Independent role of PP2A and mTORc1 in palmitate induced podocyte death

Biochimie

Volumn 112, Issue , 2015, Pages 73-84

  Kumar, Sandeep ^a   Tikoo, Kulbhushan ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Apoptosis; Insulin resistance; mTORc1; Podocyte death; Protein phosphatase 2A

Indexed keywords

GLYCOGEN SYNTHASE KINASE 3BETA; INSULIN; MAMMALIAN TARGET OF RAPAMYCIN; MAMMALIAN TARGET OF RAPAMYCIN COMPLEX 1; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; OKADAIC ACID; PALMITIC ACID; PHOSPHOPROTEIN PHOSPHATASE 2A; PROTEIN KINASE B; RAPAMYCIN; SERINE; SIRTUIN 1; TRANSCRIPTION FACTOR FKHR; ENZYME INHIBITOR; MECHANISTIC TARGET OF RAPAMYCIN COMPLEX 1; MULTIPROTEIN COMPLEX; PHOSPHOPROTEIN PHOSPHATASE 2; PROTEIN P53; SIRT1 PROTEIN, HUMAN; TARGET OF RAPAMYCIN KINASE; TP53 PROTEIN, HUMAN;

APOPTOSIS; ARTICLE; CELL DEATH; CONTROLLED STUDY; DEACETYLATION; DIABETES MELLITUS; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; ENZYME PHOSPHORYLATION; HUMAN; HUMAN CELL; HUMAN URINE DERIVED PODOCYTE LIKE EPITHELIAL CELL; INFLAMMATION; INSULIN RESISTANCE; KIDNEY DISEASE; LOW DRUG DOSE; PODOCYTE; PROTEIN ANALYSIS; PROTEIN DEGRADATION; PROTEIN EXPRESSION; PROTEIN FUNCTION; SIGNAL TRANSDUCTION; DIABETIC NEPHROPATHY; DRUG EFFECTS; GENETICS; METABOLISM; PATHOLOGY;

CELL DEATH; DIABETIC NEPHROPATHIES; ENZYME INHIBITORS; HUMANS; MAP KINASE SIGNALING SYSTEM; MULTIPROTEIN COMPLEXES; PALMITIC ACID; PODOCYTES; PROTEIN PHOSPHATASE 2; SIRTUIN 1; TOR SERINE-THREONINE KINASES; TUMOR SUPPRESSOR PROTEIN P53;

EID: 84925011584     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.02.009     Document Type: Article

References (49)

1. M. Svensson, and J.W. Eriksson Insulin resistance in diabetic nephropathy- a cause or consequence? Diabetes Metab. Res. Rev 22 2006 401 410
2. P.-M. Badin, I.K. Vila, K. Louche, A. Mairal, M.-A. Marques, V. Bourlier, G.v. Tavernier, D. Langin, and C. Moro High-fat diet-mediated lipotoxicity and insulin resistance is related to impaired lipase expression in mouse skeletal muscle Endocrinol. 154 2013 1444 1453
3. R. Ragheb, G.M. Shanab, A.M. Medhat, D.M. Seoudi, K. Adeli, and I.G. Fantus Free fatty acid-induced muscle insulin resistance and glucose uptake dysfunction: evidence for PKC activation and oxidative stress-activated signaling pathways Biochem. Biophys. Res. Commun. 389 2009 211 216
4. M.E. Pagtalunan, P.L. Miller, S. Jumping-Eagle, R.G. Nelson, B.D. Myers, H.G. Rennke, N.S. Coplon, L. Sun, and T.W. Meyer Podocyte loss and progressive glomerular injury in type II diabetes J. Clin. Invest. 99 1997 342 348
5. T.B. Huber, and T. Benzing The slit diaphragm: a signaling platform to regulate podocyte function Curr. Opin. Nephrol. Hypertens. 14 2005 211 216
6. J.R. Sedor, S.M. Madhavan, J.H. Kim, and M. Konieczkowski Out on a LIM: chronic kidney disease, podocyte phenotype and the Wilm's tumor interacting protein (WTIP) Trans. Am. Clin. Climatol. Assoc. 122 2011 184 197
7. R.J.M. Coward, G.I. Welsh, A. Koziell, S. Hussain, R. Lennon, L. Ni, J.M. Tavara, P.W. Mathieson, and M.A. Saleem Nephrin is critical for the action of insulin on human glomerular podocytes Diabetes 56 2007 1127 1135
8. K. Susztak, A.C. Raff, M. Schiffer, and E.P. Battinger Glucose-induced reactive oxygen species cause apoptosis of podocytes and podocyte depletion at the onset of diabetic nephropathy Diabetes 55 2006 225 233
9. S. Hoshi, K.-i. Nomoto, J. Kuromitsu, S. Tomari, and M. Nagata High glucose induced VEGF expression via PKC and ERK in glomerular podocytes Biochem. Biophys. Res. Commun. 290 2002 177 184
10. S. Nakamura, T. Takamura, N. Matsuzawa-Nagata, H. Takayama, H. Misu, H. Noda, S. Nabemoto, S. Kurita, T. Ota, and H. Ando Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria J. Biol. Chem. 284 2009 14809 14818
11. S.E. Mazibuko, C.J.F. Muller, E. Joubert, D. de Beer, R. Johnson, A.R. Opoku, and J. Louw Amelioration of palmitate-induced insulin resistance in C2C12 muscle cells by rooibos (Aspalathus linearis) Phytomedicine 20 2013 813 819
12. R. Lennon, D. Pons, M.A. Sabin, C. Wei, J.P. Shield, R.J. Coward, J.M. Tavara, P.W. Mathieson, M.A. Saleem, and G.I. Welsh Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy Nephrol. Dial. Transplant. 24 2009 3288 3296
13. J. Sieber, M.T. Lindenmeyer, K. Kampe, K.N. Campbell, C.D. Cohen, H. Hopfer, P. Mundel, and A.W. Jehle Regulation of podocyte survival and endoplasmic reticulum stress by fatty acids Am. J. Physiol. Renal Physiol. 299 2010 F821 F829
14. T. Galbo, G.S. Olsen, B. Quistorff, and E. Nishimura Free fatty acid-induced PP2A hyperactivity selectively impairs hepatic insulin action on glucose metabolism PLoS One 6 2011 e27424
15. A. Kowluru, and A. Matti Hyperactivation of protein phosphatase 2A in models of glucolipotoxicity and diabetes: potential mechanisms and functional consequences Biochem. Pharmacol. 84 2012 591 597
16. K. Inoki, H. Mori, J. Wang, T. Suzuki, S. Hong, S. Yoshida, S.M. Blattner, T. Ikenoue, M.A. Raegg, M.N. Hall, mTORC1 activation in podocytes is a critical step in the development of diabetic nephropathy in mice, J. Clin. Invest. 121, 2181-2186.
17. M. Godel, B. Hartleben, N. Herbach, S. Liu, S. Zschiedrich, S. Lu, A. Debreczeni-Mar, M.T. Lindenmeyer, M.-P. Rastaldi, and G. Hartleben Role of mTOR in podocyte function and diabetic nephropathy in humans and mice J. Clin. Invest. 121 2011 2197 2209
18. J. Copp, G. Manning, and T. Hunter TORC-specific phosphorylation of mammalian target of rapamycin (mTOR): phospho-Ser2481 is a marker for intact mTOR signaling complex 2 Cancer Res. 69 2009 1821 1827
19. R. Lennon, D. Pons, M.A. Sabin, C. Wei, J.P. Shield, R.J. Coward, J.M. Tavara P.W. Mathieson, M.A. Saleem, and G.I. Welsh Saturated fatty acids induce insulin resistance in human podocytes: implications for diabetic nephropathy Nephrol. Dial. Transplant. 24 2009 3288 3296
20. M.A. Sabin, M. De Hora, J.M. Holly, L.P. Hunt, A.L. Ford, S.R. Williams, J.S. Baker, C.J. Retallick, E.C. Crowne, and J.P. Shield Fasting nonesterified fatty acid profiles in childhood and their relationship with adiposity, insulin sensitivity, and lipid levels Pediatrics 120 2007 e1426 1433
21. J. Gupta, A.B. Gaikwad, K. Tikoo, Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats, J. Cell. Biochem. 111, 944-954.
22. A. Gaikwad, J. Gupta, K. Tikoo, Epigenetic changes and alteration of Fbn1 and Col3A1 gene expression under hyperglycaemic and hyperinsulinaemic conditions, Biochem. J. 432, 333-341.
23. J. Gupta, and K. Tikoo Involvement of insulin-induced reversible chromatin remodeling in altering the expression of oxidative stress-responsive genes under hyperglycemia in 3T3-L1 preadipocytes Gene 504 2012 181 191
24. J. Kaur, and K. Tikoo p300/CBP dependent hyperacetylation of histones potentiates anticancer activity of gefitinib nanoparticles Biochim. Biophys. Acta 1833 2013 1028 1040
25. M.A. Saleem, M.J. O'Hare, J. Reiser, R.J. Coward, C.D. Inward, T. Farren, C.Y. Xing, L. Ni, P.W. Mathieson, and P. Mundel A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression J. Am. Soc. Nephrol. 13 2002 630 638
26. S. Chittiprol, P. Chen, D. Petrovic-Djergovic, T. Eichler, and R.F. Ransom Marker expression, behaviors, and responses vary in different lines of conditionally immortalized cultured podocytes Am. J. Physiol. Renal Physiol. 301 2011 F660 F671
27. T. Sakairi, Y. Abe, H. Kajiyama, L.D. Bartlett, L.V. Howard, P.S. Jat, and J.B. Kopp Conditionally immortalized human podocyte cell lines established from urine Am. J. Physiol. Renal Physiol. 298 2010 F557 F567
28. N.J. Bryant, R. Govers, and D.E. James Regulated transport of the glucose transporter GLUT4 Nat. Rev. Mol. Cell. Biol. 3 2002 267 277
29. C.M. Taniguchi, B. Emanuelli, and C.R. Kahn Critical nodes in signalling pathways: insights into insulin action Nat. Rev. Mol. Cell. Biol. 7 2006 85 96
30. X. Zhang, N. Tang, T.J. Hadden, and A.K. Rishi Akt, FoxO and regulation of apoptosis Biochim. Biophys. Acta Mol. Cell. Res. 1813 1978 1986
31. R.J. Southgate, C.R. Bruce, A.L. Carey, G.R. Steinberg, K. Walder, R. Monks, M.J. Watt, J.A. Hawley, M.J. Birnbaum, and M.A. Febbraio PGC-a gene expression is down-regulated by Akt-mediated phosphorylation and nuclear exclusion of FoxO1 in insulin-stimulated skeletal muscle FASEB J. 19 2005 2072 2074
32. M. Laplante, and D.M. Sabatini mTOR signaling at a glance J. Cell Sci. 122 2009 3589 3594
33. G.G. Chiang, and R.T. Abraham Phosphorylation of mammalian target of rapamycin (mTOR) at Ser-2448 is mediated by p70S6 kinase J. Biol. Chem. 280 2005 25485 25490
34. T.B. Huber, M. Kattgen, B. Schilling, G. Walz, and T. Benzing Interaction with podocin facilitates nephrin signaling J. Biol. Chem. 276 2001 41543 41546
35. Y. Du, A. Kowluru, and T.S. Kern PP2A contributes to endothelial death in high glucose: inhibition by benfotiamine Am. J. Physiol. Regul. Integr. Comp. Physiol. 299 2010 R1610 R1617
36. S. Kobayashi, T. Kishimoto, S. Kamata, M. Otsuka, M. Miyazaki, and H. Ishikura Rapamycin, a specific inhibitor of the mammalian target of rapamycin, suppresses lymphangiogenesis and lymphatic metastasis Cancer Sci. 98 2007 726 733
37. K. Matsui, S. Breitender-Geleff, A. Soleiman, H. Kowalski, and D. Kerjaschki Podoplanin, a novel 43-kDa membrane protein, controls the shape of podocytes Nephrol. Dial. Transplant. 14 Suppl. 1 1999 9 11
38. A. Greka, and P. Mundel Cell biology and pathology of podocytes Annu. Rev. Physiol. 74 2012 299 323
39. M.A. Saleem, M.J. O'Hare, J. Reiser, R.J. Coward, C.D. Inward, T. Farren, C.Y. Xing, L. Ni, P.W. Mathieson, and P. Mundel A conditionally immortalized human podocyte cell line demonstrating nephrin and podocin expression J. Am. Soc. Nephrol. 13 2002 630 638
40. G.I. Welsh, L.J. Hale, V. Eremina, M. Jeansson, Y. Maezawa, R. Lennon, D.A. Pons, R.J. Owen, S.C. Satchell, M.J. Miles, C.J. Caunt, C.A. McArdle, H. Pavenstadt, J.M. Tavare, A.M. Herzenberg, C.R. Kahn, P.W. Mathieson, S.E. Quaggin, M.A. Saleem, and R.J. Coward Insulin signaling to the glomerular podocyte is critical for normal kidney function Cell. Metab. 12 2010 329 340
41. C. Mandavia, and J.R. Sowers Phosphoprotein phosphatase PP2A regulation of insulin receptor substrate 1 and insulin metabolic signaling Cardiorenal Med. 2 2012 308 313
42. L. Yan, V.A. Lavin, L.R. Moser, Q. Cui, C. Kanies, and E. Yang PP2A regulates the pro-apoptotic activity of FOXO1 J. Biol. Chem. 283 2008 7411 7420
43. Y. Zhao, Y. Wang, and W.G. Zhu Applications of post-translational modifications of FoxO family proteins in biological functions J. Mol. Cell. Biol. 3 2011 276 282
44. C. Van Hoof, and J. Goris Phosphatases in apoptosis: to be or not to be, PP2A is in the heart of the question Biochim. Biophys. Acta Mol. Cell. Res. 1640 2003 97 104
45. B. Nave, M. Ouwens, D. Withers, D. Alessi, and P. Shepherd Mammalian target of rapamycin is a direct target for protein kinase B: identification of a convergence point for opposing effects of insulin and amino-acid deficiency on protein translation Biochem. J. 344 1999 427 431
46. S. Zhang, G. Cai, B. Fu, Z. Feng, R. Ding, X. Bai, W. Liu, L. Zhuo, L. Sun, F. Liu, SIRT1 is required for the effects of rapamycin on high glucose-inducing mesangial cells senescence, Mech. Ageing Dev. 133, 387-400.
47. H.S. Ghosh, M. McBurney, and P.D. Robbins SIRT1 negatively regulates the mammalian target of rapamycin PLoS One 5 2010 e9199
48. M.V. Astle, K.M. Hannan, P.Y. Ng, R.S. Lee, A.J. George, A.K. Hsu, Y. Haupt, R.D. Hannan, and R.B. Pearson AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy Oncogene 31 2012 1949 1962
49. D.D. Vadysirisack, F. Baenke, B. Ory, K. Lei, and L.W. Ellisen Feedback control of p53 translation by REDD1 and mTORC1 limits the p53-dependent DNA damage response Mol. Cell. Biol. 31 2011 4356 4365