The relationship between FCN2 genotypes and serum ficolin-2 (L-ficolin) protein concentrations from a large cohort of neonates

Human Immunology

Volumn 74, Issue 7, 2013, Pages 867-871

  Kilpatrick, David C ^a   Swierzko, Anna St ^b   Matsushita, Misao ^c   Domzalska Popadiuk, Iwona ^d   Borkowska Klos, Monika ^e   Szczapa, Jerzy ^e   Cedzynski, Maciej ^b  

^a SCOTTISH NATIONAL BLOOD TRANSFUSION SERVICE   (United Kingdom)

^b INSTITUTE OF MEDICAL BIOLOGY   (Poland)

^c TOKAI UNIVERSITY   (Japan)

^d MEDICAL UNIVERSITY OF GDANSK   (Poland)

^e POZNAN UNIVERSITY OF MEDICAL SCIENCES   (Poland)

Author keywords

[No Author keywords available]

Indexed keywords

FICOLIN; FICOLIN 2; UNCLASSIFIED DRUG;

ARTICLE; COHORT ANALYSIS; DISEASE ASSOCIATION; EXON; FCN2 GENE; GENE; GENE FREQUENCY; GENE LOCUS; GENE MUTATION; GENETIC ASSOCIATION; GENOTYPE; HISTOCOMPATIBILITY; HUMAN; HUMAN TISSUE; LOW BIRTH WEIGHT; NEWBORN; PERINATAL INFECTION; PREGNANCY OUTCOME; PREMATURE LABOR; PREMATURITY; PRIORITY JOURNAL; PROMOTER REGION; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM; UMBILICAL CORD BLOOD;

COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; FEMALE; GENETIC ASSOCIATION STUDIES; GENOTYPE; HUMANS; INFANT, NEWBORN; INFECTION; LABOR, OBSTETRIC; LECTINS; POLYMORPHISM, SINGLE NUCLEOTIDE; PREGNANCY; PREMATURE BIRTH; TRIPLETS; TWINS;

EID: 84878599290     PISSN: 01988859     EISSN: 18791166     Source Type: Journal    
DOI: 10.1016/j.humimm.2013.04.011     Document Type: Article

References (14)

1. Matsushita M. Ficolins in complement activation. Mol Immunol 2013;55:22-6.
2. Kilpatrick D.C., Chalmers J.D. Human L-ficolin (ficolin-2) and its clinical significance. J Biomed Biotechnol 2012, Article ID 138797. 10.1155/2012/138797.
3. Garlatti V., Belloy N., Martin L., Lacroix M., Matsushita M., Endo Y., et al. Structural insights into the innate immune recognition specificities of L- and H-ficolins. EMBO J 2007, 26:623-633.
4. Kilpatrick D.C., Chalmers J.D., MacDonald S.L., Murray M., Mohammed A., Hart S.P., et al. Stable bronchiectasis is associated with low serum L-ficolin concentrations. Clin Resp J 2009, 3:29-33.
5. Chalmers J.D., Kilpatrick D.C., McHugh B., Smith M.P., Govan J.R.W., Doherty C., et al. Single nucleotide polymorphisms in the ficolin-2 gene predispose to Pseudomonas aeruginosa infection and disease severity in non-cystic fibrosis bronchiectasis. Thorax 2012, 66(Suppl. 4):A1-A2.
6. Hummelshoj T., Munthe-Fog L., Madsen H.O., Fujita T., Matsushita M., Garred P. Polymorphisms in the FCN2 gene determine serum variation and function of ficolin-2. Hum Mol Genet 2005, 14:1651-1658.
7. Herpers B.L., Immink M.M., de Jong B.A.W., van Velzen-Blad H., de Jongh B.M., van Hannen E.J. Coding and non-coding polymorphisms in the lectin pathway activator L-ficolin gene in 188 Dutch blood bank donors. Mol Immunol 2006, 43:851-855.
8. Munthe-Fog L., Hummelshoj T., Hansen B.E., et al. The impact of FCN2 polymorphisms and haplotypes on the ficolin-2 serum levels. Scand J Immunol 2007, 65:383-392.
9. Cedzynski M., Nuytinck L., Atkinson A.P.M., Swierzko A., Zeman K., Szemrai J., et al. Extremes of L-ficolin concentration in children with recurrent infections are associated with single nucleotide polymorphisms in the FCN2 gene. Clin Exp Immunol 2007, 150:99-104.
10. Swierzko A.S., Atkinson A.P.M., Cedzynski M., MacDonald S.L., Szala A., Domzalska-Popadiuk I., et al. Two factors of the lectin pathway of complement, L-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol Immunol 2009, 46:551-558.
11. Swierzko A.S., Szala A., Cedzynski M., Domzalska-Popadiuk I., Borkowska-Klos M., Jopek A., et al. Mannan-binding lectin genotypes and genotype-phenotype relationships in a large cohort of Polish neonates. Hum Immunol 2009, 70:68-72.
12. Kilpatrick D.C., Fujita T., Matsushita M. P35, an opsonic lectin of the ficolin family, in human blood from neonates, normal adults, and recurrent miscarriage patients. Immunol Lett 1999, 67:109-112.
13. Matsushita M, Kilpatrick DC, Shiraki H, Lui Y, Tateishi K, Tsujimura M, et al. Ficolins. In: Gadjeva M, editor. Methods in molecular biology, complement systems: methods and protocols. Humana Press, in press.
14. Ruskamp J.M., Hoekstra M.O., Postma D.S., Kerkhof M., Bottema R.W., Koppelman G.H., et al. Exploring the role of polymorphisms in ficolin genes in respiratory tract infections in children. Clin Exp Immunol 2009, 155:433-440.