Differential role of the lectin pathway of complement activation in susceptibility to neonatal sepsis

Clinical Infectious Diseases

Volumn 51, Issue 2, 2010, Pages 153-162

  Schlapbach, Luregn J ^a   Mattmann, Maika ^a   Thiel, Steffen ^b   Boillat, Colette ^a   Otth, Margrith ^a,b   Nelle, Mathias ^a   Wagner, Bendicht ^a   Jensenius, Jens C ^c   Aebi, Christoph ^a,b  

^a Departments of Pediatrics   (United States)

^b UNIVERSITY OF BERN   (Switzerland)

^c AARHUS UNIVERSITY   (Denmark)

Author keywords

[No Author keywords available]

Indexed keywords

FICOLIN; H FICOLIN; L FICOLIN; LECTIN; MANNAN BINDING LECTIN; MANNAN BINDING LECTIN ASSOCIATED SERINE PROTEINASE; MASP 2 PROTEIN; MASP 3 PROTEIN; UNCLASSIFIED DRUG; COMPLEMENT;

ARTICLE; CASE CONTROL STUDY; CLINICAL ARTICLE; COMPLEMENT ACTIVATION; CONTROLLED STUDY; DISEASE ASSOCIATION; DISEASE PREDISPOSITION; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROMETRY; GESTATIONAL AGE; GRAM NEGATIVE SEPSIS; GRAM POSITIVE INFECTION; HIGH RISK INFANT; HUMAN; INFANT; MALE; NEWBORN SEPSIS; PRIORITY JOURNAL; UMBILICAL CORD BLOOD; BACTEREMIA; COMPLEMENT LECTIN PATHWAY; FLUOROIMMUNOASSAY; GRAM NEGATIVE INFECTION; IMMUNOLOGY; NEWBORN; PATHOLOGY; SEPSIS;

BACTEREMIA; CASE-CONTROL STUDIES; COMPLEMENT PATHWAY, MANNOSE-BINDING LECTIN; COMPLEMENT SYSTEM PROTEINS; ENZYME-LINKED IMMUNOSORBENT ASSAY; FEMALE; FLUOROIMMUNOASSAY; GRAM-NEGATIVE BACTERIAL INFECTIONS; GRAM-POSITIVE BACTERIAL INFECTIONS; HUMANS; INFANT, NEWBORN; MALE; SEPSIS;

EID: 77954804740     PISSN: 10584838     EISSN: None     Source Type: Journal    
DOI: 10.1086/653531     Document Type: Article

References (39)

1. Lawn JE, Cousens S, Zupan J. 4 million neonatal deaths: when? Where? Why? Lancet 2005; 365:891-900.
2. Fanaroff AA, Stoll BJ, Wright LL, et al. Trends in neonatal morbidity and mortality for very low birthweight infants. Am J Obstet Gynecol 2007; 196:147.e1-8.
3. Stoll BJ, Hansen N, Fanaroff AA, et al. Changes in pathogens causing early-onset sepsis in very-low-birth-weight infants. N Engl J Med 2002; 347:240-247.
4. Stoll BJ, Hansen N, Fanaroff AA, et al. Late-onset sepsis in very low birth weight neonates: the experience of the NICHD Neonatal Research Network. Pediatrics 2002; 110:285-291.
5. Stoll BJ, Hansen NI, Adams-Chapman I, et al. Neurodevelopmental and growth impairment among extremely low-birth-weight infants with neonatal infection. Jama 2004; 292:2357-2365.
6. Kenzel S, Henneke P. The innate immune system and its relevance to neonatal sepsis. Curr Opin Infect Dis 2006; 19:264-270.
7. Zaghouani H, Hoeman CM, Adkins B. Neonatal immunity: faulty Thelpers and the shortcomings of dendritic cells. Trends Immunol 2009; 30:585-591.
8. Strunk T, Richmond P, Simmer K, Currie A, Levy O, Burgner D. Neonatal immune responses to coagulase-negative staphylococci. Curr Opin Infect Dis 2007; 20:370-375.
9. Thiel S. Complement activating soluble pattern recognition molecules with collagen-like regions, mannan-binding lectin, ficolins and associated proteins. Mol Immunol 2007; 44:3875-3888.
10. Walport MJ. Complement. Second of two parts. N Engl J Med 2001; 344:1140-1144.
11. Walport MJ. Complement. First of two parts. N Engl J Med 2001; 344: 1058-1066.
12. Holmskov U, Thiel S, Jensenius JC. Collections and ficolins: humoral lectins of the innate immune defense. Annu Rev Immunol 2003; 21: 547-578.
13. Sorensen R, Thiel S, Jensenius JC. Mannan-binding-lectin-associated serine proteases, characteristics and disease associations. Springer Semin Immunopathol 2005; 27:299-319.
14. Krarup A, Sorensen UB, Matsushita M, Jensenius JC, Thiel S. Effect of capsulation of opportunistic pathogenic bacteria on binding of the pattern recognition molecules mannan-binding lectin, L-ficolin, and H-ficolin. Infect Immun 2005; 73:1052-1060.
15. Neth O, Jack DL, Dodds AW, Holzel H, Klein NJ, Turner MW. Mannose- binding lectin binds to a range of clinically relevant microorganisms and promotes complement deposition. Infect Immun 2000; 68:688-693.
16. Stengaard-Pedersen K, Thiel S, Gadjeva M, et al. Inherited deficiency of mannan-binding lectin-associated serine protease 2. N Engl J Med 2003; 349:554-560. (Pubitemid 36951367)
17. Garred P, Honore C, Ma YJ, Munthe-Fog L, Hummelshoj T. MBL2, FCN1, FCN2 and FCN3-The genes behind the initiation of the lectin pathway of complement. Mol Immunol 2009; 46:2737-2744.
18. Eisen DP, Minchinton RM. Impact of mannose-binding lectin on susceptibility to infectious diseases. Clin Infect Dis 2003; 37:1496-1505.
19. Garred P, J JS, Quist L, Taaning E, Madsen HO. Association of mannose- binding lectin polymorphisms with sepsis and fatal outcome, in patients with systemic inflammatory response syndrome. J Infect Dis 2003; 188:1394-1403.
20. Gordon AC, Waheed U, Hansen TK, et al. Mannose-binding lectin polymorphisms in severe sepsis: relationship to levels, incidence, and outcome. Shock 2006; 25:88-93.
21. Vekemans M, Robinson J, Georgala A, et al. Low mannose-binding lectin concentration is associated with severe infection in patients with hematological cancer who are undergoing chemotherapy. Clin Infect Dis 2007; 44:1593-1601.
22. de Benedetti F, Auriti C, D'Urbano LE, et al. Low serum levels of mannose binding lectin are a risk factor for neonatal sepsis. Pediatr Res 2007; 61: 325-328.
23. Dzwonek AB, Neth OW, Thiebaut R, et al. The role of mannose-binding lectin in susceptibility to infection in preterm neonates. Pediatr Res 2008; 63:680-685.
24. Frakking FN, Brouwer N, van Eijkelenburg NK, et al. Low mannosebinding lectin (MBL) levels in neonates with pneumonia and sepsis. Clin Exp Immunol 2007; 150:255-262.
25. van der Zwet WC, Catsburg A, van Elburg RM, Savelkoul PH, Vandenbroucke- Grauls CM. Mannose-binding lectin (MBL) genotype in relation to risk of nosocomial infection in pre-term neonates in the neonatal intensive care unit. Clin Microbiol Infect 2008; 14:130-135.
26. Ahrens P, Kattner E, Kohler B, et al. Mutations of genes involved in the innate immune system as predictors of sepsis in very low birth weight infants. Pediatr Res 2004; 55:652-656.
27. Kaukola T, Herva R, Perhomaa M, et al. Population cohort associating chorioamnionitis, cord inflammatory cytokines and neurologic outcome in very preterm, extremely low birth weight infants. Pediatr Res 2006; 59:478-483.
28. Schlapbach LJ, Aebi C, Hansen AG, Hirt A, Jensenius JC, Ammann RA. H-ficolin serum concentration and susceptibility to fever and neutropenia in paediatric cancer patients. Clin Exp Immunol 2009; 157: 83-89.
29. Terai I, Kobayashi K, Matsushita M, Fujita T. Human serum mannosebinding lectin (MBL)-associated serine protease-1 (MASP-1): determination of levels in body fluids and identification of two forms in serum. Clin Exp Immunol 1997; 110:317-323.
30. Swierzko A, Atkinson AP, Cedzynski M, et al. Two factors of the lectin pathway of complement, L-ficolin and mannan-binding lectin, and their associations with prematurity, low birthweight and infections in a large cohort of Polish neonates. Mol Immunol 2009; 70:68-72.
31. Schlapbach LJ, Aebi C, Fisch U, et al. Higher cord blood levels of mannose-binding lectin-associated serine protease-2 in infants with necrotising enterocolitis. Pediatr Res 2008; 64:562-566.
32. Schlapbach LJ, Kessler U, Thiel S, et al. M-ficolin in the neonatal period: associations with need for mechanical ventilation and mortality in premature infants with necrotising enterocolitis. Mol Immunol 2009; 46: 2597-2603.
33. Nielsen RG, Vind I, Munkholm P, Jensenius JC, Thiel S, Husby S. Genetic polymorphisms of mannan binding lectin (MBL), serumlevels of MBL, the MBL associated serine protease and H-ficolin in patients with Crohn's disease. Gut 2007; 56:311-312.
34. Skjoedt MO, Palarasah Y, Munthe-Fog L, et al. MBL-associated serine protease-3 circulates in high serum concentrations predominantly in complex with Ficolin-3 and regulates Ficolin-3 mediated complement activation. Immunobiology 2009 [Epub ahead of print].
35. Munthe-Fog L, Hummelshoj T, Honore C, Madsen HO, Permin H, Garred P. Immunodeficiency associated with FCN3 mutation and ficolin- 3 deficiency. N Engl J Med 2009; 360:2637-2644.
36. Matsushita M, Kuraya M, Hamasaki N, Tsujimura M, Shiraki H, Fujita T. Activation of the lectin complement pathway by H-ficolin (Hakata antigen). J Immunol 2002; 168:3502-3506.
37. Lynch NJ, Roscher S, Hartung T, et al. L-ficolin specifically binds to lipoteichoic acid, a cell wall constituent of Gram-positive bacteria, and activates the lectin pathway of complement. J Immunol 2004; 172: 1198-1202.
38. Dumestre-Perard C, Doerr E, Colomb MG, Loos M. Involvement of complement pathways in patients with bacterial septicemia. Mol Immunol 2007; 44:1631-1638.
39. Frakking FN, Brouwer N, van de Wetering MD, et al. Safety and pharmacokinetics of plasma-derived mannose-binding lectin (MBL) substitution in children with chemotherapy-induced neutropaenia. Eur J Cancer 2009; 45:505-512.