-
1
-
-
10044276783
-
Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex
-
Brugarolas, J., et al. 2004. Regulation of mTOR function in response to hypoxia by REDD1 and the TSC1/TSC2 tumor suppressor complex. Genes Dev. 18:2893-2904.
-
(2004)
Genes Dev.
, vol.18
, pp. 2893-2904
-
-
Brugarolas, J.1
-
2
-
-
0141891251
-
Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation
-
Chen, K., A. Albano, A. Ho, and J. F. Keaney, Jr. 2003. Activation of p53 by oxidative stress involves platelet-derived growth factor-beta receptor-mediated ataxia telangiectasia mutated (ATM) kinase activation. J. Biol. Chem. 278:39527-39533.
-
(2003)
J. Biol. Chem.
, vol.278
, pp. 39527-39533
-
-
Chen, K.1
Albano, A.2
Ho, A.3
Keaney Jr., J.F.4
-
3
-
-
0029802591
-
p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells
-
Chen, X., L. J. Ko, L. Jayaraman, and C. Prives. 1996. p53 levels, functional domains, and DNA damage determine the extent of the apoptotic response of tumor cells. Genes Dev. 10:2438-2451.
-
(1996)
Genes Dev.
, vol.10
, pp. 2438-2451
-
-
Chen, X.1
Ko, L.J.2
Jayaraman, L.3
Prives, C.4
-
4
-
-
15444362044
-
The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway
-
Corradetti, M. N., K. Inoki, and K. L. Guan. 2005. The stress-inducted proteins RTP801 and RTP801L are negative regulators of the mammalian target of rapamycin pathway. J. Biol. Chem. 280:9769-9772.
-
(2005)
J. Biol. Chem.
, vol.280
, pp. 9769-9772
-
-
Corradetti, M.N.1
Inoki, K.2
Guan, K.L.3
-
5
-
-
77953147974
-
Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity
-
Decaux, O., et al. 2010. Inhibition of mTORC1 activity by REDD1 induction in myeloma cells resistant to bortezomib cytotoxicity. Cancer Sci. 101:889-897.
-
(2010)
Cancer Sci.
, vol.101
, pp. 889-897
-
-
Decaux, O.1
-
6
-
-
38349056675
-
Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling
-
DeYoung, M. P., P. Horak, A. Sofer, D. Sgroi, and L. W. Ellisen. 2008. Hypoxia regulates TSC1/2-mTOR signaling and tumor suppression through REDD1-mediated 14-3-3 shuttling. Genes Dev. 22:239-251.
-
(2008)
Genes Dev.
, vol.22
, pp. 239-251
-
-
DeYoung, M.P.1
Horak, P.2
Sofer, A.3
Sgroi, D.4
Ellisen, L.W.5
-
7
-
-
0019324631
-
Polyribosomes in isolated liver cells. Preparative procedures, effects of incubation and correlation with protein synthesis
-
Dickson, A. J., and C. I. Pogson. 1980. Polyribosomes in isolated liver cells. Preparative procedures, effects of incubation and correlation with protein synthesis. Biochem. J. 186:35-45.
-
(1980)
Biochem. J.
, vol.186
, pp. 35-45
-
-
Dickson, A.J.1
Pogson, C.I.2
-
8
-
-
0036863624
-
REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species
-
Ellisen, L. W., et al. 2002. REDD1, a developmentally regulated transcriptional target of p63 and p53, links p63 to regulation of reactive oxygen species. Mol. Cell 10:995-1005.
-
(2002)
Mol. Cell
, vol.10
, pp. 995-1005
-
-
Ellisen, L.W.1
-
9
-
-
3242880238
-
H2AX: the histone guardian of the genome
-
Fernandez-Capetillo, O., A. Lee, M. Nussenzweig, and A. Nussenzweig. 2004. H2AX: the histone guardian of the genome. DNA Repair (Amst.) 3:959-967.
-
(2004)
DNA Repair (Amst.)
, vol.3
, pp. 959-967
-
-
Fernandez-Capetillo, O.1
Lee, A.2
Nussenzweig, M.3
Nussenzweig, A.4
-
10
-
-
0028030882
-
MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status
-
Florenes, V. A., et al. 1994. MDM2 gene amplification and transcript levels in human sarcomas: relationship to TP53 gene status. J. Natl. Cancer Inst. 86:1297-1302.
-
(1994)
J. Natl. Cancer Inst.
, vol.86
, pp. 1297-1302
-
-
Florenes, V.A.1
-
11
-
-
0030983331
-
Participation of the human p53 3UTR in translational repression and activation following gamma-irradiation
-
Fu, L., and S. Benchimol. 1997. Participation of the human p53 3UTR in translational repression and activation following gamma-irradiation. EMBO J. 16:4117-4125.
-
(1997)
EMBO J.
, vol.16
, pp. 4117-4125
-
-
Fu, L.1
Benchimol, S.2
-
12
-
-
18344377030
-
The p53 pathway: positive and negative feedback loops
-
Harris, S. L., and A. J. Levine. 2005. The p53 pathway: positive and negative feedback loops. Oncogene 24:2899-2908.
-
(2005)
Oncogene
, vol.24
, pp. 2899-2908
-
-
Harris, S.L.1
Levine, A.J.2
-
13
-
-
77949535410
-
Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis
-
Horak, P., et al. 2010. Negative feedback control of HIF-1 through REDD1-regulated ROS suppresses tumorigenesis. Proc. Natl. Acad. Sci. U. S. A. 107:4675-4680.
-
(2010)
Proc. Natl. Acad. Sci. U. S. A.
, vol.107
, pp. 4675-4680
-
-
Horak, P.1
-
14
-
-
59749091850
-
A complex interplay between Akt, TSC2 and the two mTOR complexes
-
Huang, J., and B. D. Manning. 2009. A complex interplay between Akt, TSC2 and the two mTOR complexes. Biochem. Soc. Trans. 37:217-222.
-
(2009)
Biochem. Soc. Trans.
, vol.37
, pp. 217-222
-
-
Huang, J.1
Manning, B.D.2
-
15
-
-
0041802820
-
Targeting mTOR signaling for cancer therapy
-
Huang, S., and P. J. Houghton. 2003. Targeting mTOR signaling for cancer therapy. Curr. Opin. Pharmacol. 3:371-377.
-
(2003)
Curr. Opin. Pharmacol.
, vol.3
, pp. 371-377
-
-
Huang, S.1
Houghton, P.J.2
-
16
-
-
20444427605
-
Stressinduced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species
-
Karawajew, L., P. Rhein, G. Czerwony, and W. D. Ludwig. 2005. Stressinduced activation of the p53 tumor suppressor in leukemia cells and normal lymphocytes requires mitochondrial activity and reactive oxygen species. Blood 105:4767-4775.
-
(2005)
Blood
, vol.105
, pp. 4767-4775
-
-
Karawajew, L.1
Rhein, P.2
Czerwony, G.3
Ludwig, W.D.4
-
17
-
-
77955354374
-
In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models
-
Kenzelmann Broz, D., and L. D. Attardi. 2010. In vivo analysis of p53 tumor suppressor function using genetically engineered mouse models. Carcinogenesis 31:1311-1318.
-
(2010)
Carcinogenesis
, vol.31
, pp. 1311-1318
-
-
Kenzelmann Broz, D.1
Attardi, L.D.2
-
18
-
-
36549026878
-
Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53
-
Lee, C. H., et al. 2007. Constitutive mTOR activation in TSC mutants sensitizes cells to energy starvation and genomic damage via p53. EMBO J. 26:4812-4823.
-
(2007)
EMBO J.
, vol.26
, pp. 4812-4823
-
-
Lee, C.H.1
-
19
-
-
0027262606
-
Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis
-
Lowe, S. W., and H. E. Ruley. 1993. Stabilization of the p53 tumor suppressor is induced by adenovirus 5 E1A and accompanies apoptosis. Genes Dev. 7:535-545.
-
(1993)
Genes Dev.
, vol.7
, pp. 535-545
-
-
Lowe, S.W.1
Ruley, H.E.2
-
20
-
-
0027319521
-
p53 is required for radiation-induced apoptosis in mouse thymocytes
-
Lowe, S. W., E. M. Schmitt, S. W. Smith, B. A. Osborne, and T. Jacks. 1993. p53 is required for radiation-induced apoptosis in mouse thymocytes. Nature 362:847-849.
-
(1993)
Nature
, vol.362
, pp. 847-849
-
-
Lowe, S.W.1
Schmitt, E.M.2
Smith, S.W.3
Osborne, B.A.4
Jacks, T.5
-
21
-
-
62449278758
-
Targeting p53 for enhanced radio-and chemo-sensitivity
-
Lu, C., and W. S. El-Deiry. 2009. Targeting p53 for enhanced radio-and chemo-sensitivity. Apoptosis 14:597-606.
-
(2009)
Apoptosis
, vol.14
, pp. 597-606
-
-
Lu, C.1
El-Deiry, W.S.2
-
22
-
-
58149395816
-
RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/ activation
-
Malagelada, C., Z. H. Jin, and L. A. Greene. 2008. RTP801 is induced in Parkinson's disease and mediates neuron death by inhibiting Akt phosphorylation/ activation. J. Neurosci. 28:14363-14371.
-
(2008)
J. Neurosci.
, vol.28
, pp. 14363-14371
-
-
Malagelada, C.1
Jin, Z.H.2
Greene, L.A.3
-
23
-
-
0028823020
-
Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53
-
Montes de Oca Luna, R., D. S. Wagner, and G. Lozano. 1995. Rescue of early embryonic lethality in mdm2-deficient mice by deletion of p53. Nature 378:203-206.
-
(1995)
Nature
, vol.378
, pp. 203-206
-
-
Montes de Oca Luna, R.1
Wagner, D.S.2
Lozano, G.3
-
24
-
-
63049094489
-
Inactivation of p53 and Pten promotes invasive bladder cancer
-
Puzio-Kuter, A. M., et al. 2009. Inactivation of p53 and Pten promotes invasive bladder cancer. Genes Dev. 23:675-680.
-
(2009)
Genes Dev.
, vol.23
, pp. 675-680
-
-
Puzio-Kuter, A.M.1
-
25
-
-
10044276784
-
The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila
-
Reiling, J. H., and E. Hafen. 2004. The hypoxia-induced paralogs Scylla and Charybdis inhibit growth by down-regulating S6K activity upstream of TSC in Drosophila. Genes Dev. 18:2879-2892.
-
(2004)
Genes Dev.
, vol.18
, pp. 2879-2892
-
-
Reiling, J.H.1
Hafen, E.2
-
26
-
-
42449114966
-
Transcriptional control of human p53-regulated genes
-
Riley, T., E. Sontag, P. Chen, and A. Levine. 2008. Transcriptional control of human p53-regulated genes. Nat. Rev. Mol. Cell. Biol. 9:402-412.
-
(2008)
Nat. Rev. Mol. Cell. Biol.
, vol.9
, pp. 402-412
-
-
Riley, T.1
Sontag, E.2
Chen, P.3
Levine, A.4
-
27
-
-
14644395545
-
REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase
-
Schwarzer, R., et al. 2005. REDD1 integrates hypoxia-mediated survival signaling downstream of phosphatidylinositol 3-kinase. Oncogene 24:1138-1149.
-
(2005)
Oncogene
, vol.24
, pp. 1138-1149
-
-
Schwarzer, R.1
-
28
-
-
0026446686
-
Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding
-
Shaulian, E., A. Zauberman, D. Ginsberg, and M. Oren. 1992. Identification of a minimal transforming domain of p53: negative dominance through abrogation of sequence-specific DNA binding. Mol. Cell. Biol. 12:5581-5592.
-
(1992)
Mol. Cell. Biol.
, vol.12
, pp. 5581-5592
-
-
Shaulian, E.1
Zauberman, A.2
Ginsberg, D.3
Oren, M.4
-
29
-
-
0036118562
-
Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis
-
Shoshani, T., et al. 2002. Identification of a novel hypoxia-inducible factor 1-responsive gene, RTP801, involved in apoptosis. Mol. Cell. Biol. 22:2283-2293.
-
(2002)
Mol. Cell. Biol.
, vol.22
, pp. 2283-2293
-
-
Shoshani, T.1
-
30
-
-
21744459535
-
Regulation of mTOR and cell growth in response to energy stress by REDD1
-
Sofer, A., K. Lei, C. M. Johannessen, and L. W. Ellisen. 2005. Regulation of mTOR and cell growth in response to energy stress by REDD1. Mol. Cell. Biol. 25:5834-5845.
-
(2005)
Mol. Cell. Biol.
, vol.25
, pp. 5834-5845
-
-
Sofer, A.1
Lei, K.2
Johannessen, C.M.3
Ellisen, L.W.4
-
31
-
-
26244459242
-
Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin
-
Takagi, M., M. J. Absalon, K. G. McLure, and M. B. Kastan. 2005. Regulation of p53 translation and induction after DNA damage by ribosomal protein L26 and nucleolin. Cell 123:49-63.
-
(2005)
Cell
, vol.123
, pp. 49-63
-
-
Takagi, M.1
Absalon, M.J.2
McLure, K.G.3
Kastan, M.B.4
-
32
-
-
0037011958
-
p53 mutant mice that display early ageing-associated phenotypes
-
Tyner, S. D., et al. 2002. p53 mutant mice that display early ageing-associated phenotypes. Nature 415:45-53.
-
(2002)
Nature
, vol.415
, pp. 45-53
-
-
Tyner, S.D.1
-
33
-
-
65349103899
-
Blinded by the light: the growing complexity of p53
-
Vousden, K. H., and C. Prives. 2009. Blinded by the light: the growing complexity of p53. Cell 137:413-431.
-
(2009)
Cell
, vol.137
, pp. 413-431
-
-
Vousden, K.H.1
Prives, C.2
-
34
-
-
0029086989
-
The role of free radicals and p53 in neuron apoptosis in vivo
-
Wood, K. A., and R. J. Youle. 1995. The role of free radicals and p53 in neuron apoptosis in vivo. J. Neurosci. 15:5851-5857.
-
(1995)
J. Neurosci.
, vol.15
, pp. 5851-5857
-
-
Wood, K.A.1
Youle, R.J.2
-
35
-
-
0037073713
-
Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage
-
Wulf, G. M., Y. C. Liou, A. Ryo, S. W. Lee, and K. P. Lu. 2002. Role of Pin1 in the regulation of p53 stability and p21 transactivation, and cell cycle checkpoints in response to DNA damage. J. Biol. Chem. 277:47976-47979.
-
(2002)
J. Biol. Chem.
, vol.277
, pp. 47976-47979
-
-
Wulf, G.M.1
Liou, Y.C.2
Ryo, A.3
Lee, S.W.4
Lu, K.P.5
-
36
-
-
33746855405
-
The identification of an internal ribosomal entry site in the 5-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage
-
Yang, D. Q., M. J. Halaby, and Y. Zhang. 2006. The identification of an internal ribosomal entry site in the 5-untranslated region of p53 mRNA provides a novel mechanism for the regulation of its translation following DNA damage. Oncogene 25:4613-4619.
-
(2006)
Oncogene
, vol.25
, pp. 4613-4619
-
-
Yang, D.Q.1
Halaby, M.J.2
Zhang, Y.3
-
37
-
-
79955779584
-
mTOR links oncogenic signaling to tumor cell metabolism
-
Yecies, J. L., and B. D. Manning. 2011. mTOR links oncogenic signaling to tumor cell metabolism. J. Mol. Med. 89:221-228.
-
(2011)
J. Mol. Med.
, vol.89
, pp. 221-228
-
-
Yecies, J.L.1
Manning, B.D.2
|