Unique ligand binding sites on CXCR4 probed by a chemical biology approach: Implications for the design of selective human immunodeficiency virus type 1 inhibitors

Journal of Virology

Volumn 79, Issue 24, 2005, Pages 15398-15404

  Choi, Won Tak ^a   Tian, Shaomin ^a   Dong, Chang Zhi ^a   Kumar, Santosh ^a   Liu, Dongxiang ^a   Madani, Navid ^b   An, Jing ^a,c   Sodroski, Joseph G ^b   Huang, Ziwei ^a,d  

^a UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^b HARVARD MEDICAL SCHOOL   (United States)

^c Chemokine Pharmaceutical Inc   (United States)

^d BURNHAM INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ANTI HUMAN IMMUNODEFICIENCY VIRUS AGENT; CHEMOKINE; CHEMOKINE RECEPTOR CXCR4; CHEMOKINE RECEPTOR CXCR4 ANTAGONIST; DEXTRO AMINO ACID; GLYCOPROTEIN GP 120; MACROPHAGE INFLAMMATORY PROTEIN 2; STROMAL CELL DERIVED FACTOR 1ALPHA; SYNTHETICALLY AND MODULARLY MODIFIED CHEMOKINE; UNCLASSIFIED DRUG; VIRUS PROTEIN;

AMINO ACID SUBSTITUTION; ARTICLE; BINDING AFFINITY; BINDING SITE; CONTROLLED STUDY; DRUG TARGETING; HUMAN; HUMAN CELL; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; PRIORITY JOURNAL; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; VIRUS CELL INTERACTION; VIRUS INHIBITION;

ANTI-HIV AGENTS; BINDING SITES; CELL LINE; CHEMOKINES, CXC; HIV-1; HUMANS; LIGANDS; PROTEIN BINDING; RECEPTORS, CXCR4; STROMAL CELLS; VIRUS REPLICATION;

HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1;

EID: 29744432220     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.79.24.15398-15404.2005     Document Type: Article

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