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Volumn 78, Issue 6, 2010, Pages 2801-2811

Potent neutralization of staphylococcal enterotoxin b by synergistic action of chimeric antibodies

Author keywords

[No Author keywords available]

Indexed keywords

CHIMERIC ANTIBODY; CYTOKINE; HLA DR3 ANTIGEN; IMMUNOGLOBULIN G1; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; STAPHYLOCOCCUS ENTEROTOXIN B;

EID: 77952718853     PISSN: 00199567     EISSN: 10985522     Source Type: Journal    
DOI: 10.1128/IAI.01121-09     Document Type: Article
Times cited : (35)

References (54)
  • 1
    • 1542362406 scopus 로고    scopus 로고
    • Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide
    • Arad, G., D. Hillman, R. Levy, and R. Kaempfer. 2004. Broad-spectrum immunity against superantigens is elicited in mice protected from lethal shock by a superantigen antagonist peptide. Immunol. Lett. 91:141-145.
    • (2004) Immunol. Lett. , vol.91 , pp. 141-145
    • Arad, G.1    Hillman, D.2    Levy, R.3    Kaempfer, R.4
  • 2
    • 0034978628 scopus 로고    scopus 로고
    • Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock
    • Arad, G., D. Hillman, R. Levy, and R. Kaempfer. 2001. Superantigen antagonist blocks Th1 cytokine gene induction and lethal shock. J. Leukoc. Biol. 69:921-927.
    • (2001) J. Leukoc. Biol. , vol.69 , pp. 921-927
    • Arad, G.1    Hillman, D.2    Levy, R.3    Kaempfer, R.4
  • 3
    • 0034030865 scopus 로고    scopus 로고
    • Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation
    • Arad, G., R. Levy, D. Hillman, and R. Kaempfer. 2000. Superantigen antagonist protects against lethal shock and defines a new domain for T-cell activation. Nat. Med. 6:414-421.
    • (2000) Nat. Med. , vol.6 , pp. 414-421
    • Arad, G.1    Levy, R.2    Hillman, D.3    Kaempfer, R.4
  • 4
    • 0000706170 scopus 로고
    • Enterotoxins
    • In C S. F. Easom and C. Adlam (ed.), Academic Press, Inc., New York, NY.
    • Bergdoll, M. S. 1983. Enterotoxins, p. 559-598. In C. S. F. Easom and C. Adlam (ed.), Staphylococci and staphylococcal infections. Academic Press, Inc., New York, NY.
    • (1983) Staphylococci and Staphylococcal Infections , pp. 559-598
    • Bergdoll, M.S.1
  • 5
    • 0038690047 scopus 로고    scopus 로고
    • Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity
    • Boles, J. W., M. L. M. Pitt, R. D. LeClaire, P. H. Gibbs, E. Torres, B. Dyas, R. G. Ulrich, and S. Bavari. 2003. Generation of protective immunity by inactivated recombinant staphylococcal enterotoxin B vaccine in nonhuman primates and identification of correlates of immunity. Clin. Immunol. 108:51-59.
    • (2003) Clin. Immunol. , vol.108 , pp. 51-59
    • Boles, J.W.1    Pitt, M.L.M.2    Leclaire, R.D.3    Gibbs, P.H.4    Torres, E.5    Dyas, B.6    Ulrich, R.G.7    Bavari, S.8
  • 6
    • 0037819344 scopus 로고    scopus 로고
    • An overview of the current clinical use of the anti-CD20 monoclonal antibody Rituximab
    • Boye, J., T. Elter, and A. Engert. 2003. An overview of the current clinical use of the anti-CD20 monoclonal antibody Rituximab. Ann. Oncol. 14:520-535.
    • (2003) Ann. Oncol. , vol.14 , pp. 520-535
    • Boye, J.1    Elter, T.2    Engert, A.3
  • 8
    • 33646352962 scopus 로고    scopus 로고
    • Potent antibody therapeutics by design
    • Carter, P. J. 2006. Potent antibody therapeutics by design. Nat. Rev. Immunol. 6:343-357.
    • (2006) Nat. Rev. Immunol. , vol.6 , pp. 343-357
    • Carter, P.J.1
  • 9
    • 0041402681 scopus 로고    scopus 로고
    • Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: A European randomized, double-blind, placebo-controlled trial
    • Darenberg, J., N. Ihendyane, J. Sjölin, E. Aufwerber, S. Haidl, P. Follin, J. Andersson, and A. Norrby-Teglund. 2003. Intravenous immunoglobulin G therapy in streptococcal toxic shock syndrome: a European randomized, double-blind, placebo-controlled trial. Clin. Infect. Dis. 37:333-340.
    • (2003) Clin. Infect. Dis. , vol.37 , pp. 333-340
    • Darenberg, J.1    Ihendyane, N.2    Sjölin, J.3    Aufwerber, E.4    Haidl, S.5    Follin, P.6    Andersson, J.7    Norrby-Teglund, A.8
  • 10
    • 1642319406 scopus 로고    scopus 로고
    • Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: Implications for therapy of toxic shock syndrome
    • Darenberg, J., B. Söderquist, B. Henriques Normark, and A. Norrby-Teglund. 2004. Differences in potency of intravenous polyspecific immunoglobulin G against streptococcal and staphylococcal superantigens: implications for therapy of toxic shock syndrome. Clin. Infect. Dis. 38:836-842.
    • (2004) Clin. Infect. Dis. , vol.38 , pp. 836-842
    • Darenberg, J.1    Söderquist, B.2    Henriques Normark, B.3    Norrby-Teglund, A.4
  • 11
    • 0037097542 scopus 로고    scopus 로고
    • Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: A novel model for superantigen vaccines
    • DaSilva, L., B. C. Welcher, R. G. Ulrich, M. J. Aman, C. S. David, and S. Bavari. 2002. Humanlike immune response of human leukocyte antigen-DR3 transgenic mice to staphylococcal enterotoxins: a novel model for superantigen vaccines. The J. Infect. Dis. 185:1754-1760.
    • (2002) The J. Infect. Dis. , vol.185 , pp. 1754-1760
    • Dasilva, L.1    Welcher, B.C.2    Ulrich, R.G.3    Aman, M.J.4    David, C.S.5    Bavari, S.6
  • 13
    • 0024503250 scopus 로고
    • High-affinity binding of staphylococcal enterotoxins a and B to HLA-DR
    • DOI 10.1038/339221a0
    • Fraser, J. D. 1989. High-affinity binding of staphylococcal enterotoxins A and B to HLA-DR. Nature 339:221-223. (Pubitemid 19126393)
    • (1989) Nature , vol.339 , Issue.6221 , pp. 221-223
    • Fraser, J.D.1
  • 14
    • 52049123299 scopus 로고    scopus 로고
    • The bacterial superantigen and superantigen-like proteins
    • Fraser, J. D., and T. Proft. 2008. The bacterial superantigen and superantigen-like proteins. Immunol. Rev. 225:226-243.
    • (2008) Immunol. Rev. , vol.225 , pp. 226-243
    • Fraser, J.D.1    Proft, T.2
  • 15
    • 0020073392 scopus 로고
    • Bacterial toxins: A table of lethal amounts
    • Gill, D. M. 1982. Bacterial toxins: a table of lethal amounts. Microbiol. Mol. Biol. Rev. 46:86-94.
    • (1982) Microbiol. Mol. Biol. Rev. , vol.46 , pp. 86-94
    • Gill, D.M.1
  • 16
    • 0008106202 scopus 로고
    • A practical guide to making hybridomas
    • B. Swaminathan and G. Prakash (ed.), Marcel-Dekker, New York, NY
    • Goldsby, R. A. 1989. A practical guide to making hybridomas, p. 367. In B. Swaminathan and G. Prakash (ed.), Nucleic acid and monoclonal antibody probes. Marcel-Dekker, New York, NY.
    • (1989) Nucleic Acid and Monoclonal Antibody Probes , pp. 367
    • Goldsby, R.A.1
  • 17
    • 0028332839 scopus 로고
    • Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin
    • Hamad, A., A. Herman, P. Marrack, and J. Kappler. 1994. Monoclonal antibodies defining functional sites on the toxin superantigen staphylococcal enterotoxin B. J. Exp. Med. 180:615-621.
    • (1994) B. J. Exp. Med. , vol.180 , pp. 615-621
    • Hamad, A.1    Herman, A.2    Marrack, P.3    Kappler, J.4
  • 18
    • 0025898690 scopus 로고
    • Superantigens: Mechanism of T-cell stimulation and role in immune responses
    • Herman, A., J. W. Kappler, P. Marrack, and A. M. Pullen. 1991. Superantigens: mechanism of T-cell stimulation and role in immune responses. Annu. Rev. Immunol. 9:745-772.
    • (1991) Annu. Rev. Immunol. , vol.9 , pp. 745-772
    • Herman, A.1    Kappler, J.W.2    Marrack, P.3    Pullen, A.M.4
  • 19
    • 1242272034 scopus 로고    scopus 로고
    • Design of chimeric receptor mimics with different TCR Vβ isoforms: Type-specific inhibition of superantigen pathogenesis
    • Hong-Geller, E., M. Möllhoff, P. R. Shiflett, and G. Gupta. 2004. Design of chimeric receptor mimics with different TCR Vβ isoforms: type-specific inhibition of superantigen pathogenesis. J. Biol. Chem. 279:5676-5684.
    • (2004) J. Biol. Chem. , vol.279 , pp. 5676-5684
    • Hong-Geller, E.1    Möllhoff, M.2    Shiflett, P.R.3    Gupta, G.4
  • 25
    • 0033054709 scopus 로고    scopus 로고
    • Understanding the mechanism of action of bacterial superantigens from a decade of research
    • Lavoie, P. M., J. Thibodeau, F. Erard, and R. P. Sékaly. 1999. Understanding the mechanism of action of bacterial superantigens from a decade of research. Immunol. Rev. 168:257-269.
    • (1999) Immunol. Rev. , vol.168 , pp. 257-269
    • Lavoie, P.M.1    Thibodeau, J.2    Erard, F.3    Sékaly, R.P.4
  • 26
    • 0036117817 scopus 로고    scopus 로고
    • Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination
    • LeClaire, R. D., R. E. Hunt, and S. Bavari. 2002. Protection against bacterial superantigen staphylococcal enterotoxin B by passive vaccination. Infect. Immun. 70:2278-2281.
    • (2002) Infect. Immun. , vol.70 , pp. 2278-2281
    • Leclaire, R.D.1    Hunt, R.E.2    Bavari, S.3
  • 28
    • 0033008083 scopus 로고    scopus 로고
    • The structural basis of T-cell activation by superantigens
    • Li, H., A. Llera, E. L. Malchiodi, and R. A. Mariuzza. 1999. The structural basis of T-cell activation by superantigens. Annu. Rev. Immunol. 17:435-466.
    • (1999) Annu. Rev. Immunol. , vol.17 , pp. 435-466
    • Li, H.1    Llera, A.2    Malchiodi, E.L.3    Mariuzza, R.A.4
  • 29
    • 10244230866 scopus 로고    scopus 로고
    • Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines
    • Lowell, G., C. Colleton, D. Frost, R. Kaminski, M. Hughes, J. Hatch, C. Hooper, J. Estep, L. Pitt, M. Topper, R. Hunt, W. Baker, and W. Baze. 1996. Immunogenicity and efficacy against lethal aerosol staphylococcal enterotoxin B challenge in monkeys by intramuscular and respiratory delivery of proteosome-toxoid vaccines. Infect. Immun. 64:4686-4693.
    • (1996) Infect. Immun. , vol.64 , pp. 4686-4693
    • Lowell, G.1    Colleton, C.2    Frost, D.3    Kaminski, R.4    Hughes, M.5    Hatch, J.6    Hooper, C.7    Estep, J.8    Pitt, L.9    Topper, M.10    Hunt, R.11    Baker, W.12    Baze, W.13
  • 30
    • 0029935619 scopus 로고    scopus 로고
    • Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: Immunogenicity and efficacy against lethal SEB intoxication in mice
    • Lowell, G., R. Kaminski, S. Grate, R. Hunt, C. Charney, S. Zimmer, and C. Colleton. 1996. Intranasal and intramuscular proteosome-staphylococcal enterotoxin B (SEB) toxoid vaccines: immunogenicity and efficacy against lethal SEB intoxication in mice. Infect. Immun. 64:1706-1713.
    • (1996) Infect. Immun. , vol.64 , pp. 1706-1713
    • Lowell, G.1    Kaminski, R.2    Grate, S.3    Hunt, R.4    Charney, C.5    Zimmer, S.6    Colleton, C.7
  • 31
    • 0033524159 scopus 로고    scopus 로고
    • Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: A randomised phase III trial
    • Maini, R., E. W. St. Clair, F. Breedveld, D. Furst, J. Kalden, M. Weisman, J. Smolen, P. Emery, G. Harriman, M. Feldmann, and P. Lipsky. 1999. Infliximab (chimeric anti-tumour necrosis factor alpha monoclonal antibody) versus placebo in rheumatoid arthritis patients receiving concomitant methotrexate: a randomised phase III trial. Lancet 354:1932-1939.
    • (1999) Lancet , vol.354 , pp. 1932-1939
    • Maini, R.1    St Clair, E.W.2    Breedveld, F.3    Furst, D.4    Kalden, J.5    Weisman, M.6    Smolen, J.7    Emery, P.8    Harriman, G.9    Feldmann, M.10    Lipsky, P.11
  • 32
    • 0025070203 scopus 로고
    • The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells
    • Marrack, P., M. Blackman, E. Kushnir, and J. Kappler. 1990. The toxicity of staphylococcal enterotoxin B in mice is mediated by T cells. J. Exp. Med. 171:455-464.
    • (1990) J. Exp. Med. , vol.171 , pp. 455-464
    • Marrack, P.1    Blackman, M.2    Kushnir, E.3    Kappler, J.4
  • 33
    • 37049178741 scopus 로고
    • The staphylococcal enterotoxins and their relatives
    • Marrack, P., and J. Kappler. 1990. The staphylococcal enterotoxins and their relatives. Science 248:705-711.
    • (1990) Science , vol.248 , pp. 705-711
    • Marrack, P.1    Kappler, J.2
  • 35
    • 0026596020 scopus 로고
    • T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B critical role of tumor necrosis factor
    • Miethke, T., C. Wahl, K. Heeg, B. Echtenacher, P. Krammer, and H. Wagner. 1992. T cell-mediated lethal shock triggered in mice by the superantigen staphylococcal enterotoxin B: critical role of tumor necrosis factor. J. exp. Med. 175:91-98.
    • (1992) J. Exp. Med. , vol.175 , pp. 91-98
    • Miethke, T.1    Wahl, C.2    Heeg, K.3    Echtenacher, B.4    Krammer, P.5    Wagner, H.6
  • 36
    • 11244265812 scopus 로고    scopus 로고
    • Modeling of receptor mimics that inhibit superantigen pathogenesis
    • Möllhoff, M., H. B. V. Zanden, P. R. Shiflett, and G. Gupta,. 2005. Modeling of receptor mimics that inhibit superantigen pathogenesis. J. Mol. Recog. 18:73-83.
    • (2005) J. Mol. Recog. , vol.18 , pp. 73-83
    • Möllhoff, M.1    Zanden, H.B.V.2    Shiflett, P.R.3    Gupta, G.4
  • 37
    • 0031968581 scopus 로고    scopus 로고
    • Varying titers of neutralizing antibodies to streptococcal super-antigens in different preparations of normal polyspecific immunoglobulin G: Implications for therapeutic efficacy
    • Norrby-Teglund, A., H. Basma, J. Andersson, M. Allison, D. E. Low, and M. Kotb. 1998. Varying titers of neutralizing antibodies to streptococcal super-antigens in different preparations of normal polyspecific immunoglobulin G: implications for therapeutic efficacy. Clin. Infect. Dis. 26:631-638.
    • (1998) Clin. Infect. Dis. , vol.26 , pp. 631-638
    • Norrby-Teglund, A.1    Basma, H.2    Andersson, J.3    Allison, M.4    Low, D.E.5    Kotb, M.6
  • 38
    • 0030584899 scopus 로고    scopus 로고
    • Plasma from patients with severe invasive group a streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T cell proliferation and cytokine production
    • Norrby-Teglund, A., R. Kaul, D. Low, A. McGeer, D. Newton, J. Andersson, U. Andersson, and M. Kotb. 1996. Plasma from patients with severe invasive group A streptococcal infections treated with normal polyspecific IgG inhibits streptococcal superantigen-induced T-cell proliferation and cytokine production. J. Immunol. 156:3057-3064. (Pubitemid 126660657)
    • (1996) Journal of Immunology , vol.156 , Issue.8 , pp. 3057-3064
    • Norrby-Teglund, A.1    Kaul, R.2    Low, D.E.3    McGeer, A.4    Newton, D.W.5    Andersson, J.6    Andersson, U.7    Kotb, M.8
  • 39
    • 0034034354 scopus 로고    scopus 로고
    • Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody
    • Pang, L. T. Y., W. W. S. Kum, and A. W. Chow. 2000. Inhibition of staphylococcal enterotoxin B-induced lymphocyte proliferation and tumor necrosis factor alpha secretion by MAb5, an anti-toxic shock syndrome toxin 1 monoclonal antibody. Infect. Immun. 68:3261-3268.
    • (2000) Infect. Immun. , vol.68 , pp. 3261-3268
    • Pang, L.T.Y.1    Kum, W.W.S.2    Chow, A.W.3
  • 40
    • 0031038715 scopus 로고    scopus 로고
    • An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries
    • DOI 10.1016/S0378-1119(96)00628-2, PII S0378111996006282
    • Persic, L., A. Roberts, J. Wilton, A. Cattaneo, A. Bradbury, and H. R. Hoogenboom. 1997. An integrated vector system for the eukaryotic expression of antibodies or their fragments after selection from phage display libraries. Gene 187:9-18. (Pubitemid 27110429)
    • (1997) Gene , vol.187 , Issue.1 , pp. 9-18
    • Persic, L.1    Roberts, A.2    Wilton, J.3    Cattaneo, A.4    Bradbury, A.5    Hoogenboom, H.R.6
  • 41
    • 1842633622 scopus 로고    scopus 로고
    • Interplay between super-antigens and immunoreceptors
    • Petersson, K., G. Forsberg, and B. Walse. 2004. Interplay between super-antigens and immunoreceptors. Scand. J. Immunol. 59:345-355.
    • (2004) Scand. J. Immunol. , vol.59 , pp. 345-355
    • Petersson, K.1    Forsberg, G.2    Walse, B.3
  • 43
    • 31844432403 scopus 로고    scopus 로고
    • Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice
    • Rajagopalan, G., K. Iijima, M. Singh, H. Kita, R. Patel, and C. S. David. 2006. Intranasal exposure to bacterial superantigens induces airway inflammation in HLA class II transgenic mice. Infect. Immun. 74:1284-1296.
    • (2006) Infect. Immun. , vol.74 , pp. 1284-1296
    • Rajagopalan, G.1    Iijima, K.2    Singh, M.3    Kita, H.4    Patel, R.5    David, C.S.6
  • 44
    • 7044286500 scopus 로고    scopus 로고
    • In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists
    • Rajagopalan, G., M. M. Sen, and C. S. David. 2004. In vitro and in vivo evaluation of staphylococcal superantigen peptide antagonists. Infect. Immun. 72:6733-6737.
    • (2004) Infect. Immun. , vol.72 , pp. 6733-6737
    • Rajagopalan, G.1    Sen, M.M.2    David, C.S.3
  • 47
    • 0027394682 scopus 로고
    • Role of superantigens in human disease
    • Schlievert, P. M. 1993. Role of superantigens in human disease. J. Infect. Dis. 167:997-1002.
    • (1993) J. Infect. Dis. , vol.167 , pp. 997-1002
    • Schlievert, P.M.1
  • 48
    • 33748288117 scopus 로고    scopus 로고
    • Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: Implications for treatment of streptococcal toxic shock syndrome
    • Schrage, B., G. Duan, L. P. Yang, J. D. Fraser, and T. Proft. 2006. Different preparations of intravenous immunoglobulin vary in their efficacy to neutralize streptococcal superantigens: implications for treatment of streptococcal toxic shock syndrome. Clin. Infect. Dis. 43:743-746.
    • (2006) Clin. Infect. Dis. , vol.43 , pp. 743-746
    • Schrage, B.1    Duan, G.2    Yang, L.P.3    Fraser, J.D.4    Proft, T.5
  • 49
    • 33748057490 scopus 로고    scopus 로고
    • Human intravenous immunoglobulin for experimental streptococcal toxic shock: Bacterial clearance and modulation of inflammation
    • Sriskandan, S., M. Ferguson, V. Elliot, L. Faulkner, and J. Cohen. 2006. Human intravenous immunoglobulin for experimental streptococcal toxic shock: bacterial clearance and modulation of inflammation. J. Antimicrob. Chemother. 58:117-124.
    • (2006) J. Antimicrob. Chemother. , vol.58 , pp. 117-124
    • Sriskandan, S.1    Ferguson, M.2    Elliot, V.3    Faulkner, L.4    Cohen, J.5
  • 50
    • 0032776148 scopus 로고    scopus 로고
    • HLA class II transgenic mice as models of human diseases
    • Taneja, V., and C. S. David. 1999. HLA class II transgenic mice as models of human diseases. Immunol. Rev. 169:67-79.
    • (1999) Immunol. Rev. , vol.169 , pp. 67-79
    • Taneja, V.1    David, C.S.2
  • 51
    • 0035554680 scopus 로고    scopus 로고
    • Lessons from animal models for human autoimmune diseases
    • Taneja, V., and C. S. David. 2001. Lessons from animal models for human autoimmune diseases. Nat. Immunol. 2:781-784.
    • (2001) Nat. Immunol. , vol.2 , pp. 781-784
    • Taneja, V.1    David, C.S.2
  • 52
    • 0032211007 scopus 로고    scopus 로고
    • Development of engineered vaccines effective against structurally related bacterial superantigens
    • Ulrich, R. G., M. A. Olson, and S. Bavari. 1998. Development of engineered vaccines effective against structurally related bacterial superantigens. Vaccine 16:1857-1864.
    • (1998) Vaccine , vol.16 , pp. 1857-1864
    • Ulrich, R.G.1    Olson, M.A.2    Bavari, S.3
  • 54
    • 0033958471 scopus 로고    scopus 로고
    • Universal PCR amplification of mouse immunoglobulin gene variable regions: The design of degenerate primers and an assessment of the effect of DNA polymerase 3' to 5' exonuclease activity
    • DOI 10.1016/S0022-1759(99)00184-2, PII S0022175999001842
    • Wang, Z., M. Raifu, M. Howard, L. Smith, D. Hansen, R. Goldsby, and D. Ratner. 2000. Universal PCR amplification of mouse immunoglobulin gene variable regions: the design of degenerate primers and an assessment of the effect of DNA polymerase 3 to 5 exonuclease activity. J. Immunol. Methods 233:167-177. (Pubitemid 30058245)
    • (2000) Journal of Immunological Methods , vol.233 , Issue.1-2 , pp. 167-177
    • Wang, Z.1    Raifu, M.2    Howard, M.3    Smith, L.4    Hansen, D.5    Goldsby, R.6    Ratner, D.7


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