Generation, characterization, and epitope mapping of neutralizing and protective monoclonal antibodies against staphylococcal enterotoxin B-induced lethal shock

Journal of Biological Chemistry

Volumn 286, Issue 11, 2011, Pages 9737-9747

  Varshney, Avanish K ^a   Wang, Xiaobo ^a   Cook, Emily ^a   Dutta, Kaushik ^b   Scharff, Matthew D ^a   Goger, Michael J ^b   Fries, Bettina C ^a  

^a ALBERT EINSTEIN COLLEGE OF MEDICINE   (United States)

^b NEW YORK STRUCTURAL BIOLOGY CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

C TERMINUS; CONFORMATIONAL EPITOPES; ENHANCED SENSITIVITY; EPITOPE MAPPING; IN-VITRO; METHICILLIN; MITOGENIC EFFECTS; MONO-THERAPY; MURINE MODEL; MURINE MONOCLONAL ANTIBODY; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCAL ENTEROTOXIN B; STAPHYLOCOCCUS AUREUS; TRANSGENIC MICE;

CELL PROLIFERATION; ENZYME INHIBITION; MONOCLONAL ANTIBODIES; SURFACE PLASMON RESONANCE;

ANTIGENS;

GAMMA INTERFERON; HLA DR3 ANTIGEN; INTERLEUKIN 2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 14G8; MONOCLONAL ANTIBODY 20B1; MONOCLONAL ANTIBODY 4C7; MONOCLONAL ANTIBODY 6D3; NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS ENTEROTOXIN B; UNCLASSIFIED DRUG;

AMINO ACID SUBSTITUTION; ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIGEN BINDING; ARTICLE; BINDING SITE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DRUG DOSE COMPARISON; DRUG EFFICACY; DRUG SPECIFICITY; EPITOPE MAPPING; IMMUNOGLOBULIN GENE; IMMUNOTHERAPY; LYMPHOCYTE PROLIFERATION; METHICILLIN RESISTANT STAPHYLOCOCCUS AUREUS; MONOTHERAPY; MOUSE; NONHUMAN; PRIORITY JOURNAL; SEPTIC SHOCK; SEQUENCE ANALYSIS; SITE DIRECTED MUTAGENESIS; STAPHYLOCOCCUS AUREUS; STAPHYLOCOCCUS ENTEROTOXIN B INDUCED LETHAL SHOCK; T LYMPHOCYTE;

ANIMALS; ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL, MURINE-DERIVED; ANTIBODIES, NEUTRALIZING; ENTEROTOXINS; EPITOPE MAPPING; HLA-DR3 ANTIGEN; METHICILLIN RESISTANCE; METHICILLIN-RESISTANT STAPHYLOCOCCUS AUREUS; MICE; MICE, INBRED BALB C; MICE, TRANSGENIC; MUTAGENESIS, SITE-DIRECTED; SHOCK;

MURINAE; MUS; MUS MUSCULUS; STAPHYLOCOCCUS AUREUS;

EID: 79953170197     PISSN: 00219258     EISSN: 1083351X     Source Type: Journal    
DOI: 10.1074/jbc.M110.212407     Document Type: Article

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