High glucose induced VEGF expression via PKC and ERK in glomerular podocytes

Biochemical and Biophysical Research Communications

Volumn 290, Issue 1, 2002, Pages 177-184

  Hoshi, Sachi ^a,b   Tomari, Shinsuke ^a   Nomoto, Ken ichi ^b   Kuromitsu, Junro ^b   Nagata, Michio ^a  

^a UNIVERSITY OF TSUKUBA   (Japan)

^b EISAI CO LTD   (Japan)

Author keywords

Activator protein 1; Diabetic nephropathy; Extracellular signal regulated kinase; High glucose; Podocyte; Protein kinase C; Vascular endothelial growth factor

Indexed keywords

2 (2 AMINO 3 METHOXYPHENYL)CHROMONE; 2 [1 (3 DIMETHYLAMINOPROPYL) 3 INDOLYL] 3 (3 INDOLYL)MALEIMIDE; GLUCOSE; ISOENZYME; LEUCINE; MESSENGER RNA; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE INHIBITOR; PHORBOL 13 ACETATE 12 MYRISTATE; PROTEIN KINASE C; PROTEIN KINASE C ALPHA; PROTEIN KINASE C BETA; PROTEIN KINASE C INHIBITOR; TRANSCRIPTION FACTOR AP 1; TRITIUM; VASCULOTROPIN;

ANIMAL CELL; ARTICLE; CELL DIFFERENTIATION; CELL LINE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; MOUSE; NONHUMAN; PODOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; TRANSCRIPTION INITIATION;

EID: 0036289551     PISSN: 0006291X     EISSN: None     Source Type: Journal    
DOI: 10.1006/bbrc.2001.6138     Document Type: Article

References (42)

1. Diabetic nephropathy in type II diabetes
2. The effect of intensive treatment of diabetes on the development and progression of long-term complications in insulin dependent diabetes mellitus
3. Intensive blood control with sulphonylurea or insulin compared with conventional treatment and the risk of complication in patients with type 2 diabetes
4. Role of vascular endothelial growth factor in regulation of angiogenesis
5. Role of vascular endothelial growth factor in regulation of angiogenesis
6. Antibodies against vascular endothelial growth factor improve early dysfunction in experimental diabetes
7. Molecular and a biological properties of the vascular endothelial growth factor family of proteins
8. Increased renal expression of vascular endothelial growth factor (VEGF) and its receptor VEGFR-2 in experimental diabetes
9. Suppression of transforming growth factor beta and vascular endothelial growth factor in diabetic nephropathy in rats by a novel advanced glycation end product inhibitor OPB-91485
10. Expression of vascular permeability factor/vascular endothelial growth factor in normal renal tissue
11. Vascular permiabilty factor mRNA and protein expression in human kidney
12. 125I]VEGF binding sites
13. Detection of multiple vascular endothelial growth factor splice isoforms in glomerular podocyte
14. Podocytes loss and progressive glomerular injury in type II diabetes
15. Clinical and pathological course of renal disease in non-insulin-dependent diabetes mellitus: The Pima Indian experience
16. Early events leading to renal injury in obese Zucker (fatty) rats with type II diabetes
17. Progression of diabetic nephropathy. Insights from cell culture studies and animal models
18. Podocyte injury promotes progressive nephropathy in Zucker diabetic fatty rats
19. Rearrangements of the cytoskeleton and cell contacts induce process formation during differentiation of conditionally immortalized mouse podocytes cell lines
20. The bisindolymaleimide GF109203X is a potent and selective inhibitor of protein kinase C
21. PD98059 is a specific inhibitor of the activation of mitogen-activated protein kinase in vitro and in vivo
22. Regulation of vascular smooth muscle cell proliferation by nuclear factor-κB and its inhibitor, I-kappaB
23. The mouse gene for vascular endothelial growth factor. Genomic structure, definition of transcriptional unit, and characterization of transcriptional and post-transcriptional regulatory sequence
24. Inhibitory effect of E3330, a novel quinone derivative able to suppress tumor necrosis factor-α generation, on activation of nuclear factor-κB
25. TGF-β signals through a heteroeric protein kinase receptor complex
26. Role of vascular endothelial growth factor in diabetic vascular complications
27. The role of the glomerular epithelial cell in the maintenance of the glomerular filtration barrier
28. Molecular biology of diabetic glomerulosclerosis
29. Glucose-induced protein kinase C activation regulates vascular permiability factor mRNA expression and peptide production by human vascular smooth muscle cells in vitro
30. Protein kinase C and lipid signaling for sustained cellular responses
31. Preferential elevation of protein kinase C isoform βII diacylglycerol levels in the aorta and heart of diabetic rats: Differential reversibility to glycemic control by islet cell transplantation
32. Normalization of diacylglycerol-protein kinase C activation by vitamin E in aorta of diabetic rats and cultured rat smooth muscle cells exposed to elevated glucose levels
33. Increase in diacylglycerol mass in isolated glomeruli by glucose from de novo synthesis of glycerolipids
34. Characterization of protein kinase C β isoform activation on the gene expression of transforming growth factor-β, extracellular matrix components, and prostanoids in the glomeruli of diabetic rats
35. Amelioration of vascular dysfunction in diabetic rat by an oral PKC β inhibitor
36. The role of hyperglycemia and hyperinsulinaemia in causing vascular dysfunction in diabetes
37. Protein kinase C activation in the development of diabetic complications
38. The MAPK signaling cascade
39. Activation of ternary complex factor Elk-1 by MAP kinase
40. The regulation of AP-1 activity by mitogen-activated protein kinases
41. AP-1 function and regulation