Intracellular neutralization of Shiga toxin 2 by an A subunit-specific human monoclonal antibody

Infection and Immunity

Volumn 76, Issue 5, 2008, Pages 1931-1939

  Krautz Peterson, Greice ^a   Chapman Bonofiglio, Susan ^a   Boisvert, Karen ^b   Feng, Hanping ^a   Herman, Ira M ^c   Tzipori, Saul ^a   Sheoran, Abhineet S ^a  

^a TUFTS UNIVERSITY   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c TUFTS UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HUMAN MONOCLONAL ANTIBODY; MONOCLONAL ANTIBODY 5C12; MONOCLONAL ANTIBODY 5H8; NEUTRALIZING ANTIBODY; VEROTOXIN 2; BACTERIUM ANTIBODY; MONOCLONAL ANTIBODY;

ANTIBODY SPECIFICITY; ARTICLE; CELL MEMBRANE; CELL SURFACE; CELL TRANSPORT; CONTROLLED STUDY; CYTOSOL; CYTOTOXICITY; DRUG EFFICACY; DRUG MECHANISM; DRUG TRANSPORT; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOME; EXTRACELLULAR SPACE; FEMALE; GOLGI COMPLEX; HELA CELL; HUMAN; HUMAN CELL; IN VITRO STUDY; PRIORITY JOURNAL; PROTEIN LOCALIZATION; RECEPTOR BINDING; CHEMISTRY; CONFOCAL MICROSCOPY; DRUG ANTAGONISM; FLUORESCENCE MICROSCOPY; IMMUNOLOGY; PROTEIN BINDING; SERODIAGNOSIS;

ANTIBODIES, BACTERIAL; ANTIBODIES, MONOCLONAL; CELL MEMBRANE; CYTOSOL; ENDOCYTOSIS; ENDOPLASMIC RETICULUM; ENDOSOMES; GOLGI APPARATUS; HELA CELLS; HUMANS; MICROSCOPY, CONFOCAL; MICROSCOPY, FLUORESCENCE; NEUTRALIZATION TESTS; PROTEIN BINDING; SHIGA TOXIN 2;

EID: 42949178089     PISSN: 00199567     EISSN: None     Source Type: Journal    
DOI: 10.1128/IAI.01282-07     Document Type: Article

References (34)

1. Baravalle, G., D. Schober, M. Huber, N. Bayer, R. F. Murphy, and R. Fuchs. 2005. Transferrin recycling and dextran transport to lysosomes is differentially affected by bafilomycin, nocodazole, and low temperature. Cell Tissue Res. 320:99-113.
2. Boerlin, P., S. A. McEwen, F. Boerlin-Petzold, J. B. Wilson, R. P. Johnson, and C. L. Gyles. 1999. Associations between virulence factors of Shiga toxin-producing Escherichia coli and disease in humans. J. Clin. Microbiol. 37:497-503.
3. Bomsel, M., M. Heyman, H. Hocini, S. Lagaye, L. Belec, C. Dupont, and C. Desgranges. 1998. Intracellular neutralization of HIV transcytosis across tight epithelial barriers by anti-HIV envelope protein dIgA or IgM. Immunity 9:277-287.
4. Burns, J. W., M. Siadat-Pajouh, A. A. Krishnaney, and H. B. Greenberg. 1996. Protective effect of rotavirus VP6-specific IgA monoclonal antibodies that lack neutralizing activity. Science 272:104-107.
5. Donohue-Rolfe, A., D. W. Acheson, A. V. Kane, and G. T. Keusch. 1989. Purification of Shiga toxin and Shiga-like toxins I and II by receptor analog affinity chromatography with immobilized P1 glycoprotein and production of cross-reactive monoclonal antibodies. Infect. Immun. 57:3888-3893.
6. Edelson, B. T., and E. R. Unanue. 2001. Intracellular antibody neutralizes Listeria growth. Immunity 14:503-512.
7. Endo, Y., K. Tsurugi, T. Yutsudo, Y. Takeda, T. Ogasawara, and K. Igarashi. 1988. Site of action of a Vero toxin (VT2) from Escherichia coli O157:H7 and of Shiga toxin on eukaiyotic ribosomes. RNA N-glycosidase activity of the toxins. Eur. J. Biochem. 171:45-50.
8. Falguieres, T., F. Mallard, C. Baron, D. Hanau, C. Lingwood, B. Goud, J. Salamero, and L. Johannes. 2001. Targeting of Shiga toxin B-subunit to retrograde transport route in association with detergent-resistant membranes. Mol. Biol. Cell 12:2453-2468.
9. Fraser, M. E., M. Fujinaga, M. M. Cherney, A. R. Melton-Celsa, E. M. Twiddy, A. D. O'Brien, and M. N. James. 2004. Structure of Shiga toxin type 2 (Stx2) from Escherichia coli O157:H7. J. Biol. Chem. 279:27511-27517.
10. Friedrich, A. W., M. Bielaszewska, W. L. Zhang, M. Pulz, T. Kuczius, A. Ammon, and H. Karch. 2002. Escherichia coli harboring Shiga toxin 2 gene variants: frequency and association with clinical symptoms. J. Infect. Dis. 185:74-84.
11. Griffin, P. M., and R. V. Tauxe. 1991. The epidemiology of infections caused by Escherichia coli O157:H7, other enterohemorrhagic E. coli, and the associated hemolytic-uremic syndrome. Epidemiol. Rev. 13:60-98.
12. Johannes, L., D. Tenza, C. Antony, and B. Goud. 1997. Retrograde transport of KDEL-bearing B-fragment of Shiga toxin. J. Biol. Chem. 272:19554-19561.
13. Keusch, G. T., M. Jacewicz, and S. Z. Hirschman. 1972. Quantitative microassay in cell culture for enterotoxin of Shigella dysenteriae. J. Infect. Dis. 125:539-541.
14. Lee, D. W., X. Zhao, S. Scarselletta, P. J. Schweinsberg, E. Eisenberg, B. D. Grant, and L. E. Greene. 2005. ATP binding regulates oligomerization and endosome association of RME-1 family proteins. J. Biol. Chem. 280:17213-17220.
15. Lencer, W. I., and R. S. Blumberg. 2005. A passionate kiss, then run: exostosis and recycling of IgG by FcRn. Trends Cell Biol. 15:5-9.
16. Lingwood, C. A. 1996. Role of verotoxin receptors in pathogenesis. Trends Microbiol. 4:147-153.
17. Mallard, F., C. Antony, D. Tenza, J. Salamero, B. Goud, and L. Johannes. 1998. Direct pathway from early/recycling endosomes to the Golgi apparatus revealed through the study of Shiga toxin B-fragment transport. J. Cell Biol. 143:973-990.
18. Maxfield, F. R., and T. E. McGraw. 2004. Endocytic recycling. Nat. Rev. Mol. Cell. Biol. 5:121-132.
19. Mazanec, M. B., C. L. Coudret, and D. R. Fletcher. 1995. Intracellular neutralization of influenza virus by immunoglobulin A anti-hemagglutinin monoclonal antibodies. J. Virol. 69:1339-1343.
20. Mazanec, M. B., C. S. Kaetzel, M. E. Lamm, D. Fletcher, J. Peterra, and J. G. Nedrud. 1995. Intracellular neutralization of Sendai and influenza viruses by IgA monoclonal antibodies. Adv. Exp. Med. Biol. 371A:651-654.
21. Milford, D. V., C. M. Taylor, B. Guttridge, S. M. Hall, B. Rowe, and H. Kleanthous. 1990. Haemolytic uraemic syndromes in the British Isles 1985-8: association with verocytotoxin producing Escherichia coli. 1. Clinical and epidemiological aspects. Arch. Dis. Child. 65:716-721.
22. Mukherjee, J., K. Chios, D. Fishwild, D. Hudson, S. O'Donnell, S. M. Rich, A. Donohue-Rolfe, and S. Tzipori. 2002. Human Stx2-specific monoclonal antibodies prevent systemic complications of Escherichia coli O157:H7 infection. Infect. Immun. 70:612-619.
23. Mukherjee, J., K. Chios, D. Fishwild, D. Hudson, S. O'Donnell, S. M. Rich, A. Donohue-Rolfe, and S. Tzipori. 2002. Production and characterization of protective human antibodies against Shiga toxin 1. Infect. Immun. 70:5896-5899.
24. Natarajan, R., and A. D. Linstedt. 2004. A cycling cis-Golgi protein mediates endosome-to-Golgi traffic. Mol. Biol. Cell 15:4798-4806.
25. Ostroff, S. M., P. I. Tarr, M. A. Neill, J. H. Lewis, N. Hargrett-Bean, and J. M. Kobayashi. 1989. Toxin genotypes and plasmid profiles as determinants of systemic sequelae in Escherichia coli O157:H7 infections. J. Infect. Dis. 160:994-998.
26. Picciano, J. A., N. Ameen, B. D. Grant, and N. A. Bradbury. 2003. Rme-1 regulates the recycling of the cystic fibrosis transmembrane conductance regulator. Am. J. Physiol. Cell Physiol. 285:C1009-C1018.
27. Russmann, H., H. Schmidt, J. Heesemann, A. Caprioli, and H. Karch. 1994. Variants of Shiga-like toxin II constitute a major toxin component in Escherichia coli O157 strains from patients with haemolytic uraemic syndrome. J. Med. Microbiol. 40:338-343.
28. Sandvig, K., and B. van Deurs. 1996. Endocytosis, intracellular transport, and cytotoxic action of Shiga toxin and ricin. Physiol. Rev. 76:949-966.
29. Sekino, T., N. Kiyokawa, T. Taguchi, K. Ohmi, H. Nakajima, T. Suzuki, S. Furukawa, H. Nakao, T. Takeda, and J. Fujimoto. 2002. Inhibition of Shiga toxin cytotoxicity in human renal cortical epithelial cells by nitrobenzylthioinosine. J. Infect. Dis. 185:785-796.
30. Sheoran, A. S., S. Chapman-Bonofiglio, B. R. Harvey, J. Mukherjee, G. Georgiou, A. Donohue-Rolfe, and S. Tzipori. 2005. Human antibody against Shiga toxin 2 administered to piglets after the onset of diarrhea due to Escherichia coli O157:H7 prevents fatal systemic complications. Infect. Immun. 73:4607-4613.
31. Sheoran, A. S., S. Chapman, P. Singh, A. Donohue-Rolfe, and S. Tzipori. 2003. Stx2-specific human monoclonal antibodies protect mice against lethal infection with Escherichia coli expressing Stx2 variants. Infect. Immun. 71:3125-3130.
32. Tzipori, S., A. Sheoran, D. Akiyoshi, A. Donohue-Rolfe, and H. Trachtman. 2004. Antibody therapy in the management of Shiga toxin-induced hemolytic-uremic syndrome. Clin. Microbiol. Rev. 17:926-941, table of contents.
33. Virgin, H. W. t., M. A. Mann, and K. L. Tyler. 1994. Protective antibodies inhibit reovirus internalization and uncoating by intracellular proteases. J. Virol. 68:6719-6729.
34. Zhu, X., G. Meng, B. L. Dickinson, X. Li, E. Mizoguchi, L. Miao, Y. Wang, C. Robert, B. Wu, P. D. Smith, W. I. Lencer, and R. S. Blumberg. 2001. MHC class I-related neonatal Fc receptor for IgG is functionally expressed in monocytes, intestinal macrophages, and dendritic cells. J. Immunol. 166:3266-3276.