Monoclonal antibody 11E10, which neutralizes Shiga toxin type 2 (Stx2), recognizes three regions on the Stx2 A subunit, blocks the enzymatic action of the toxin in vitro, and alters the overall cellular distribution of the toxin

Infection and Immunity

Volumn 77, Issue 7, 2009, Pages 2730-2740

  Smith, Michael J ^a   Melton Celsa, Angela R ^a   Sinclair, James F ^a   Carvalho, Humberto M ^a   Robinson, Cory M ^a   O'Brien, Alison D ^a  

^a UNIFORMED SERVICES UNIVERSITY OF THE HEALTH SCIENCES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 11E10; PROTEIN SUBUNIT; UNCLASSIFIED DRUG; VEROTOXIN 1; VEROTOXIN 2;

AMINO ACID SEQUENCE; ANIMAL CELL; ANIMAL EXPERIMENT; ANTIGEN BINDING; ARTICLE; CELLULAR DISTRIBUTION; CONTROLLED STUDY; CRYSTAL STRUCTURE; CYTOTOXICITY; ENZYME ACTIVITY; IN VITRO STUDY; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN SYNTHESIS; VERO CELL; WESTERN BLOTTING;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; CERCOPITHECUS AETHIOPS; EPITOPE MAPPING; MALE; MODELS, MOLECULAR; NEUTRALIZATION TESTS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; SHIGA TOXIN 2; VERO CELLS;

EID: 67650096429     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.00005-09     Document Type: Article

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