Podocyte loss and progressive glomerular injury in type II diabetes

Journal of Clinical Investigation

Volumn 99, Issue 2, 1997, Pages 342-348

  Pagtalunan, Maria Enrica ^a,b   Miller, Peter L ^a,b   Jumping Eagle, Sara ^a,b   Nelson, Robert G ^c   Myers, Bryan D ^a,b   Rennke, Helmut G ^d   Coplon, Norman S ^a,b   Sun, Limei ^a,b   Meyer, Timothy W ^a,b  

^a VA PALO ALTO HEALTH CARE SYSTEM   (United States)

^b STANFORD UNIVERSITY   (United States)

^c NATIONAL INSTITUTE OF DIABETES AND DIGESTIVE AND KIDNEY DISEASES   (United States)

^d BRIGHAM AND WOMEN S HOSPITAL   (United States)

Author keywords

epithelial cell; glomerulus; mesangium; proteinuria; sclerosis

Indexed keywords

ARTICLE; CLINICAL ARTICLE; DISEASE ASSOCIATION; ELECTRON MICROSCOPY; GLOMERULOSCLEROSIS; GLOMERULUS; GLOMERULUS BASEMENT MEMBRANE; HUMAN; HUMAN TISSUE; KIDNEY DISEASE; MESANGIUM; MICROALBUMINURIA; NON INSULIN DEPENDENT DIABETES MELLITUS; PODOCYTE; PRIORITY JOURNAL; PROTEINURIA; SCLEROSIS;

EID: 0031029379     PISSN: 00219738     EISSN: None     Source Type: Journal    
DOI: 10.1172/JCI119163     Document Type: Article

References (40)

1. Kroustrup, J.P., H.J.G. Gundersen, and R. Østerby. 1977. Glomerular size and structure in diabetes mellitus. Diabetologia. 13:207-210.
2. Mauer, S.M., M.W. Steffes, E.L. Ellis, D.E.R. Sutherland, D.M. Brown, and F.C. Goetz. 1984. Structural-functional relationships in diabetic nephropathy. J. Clin. Invest. 74:1143-1155.
3. Østerby, R., H.-H. Parving, E. Hommel, H.E. Jørgensen, and H. Løkkegaard. 1990. Glomerular structure and function in diabetic nephropathy. Early to advanced stages. Diabetes. 39:1057-1063.
4. Mauer, S.M. 1994. Structural-functional correlations of diabetic nephropathy. Kidney Int. 45:612-622.
5. Parving, H.-H., M.-A. Gall, P. Skøtt, H.E. Jørgensen, H. Løkkegaard, F. Jørgensen, B. Nielsen, and S. Larsen. 1992. Prevalence and causes of albuminuria in non-insulin-dependent diabetic patients. Kidney Int. 41:758-762.
6. Gambara, V., G. Mecca, G. Remuzzi, and T. Bertani. 1993 Heterogeneous nature of renal lesions in type II diabetes. J. Am. Soc. Nephrol 3:1458-1466.
7. Knowler, W.C., D.J. Pettitt, M.F. Saad, and P.H. Bennett. 1990. Diabetes mellitus in the Pima Indians: Incidence, risk factors, and pathogenesis. Diabetes Metab. Rev. 6:1-27.
8. Nelson, R.G., W.C. Knowler, D.R. McCance, M.L. Sievers, D.J. Pettitt, M.A. Charles, R.L. Hanson, Q.Z. Liu, and P.H. Bennett. 1993. Determinants of end-stage renal disease in Pima Indians with type 2 (non-insulin-dependent) diabetes mellitus and proteinuria. Diabetolagia. 36:1087-1093.
9. Fries, J.W.U., D.J. Sandstrom, T.W. Meyer, and H.G. Rennke. 1989. Glomerular hypertrophy and epithelial cell injury modulate progressive glomerulosclerosis in the rat. Lab. Invest. 60:205-218.
10. Nagata, M., and W. Kriz. 1992. Glomerular damage after uninephrectomy in young rats. II. Mechanical stress on podocytes as a pathway to sclerosis. Kidney Int. 42:148-160.
11. Kretzler, M., I. Koeppen-Hagemann, and W. Kriz. 1994. Podocyte damage is a critical step in the development of glomerulosclerosis in the uninephrectomised-desoxycorticosterone hypertensive rat. Virchows Arch. 425:181-193.
12. Myers, B.D., R.G. Nelson, G.W. Williams, P.H. Bennett, S.A. Hardy, R.L. Berg, N. Loon, W.C. Knowler, and W.E. Mitch. 1991. Glomerular function in Pima Indians with non-insulin-dependent diabetes mellitus of recent onset. J. Clin. Invest. 88:524-530.
13. Myers, B.D., R.G. Nelson, M. Tan, G.J. Beck, P.H. Bennett, W.C. Knowler, K. Blouch, and W.E. Mitch. 1995. Progression of overt nephropathy in non-insulin-dependent diabetes. Kidney Int. 47:1781-1789.
14. Pagtalunan, M.E., R. Oberbauer, M. Haas, M. Barlan, G. Mayer, J.L. Olson, and T.W. Meyer. 1996. Atubular glomeruli in patients with chronic allograft rejection. Transplantation (Baltimore). 61:1166-1171.
15. Lane, P.H., M.W. Steffes, and S.M. Mauer. 1992. Estimation of glomerular volume. A comparison of four methods. Kidney Int. 41:1085-1089.
16. Marcussen, N. 1992. Biology of disease. Atubular glomeruli and the structural basis for chronic renal failure. Lab. Invest. 66:265-284.
17. Lafayette, R.A., G. Mayer, and T.W. Meyer. 1993. The effects of blood pressure reduction on cyclosporine nephrotoxicity in the rat. J. Am. Soc. Nephrol. 3:1892-1899.
18. Østerby, R., and H.J.G. Gundersen. 1980. Fast accumulation of basement membrane material and the rate of morphologic changes in acute experimental diabetic glomerular hypertrophy. Diabetologia. 18:493-500.
19. Jensen, E.B., H.J.G. Gundersen, and R. Østerby. 1979. Determination of membrane thickness distribution from orthogonal intercepts. J. Microsc. (Oxf.) 115:19-33.
20. Pagtalunan, M.E., R. Rasch, H.G. Rennke, and T.W. Meyer. 1995. Morphometric analysis of effects of angiotensin II on glomerular structure in rats. Am. J. Physiol. 268:F82-F88.
21. Drumond, M.C., and W.M. Deen. 1994. Structural determinants of glomerular hydraulic permeability. Am. J Physiol. 266:F1-F12.
22. Weibel, E.R. 1979. Stereological Methods. Practical Methods for Biological Morphometry. Vol. 1. Academic Press, Inc., London. 40-116.
23. Ting, R.H., B. Krystal, and B.D. Myers. 1994. The biophysical basis of hypofiltration in nephrotic humans with membranous nephropathy. Kidney Int. 45:390-397.
24. Østerby, R., H.-H. Parving, G. Nyberg, E. Hommel, H.E. Jørgensen, H. Løkkegaard, and C. Svalander. 1988. A strong correlation between glomerular filtration rate and filtration surface in diabetic nephropathy. Diabetologia. 31: 265-270.
25. Hostetter, T.H., J.L. Troy, and B.M. Brenner. 1981. Glomerular hemodynamics in experimental diabetes melllitus. Kidney Int. 19:410-415.
26. Østerby, R., and H.J.G. Gunderson. 1980. Fast accumulation of basement membrane material and the rate of morphological changes in acute experimental diabetic glomerular hypertrophy. Diabetologia. 18:493-500.
27. Mogensen, C.E. 1990. Prediction of clinical diabetic nephropathy in IDDM patients. Diabetes. 39:761-767.
28. Nelson, R.G., W.C. Knowler, D.J. Pettitt, M.F. Saad, M.A. Charles, and P.H. Bennett. 1991. Assessment of risk of overt nephropathy in diabetic patients from albumin excretion in untimed urine specimens. Arch. Intern. Med. 151:1761-1765.
29. Chavers, B.M., R.W. Bilous, E.N. Ellis, M.W. Steffes, and S.M. Mauer. 1989. Glomerular lesions and urinary albumin excretion in type I diabetes without overt proteinuria. N. Engl. J. Med. 320:966-970.
30. Walker, J.D., C.F. Close, S.L. Jones, M. Rafftery, H. Keen, G. Viberti, and R. Østerby. 1992. Glomerular structure in type-1 diabetic patients with normo- and microalbuminuria. Kidney Int. 41:741-748.
31. Banstad, H.-J., R. Østerby, K. Dahl-Jorgensen, K.J. Berg. A. Hartmann, G. Nyberg, S. Frahm Bjorn, and K.F. Hannsen. 1993. Early glomerulopathy is present in young, type 1 diabetic patients with microalbuminuria. Diabetologia. 36:523-529.
32. Østerby, R. 1995. Microalbuminuria in diabetes mellitus - is there a structural basis? Nephrol. Dial. Transplant. 10:12-14.
33. Austen, S.M., J.S. Lieberman, L.D. Newton, M. Mejia, W.A. Peters, and B.D. Myers. 1993. Slope of serial glomerular filtration rate and the progression of diabetic glomerular disease. J. Am. Soc. Nephrol. 3:1358-1370.
34. Rennke, H.G. 1994. How does glomerular epithelial cell injury contribute to progressive glomerular damage? Kidney Int. 45:S58-S63.
35. Kerjaschki, D. 1994. Dysfunctions of cell biological mechanisms of visceral epithelial cells (podocytes) in glomerular diseases. Kidney Int. 45:300-313.
36. Schmidt, K., C. Pesce, Q. Liu, R.G. Nelson, P.H. Bennett, H. Karnitschnig, L.J. Striker, and G.E. Striker. 1992. Large glomerular size in Pima Indians: lack of change with diabetic nephropathy. J. Am. Soc. Nephrol. 3:229-235.
37. Nyengaard, J.R., and T.F. Bendtsen. 1992. Glomerular number and size in relation to age, kidney weight, and body surface in normal man. Anat. Rec. 232:194-201.
38. Kunzelman, C.L., W.C. Knowler, D.F. Pettitt, and P.H. Bennett. 1989. Incidence of proteinuria in type 2 diabetes mellitus in the Pima Indians. Kidney Int. 35:681-687.
39. Hayashi, H., R. Karasawa, H. Inn, T. Saitou, M. Ueno, S. Nishi, Y. Suzuki, S. Ogino, Y. Maruyama, Y. Kouda, et al., 1992. An electron microscopic study of glomeruli in Japanese patients with non-insulin dependent diabetes mellitus. Kidney Int. 41:749-757.
40. Østerby, R., M.-A. Gall, A. Schmitz, F.S. Nielsen, G. Nyberg, and H.-H. Parving. 1993. Glomerular structure and function in proteinuric type 2 (non-insulin-dependent) diabetic patients. Diabetologia. 36:1064-1070.