-binding lectin (MBL) co-receptor calreticulin interacts with MBL through the binding site for MBL-associated serine proteases. FEBS J. 2008, 275:515-526.
159. Palaniyar N., Nadesalingam J., Clark H., Shih M.J., Dodds A.W., Reid K.B. Nucleic acid is a novel ligand for innate, immune pattern recognition collectins surfactant proteins A and D and mannose-binding lectin. J. Biol. Chem. 2004, 279:32728-32736.
160. Pan Q., Chen H., Wang F., Jeza V.T., Hou W., Zhao Y., Xiang T., Zhu Y., Endo Y., Fujita T., Zhang X.L. L-ficolin binds to the glycoproteins hemagglutinin and neuraminidase and inhibits influenza A virus infection both in vitro and in vivo. J. Innate Immun. 2012, 4:312-324.
161. Panda S., Zhang J., Tan N.S., Ho B., Ding J.L. Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria. EMBO J. 2013, 32:2905-2919.
162. Panda S., Zhang J., Tan N.S., Ho B., Ding J.L. Natural IgG antibodies provide innate protection against ficolin-opsonized bacteria. EMBO J. 2014, 33:1977.
163. Panda S., Zhang J., Yang L., Anand G.S., Ding J.L. Molecular interaction between natural IgG and ficolin-mechanistic insights on adaptive-innate immune crosstalk. Sci. Rep. 2014, 4:3675.
164. Parej K., Hermann A., Donath N., Zavodszky P., Gal P., Dobo J. Dissociation and re-association studies on the interaction domains of mannan-binding lectin (MBL)-associated serine proteases, MASP-1 and MASP-2, provide evidence for heterodimer formation. Mol. Immunol. 2014, 59:1-9.
165. Prohaszka Z., Munthe-Fog L., Ueland T., Gombos T., Yndestad A., Forhecz Z., Skjoedt M.O., Pozsonyi Z., Gustavsen A., Janoskuti L., Karadi I., Gullestad L., Dahl C.P., Askevold E.T., Fust G., Aukrust P., Mollnes T.E., Garred P. Association of ficolin-3 with severity and outcome of chronic heart failure. PLoS One 2013, 8:e60976.
166. Rooryck C., Diaz-Font A., Osborn D.P., Chabchoub E., Hernandez-Hernandez V., Shamseldin H., Kenny J., Waters A., Jenkins D., Kaissi A.A., Leal G.F., Dallapiccola B., Carnevale F., Bitner-Glindzicz M., Lees M., Hennekam R., Stanier P., Burns A.J., Peeters H., Alkuraya F.S., Beales P.L. Mutations in lectin complement pathway genes COLEC11 and MASP1 cause 3MC syndrome. Nat. Genet. 2011, 43:197-203.
167. Roos A., Rastaldi M.P., Calvaresi N., Oortwijn B.D., Schlagwein N., van Gijlswijk-Janssen D.J., Stahl G.L., Matsushita M., Fujita T., van Kooten C., Daha M.R. Glomerular activation of the lectin pathway of complement in IgA nephropathy is associated with more severe renal disease. J. Am. Soc. Nephrol. 2006, 17:1724-1734.
168. Rosbjerg A., Munthe-Fog L., Garred P., Skjoedt M.O. Heterocomplex formation between MBL/ficolin/CL-11-associated serine protease-1 and -3 and MBL/ficolin/CL-11-associated protein-1. J. Immunol. 2014, 192:4352-4360.
169. Ross G.D., Reed W., Dalzell J.G., Becker S.E., Hogg N. Macrophage cytoskeleton association with CR3 and CR4 regulates receptor mobility and phagocytosis of iC3b-opsonized erythrocytes. J. Leukoc. Biol. 1992, 51:109-117.
170. Roy S., Biswas S., Saroha A., Sahu D., Das H.R. Enhanced expression and fucosylation of ficolin3 in plasma of RA patients. Clin. Biochem. 2013, 46:160-163.
171. Runza V.L., Hehlgans T., Echtenacher B., Zahringer U., Schwaeble W.J., Mannel D.N. Localization of the mouse defense lectin ficolin B in lysosomes of activated macrophages. J. Endotoxin Res. 2006, 12:120-126.
172. Ruskamp J.M., Hoekstra M.O., Postma D.S., Kerkhof M., Bottema R.W., Koppelman G.H., Rovers M.M., Wijga A.H., de Jongste J.C., Brunekreef B., Sanders E.A. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. Clin. Exp. Immunol. 2009, 155:433-440.
173. Sarvari J., Mojtahedi Z., Kuramitsu Y., Malek-Hosseini S.A., Shamsi Shahrabadi M., Ghaderi A., Nakamura K. Differential expression of haptoglobin isoforms in chronic active hepatitis, cirrhosis and HCC related to HBV infection. Oncol. Lett. 2011, 2:871-877.
174. Savill J.S., Henson P.M., Haslett C. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism. J.Clin. Invest. 1989, 84:1518-1527.
175. Schelenz S., Kirchhof N., Bidula S., Wallis R., Sexton D.W. Opsonizing properties of rat ficolin-A in the defence against Cryptococcus neoformans. Immunobiology 2013, 218:477-483.
176. Schlapbach L.J., Aebi C., Hansen A.G., Hirt A., Jensenius J.C., Ammann R.A. H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients. Clin. Exp. Immunol. 2009, 157:83-89.
177. Schlapbach L.J., Kessler U., Thiel S., Hansen A.G., Nelle M., Ammann R.A., Aebi C., Jensenius J.C. M-ficolin in the neonatal period: Associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Mol. Immunol. 2009, 46:2597-2603.
178. Schlapbach L.J., Kjaer T.R., Thiel S., Mattmann M., Nelle M., Wagner B.P., Ammann R.A., Aebi C., Jensenius J.C. M-ficolin concentrations in cord bloodare related to circulating phagocytes and to early-onset sepsis. Pediatr. Res. 2012, 71:368-374.
179. Schlapbach L.J., Mattmann M., Thiel S., Boillat C., Otth M., Nelle M., Wagner B., Jensenius J.C., Aebi C. Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis. Clin. Infect. Dis. 2010, 51:153-162.
180. Schlapbach L.J., Thiel S., Kessler U., Ammann R.A., Aebi C., Jensenius J.C. Congenital H-ficolin deficiency in premature infants with severe necrotising enterocolitis. Gut 2011, 60:1438-1439.
181. Schmid M., Hunold K., Weber-Steffens D., Mannel D.N. Ficolin-B marks apoptotic and necrotic cells. Immunobiology 2012, 217:610-615.
182. Sekine H., Kenjo A., Azumi K., Ohi G., Takahashi M., Kasukawa R., Ichikawa N., Nakata M., Mizuochi T., Matsushita M., Endo Y., Fujita T. An ancient lectin-dependent complement system in an ascidian: novel lectin isolated from the plasma of the solitary ascidian, Halocynthia roretzi. J. Immunol. 2001, 167:4504-4510.
183. Sirmaci A., Walsh T., Akay H., Spiliopoulos M., Sakalar Y.B., Hasanefendioglu-Bayrak A., Duman D., Farooq A., King M.C., Tekin M. MASP1 mutations in patients with facial, umbilical, coccygeal, and auditory findings of Carnevale, Malpuech, OSA, and Michels syndromes. Am. J. Hum. Genet. 2010, 87:679-686.
184. Skjoedt M.O., Hummelshoj T., Palarasah Y., Honore C., Koch C., Skjodt K., Garred P. A novel mannose-binding lectin/ficolin-associated protein is highly expressed in heart and skeletal muscle tissues and inhibits complement activation. J.Biol. Chem. 2010, 285:8234-8243.
185. Skjoedt M.O., Roversi P., Hummelshoj T., Palarasah Y., Rosbjerg A., Johnson S., Lea S.M., Garred P. Crystal structure and functional characterization of the complement regulator mannose-binding lectin (MBL)/ficolin-associated protein-1 (MAP-1). J. Biol. Chem. 2012, 287:32913-32921.
186. Sorensen B., Jones J.F., Vernon S.D., Rajeevan M.S. Transcriptional control of complement activation in an exercise model of chronic fatigue syndrome. Mol. Med. 2009, 15:34-42.
187. Stover C.M., Thiel S., Thelen M., Lynch N.J., Vorup-Jensen T., Jensenius J.C., Schwaeble W.J. Two constituents of the initiation complex of the mannan-binding lectin activation pathway of complement are encoded by a single structural gene. J.Immunol. 1999, 162:3481-3490.
188. Sugimoto R., Yae Y., Akaiwa M., Kitajima S., Shibata Y., Sato H., Hirata J., Okochi K., Izuhara K., Hamasaki N. Cloning and characterization of the Hakata antigen, a member of the ficolin/opsonin p35 lectin family. J. Biol. Chem. 1998, 273:20721-20727.
189. Svendsen C.B., Hummelshoj T., Munthe-Fog L., Milman N., Garred P., Laursen I.A., Christiansen M., Krogfelt K.A. Ficolins and Mannose-Binding Lectin in Danish patients with sarcoidosis. Respir. Med. 2008, 102:1237-1242.
190. Swierzko A., Lukasiewicz J., Cedzynski M., Maciejewska A., Jachymek W., Niedziela T., Matsushita M., Lugowski C. New functional ligands for ficolin-3 among lipopolysaccharides of Hafnia alvei. Glycobiology 2012, 22:267-280.
191. Szala A., Sawicki S., Swierzko A.S., Szemraj J., Sniadecki M., Michalski M., Kaluzynski A., Lukasiewicz J., Maciejewska A., Wydra D., Kilpatrick D.C., Matsushita M., Cedzynski M. Ficolin-2 and ficolin-3 in women with malignant and benign ovarian tumours. Cancer Immunol. Immunother. 2013, 62:1411-1419.
192. Takahashi K., Moyo P., Chigweshe L., Chang W.C., White M.R., Hartshorn K.L. Efficacy of recombinant chimeric lectins, consisting of mannose binding lectin and L-ficolin, against influenza A viral infection in mouse model study. Virus Res. 2013, 178:495-501.
193. Takahashi M., Endo Y., Fujita T., Matsushita M. A truncated form of mannose-binding lectin-associated serine protease (MASP)-2 expressed by alternative polyadenylation is a component of the lectin complement pathway. Int. Immunol. 1999, 11:859-863.
194. Takahashi M., Ishida Y., Iwaki D., Kanno K., Suzuki T., Endo Y., Homma Y., Fujita T. Essential role of mannose-binding lectin-associated serine protease-1 in activation of the complement factor D. J. Exp. Med. 2010, 207:29-37.
195. Takahashi M., Iwaki D., Kanno K., Ishida Y., Xiong J., Matsushita M., Endo Y., Miura S., Ishii N., Sugamura K., Fujita T. Mannose-binding lectin (MBL)-associated serine protease (MASP)-1 contributes to activation of the lectin complement pathway. J. Immunol. 2008, 180:6132-6138.
196. Takahashi M., Iwaki D., Matsushita A., Nakata M., Matsushita M., Endo Y., Fujita T. Cloning and characterization of mannose-binding lectin from lamprey (Agnathans). J. Immunol. 2006, 176:4861-4868.
197. Tanio M., Kohno T. Histidine-regulated activity of M-ficolin. Biochem. J. 2009, 417:485-491.
198. Tanio M., Kondo S., Sugio S., Kohno T. Overexpression, purification and preliminary crystallographic analysis of human M-ficolin fibrinogen-like domain. Acta Crystallogr. Sect. F. Struct. Biol. Cryst. Commun. 2006, 62:652-655.
199. Tanio M., Kondo S., Sugio S., Kohno T. Trivalent recognition unit of innate immunity system: crystal structure of trimeric human M-ficolin fibrinogen-like domain. J.Biol. Chem. 2007, 282:3889-3895.
200. Tanio M., Kondo S., Sugio S., Kohno T. Trimeric structure and conformational equilibrium of M-ficolin fibrinogen-like domain. J. Synchrotron Radiat. 2008, 15:243-245.
201. Tanio M., Wakamatsu K., Kohno T. Binding site of C-reactive protein on M-ficolin. Mol. Immunol. 2009, 47:215-221.
202. Teh C., Le Y., Lee S.H., Lu J. M-ficolin is expressed on monocytes and is a lectin binding to N-acetyl-D-glucosamine and mediates monocyte adhesion and phagocytosis of Escherichia coli. Immunology 2000, 101:225-232.
203. Teillet F., Gaboriaud C., Lacroix M., Martin L., Arlaud G.J., Thielens N.M. Crystal structure of the CUB1-EGF-CUB2 domain of human MASP-1/3 and identification of its interaction sites with mannan-binding lectin and ficolins. J. Biol. Chem. 2008, 283:25715-25724.
204. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol. Immunol. 2007, 44:3875-3888.
205. Thiel S., Vorup-Jensen T., Stover C.M., Schwaeble W., Laursen S.B., Poulsen K., Willis A.C., Eggleton P., Hansen S., Holmskov U., Reid K.B., Jensenius J.C. A second serine protease associated with mannan-binding lectin that activates complement. Nature 1997, 386:506-510.
206. Thomsen T., Schlosser A., Holmskov U., Sorensen G.L. Ficolins and FIBCD1: soluble and membrane bound pattern recognition molecules with acetyl group selectivity. Mol. Immunol. 2011, 48:369-381.
207. Tsujimura M., Miyazaki T., Kojima E., Sagara Y., Shiraki H., Okochi K., Maeda Y. Serum concentration of Hakata antigen, a member of the ficolins, is linked with inhibition of Aerococcus viridans growth. Clin. Chim. Acta 2002, 325:139-146.
208. Vander Cruyssen B., Nuytinck L., Boullart L., Elewaut D., Waegeman W., Van Thielen M., De Meester E., Lebeer K., Rossau R., De Keyser F. Polymorphisms in the ficolin 1 gene (FCN1) are associated with susceptibility to the development of rheumatoid arthritis. Rheumatol. Oxf. 2007, 46:1792-1795.
209. Verma A., White M., Vathipadiekal V., Tripathi S., Mbianda J., Ieong M., Qi L., Taubenberger J.K., Takahashi K., Jensenius J.C., Thiel S., Hartshorn K.L. Human H-ficolin inhibits replication of seasonal and pandemic influenza A viruses. J.Immunol. 2012, 189:2478-2487.
210. Wang C.C., Yim K.W., Poon T.C., Choy K.W., Chu C.Y., Lui W.T., Lau T.K., Rogers M.S., Leung T.N. Innate immune response by ficolin binding in apoptotic placenta is associated with the clinical syndrome of preeclampsia. Clin. Chem. 2007, 53:42-52.
211. Wittenborn T., Thiel S., Jensen L., Nielsen H.J., Jensenius J.C. Characteristics and biological variations of M-ficolin, a pattern recognition molecule, in plasma. J. Innate Immun. 2010, 2:167-180.
212. Yae Y., Inaba S., Sato H., Okochi K., Tokunaga F., Iwanaga S. Isolation and characterization of a thermolabile beta-2 macroglycoprotein ('thermolabile substance' or 'Hakata antigen') detected by precipitating (auto) antibody in sera of patients with systemic lupus erythematosus. Biochim. Biophys. Acta 1991, 1078:369-376.
213. Yang L., Zhang J., Ho B., Ding J.L. Histidine-mediated pH-sensitive regulation of M-ficolin:GlcNAc binding activity in innate immunity examined by molecular dynamics simulations. PLoS One 2011, 6:e19647.
214. Zhang D.F., Huang X.Q., Wang D., Li Y.Y., Yao Y.G. Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China. Hum. Genet. 2013, 132:629-640.
215. Zhang J., Koh J., Lu J., Thiel S., Leong B.S., Sethi S., He C.Y., Ho B., Ding J.L. Local inflammation induces complement crosstalk which amplifies the antimicrobial response. PLoS Pathog. 2009, 5:e1000282.
216. Zhang J., Yang L., Ang Z., Yoong S.L., Tran T.T., Anand G.S., Tan N.S., Ho B., Ding J.L. Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense. J. Immunol. 2010, 185:6899-6910.