C1q and mannose binding lectin engagement of cell surface calreticulin and CD91 initiates macropinocytosis and uptake of apoptotic cells

Journal of Experimental Medicine

Volumn 194, Issue 6, 2001, Pages 781-795

  Ogden, C A ^a   DeCathelineau, A ^a   Hoffmann, P R ^a   Bratton, D ^a   Fadok, B ^a   Ghebrehiwet, V A ^a   Henson, P M ^a  

^a NATIONAL JEWISH MEDICAL AND RESEARCH CENTER   (United States)

Author keywords

Apoptosis; C1q; Macropinocytosis; MBL; Phagocytosis

Indexed keywords

ALPHA 2 MACROGLOBULIN; CALRETICULIN; COMPLEMENT COMPONENT C1Q; MANNOSE BINDING PROTEIN;

APOPTOSIS; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; IMMUNE SYSTEM; PINOCYTOSIS; PRIORITY JOURNAL;

APOPTOSIS; CALCIUM-BINDING PROTEINS; CALRETICULIN; CARRIER PROTEINS; CELLS, CULTURED; COLLAGEN; COLLECTINS; COMPLEMENT C1Q; HUMANS; JURKAT CELLS; LDL-RECEPTOR RELATED PROTEIN 1; LECTINS; MACROPHAGES; MONOCYTES; PHAGOCYTOSIS; PINOCYTOSIS; RECEPTORS, IMMUNOLOGIC; RIBONUCLEOPROTEINS; SIGNAL TRANSDUCTION;

EID: 0035903289     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.194.6.781     Document Type: Article

References (130)

1. Collectins: Collagenous C-type lectins of the innate immune defense system
2. Structural aspects of collectins and receptors for collectins
3. The biosynthesis of C1q, the collagen-like and Fc-recognizing molecule of the complement system
4. Hereditary C1q deficiency and systemic lupus erythematosus
5. The lupus paradox
6. Molecular basis of hereditary C1q deficiency
7. Systemic lupus erythematosus with C1q deficiency
8. Genetic susceptibility to lupus nephritis
9. Mannose-binding protein genetic polymorphisms in black patients with systemic lupus erythematosus
10. Mutation of gene of mannose-binding protein associated with chronic hepatitis B viral infection
11. Mannose-binding protein gene polymorphism in systemic lupus erythematosus
12. Association of variant alleles of mannose binding lectin with severity of pulmonary disease in cystic fibrosis: Cohort study
13. Homozygous C1q deficiency causes glomerulonephritis associated with multiple apoptotic bodies
14. Systemic exposure to irradiated apoptotic cells induces autoantibody production
15. A hierarchical role for classical pathway complement proteins in the clearance of apoptotic cells in vivo
16. C1q binds directly and specifically to surface blebs of apoptotic human kerati-nocytes: Complement deficiency and systemic lupus erythematosus revisited
17. The globular heads of C1q specifically recognize surface blebs of apoptotic vascular endothelial cells
18. Modulation of multiple neutrophil functions by preparative methods or trace concentrations of bacterial lipopolysaccharide
19. CD36 is required for phagocytosis of apoptotic cells by human macrophages that use either a phosphatidylserine receptor or the vitronectin receptor (alpha v beta 3)
20. A human serum mannose-binding protein inhibits in vitro infection by the human immunodeficiency virus
21. Isolation, by partial pepsin digestion, of the three collagen-like regions present in subcomponent C1q of the first component of human complement
22. Macro-phage recognition of cells undergoing programmed cell death (apoptosis)
23. Phagocytosis of apoptotic bodies by liver endothelial cells
24. Different populations of macrophages use either the vitronectin receptor or the phosphatidylserine receptor to recognize and remove apoptotic cells
25. Apoptosis: Getting rid of the bodies
26. Corpse clearance defines the meaning of cell death
27. Recognition and phagocytosis of cells under-going apoptosis
28. Roles of ICAM-3 and CD14 in the recognition and phagocytosis of apoptotic cells by macrophages
29. Macrophage recognition of ICAM-3 on apoptotic leukocytes
30. Human CD14 mediates recognition and phagocytosis of apoptotic cells
31. CD14-dependent clearance of apoptotic cells: Relevance to the immune system
32. Non-inflammatory/anti-inflammatory CD14 responses: CD14 in apoptosis
33. The 94- to 97-kDa mouse macrophage membrane protein that recognizes oxidized low density lipoprotein and phosphati-dylserine-rich liposomes is identical to macrosialin, the mouse homologue of human CD68
34. The macrophage scavenger receptor type A is expressed by activated macrophages and protects the host against lethal endotoxic shock
35. Apoptotic thymocyte clearance in scavenger receptor class A-deficient mice is apparently normal
36. Role for the class A macrophage scavenger receptor in the phagocytosis of apoptotic thymocytes in vitro
37. Elimination of unwanted cells by phagocytes
38. Scavenger receptor family proteins: Roles for atherosclerosis, host defence and disorders of the central nervous system
39. Lectin-like oxidized low-density lipoprotein receptor 1 mediates phagocytosis of aged/apoptotic cells in endothelial cells
40. Promotion of the uptake of PS liposomes and apoptotic cells by a product of growth arrest-specific gene, gas6
41. Mutation of the receptor tyrosine kinase gene Mertk in the retinal dystrophic RCS rat
42. Homozygous deletion in the coding sequence of the c-mer gene in RCS rats unravels general mechanisms of physiological cell adhesion and apoptosis
43. Anti-beta2 glycoprotein I antibodies prevent the De-activation of platelets and sustain their phagocytic clearance
44. Phagocytosis of apoptotic inflammatory cells by microglia and modulation by different cytokines: Mechanism for removal of apoptotic cells in the inflamed nervous system
45. Dendritic cell presentation of antigens from apoptotic cells in a proinflammatory context: Role of opsonizing anti-beta2-glyco-protein I antibodies
46. Complement-dependent clearance of apoptotic cells by human macrophages
47. A receptor for phosphatidylserine-specific clearance of apoptotic cells
48. Complement dependent immune phagocytosis. I. Requirements for C'1, C'4, C'2, C'3
49. The C1q and collectin binding site within C1q receptor (cell surface calreticulin)
50. C1q - How many functions? How many receptors?
51. C1q receptors: Regulating specific functions of phagocytic cells
52. C1qRP, the C1q receptor that enhances phagocytosis, is detected specifically in human cells of myeloid lineage, endothelial cells, and platelets
53. gC1q-R/p32, a C1q-binding protein, is a receptor for the InlB invasion protein of Listeria monocytogenes
54. Detection of complement C1q receptors on human spermatozoa
55. Participation of C1q and its receptor in adherence of human diploid fibroblast
56. Smooth muscle and epithelial cells express specific binding sites for the C1q component of complement
57. Collectins and pulmonary innate immunity
58. The multiligand-binding protein gC1qR, a putative C1q receptor, is a mitochondrial protein
59. The C1q receptor
60. Characterization of the human C1q receptor
61. C1q receptor on murine cells
62. Identification of a gC1q-binding protein (gC1q-R) on the surface of human neutrophils. Subcellular localization and binding properties in comparison with the cC1q-R
63. Complement component C1q and its receptor are involved in the interaction of human sperm with zona-free hamster eggs
64. Evidence that the two C1q binding membrane proteins, gC1q-R and cC1q-R, associate to form a complex
65. C1q receptor
66. Structure and function of gC1q-R: A multiligand binding cellular protein
67. Collagen-like complement component C1q is a membrane protein of human monocyte-derived macrophages that mediates endocytosis
68. Regulation of C1q receptor expression on human polymorphonuclear leukocytes
69. Complement receptor type 1 (CR1, CD35) is a receptor for C1q
70. The binding protein for globular heads of complement C1q, gC1qR. Functional expression and characterization as a novel vitronectin binding factor
71. Characterization of the murine gene of gC1qBP, a novel cell protein that binds the globular heads of C1q, vitronectin, high molecular weight kininogen and factor XII
72. Regulation of human lung fibroblast C1q-receptors by transforming growth factor-beta and tumor necrosis factoralpha
73. Characterisation of the rat and mouse homologues of gC1qBP, a 33 kDa glycoprotein that binds to the globular 'heads' of C1q
74. Human leukocyte C1q receptor binds other soluble proteins with collagen domains
75. Structure and homology of the human C1q receptor
76. Localization of the receptor-binding site in the collectin family of proteins
77. Collectins, collectin receptors and the lectin pathway of complement activation
78. Calreticulin: One protein, one gene, many functions
79. Distribution of receptors to collagen and globular domains of C1q in human lung fibroblasts
80. cDNA cloning and primary structure analysis of C1qRp, the human C1q/MBP/SPA receptor that mediates enhanced phagocytosis in vitro
81. Staphylococcus aureus protein A recognizes platelet gC1qR/p33: A novel mechanism for staphylococcal interactions with platelets
82. Platelet C1q receptor interactions with collagen- and C1q-coated surfaces
83. Modulation of platelet responses to collagen by C1q receptors
84. Isolation of a human endothelial cell C1q receptor (C1qR)
85. Identification of a novel 33-kDa C1q-binding site on human blood platelets
86. Human umbilical vein endothelial cells possess binding sites for the globular domain of C1q
87. The C1q-binding cell membrane proteins cC1q-R and gC1q-R are released from activated cells: Subcellular distribution and immunochemical characterization
88. Interaction of C1q and the collectins with the potential receptors calreticulin (cC1qR/collectin receptor) and megalin
89. Mannose binding protein (MBP) enhances mononuclear phagocyte function via a receptor that contains the 126,000 Mr component of the C1q receptor
90. Anti-C1q receptor/calreticulin autoantibodies in patients with systemic lupus erythematosus (SLE)
91. Opsonization of apoptotic cells. Implications for uptake and autoimmunity
92. Calreticulin is essential for integrin-mediated calcium signalling and cell adhesion
93. Calreticulin
94. Ligand-specific, transient interaction between integrins and calreticulin during cell adhesion to extracellular matrix proteins is dependent upon phosphorylation/dephosphorylation events
95. Bi-directional signal transduction by integrin receptors
96. Calreticulin is expressed on the cell surface of activated human peripheral blood T lymphocytes in association with major histocompatibility complex class I molecules
97. C1q receptors
98. CD91 is a common receptor for heat shock proteins gp96, hsp90, hsp70, and calreticulin
99. Macropinosome maturation and fusion with tubular lysosomes in macrophages
100. M-CSF-induced macropinocytosis increases solute endocytosis but not receptor-mediated endocytosis in mouse macrophages
101. Macro-phage colony-stimulating factor (rM-CSF) stimulates pinocytosis in bone marrow-derived macrophages
102. The coated pit and macropinocytic pathways serve distinct endosome populations
103. Studies on the mechanism of phagocytosis. I. Requirements for circumferential attachment of particle-bound ligands to specific receptors on the macrophage plasma membrane
104. Studies on the mechanism of phagocytosis. II. The interaction of macrophages with anti-immunoglobulin IgC-coated bone marrow-derived lymphocytes
105. Surfactant protein A enhances alveolar macrophage phagocytosis of apoptotic neutrophils
106. C1q binding to liposomes is surface charge dependent and is inhibited by peptides consisting of residues 14-26 of the human C1qA chain in a sequence independent manner
107. Human T cells express specific binding sites for C1q. Role in T cell activation and proliferation
108. Interaction of C1q with its receptor on cultured cell lines induces an anti-proliferative response
109. Signal transduction mechanisms of C1q-mediated superoxide production. Evidence for the involvement of temporally distinct staurosporine-insensitive and sensitive pathways
110. Phagocytic cell molecules that bind the collagen-like region of C1q. Involvement in the C1q-mediated enhancement of phagocytosis
111. Evidence that C1q binds specifically to CH2-like immunoglobulin gamma motifs present in the autoantigen calreticulin and interferes with complement activation
112. Complement C1q inhibits cellular spreading and stimulates adenylyl cyclase activity of fibroblasts
113. Endothelial liver cell recognition of apoptotic peripheral blood lymphocytes
114. Recognizing death: Liver phagocytosis of apoptotic cells
115. Modulation of cell surface expression of liver carbohydrate receptors during in vivo induction of apoptosis with lead nitrate
116. Activation of the alternative pathway of human complement by apoptotic human umbilical vein endothelial cells
117. C-Reactive protein binds to apoptotic cells, protects the cells from assembly of the terminal complement components, and sustains an antiinflammatory innate immune response: Implications for systemic autoimmunity
118. The role of phosphatidylserine in recognition of apoptotic cells by phagocytes
119. Phagocytosis of aged human neutrophils by macrophages is mediated by a novel "charge-sensitive" recognition mechanism
120. Localisation of the C1q binding site within C1q receptor/calreticulin
121. Identification of a novel 33-kDa binding site on human platelets
122. Complement receptors in neutrophils
123. Macrophage heterogeneity
124. Necrotic but not apoptotic cell death releases heat shock proteins, which deliver a partial maturation signal to dendritic cells and activate the NF-kappaB pathway
125. The multiligand alpha 2-macroglobulin receptor/low density, lipoprotein receptor-related protein (alpha 2MR/LRP). Binding and endocytosis of fluid phase and membrane-associated ligands
126. CED-1 is a transmembrane receptor that mediates cell corpse engulfment in C. elegans
127. Genes required for the engulfment of cell corpses during programmed cell death in Caenorhabditis elegans
128. Absence of induction of IL-1 production in human monocytes by complement fragments
129. Consumption of classical complement components by heart subcellular membranes in vitro and in patients after acute myocardial infarction
130. CD91: A receptor for heat shock protein gp96