Generation and characterization of high affinity human monoclonal antibodies that neutralize staphylococcal enterotoxin B

Journal of Immune Based Therapies and Vaccines

Volumn 8, Issue , 2010, Pages

  Drozdowski, Brian ^a   Zhou, Yuhong ^a   Kline, Brad ^a   Spidel, Jared ^a   Chan, Yin Yin ^a   Albone, Earl ^a   Turchin, Howard ^a   Chao, Qimin ^a   Henry, Marianne ^a   Balogach, Jacqueline ^a   Routhier, Eric ^a   Bavari, Sina ^b   Nicolaides, Nicholas C ^a   Sass, Philip M ^a   Grasso, Luigi ^a  

^a Morphotek Inc   (United States)

^b UNITED STATES ARMY MEDICAL RESEARCH INSTITUTE OF INFECTIOUS DISEASES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; HUMAN MONOCLONAL ANTIBODY 154; NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIBODY AFFINITY; ANTIBODY SPECIFICITY; ARTICLE; CELL LYSATE; DEVICE; DRUG ACTIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; HUMAN; HUMAN CELL; HYBRIDOMA; IMMUNOBLOTTING; IMMUNOTHERAPY; IN VITRO STUDY; IN VIVO STUDY; LETHALITY; LYMPHOCYTE; MOUSE; NONHUMAN; STAPHYLOCOCCUS AUREUS;

EID: 78650274754     PISSN: None     EISSN: 14768518     Source Type: Journal    
DOI: 10.1186/1476-8518-8-9     Document Type: Article

References (31)

1. Lowy FD. Staphylococcus aureus infections. N Engl J Med 1998, 339:520-532. 10.1056/NEJM199808203390806, 9709046.
2. Holbrook KA, Klein RS, Hartel D, Elliott DA, Barsky TB, Rothschild LH, Lowy FD. Staphylococcus aureus nasal colonization in HIV-seropositive and HIV-seronegative drug users. J Acquir Immune Defic Syndr Hum Retrovirol 1997, 16:301-306.
3. Miller M, Cook HA, Furuya EY, Bhat M, Lee MH, Vavagiakis P, Visintainer P, Vasquez G, Larson E, Lowy FD. Staphylococcus aureus in the community: colonization versus infection. PLoS One 2009, 4:e6708. 10.1371/journal.pone.0006708, 2724739, 19693269.
4. Lina G, Bohach GA, Nair SP, Hiramatsu K, Jouvin-Marche E, Mariuzza R. Standard nomenclature for the superantigens expressed by Staphylococcus. J Infect Dis 2004, 189:2334-2336. 10.1086/420852, 15181583.
5. Ono HK, Omoe K, Imanishi K, Iwakabe Y, Hu DL, Kato H, Saito N, Nakane A, Uchiyama T, Shinagawa K. Identification and characterization of two novel staphylococcal enterotoxins, types S and T. Infect Immun 2008, 76:4999-5005. 10.1128/IAI.00045-08, 2573384, 18710864.
6. Chiang YC, Liao WW, Fan CM, Pai WY, Chiou CS, Tsen HY. PCR detection of Staphylococcal enterotoxins (SEs) N, O, P, Q, R, U, and survey of SE types in Staphylococcus aureus isolates from food-poisoning cases in Taiwan. Int J Food Microbiol 2008, 121:66-73. 10.1016/j.ijfoodmicro.2007.10.005, 18068843.
7. Mattix ME, Hunt RE, Wilhelmsen CL, Johnson AJ, Baze WB. Aerosolized staphylococcal enterotoxin B-induced pulmonary lesions in rhesus monkeys (Macaca mulatta). Toxicol Pathol 1995, 23:262-268. 10.1177/019262339502300304, 7659951.
8. Ulrich RG. Staphylococcal Enterotoxin B And Related Toxins. Medical aspects of chemical and biological warfare 2007, 311-322.
9. Boles JW, Pitt ML, LeClaire RD, Gibbs PH, Torres E, Dyas B, Ulrich RG, Bavari S. Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity. Clin Immunol 2003, 108:51-59. 10.1016/S1521-6616(03)00066-4, 12865071.
10. Woody MA, Krakauer T, Stiles BG. Staphylococcal enterotoxin B mutants (N23K and F44S): biological effects and vaccine potential in a mouse model. Vaccine 1997, 15:133-139. 10.1016/S0264-410X(96)00166-1, 9066029.
11. Yang X, Buonpane RA, Moza B, Rahman AK, Wang N, Schlievert PM, McCormick JK, Sundberg EJ, Kranz DM. Neutralization of multiple staphylococcal superantigens by a single-chain protein consisting of affinity-matured, variable domain repeats. J Infect Dis 2008, 198:344-348. 10.1086/589776, 2649774, 18522504.
12. Wang S, Li Y, Xiong H, Cao J. A broad-spectrum inhibitory peptide against staphylococcal enterotoxin superantigen SEA, SEB and SEC. Immunol Lett 2008, 121:167-172. 10.1016/j.imlet.2008.10.007, 19028523.
13. Arad G, Levy R, Hillman D, Kaempfer R. Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nat Med 2000, 6:414-421. 10.1038/74672, 10742148.
14. Buonpane RA, Churchill HR, Moza B, Sundberg EJ, Peterson ML, Schlievert PM, Kranz DM. Neutralization of staphylococcal enterotoxin B by soluble, high-affinity receptor antagonists. Nat Med 2007, 13:725-729. 10.1038/nm1584, 17515896.
15. Hamad AR, Herman A, Marrack P, Kappler JW. Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B. J Exp Med 1994, 180:615-621. 10.1084/jem.180.2.615, 2191591, 7519243.
16. Pang LT, Kum WW, Chow AW. Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. Infect Immun 2000, 68:3261-3268. 10.1128/IAI.68.6.3261-3268.2000, 97575, 10816471.
17. LeClaire RD, Hunt RE, Bavari S. Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination. Infect Immun 2002, 70:2278-2281. 10.1128/IAI.70.5.2278-2281.2002, 127924, 11953360.
18. LeClaire RD, Bavari S. Human antibodies to bacterial superantigens and their ability to inhibit T-cell activation and lethality. Antimicrob Agents Chemother 2001, 45:460-463. 10.1128/AAC.45.2.460-463.2001, 90313, 11158741.
19. Tilahun ME, Rajagopalan G, Shah-Mahoney N, Lawlor RG, Tilahun AY, Xie C, Natarajan K, Margulies DH, Ratner DI, Osborne BA, et al. Potent neutralization of staphylococcal enterotoxin B by synergistic action of chimeric antibodies. Infect Immun 2010, 78:2801-2811. 10.1128/IAI.01121-09, 2876561, 20308304.
20. Li J, Sai T, Berger M, Chao Q, Davidson D, Deshmukh G, Drozdowski B, Ebel W, Harley S, Henry M, et al. Human antibodies for immunotherapy development generated via a human B cell hybridoma technology. Proc Natl Acad Sci USA 2006, 103:3557-3562. 10.1073/pnas.0511285103, 1383494, 16505368.
21. Grunow R, Jahn S, Porstmann T, Kiessig SS, Steinkellner H, Steindl F, Mattanovich D, Gurtler L, Deinhardt F, Katinger H, et al. The high efficiency, human B cell immortalizing heteromyeloma CB-F7. Production of human monoclonal antibodies to human immunodeficiency virus. J Immunol Methods 1988, 106:257-265. 10.1016/0022-1759(88)90206-2, 2828478.
22. Ulrich RG, Olson MA, Bavari S. Development of engineered vaccines effective against structurally related bacterial superantigens. Vaccine 1998, 16:1857-1864. 10.1016/S0264-410X(98)00176-5, 9795392.
23. Dinges MM, Orwin PM, Schlievert PM. Exotoxins of Staphylococcus aureus. Clin Microbiol Rev 2000, 13:16-34. table, 10.1128/CMR.13.1.16-34.2000, 88931, 10627489.
24. Proft T, Fraser JD. Bacterial superantigens. Clin Exp Immunol 2003, 133:299-306. 10.1046/j.1365-2249.2003.02203.x, 1808794, 12930353.
25. Swaminathan S, Furey W, Pletcher J, Sax M. Crystal structure of staphylococcal enterotoxin B, a superantigen. Nature 1992, 359:801-806. 10.1038/359801a0, 1436058.
26. Sundstrom M, Abrahmsen L, Antonsson P, Mehindate K, Mourad W, Dohlsten M. The crystal structure of staphylococcal enterotoxin type D reveals Zn2+-mediated homodimerization. EMBO J 1996, 15:6832-6840. 452508, 9003758.
27. Schad EM, Zaitseva I, Zaitsev VN, Dohlsten M, Kalland T, Schlievert PM, Ohlendorf DH, Svensson LA. Crystal structure of the superantigen staphylococcal enterotoxin type A. EMBO J 1995, 14:3292-3301. 394397, 7628431.
28. Bavari S, Ulrich RG, LeClaire RD. Cross-reactive antibodies prevent the lethal effects of Staphylococcus aureus superantigens. J Infect Dis 1999, 180:1365-1369. 10.1086/314977, 10479174.
29. Nishi JI, Kanekura S, Takei S, Kitajima I, Nakajima T, Wahid MR, Masuda K, Yoshinaga M, Maruyama I, Miyata K. B cell epitope mapping of the bacterial superantigen staphylococcal enterotoxin B: the dominant epitope region recognized by intravenous IgG. J Immunol 1997, 158:247-254.
30. Visvanathan K, Charles A, Bannan J, Pugach P, Kashfi K, Zabriskie JB. Inhibition of bacterial superantigens by peptides and antibodies. Infect Immun 2001, 69:875-884. 10.1128/IAI.69.2.875-884.2001, 97965, 11159981.
31. Roy CJ, Warfield KL, Welcher BC, Gonzales RF, Larsen T, Hanson J, David CS, Krakauer T, Bavari S. Human leukocyte antigen-DQ8 transgenic mice: a model to examine the toxicity of aerosolized staphylococcal enterotoxin B. Infect Immun 2005, 73:2452-2460. 10.1128/IAI.73.4.2452-2460.2005, 1087414, 15784591.