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Volumn 395, Issue 1-2, 2013, Pages 71-78

Neutralizing monoclonal antibodies against ricin's enzymatic subunit interfere with protein disulfide isomerase-mediated reduction of ricin holotoxin in vitro

Author keywords

Antibody; Intracellular; Neutralization; Toxin

Indexed keywords

IMMUNOGLOBULIN G1; IMMUNOGLOBULIN G2; MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY GD12; MONOCLONAL ANTIBODY R70; MONOCLONAL ANTIBODY SYH7; NEUTRALIZING ANTIBODY; PROTEIN DISULFIDE ISOMERASE; RICIN; UNCLASSIFIED DRUG;

EID: 84881552466     PISSN: 00221759     EISSN: 18727905     Source Type: Journal    
DOI: 10.1016/j.jim.2013.06.004     Document Type: Article
Times cited : (25)

References (36)
  • 4
    • 0022658023 scopus 로고
    • Monoclonal antibodies against ricin: effects on toxin function
    • Colombatti M., Pezzini A., Colombatti A. Monoclonal antibodies against ricin: effects on toxin function. Hybridoma 1986, 5:9.
    • (1986) Hybridoma , vol.5 , pp. 9
    • Colombatti, M.1    Pezzini, A.2    Colombatti, A.3
  • 5
    • 0023664263 scopus 로고
    • The mechanism of action of ricin and related toxins on eukaryotic ribosomes
    • Endo Y., Mitsui K., Motizuki M., Tsurugi K. The mechanism of action of ricin and related toxins on eukaryotic ribosomes. J. Biol. Chem. 1987, 262:5908.
    • (1987) J. Biol. Chem. , vol.262 , pp. 5908
    • Endo, Y.1    Mitsui, K.2    Motizuki, M.3    Tsurugi, K.4
  • 6
    • 77956700490 scopus 로고    scopus 로고
    • Structural and mechanistic insight into how antibodies inhibit serine proteases
    • Ganesan R., Eigenbrot C., Kirchhofer D. Structural and mechanistic insight into how antibodies inhibit serine proteases. Biochem. J. 2010, 430:179.
    • (2010) Biochem. J. , vol.430 , pp. 179
    • Ganesan, R.1    Eigenbrot, C.2    Kirchhofer, D.3
  • 7
    • 34848927255 scopus 로고    scopus 로고
    • Substrate recognition by the protein disulfide isomerases
    • Hatahet F., Ruddock L.W. Substrate recognition by the protein disulfide isomerases. FEBS J. 2007, 274:5223.
    • (2007) FEBS J. , vol.274 , pp. 5223
    • Hatahet, F.1    Ruddock, L.W.2
  • 8
    • 0021143916 scopus 로고
    • Enzymatic reduction-oxidation of protein disulfides by thioredoxin
    • Holmgren A. Enzymatic reduction-oxidation of protein disulfides by thioredoxin. Methods Enzymol. 1984, 107:295.
    • (1984) Methods Enzymol. , vol.107 , pp. 295
    • Holmgren, A.1
  • 9
    • 0028102678 scopus 로고
    • Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo
    • Lemley P.V., Amanatides P., Wright D.C. Identification and characterization of a monoclonal antibody that neutralizes ricin toxicity in vitro and in vivo. Hybridoma 1994, 13:417.
    • (1994) Hybridoma , vol.13 , pp. 417
    • Lemley, P.V.1    Amanatides, P.2    Wright, D.C.3
  • 10
    • 79960813480 scopus 로고    scopus 로고
    • Ricin trafficking in plant and mammalian cells
    • Lord J.M., Spooner R.A. Ricin trafficking in plant and mammalian cells. Toxins (Basel) 2011, 3:787.
    • (2011) Toxins (Basel) , vol.3 , pp. 787
    • Lord, J.M.1    Spooner, R.A.2
  • 11
    • 2442626550 scopus 로고    scopus 로고
    • Immunological characteristics associated with the protective efficacy of antibodies to ricin
    • Maddaloni M., Cooke C., Wilkinson R., Stout A.V., Eng L., Pincus S.H. Immunological characteristics associated with the protective efficacy of antibodies to ricin. J. Immunol. 2004, 172:6221.
    • (2004) J. Immunol. , vol.172 , pp. 6221
    • Maddaloni, M.1    Cooke, C.2    Wilkinson, R.3    Stout, A.V.4    Eng, L.5    Pincus, S.H.6
  • 12
    • 0033554871 scopus 로고    scopus 로고
    • Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story
    • McKee M.L., FitzGerald D.J. Reduction of furin-nicked Pseudomonas exotoxin A: an unfolding story. Biochemistry 1999, 38:16507.
    • (1999) Biochemistry , vol.38 , pp. 16507
    • McKee, M.L.1    FitzGerald, D.J.2
  • 14
    • 73449123743 scopus 로고    scopus 로고
    • A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin
    • Neal L.M., O'Hara J., Brey R.N., Mantis N.J. A monoclonal immunoglobulin G antibody directed against an immunodominant linear epitope on the ricin A chain confers systemic and mucosal immunity to ricin. Infect. Immun. 2010, 78:552.
    • (2010) Infect. Immun. , vol.78 , pp. 552
    • Neal, L.M.1    O'Hara, J.2    Brey, R.N.3    Mantis, N.J.4
  • 16
    • 84857812737 scopus 로고    scopus 로고
    • Immunity to ricin: fundamental insights into toxin-antibody interactions
    • O'Hara J.M., Yermakova A., Mantis N.J. Immunity to ricin: fundamental insights into toxin-antibody interactions. Curr. Top. Microbiol. Immunol. 2012, 357:209.
    • (2012) Curr. Top. Microbiol. Immunol. , vol.357 , pp. 209
    • O'Hara, J.M.1    Yermakova, A.2    Mantis, N.J.3
  • 17
    • 84888275921 scopus 로고    scopus 로고
    • Comparative efficacy in mice of two lead candidate ricin toxin a subunit (RTA) vaccine
    • O'Hara J.M., Brey R.N., Mantis N.J. Comparative efficacy in mice of two lead candidate ricin toxin a subunit (RTA) vaccine. Clin. Vaccine Immunol. 2013, 287:7367-7373.
    • (2013) Clin. Vaccine Immunol. , vol.287 , pp. 7367-7373
    • O'Hara, J.M.1    Brey, R.N.2    Mantis, N.J.3
  • 18
    • 84857746992 scopus 로고    scopus 로고
    • Reductive activation of type 2 ribosome inactivating proteins (RIPs 2) is promoted by transmembrane thioredoxin-related protein (TMX)
    • Pasetto M., Barison E., Castagna M., Della Cristina P., Anselmi C., Colombatti M. Reductive activation of type 2 ribosome inactivating proteins (RIPs 2) is promoted by transmembrane thioredoxin-related protein (TMX). J. Biol. Chem. 2012.
    • (2012) J. Biol. Chem.
    • Pasetto, M.1    Barison, E.2    Castagna, M.3    Della Cristina, P.4    Anselmi, C.5    Colombatti, M.6
  • 20
    • 0030929658 scopus 로고    scopus 로고
    • Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol
    • Rapak A., Falnes P.O., Olsnes S. Retrograde transport of mutant ricin to the endoplasmic reticulum with subsequent translocation to cytosol. Proc. Natl. Acad. Sci. U. S. A. 1997, 94:3783.
    • (1997) Proc. Natl. Acad. Sci. U. S. A. , vol.94 , pp. 3783
    • Rapak, A.1    Falnes, P.O.2    Olsnes, S.3
  • 21
    • 84873527715 scopus 로고    scopus 로고
    • The need for continued development of ricin countermeasures
    • Reisler R.B., Smith L.A. The need for continued development of ricin countermeasures. Adv. Prev. Med. 2012, 2012:149737.
    • (2012) Adv. Prev. Med. , vol.2012 , pp. 149737
    • Reisler, R.B.1    Smith, L.A.2
  • 22
    • 84455167671 scopus 로고    scopus 로고
    • Hot spots for allosteric regulation on protein surfaces
    • Reynolds K.A., McLaughlin R.N., Ranganathan R. Hot spots for allosteric regulation on protein surfaces. Cell 2011, 147:1564.
    • (2011) Cell , vol.147 , pp. 1564
    • Reynolds, K.A.1    McLaughlin, R.N.2    Ranganathan, R.3
  • 23
    • 0023091105 scopus 로고
    • Structure and evolution of ricin B chain
    • Rutenber E., Ready M., Robertus J.D. Structure and evolution of ricin B chain. Nature 1987, 326:624.
    • (1987) Nature , vol.326 , pp. 624
    • Rutenber, E.1    Ready, M.2    Robertus, J.D.3
  • 26
    • 84868584302 scopus 로고    scopus 로고
    • A systematic comparison of free and bound antibodies reveals binding-related conformational changes
    • Sela-Culang I., Alon S., Ofran Y. A systematic comparison of free and bound antibodies reveals binding-related conformational changes. J. Immunol. 2012, 189:4890-4899.
    • (2012) J. Immunol. , vol.189 , pp. 4890-4899
    • Sela-Culang, I.1    Alon, S.2    Ofran, Y.3
  • 27
    • 84857880542 scopus 로고    scopus 로고
    • How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum
    • Spooner R.A., Lord J.M. How ricin and Shiga toxin reach the cytosol of target cells: retrotranslocation from the endoplasmic reticulum. Curr. Top. Microbiol. Immunol. 2012, 357:19.
    • (2012) Curr. Top. Microbiol. Immunol. , vol.357 , pp. 19
    • Spooner, R.A.1    Lord, J.M.2
  • 29
    • 0035937408 scopus 로고    scopus 로고
    • Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin
    • Tsai B., Rodighiero C., Lencer W.I., Rapoport T.A. Protein disulfide isomerase acts as a redox-dependent chaperone to unfold cholera toxin. Cell 2001, 104:937.
    • (2001) Cell , vol.104 , pp. 937
    • Tsai, B.1    Rodighiero, C.2    Lencer, W.I.3    Rapoport, T.A.4
  • 32
    • 84867241458 scopus 로고    scopus 로고
    • A small phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine (RiVax)
    • Vitetta E.S., Smallshaw J.E., Schindler J. A small phase IB clinical trial of an alhydrogel-adsorbed recombinant ricin vaccine (RiVax). Clin. Vaccine Immunol. 2012, 19:1697-1699.
    • (2012) Clin. Vaccine Immunol. , vol.19 , pp. 1697-1699
    • Vitetta, E.S.1    Smallshaw, J.E.2    Schindler, J.3
  • 33
    • 84857620109 scopus 로고    scopus 로고
    • Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry
    • Walczak C.P., Bernardi K.M., Tsai B. Endoplasmic reticulum-dependent redox reactions control endoplasmic reticulum-associated degradation and pathogen entry. Antioxid. Redox Signal. 2012, 16:809.
    • (2012) Antioxid. Redox Signal. , vol.16 , pp. 809
    • Walczak, C.P.1    Bernardi, K.M.2    Tsai, B.3
  • 34
    • 80053636763 scopus 로고    scopus 로고
    • Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB)
    • Yermakova A., Mantis N.J. Protective immunity to ricin toxin conferred by antibodies against the toxin's binding subunit (RTB). Vaccine 2011, 29:7925.
    • (2011) Vaccine , vol.29 , pp. 7925
    • Yermakova, A.1    Mantis, N.J.2
  • 35
    • 84880097159 scopus 로고    scopus 로고
    • Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments
    • (PMID: 23603317, in press)
    • Yermakova A., Mantis N.J. Neutralizing activity and protective immunity to ricin toxin conferred by B subunit (RTB)-specific Fab fragments. Toxicon 2013, (PMID: 23603317, in press). 10.1016/j.toxicon.2013.04.005.
    • (2013) Toxicon
    • Yermakova, A.1    Mantis, N.J.2
  • 36
    • 84866286563 scopus 로고    scopus 로고
    • Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies
    • Yermakova A., Vance D.J., Mantis N.J. Sub-domains of ricin's B subunit as targets of toxin neutralizing and non-neutralizing monoclonal antibodies. PLoS One 2012, 7:e44317.
    • (2012) PLoS One , vol.7
    • Yermakova, A.1    Vance, D.J.2    Mantis, N.J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.