Mechanisms mediating enhanced neutralization efficacy of staphylococcal enterotoxin B by combinations of monoclonal antibodies

Journal of Biological Chemistry

Volumn 290, Issue 11, 2015, Pages 6715-6730

  Dutta, Kaushik ^a   Varshney, Avanish K ^b,c   Franklin, Matthew C ^a   Goger, Michael ^a   Wang, Xiaobo ^c   Fries, Bettina C ^b,c  

^a NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

^b STONY BROOK UNIVERSITY   (United States)

^c ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBODIES; CELL MEMBRANES; EPITOPES; MAPPING; MIXTURES; MONOCLONAL ANTIBODIES; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY;

BINARY AND TERNARY COMPLEXES; CONFORMATIONAL CHANGE; CONFORMATIONAL EPITOPES; DIFFERENT MECHANISMS; LOW CONCENTRATIONS; MAJOR HISTOCOMPATIBILITY COMPLEX CLASS; STAPHYLOCOCCAL ENTEROTOXIN B; STRUCTURAL INFORMATION;

T-CELLS;

EPITOPE; IMMUNOGLOBULIN F(AB) FRAGMENT; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14G8; MONOCLONAL ANTIBODY 20B1; MONOCLONAL ANTIBODY 6D3; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG; ENTEROTOXIN; ENTEROTOXIN B, STAPHYLOCOCCAL; SUPERANTIGEN;

ALLOSTERISM; ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; CONFORMATIONAL TRANSITION; CONTROLLED STUDY; CRYSTALLOGRAPHY; EPITOPE MAPPING; IN VITRO STUDY; IN VIVO STUDY; MACROPHAGE; MOLECULAR MECHANICS; MOUSE; NEUTROPHIL; NONHUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PRIORITY JOURNAL; PROTEIN CROSS LINKING; X RAY CRYSTALLOGRAPHY; AMINO ACID SEQUENCE; ANIMAL; ANTAGONISTS AND INHIBITORS; CHEMISTRY; IMMUNOLOGY; IMMUNOTHERAPY; MICROBIOLOGY; MOLECULAR DOCKING; MOLECULAR GENETICS; SEQUENCE ALIGNMENT; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; CRYSTALLOGRAPHY, X-RAY; ENTEROTOXINS; EPITOPE MAPPING; EPITOPES; IMMUNOTHERAPY; MICE; MOLECULAR DOCKING SIMULATION; MOLECULAR SEQUENCE DATA; SEQUENCE ALIGNMENT; STAPHYLOCOCCAL INFECTIONS; STAPHYLOCOCCUS AUREUS; SUPERANTIGENS;

EID: 84924898040     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M114.630715     Document Type: Article

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