Specifically binding of L-ficolin to N-glycans of HCV envelope glycoproteins E1 and E2 leads to complement activation

Cellular and Molecular Immunology

Volumn 6, Issue 4, 2009, Pages 235-244

  Liu, Jun ^a   Ali, Mohammed A M ^a   Shi, Yinghua ^a   Zhao, Yinglan ^a   Luo, Fenglin ^a   Yu, Jin ^a   Xiang, Tian ^a,d   Tang, Jie ^a   Li, Dongqing ^a   Hu, Quan ^b   Ho, Wenzhe ^c   Zhang, Xiaolian ^a  

^a WUHAN UNIVERSITY   (China)

^b Center for Disease Control and Prevention of Wuhan   (China)

^c UNIVERSITY OF PENNSYLVANIA   (United States)

^d Central Hospital of Enshi Autonomous Prefecture   (China)

Author keywords

Complement; Envelope glycoproteins; Hepatitis C virus; L ficolin; Viral hepatitis

Indexed keywords

GLYCAN DERIVATIVE; GLYCOPROTEIN E1; GLYCOPROTEIN E2; L FICOLIN; LECTIN; RECOMBINANT PROTEIN; UNCLASSIFIED DRUG; E1 PROTEIN, HEPATITIS C VIRUS; FICOLIN; GLYCOPROTEIN E2, HEPATITIS C VIRUS; POLYSACCHARIDE; VIRUS ENVELOPE PROTEIN; GLYCAN;

ADULT; ARTICLE; CELL STRAIN HEPG2; COMPLEMENT ACTIVATION; COMPLEMENT SYSTEM; CONTROLLED STUDY; CYTOLYSIS; ESCHERICHIA COLI; FEMALE; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IN VITRO STUDY; LIVER CELL; MAJOR CLINICAL STUDY; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PROTEIN BINDING; PROTEIN BLOOD LEVEL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN PROTEIN INTERACTION; SALMONELLA TYPHIMURIUM; VIRUS ENVELOPE; VIRUS STRAIN; BIOSYNTHESIS; BLOOD; CELL LINE; CYTOTOXICITY; GENETICS; IMMUNOLOGY; METABOLISM; MIDDLE AGED; PATHOGENICITY; PATHOLOGY; VIROLOGY; VIRUS HEPATITIS; HEPATOMA CELL; HUMAN CELL; LIVER CELL CULTURE; MOLECULAR RECOGNITION; PATHOPHYSIOLOGY; SIGNAL TRANSDUCTION; VIRUS CELL INTERACTION;

HEPATITIS C VIRUS;

CELL LINE; COMPLEMENT ACTIVATION; CYTOTOXICITY, IMMUNOLOGIC; FEMALE; HEPACIVIRUS; HEPATITIS, VIRAL, HUMAN; HEPATOCYTES; HUMANS; LECTINS; MALE; MIDDLE AGED; POLYSACCHARIDES; PROTEIN BINDING; VIRAL ENVELOPE PROTEINS;

EID: 69949118734     PISSN: 16727681     EISSN: None     Source Type: Journal    
DOI: 10.1038/cmi.2009.32     Document Type: Article

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