Hepatic expression profiling shows involvement of PKC epsilon, DGK eta, Tnfaip, and Rho kinase in type 2 diabetic nephropathy rats

Journal of Cellular Biochemistry

Volumn 111, Issue 4, 2010, Pages 944-954

  Gupta, Jeena ^a   Gaikwad, Anil Bhanudas ^a   Tikoo, Kulbhushan ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

Diabetic nephropathy; Liver; PKC epsilon; Rho kinase; Type 2 diabetes

Indexed keywords

COMPLEMENTARY DNA; DIACYLGLYCEROL KINASE; DIACYLGLYCEROL KINASE ETA; PROTEIN KINASE C EPSILON; RHO KINASE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; TUMOR NECROSIS FACTOR ALPHA INDUCED PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DIABETIC NEPHROPATHY; DISEASE ASSOCIATION; DISEASE COURSE; ENZYME ACTIVITY; GENE CONTROL; GENE EXPRESSION PROFILING; GENETIC TRANSCRIPTION; IMMUNOHISTOCHEMISTRY; LIPID DIET; LIVER; MALE; MICROARRAY ANALYSIS; NON INSULIN DEPENDENT DIABETES MELLITUS; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; RISK FACTOR; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; BLOOD GLUCOSE; BLOOD UREA NITROGEN; BODY WEIGHT; CARRIER PROTEINS; CHOLESTEROL; CREATININE; DIABETES MELLITUS, TYPE 2; DIABETIC NEPHROPATHIES; DIACYLGLYCEROL KINASE; GENE EXPRESSION PROFILING; GENE EXPRESSION REGULATION; INSULIN; LIVER; MALE; PROTEIN KINASE C-EPSILON; PROTO-ONCOGENE PROTEINS C-AKT; RATS; RATS, SPRAGUE-DAWLEY; RHO-ASSOCIATED KINASES; SIGNAL TRANSDUCTION; TRIGLYCERIDES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 78049300054     PISSN: 07302312     EISSN: 10974644     Source Type: Journal    
DOI: 10.1002/jcb.22783     Document Type: Article

References (55)

1. Almon RR, DuBois DC, Lai W, Xue B, Nie J, Jusko WJ. 2009. Gene expression analysis of hepatic roles in cause and development of diabetes in Goto-Kakizaki rats. J Endocrinol 200: 331-346.
2. Begum N, Sandu OA, Duddy N. 2002. Negative regulation of rho signaling by insulin and its impact on actin cytoskeleton organization in vascular smooth muscle cells: Role of nitric oxide and cyclic guanosine monophosphate signaling pathways. Diabetes 51: 2256-2263.
3. Belfiore F, Iannello S. 1998. Insulin resistance in obesity: Metabolic mechanisms and measurement methods. Mol Genet Metab 65: 121-128.
4. Berti L, Mosthaf L, Kroder G, Kellerer M, Tippmer S, Mushack J, Seffer E, Seedorf K, Haring H. 1994. Glucose-induced translocation of protein kinase C isoforms in rat-1 fibroblasts is paralleled by inhibition of the insulin receptor tyrosine kinase. J Biol Chem 269: 3381-3386.
5. Chomczynski P, Sacchi N. 1987. Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction. Anal Biochem 162: 156-159.
6. Considine RV, Nyce MR, Allen LE, Morales LM, Triester S, Serrano J, Colberg J, Lanza-Jacoby S, Caro JF. 1995. Protein kinase C is increased in the liver of humans and rats with non-insulin-dependent diabetes mellitus: An alteration not due to hyperglycemia. J Clin Invest 95: 2938-2944.
7. Day CP. 2006. Non-alcoholic fatty liver disease: Current concepts and management strategies. Clin Med 6: 19-25.
8. Diaz-Flores E, Siliceo M, Martinez AC, Merida I. 2003. Membrane translocation of protein kinase Ctheta during T lymphocyte activation requires phospholipase C-gamma-generated diacylglycerol. J Biol Chem 278: 29208-29215.
9. Gaikwad AB, Viswanad B, Ramarao P. 2007. PPAR gamma agonists partially restores hyperglycemia-induced aggravation of vascular dysfunction to angiotensin II in thoracic aorta isolated from rats with insulin resistance. Pharmacol Res 55: 400-407.
10. Ge Y, Elghetany MT. 2005. CD36: A multiligand molecule. Lab Hematol 11: 31-37.
11. Gibbs RA, Weinstock GM, Metzker ML, Muzny DM, Sodergren EJ, Scherer S, Scott G, Steffen D, Worley KC, Burch PE, Okwuonu G, Hines S, Lewis L, DeRamo C, Delgado O, Dugan-Rocha S, Miner G, Morgan M, Hawes A, Gill R, Celera, Holt RA, Adams MD, Amanatides PG, Baden-Tillson H, Barnstead M, Chin S, Evans CA, Ferriera S, Fosler C, Glodek A, Gu Z, Jennings D, Kraft CL, Nguyen T, Pfannkoch CM, Sitter C, Sutton GG, Venter JC, Woodage T, Smith D, Lee HM, Gustafson E, Cahill P, Kana A, Doucette-Stamm L, Weinstock K, Fechtel K, Weiss RB, Dunn DM, Green ED, Blakesley RW, Bouffard GG, De Jong PJ, Osoegawa K, Zhu B, Marra M, Schein J, Bosdet I, Fjell C, Jones S, Krzywinski M, Mathewson C, Siddiqui A, Wye N, McPherson J, Zhao S, Fraser CM, Shetty J, Shatsman S, Geer K, Chen Y, Abramzon S, Nierman WC, Havlak PH, Chen R, Durbin KJ, Egan A, Ren Y, Song XZ, Li B, Liu Y, Qin X, Cawley S, Cooney AJ, D'Souza LM, Martin K, Wu JQ, Gonzalez-Garay ML, Jackson AR, Kalafus KJ, McLeod MP, Milosavljevic A, Virk D, Volkov A, Wheeler DA, Zhang Z, Bailey JA, Eichler EE, Tuzun E, et al. 2004. Genome sequence of the Brown Norway rat yields insights into mammalian evolution. Nature 428: 493-521.
12. Gien J, Seedorf GJ, Balasubramaniam V, Tseng N, Markham N, Abman SH. 2008. Chronic intrauterine pulmonary hypertension increases endothelial cell Rho kinase activity and impairs angiogenesis in vitro. Am J Physiol Lung Cell Mol Physiol 295: L680-L687.
13. 2+ sensitization of smooth muscle. J Biol Chem 272: 10704-10709.
14. Heishi M, Ichihara J, Teramoto R, Itakura Y, Hayashi K, Ishikawa H, Gomi H, Sakai J, Kanaoka M, Taiji M, Kimura T. 2006. Global gene expression analysis in liver of obese diabetic db/db mice treated with metformin. Diabetologia 49: 1647-1655.
15. Hsueh WA, Law RE. 1999. Insulin signaling in the arterial wall. Am J Cardiol 84: 21J-24J.
16. Ilnytska O, Lyzogubov VV, Stevens MJ, Drel VR, Mashtalir N, Pacher P, Yorek MA, Obrosova IG. 2006. Poly(ADP-ribose) polymerase inhibition alleviates experimental diabetic sensory neuropathy. Diabetes 55: 1686-1694.
17. Jones DR, Sanjuan MA, Merida I. 2000. Type Ialpha phosphatidylinositol 4-phosphate 5-kinase is a putative target for increased intracellular phosphatidic acid. FEBS Lett 476: 160-165.
18. Kanoh H, Yamada K, Sakane F. 2002. Diacylglycerol kinases: Emerging downstream regulators in cell signaling systems. J Biochem 131: 629-633.
19. Kellerer M, Mushack J, Mischak H, Haring HU. 1997. Protein kinase C (PKC) epsilon enhances the inhibitory effect of TNF alpha on insulin signaling in HEK293 cells. FEBS Lett 418: 119-122.
20. Knoll KE, Pietrusz JL, Liang M. 2005. Tissue-specific transcriptome responses in rats with early streptozotocin-induced diabetes. Physiol Genomics 21: 222-229.
21. Krook A, Roth RA, Jiang XJ, Zierath JR, Wallberg-Henriksson H. 1998. Insulin-stimulated Akt kinase activity is reduced in skeletal muscle from NIDDM subjects. Diabetes 47: 1281-1286.
22. Kume E, Aruga C, Ishizuka Y, Takahashi K, Miwa S, Itoh M, Fujimura H, Toriumi W, Kitamura K, Doi K. 2005. Gene expression profiling in streptozotocin treated mouse liver using DNA microarray. Exp Toxicol Pathol 56: 235-244.
23. Langberg EC, Gu HF, Nordman S, Efendic S, Ostenson CG. 2007. Genetic variation in receptor protein tyrosine phosphatase sigma is associated with type 2 diabetes in Swedish Caucasians. Eur J Endocrinol 157: 459-464.
24. Lewis GF, Carpentier A, Adeli K, Giacca A. 2002. Disordered fat storage and mobilization in the pathogenesis of insulin resistance and type 2 diabetes. Endocr Rev 23: 201-229.
25. Liang M, Cowley AW, Greene AS. 2004. High throughput gene expression profiling: A molecular approach to integrative physiology. J Physiol 554: 22-30.
26. Luo B, Prescott SM, Topham MK. 2003. Association of diacylglycerol kinase zeta with protein kinase C alpha: Spatial regulation of diacylglycerol signaling. J Cell Biol 160: 929-937.
27. Luo B, Prescott SM, Topham MK. 2004. Diacylglycerol kinase zeta regulates phosphatidylinositol 4-phosphate 5-kinase Ialpha by a novel mechanism. Cell Signal 16: 891-897.
28. Moomaw JF, Casey PJ. 1992. Mammalian protein geranylgeranyltransferase. Subunit composition and metal requirements. J Biol Chem 267: 17438-17443.
29. Ninichuk V, Clauss S, Kulkarni O, Schmid H, Segerer S, Radomska E, Eulberg D, Buchner K, Selve N, Klussmann S. 2008. Late onset of Ccl2 blockade with the Spiegelmer mNOX-E36-3'PEG prevents glomerulosclerosis and improves glomerular filtration rate in db/db mice. Am J Pathol 172: 628.
30. Qu X, Seale JP, Donnelly R. 1999. Tissue and isoform-selective activation of protein kinase C in insulin-resistant obese Zucker rats-effects of feeding. J Endocrinol 162: 207-214.
31. Raza H, Prabu SK, Robin MA, Avadhani NG. 2004. Elevated mitochondrial cytochrome P450 2E1 and glutathione S-transferase A4-4 in streptozotocin-induced diabetic rats: Tissue-specific variations and roles in oxidative stress. Diabetes 53: 185-194.
32. Rikitake Y, Liao JK. 2005. Rho-kinase mediates hyperglycemia-induced plasminogen activator inhibitor-1 expression in vascular endothelial cells. Circulation 111: 3261-3268.
33. Rong JX, Qiu Y, Hansen MK, Zhu L, Zhang V, Xie M, Okamoto Y, Mattie MD, Higashiyama H, Asano S, Strum JC, Ryan TE. 2007. Adipose mitochondrial biogenesis is suppressed in db/db and high-fat diet-fed mice and improved by rosiglitazone. Diabetes 56: 1751-1760.
34. Rosholt MN, King PA, Horton ES. 1994. High-fat diet reduces glucose transporter responses to both insulin and exercise. Am J Physiol 266: R95-R101.
35. Rossing P. 2006. Prediction, progression and prevention of diabetic nephropathy. The Minkowski Lecture 2005. Diabetologia 49: 11-19.
36. Saltiel AR, Kahn CR. 2001. Insulin signalling and the regulation of glucose and lipid metabolism. Nature 414: 799-806.
37. Samuel VT, Liu ZX, Qu X, Elder BD, Bilz S, Befroy D, Romanelli AJ, Shulman GI. 2004. Mechanism of hepatic insulin resistance in non-alcoholic fatty liver disease. J Biol Chem 279: 32345-32353.
38. Sandu OA, Ragolia L, Begum N. 2000. Diabetes in the Goto-Kakizaki rat is accompanied by impaired insulin-mediated myosin-bound phosphatase activation and vascular smooth muscle cell relaxation. Diabetes 49: 2178-2189.
39. 2+ sensitization of contraction in vascular smooth muscle. J Biol Chem 275: 21722-21729.
40. Schmitz-Peiffer C, Browne CL, Oakes ND, Watkinson A, Chisholm DJ, Kraegen EW, Biden TJ. 1997. Alterations in the expression and cellular localization of protein kinase C isozymes epsilon and theta are associated with insulin resistance in skeletal muscle of the high-fat-fed rat. Diabetes 46: 169-178.
41. Shmueli E, Alberti KG, Record CO. 1993. Diacylglycerol/protein kinase C signalling: A mechanism for insulin resistance? J Intern Med 234: 397-400.
42. Sparks LM, Xie H, Koza RA, Mynatt R, Hulver MW, Bray GA, Smith SR. 2005. A high-fat diet coordinately downregulates genes required for mitochondrial oxidative phosphorylation in skeletal muscle. Diabetes 54: 1926-1933.
43. Srinivasan K, Patole PS, Kaul CL, Ramarao P. 2004. Reversal of glucose intolerance by pioglitazone in high fat diet-fed rats. Methods Find Exp Clin Pharmacol 26: 327-333.
44. Srinivasan K, Viswanad B, Asrat L, Kaul CL, Ramarao P. 2005. Combination of high-fat diet-fed and low-dose streptozotocin-treated rat: A model for type 2 diabetes and pharmacological screening. Pharmacol Res 52: 313-320.
45. Tan AL, Forbes JM, Cooper ME. 2007. AGE, RAGE, and ROS in diabetic nephropathy. Semin Nephrol 27: 130-143.
46. Targher G, Bertolini L, Rodella S, Tessari R, Zenari L, Lippi G, Arcaro G. 2007. Nonalcoholic fatty liver disease is independently associated with an increased incidence of cardiovascular events in type 2 diabetic patients. Diabetes Care 30: 2119-2121.
47. Targher G, Bertolini L, Rodella S, Zoppini G, Lippi G, Day C, Muggeo M. 2008a. Non-alcoholic fatty liver disease is independently associated with an increased prevalence of chronic kidney disease and proliferative/laser-treated retinopathy in type 2 diabetic patients. Diabetologia 51: 444-450.
48. Targher G, Chonchol M, Bertolini L, Rodella S, Zenari L, Lippi G, Franchini M, Zoppini G, Muggeo M. 2008b. Increased risk of CKD among type 2 diabetics with nonalcoholic fatty liver disease. J Am Soc Nephrol 19: 1564-1570.
49. Tikoo K, Bhatt DK, Gaikwad AB, Sharma V, Kabra DG. 2007a. Differential effects of tannic acid on cisplatin induced nephrotoxicity in rats. FEBS Lett 581: 2027-2035.
50. Tikoo K, Tripathi DN, Kabra DG, Sharma V, Gaikwad AB. 2007b. Intermittent fasting prevents the progression of type I diabetic nephropathy in rats and changes the expression of Sir2 and p53. FEBS Lett 581: 1071-1078.
51. Tikoo K, Meena RL, Kabra DG, Gaikwad AB. 2008a. Change in post-translational modifications of histone H3, heat-shock protein-27 and MAP kinase p38 expression by curcumin in streptozotocin-induced type I diabetic nephropathy. Br J Pharmacol 153: 1225-1231.
52. Tikoo K, Tamta A, Ali IY, Gupta J, Gaikwad AB. 2008b. Tannic acid prevents azidothymidine (AZT) induced hepatotoxicity and genotoxicity along with change in expression of PARG and histone H3 acetylation. Toxicol Lett 177: 90-96.
53. Tolman KG, Fonseca V, Dalpiaz A, Tan MH. 2007. Spectrum of liver disease in type 2 diabetes and management of patients with diabetes and liver disease. Diabetes Care 30: 734-743.
54. van Baal J, de Widt J, Divecha N, van Blitterswijk WJ. 2005. Translocation of diacylglycerol kinase theta from cytosol to plasma membrane in response to activation of G protein-coupled receptors and protein kinase C. J Biol Chem 280: 9870-9878.
55. Yang RL, Li W, Shi YH, Le GW. 2008. Lipoic acid prevents high-fat diet-induced dyslipidemia and oxidative stress: A microarray analysis. Nutrition 24: 582-588.