Potent Neutralization of Botulinum Neurotoxin/B by Synergistic Action of Antibodies Recognizing Protein and Ganglioside Receptor Binding Domain

PLoS ONE

Volumn 7, Issue 8, 2012, Pages

  Chen, Changchun ^a   Wang, Shuhui ^a   Wang, Huajing ^b,c   Mao, Xiaoyan ^d   Zhang, Tiancheng ^b,c   Ji, Guanghui ^b,c   Shi, Xin ^b,c   Xia, Tian ^b,c   Lu, Weijia ^d   Zhang, Dapeng ^b,c   Dai, Jianxin ^b,c,e   Guo, Yajun ^b,c,e  

^a SHANGHAI JIAO TONG UNIVERSITY   (China)

^b SECOND MILITARY MEDICAL UNIVERSITY   (China)

^c National Engineering Research Center for Antibody Medicine   (China)

^d LANZHOU INSTITUTE OF BIOLOGICAL PRODUCTS   (China)

^e CHINESE PLA GENERAL HOSPITAL   (China)

Author keywords

[No Author keywords available]

Indexed keywords

BOTULINUM TOXIN; BOTULINUM TOXIN A; BOTULINUM TOXIN B; BOTULINUM TOXIN E; BOTULINUM TOXIN F; GANGLIOSIDE; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 8E10; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG POTENCY; DRUG POTENTIATION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME SPECIFICITY; EPITOPE MAPPING; FEMALE; IN VIVO STUDY; MOUSE; NONHUMAN; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN DOMAIN; PROTEIN MOTIF;

AMINO ACID SEQUENCE; ANIMALS; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; ANTIBODY SPECIFICITY; BINDING SITES; BOTULINUM TOXINS; CONSERVED SEQUENCE; EPITOPE MAPPING; FEMALE; MICE; MICE, INBRED BALB C; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CELL SURFACE;

EID: 84865606365     PISSN: None     EISSN: 19326203     Source Type: Journal    
DOI: 10.1371/journal.pone.0043845     Document Type: Article

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