Mechanisms of Trypanosoma cruzi persistence in Chagas disease

Cellular Microbiology

Volumn 14, Issue 5, 2012, Pages 634-643

  Nagajyothi, Fnu ^a   Machado, Fabiana S ^b   Burleigh, Barbara A ^c   Jelicks, Linda A ^a   Scherer, Philipp E ^d   Mukherjee, Shankar ^a   Lisanti, Michael P ^e   Weiss, Louis M ^a   Garg, Nisha J ^f   Tanowitz, Herbert B ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b FEDERAL UNIVERSITY OF MINAS GERAIS   (Brazil)

^c HARVARD SCHOOL OF PUBLIC HEALTH   (United States)

^d UNIVERSITY OF TEXAS SOUTHWESTERN MEDICAL CENTER   (United States)

^e THOMAS JEFFERSON UNIVERSITY   (United States)

^f University of Texas Medical Branch School of Medicine   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ADIPONECTIN; LIPOPROTEIN; NERVE GROWTH FACTOR; NEUROTROPHIN 3; PROSTACYCLIN; PROSTAGLANDIN; THROMBOXANE A2;

ADIPOCYTE; ADIPOSE TISSUE; APOPTOSIS; AUTOIMMUNITY; BLOOD VESSEL PERMEABILITY; CD8+ T LYMPHOCYTE; CELL DIFFERENTIATION; CHAGAS DISEASE; DISEASE COURSE; HEART MUSCLE CELL; HOST CELL; HOST PARASITE INTERACTION; HUMAN; IMMUNE RESPONSE; LIPOLYSIS; NONHUMAN; NUTRIENT SUPPLY; PARASITE SURVIVAL; PARASITE TRANSMISSION; PARASITISM; PRIORITY JOURNAL; PROTEIN BINDING; RESERVOIR; REVIEW; SIGNAL TRANSDUCTION; SMOOTH MUSCLE FIBER; TRYPANOSOMA CRUZI;

ANIMALS; CHAGAS DISEASE; CHRONIC DISEASE; HOST-PATHOGEN INTERACTIONS; HUMANS; IMMUNE EVASION; MODELS, BIOLOGICAL; TRYPANOSOMA CRUZI;

TRYPANOSOMA CRUZI;

EID: 84859896399     PISSN: 14625814     EISSN: 14625822     Source Type: Journal    
DOI: 10.1111/j.1462-5822.2012.01764.x     Document Type: Review

References (58)

1. Alvarez, M.N., Peluffo, G., Piacenza, L., and Radi, R. (2011) Intraphagosomal peroxynitrite as a macrophage-derived cytotoxin against internalized Trypanosoma cruzi: consequences for oxidative killing and role of microbial peroxiredoxins in infectivity. J Biol Chem 286: 6627-6640.
2. Alves, M.J., and Colli, W. (2008) Role of the gp85/trans-sialidase superfamily of glycoproteins in the interaction of Trypanosoma cruzi with host structures. Subcell Biochem 47: 58-69.
3. Andrade, D., Serra, R., Svensjö, E., Lima, A.P., Ramos Junior, E.S., Fortes, F.S., etal. (2012) 'Trypanosoma cruzi invades host cells through the activation of endothelin and bradykinin receptors: a converging pathway leading to chagasic vasculopathy. Br J Pharmacol 165: 1333-1347.
4. Ashton, A.W., Mukherjee, S., Nagajyothi, F.N., Huang, H., Braunstein, V.L., Desruisseaux, M.S., etal. (2007) Thromboxane A2 is a key regulator of pathogenesis during Trypanosoma cruzi infection. J Exp Med 204: 929-940.
5. Ba, X., Gupta, S., Davidson, M., and Garg, N.J. (2010) Trypanosoma cruzi induces the reactive oxygen species-PARP-1-RelA pathway for up-regulation of cytokine expression in cardiomyocytes. J Biol Chem 285: 11596-11606.
6. Bechah, Y., Paddock, C.D., Capo, C., Mege, J.L., and Raoult, D. (2010) Adipose tissue serves as a reservoir for recrudescent Rickettsia prowazekii infection in a mouse model. PLoS ONE 5: e8547.
7. Bern, C. (2011) Antitrypanosomal therapy for chronic Chagas' disease. N Engl J Med 364: 2527-2534.
8. Bustamante, J.M., Bixby, L.M., and Tarleton, R.L. (2008) Drug-induced cure drives conversion to a stable and protective CD8+ T central memory response in chronic Chagas disease. Nat Med 14: 542-550.
9. Caradonna, K.L., and Burleigh, B.A. (2011) Mechanisms of host cell invasion by Trypanosoma cruzi. Adv Parasitol 76: 33-61.
10. Castro, E. (2009) Chagas' disease: lessons from routine donation testing. Transfus Med 19: 16-23.
11. Castro, H., and Tomas, A.M. (2008) Peroxidases of trypanosomatids. Antioxid Redox Signal 10: 1593-1606.
12. Chuenkova, M.V., and PereiraPerrin, M. (2009) Trypanosoma cruzi targets Akt in host cells as an intracellular antiapoptotic strategy. Sci Signal 2: ra74.
13. Chuenkova, M.V., and Pereiraperrin, M. (2011) Neurodegeneration and neuroregeneration in Chagas disease. Adv Parasitol 76: 195-233.
14. Combs, T.P., Nagajyothi, Mukherjee, S., de Almeida, C.J., Jelicks, L.A., Schubert, W., etal. (2005) The adipocyte as an important target cell for Trypanosoma cruzi infection. J Biol Chem 280: 24085-24094.
15. Dhiman, M., and Garg, N.J. (2011) NADPH oxidase inhibition ameliorates Trypanosoma cruzi-induced myocarditis during Chagas disease. J Pathol 225: 583-596.
16. Diaz, M.L., Solari, A., and Gonzalez, C.I. (2011) Differential expression of Trypanosoma cruzi I associated with clinical forms of Chagas disease: overexpression of oxidative stress proteins in acute patient isolate. J Proteomics 74: 1673-1682.
17. Diazgranados, C.A., Saavedra-Trujillo, C.H., Mantilla, M., Valderrama, S.L., Alquichire, C., and Franco-Paredes, C. (2009) Chagasic encephalitis in HIV patients: common presentation of an evolving epidemiological and clinical association. Lancet Infect Dis 9: 324-330.
18. van Empel, V.P., Bertrand, A.T., Hofstra, L., Crijns, H.J., Doevendans, P.A., and De Windt, L.J. (2005) Myocyte apoptosis in heart failure. Cardiovasc Res 67: 21-29.
19. Escriba, J.M., Ponce, E., Romero Ade, D., Vinas, P.A., Marchiol, A., Bassets, G., etal. (2009) Treatment and seroconversion in a cohort of children suffering from recent chronic Chagas infection in Yoro, Honduras. Mem Inst Oswaldo Cruz 104: 986-991.
20. Fernandes, M.C., Cortez, M., Flannery, A.R., Tam, C., Mortara, R.A., and Andrews, N.W. (2011) Trypanosoma cruzi subverts the sphingomyelinase-mediated plasma membrane repair pathway for cell invasion. J Exp Med 208: 909-921.
21. Ferrante, A.W., Jr (2007) Obesity-induced inflammation: a metabolic dialogue in the language of inflammation. J Intern Med 262: 408-414.
22. Ferreira, A.V., Segatto, M., Menezes, Z., Macedo, A.M., Gelape, C., de Oliveira Andrade, L., etal. (2011) Evidence for Trypanosoma cruzi in adipose tissue in human chronic Chagas disease. Microbes Infect 13: 1002-1005.
23. Gascon, J., Bern, C., and Pinazo, M.J. (2010) Chagas disease in Spain, the United States and other non-endemic countries. Acta Trop 115: 22-27.
24. Giddings, O.K., Eickhoff, C.S., Smith, T.J., Bryant, L.A., and Hoft, D.F. (2006) Anatomical route of invasion and protective mucosal immunity in Trypanosoma cruzi conjunctival infection. Infect Immun 74: 5549-5560.
25. Gupta, S., Wen, J.J., and Garg, N.J. (2009) Oxidative Stress in Chagas Disease. Interdiscip Perspect Infect Dis 2009: 190354.
26. Gutierrez, F.R., Guedes, P.M., Gazzinelli, R.T., and Silva, J.S. (2009) The role of parasite persistence in pathogenesis of Chagas heart disease. Parasite Immunol 31: 673-685.
27. Hyland, K.V., Leon, J.S., Daniels, M.D., Giafis, N., Woods, L.M., Bahk, T.J., etal. (2007) Modulation of autoimmunity by treatment of an infectious disease. Infect Immun 75: 3641-3650.
28. Kosteli, A., Sugaru, E., Haemmerle, G., Martin, J.F., Lei, J., Zechner, R., etal. (2010) Weight loss and lipolysis promote a dynamic immune response in murine adipose tissue. J Clin Invest 120: 3466-3479.
29. Leon, J.S., Wang, K., and Engman, D.M. (2003) Myosin autoimmunity is not essential for cardiac inflammation in acute Chagas' disease. J Immunol 171: 4271-4277.
30. Ley, V., Robbins, E.S., Nussenzweig, V., and Andrews, N.W. (1990) The exit of Trypanosoma cruzi from the phagosome is inhibited by raising the pH of acidic compartments. J Exp Med 171: 401-413.
31. Losavio, A., Jones, M.C., Sanz, O.P., Mirkin, G., Gonzalez Cappa, S.M., Muchnik, S., etal. (1989) A sequential study of the peripheral nervous system involvement in experimental Chagas' disease. Am J Trop Med Hyg 41: 539-547.
32. Lu, B., and PereiraPerrin, M. (2008) A novel immunoprecipitation strategy identifies a unique functional mimic of the glial cell line-derived neurotrophic factor family ligands in the pathogen Trypanosoma cruzi. Infect Immun 76: 3530-3538.
33. Manque, P.A., Probst, C.M., Pereira, M.C., Rampazzo, R.C., Ozaki, L.S., Pavoni, D.P., etal. (2011) Trypanosoma cruzi infection induces a global host cell response in cardiomyocytes. Infect Immun 79: 1855-1862.
34. Meciano Filho, J., Carvalho, V.C., and de Souza, R.R. (1995) Nerve cell loss in the myenteric plexus of the human esophagus in relation to age: a preliminary investigation. Gerontology 41: 18-21.
35. Nagajyothi, F., Desruisseaux, M.S., Thiruvur, N., Weiss, L.M., Braunstein, V.L., Albanese, C., etal. (2008) Trypanosoma cruzi infection of cultured adipocytes results in an inflammatory phenotype. Obesity (Silver Spring) 16: 1992-1997.
36. Nagajyothi, F., Weiss, L.M., Silver, D.L., Desruisseaux, M.S., Scherer, P.E., Herz, J., etal. (2011) Trypanosoma cruzi utilizes the host low density lipoprotein receptor in invasion. PLoS Negl Trop Dis 5: e953.
37. Nagajyothi, F., Desruisseaux, M.S., Machado, F.S., Upadhya, R., Zhao, D., Schwartz, G.J., etal. (2012) Response of adipose tissue to early infection with Trypanosoma cruzi (Brazil strain). J Infect Dis 205: 830-840.
38. Ortega-Barria, E., and Pereira, M.E. (1991) A novel T. cruzi heparin-binding protein promotes fibroblast adhesion and penetration of engineered bacteria and trypanosomes into mammalian cells. Cell 67: 411-421.
39. Padilla, A.M., Bustamante, J.M., and Tarleton, R.L. (2009) CD8+ T cells in Trypanosoma cruzi infection. Curr Opin Immunol 21: 385-390.
40. Parodi-Talice, A., Monteiro-Goes, V., Arrambide, N., Avila, A.R., Duran, R., Correa, A., etal. (2007) Proteomic analysis of metacyclic trypomastigotes undergoing Trypanosoma cruzi metacyclogenesis. J Mass Spectrom 42: 1422-1432.
41. Petersen, C.A., Krumholz, K.A., Carmen, J., Sinai, A.P., and Burleigh, B.A. (2006) Trypanosoma cruzi infection and nuclear factor kappa B activation prevent apoptosis in cardiac cells. Infect Immun 74: 1580-1587.
42. Piacenza, L., Zago, M.P., Peluffo, G., Alvarez, M.N., Basombrio, M.A., and Radi, R. (2009a) Enzymes of the antioxidant network as novel determiners of Trypanosoma cruzi virulence. Int J Parasitol 39: 1455-1464.
43. Piacenza, L., Alvarez, M.N., Peluffo, G., and Radi, R. (2009b) Fighting the oxidative assault: the Trypanosoma cruzi journey to infection. Curr Opin Microbiol 12: 415-421.
44. Pineyro, M.D., Parodi-Talice, A., Arcari, T., and Robello, C. (2008) Peroxiredoxins from Trypanosoma cruzi: virulence factors and drug targets for treatment of Chagas disease? Gene 408: 45-50.
45. Rassi, A., Jr, Rassi, A., and Marin-Neto, J.A. (2010) Chagas disease. Lancet 375: 1388-1402.
46. Rodriguez, A., Rioult, M.G., Ora, A., and Andrews, N.W. (1995) A trypanosome-soluble factor induces IP3 formation, intracellular Ca2+ mobilization and microfilament rearrangement in host cells. J Cell Biol 129: 1263-1273.
47. Shoemaker, J.P., Hoffman, R.V., Jr, and Huffman, D.G. (1970) Trypanosoma cruzi: preference for brown adipose tissue in mice by the Tulahuen strain. Exp Parasitol 27: 403-407.
48. da Silveira, A.B., Freitas, M.A., de Oliveira, E.C., Neto, S.G., Luquetti, A.O., Furness, J.B., etal. (2008) Neuronal plasticity of the enteric nervous system is correlated with chagasic megacolon development. Parasitology 135: 1337-1342.
49. Tanowitz, H., Wittner, M., Kress, Y., and Bloom, B. (1975) Studies of in vitro infection by Trypanosoma cruzi. I. Ultrastructural studies on the invasion of macrophages and L-cells. Am J Trop Med Hyg 24: 25-33.
50. Tanowitz, H.B., Burns, E.R., Sinha, A.K., Kahn, N.N., Morris, S.A., Factor, S.M., etal. (1990) Enhanced platelet adherence and aggregation in Chagas' disease: a potential pathogenic mechanism for cardiomyopathy. Am J Trop Med Hyg 43: 274-281.
51. Teixeira Vde, P., Hial, V., Gomes, R.A., Castro, E.C., Reis, M.d.G., Rodrigues, M.L., etal. (1997) Correlation between adrenal central vein parasitism and heart fibrosis in chronic chagasic myocarditis. Am J Trop Med Hyg 56: 177-180.
52. Viotti, R., Vigliano, C., Lococo, B., Bertocchi, G., Petti, M., Alvarez, M.G., etal. (2006) Long-term cardiac outcomes of treating chronic Chagas disease with benznidazole versus no treatment: a nonrandomized trial. Ann Intern Med 144: 724-734.
53. Waghabi, M.C., de Souza, E.M., de Oliveira, G.M., Keramidas, M., Feige, J.J., Araujo-Jorge, T.C., etal. (2009) Pharmacological inhibition of transforming growth factor beta signaling decreases infection and prevents heart damage in acute Chagas' disease. Antimicrob Agents Chemother 53: 4694-4701.
54. Weinkauf, C., and Pereiraperrin, M. (2009) Trypanosoma cruzi promotes neuronal and glial cell survival through the neurotrophic receptor TrkC. Infect Immun 77: 1368-1375.
55. Wen, J.-J., and Garg, N.J. (2010) Mitochondrial complex III defects contribute to inefficient respiration and ATP synthesis in the myocardium of Trypanosoma cruzi-infected mice. Antioxid Redox Signal 12: 27-37.
56. Woolsey, A.M., and Burleigh, B.A. (2004) Host cell actin polymerization is required for cellular retention of Trypanosoma cruzi and early association with endosomal/lysosomal compartments. Cell Microbiol 6: 829-838.
57. Woolsey, A.M., Sunwoo, L., Petersen, C.A., Brachmann, S.M., Cantley, L.C., and Burleigh, B.A. (2003) Novel PI 3-kinase-dependent mechanisms of trypanosome invasion and vacuole maturation. J Cell Sci 116: 3611-3622.
58. Zhang, L., and Tarleton, R.L. (1999) Parasite persistence correlates with disease severity and localization in chronic Chagas' disease. J Infect Dis 180: 480-486.