-
1
-
-
85027927015
-
Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists
-
Wu, B.; Chien, E. Y.; Mol, C. D.; Fenalti, G.; Liu, W.; Katritch, V.; Abagyan, R.; Brooun, A.; Wells, P.; Bi, F. C.; Hamel, D. J.; Kuhn, P.; Handel, T. M.; Cherezov, V.; Stevens, R. C. Structures of the CXCR4 chemokine GPCR with small-molecule and cyclic peptide antagonists Science 2010, 330 (6007) 1066-1071
-
(2010)
Science
, vol.330
, Issue.6007
, pp. 1066-1071
-
-
Wu, B.1
Chien, E.Y.2
Mol, C.D.3
Fenalti, G.4
Liu, W.5
Katritch, V.6
Abagyan, R.7
Brooun, A.8
Wells, P.9
Bi, F.C.10
Hamel, D.J.11
Kuhn, P.12
Handel, T.M.13
Cherezov, V.14
Stevens, R.C.15
-
2
-
-
0031891516
-
AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co- receptor
-
DOI 10.1038/nm0198-072
-
Donzella, G. A.; Schols, D.; Lin, S. W.; Este, J. A.; Nagashima, K. A.; Maddon, P. J.; Allaway, G. P.; Sakmar, T. P.; Henson, G.; De Clercq, E.; Moore, J. P. AMD3100, a small molecule inhibitor of HIV-1 entry via the CXCR4 co-receptor Nat. Med. 1998, 4 (1) 72-77 (Pubitemid 28133082)
-
(1998)
Nature Medicine
, vol.4
, Issue.1
, pp. 72-77
-
-
Donzella, G.A.1
Schols, D.2
Lin, S.W.3
Este, J.A.4
Nagashima, K.A.5
Maddon, P.J.6
Allaway, G.P.7
Sakmar, T.P.8
Henson, G.9
De Clercq, E.10
Moore, J.P.11
-
3
-
-
0030835663
-
Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor Fusin/CXCR-4
-
DOI 10.1016/S0166-3542(97)00025-9, PII S0166354297000259
-
Schols, D.; Este, J. A.; Henson, G.; De Clercq, E. Bicyclams, a class of potent anti-HIV agents, are targeted at the HIV coreceptor fusin/CXCR-4 Antiviral Res. 1997, 35 (3) 147-156 (Pubitemid 27351415)
-
(1997)
Antiviral Research
, vol.35
, Issue.3
, pp. 147-156
-
-
Schols, D.1
Este, J.A.2
Henson, G.3
De Clercq, E.4
-
4
-
-
0042668582
-
Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1
-
DOI 10.1016/S0042-6822(03)00185-5
-
Zhou, N.; Fang, J.; Acheampong, E.; Mukhtar, M.; Pomerantz, R. J. Binding of ALX40-4C to APJ, a CNS-based receptor, inhibits its utilization as a co-receptor by HIV-1 Virology 2003, 312 (1) 196-203 (Pubitemid 36918471)
-
(2003)
Virology
, vol.312
, Issue.1
, pp. 196-203
-
-
Zhou, N.1
Fang, J.2
Acheampong, E.3
Mukhtar, M.4
Pomerantz, R.J.5
-
5
-
-
33750527761
-
Discovery of novel, highly potent and selective β-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles
-
DOI 10.1016/j.bmc.2006.09.003, PII S0968089606007218
-
DeMarco, S. J.; Henze, H.; Lederer, A.; Moehle, K.; Mukherjee, R.; Romagnoli, B.; Robinson, J. A.; Brianza, F.; Gombert, F. O.; Lociuro, S.; Ludin, C.; Vrijbloed, J. W.; Zumbrunn, J.; Obrecht, J. P.; Obrecht, D.; Brondani, V.; Hamy, F.; Klimkait, T. Discovery of novel, highly potent and selective beta-hairpin mimetic CXCR4 inhibitors with excellent anti-HIV activity and pharmacokinetic profiles Bioorg. Med. Chem. 2006, 14 (24) 8396-8404 (Pubitemid 44667545)
-
(2006)
Bioorganic and Medicinal Chemistry
, vol.14
, Issue.24
, pp. 8396-8404
-
-
DeMarco, S.J.1
Henze, H.2
Lederer, A.3
Moehle, K.4
Mukherjee, R.5
Romagnoli, B.6
Robinson, J.A.7
Brianza, F.8
Gombert, F.O.9
Lociuro, S.10
Ludin, C.11
Vrijbloed, J.W.12
Zumbrunn, J.13
Obrecht, J.-P.14
Obrecht, D.15
Brondani, V.16
Hamy, F.17
Klimkait, T.18
-
6
-
-
0037388121
-
A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity
-
DOI 10.1073/pnas.0630420100
-
Ichiyama, K.; Yokoyama-Kumakura, S.; Tanaka, Y.; Tanaka, R.; Hirose, K.; Bannai, K.; Edamatsu, T.; Yanaka, M.; Niitani, Y.; Miyano-Kurosaki, N.; Takaku, H.; Koyanagi, Y.; Yamamoto, N. A duodenally absorbable CXC chemokine receptor 4 antagonist, KRH-1636, exhibits a potent and selective anti-HIV-1 activity Proc. Natl. Acad. Sci. U.S.A. 2003, 100 (7) 4185-4190 (Pubitemid 36418178)
-
(2003)
Proceedings of the National Academy of Sciences of the United States of America
, vol.100
, Issue.7
, pp. 4185-4190
-
-
Ichiyama, K.1
Yokoyama-Kumakura, S.2
Tanaka, Y.3
Tanaka, R.4
Hirose, K.5
Bannai, K.6
Edamatsu, T.7
Yanaka, M.8
Niitani, Y.9
Miyano-Kurosaki, N.10
Takaku, H.11
Koyanagi, Y.12
Yamamoto, N.13
-
7
-
-
0032990719
-
Enhanced inhibition of human immunodeficiency virus type 1 by Met- stromal-derived factor 1β correlates with down-modulation of CXCR4
-
Yang, O. O.; Swanberg, S. L.; Lu, Z.; Dziejman, M.; McCoy, J.; Luster, A. D.; Walker, B. D.; Herrmann, S. H. Enhanced inhibition of human immunodeficiency virus type 1 by Met-stromal-derived factor 1beta correlates with down-modulation of CXCR4 J. Virol. 1999, 73 (6) 4582-4589 (Pubitemid 29246716)
-
(1999)
Journal of Virology
, vol.73
, Issue.6
, pp. 4582-4589
-
-
Yang, O.O.1
Swanberg, S.L.2
Lu, Z.3
Dziejman, M.4
McCoy, J.5
Luster, A.D.6
Walker, B.D.7
Herrmann, S.H.8
-
8
-
-
0142102523
-
T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer
-
DOI 10.1016/S0014-5793(03)00824-X
-
Tamamura, H.; Hori, A.; Kanzaki, N.; Hiramatsu, K.; Mizumoto, M.; Nakashima, H.; Yamamoto, N.; Otaka, A.; Fujii, N. T140 analogs as CXCR4 antagonists identified as anti-metastatic agents in the treatment of breast cancer FEBS Lett. 2003, 550 (1-3) 79-83 (Pubitemid 37281361)
-
(2003)
FEBS Letters
, vol.550
, Issue.1-3
, pp. 79-83
-
-
Tamamura, H.1
Hori, A.2
Kanzaki, N.3
Hiramatsu, K.4
Mizumoto, M.5
Nakashima, H.6
Yamamoto, N.7
Otaka, A.8
Fujii, N.9
-
9
-
-
0035939252
-
Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140
-
DOI 10.1016/S0960-894X(01)00323-7, PII S0960894X01003237
-
Tamamura, H.; Omagari, A.; Hiramatsu, K.; Gotoh, K.; Kanamoto, T.; Xu, Y.; Kodama, E.; Matsuoka, M.; Hattori, T.; Yamamoto, N.; Nakashima, H.; Otaka, A.; Fujii, N. Development of specific CXCR4 inhibitors possessing high selectivity indexes as well as complete stability in serum based on an anti-HIV peptide T140 Bioorg. Med. Chem. Lett. 2001, 11 (14) 1897-1902 (Pubitemid 32675313)
-
(2001)
Bioorganic and Medicinal Chemistry Letters
, vol.11
, Issue.14
, pp. 1897-1902
-
-
Tamamura, H.1
Omagari, A.2
Hiramatsu, K.3
Gotoh, K.4
Kanamoto, T.5
Xu, Y.6
Kodama, E.7
Matsuoka, M.8
Hattori, T.9
Yamamoto, N.10
Nakashima, H.11
Otaka, A.12
Fujii, N.13
-
10
-
-
0032583575
-
A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140
-
DOI 10.1006/bbrc.1998.9871
-
Tamamura, H.; Xu, Y.; Hattori, T.; Zhang, X.; Arakaki, R.; Kanbara, K.; Omagari, A.; Otaka, A.; Ibuka, T.; Yamamoto, N.; Nakashima, H.; Fujii, N. A low-molecular-weight inhibitor against the chemokine receptor CXCR4: A strong anti-HIV peptide T140 Biochem. Biophys. Res. Commun. 1998, 253 (3) 877-882 (Pubitemid 29039238)
-
(1998)
Biochemical and Biophysical Research Communications
, vol.253
, Issue.3
, pp. 877-882
-
-
Tamamura, H.1
Xu, Y.2
Hattori, T.3
Zhang, X.4
Arakaki, R.5
Kanbara, K.6
Omagari, A.7
Otaka, A.8
Ibuka, T.9
Yamamoto, N.10
Nakashima, H.11
Fujii, N.12
-
11
-
-
0032568336
-
Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides
-
Heveker, N.; Montes, M.; Germeroth, L.; Amara, A.; Trautmann, A.; Alizon, M.; Schneider-Mergener, J. Dissociation of the signalling and antiviral properties of SDF-1-derived small peptides Curr. Biol. 1998, 8 (7) 369-376 (Pubitemid 28173995)
-
(1998)
Current Biology
, vol.8
, Issue.7
, pp. 369-376
-
-
Heveker, N.1
Montes, M.2
Germeroth, L.3
Amara, A.4
Trautmann, A.5
Alizon, M.6
Schneider-Mergener, J.7
-
12
-
-
13844311525
-
The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor
-
DOI 10.1016/j.exphem.2004.11.008
-
Pelus, L. M.; Bian, H.; Fukuda, S.; Wong, D.; Merzouk, A.; Salari, H. The CXCR4 agonist peptide, CTCE-0021, rapidly mobilizes polymorphonuclear neutrophils and hematopoietic progenitor cells into peripheral blood and synergizes with granulocyte colony-stimulating factor Exp. Hematol. 2005, 33 (3) 295-307 (Pubitemid 40261311)
-
(2005)
Experimental Hematology
, vol.33
, Issue.3
, pp. 295-307
-
-
Pelus, L.M.1
Bian, H.2
Fukuda, S.3
Wong, D.4
Merzouk, A.5
Salari, H.6
-
13
-
-
33645531381
-
Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice
-
Li, K.; Chuen, C. K.; Lee, S. M.; Law, P.; Fok, T. F.; Ng, P. C.; Li, C. K.; Wong, D.; Merzouk, A.; Salari, H.; Gu, G. J.; Yuen, P. M. Small peptide analogue of SDF-1alpha supports survival of cord blood CD34+ cells in synergy with other cytokines and enhances their ex vivo expansion and engraftment into nonobese diabetic/severe combined immunodeficient mice Stem Cells. 2006, 24 (1) 55-64
-
(2006)
Stem Cells.
, vol.24
, Issue.1
, pp. 55-64
-
-
Li, K.1
Chuen, C.K.2
Lee, S.M.3
Law, P.4
Fok, T.F.5
Ng, P.C.6
Li, C.K.7
Wong, D.8
Merzouk, A.9
Salari, H.10
Gu, G.J.11
Yuen, P.M.12
-
14
-
-
0033524834
-
Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4
-
Peled, A.; Petit, I.; Kollet, O.; Magid, M.; Ponomaryov, T.; Byk, T.; Nagler, A.; Ben-Hur, H.; Many, A.; Shultz, L.; Lider, O.; Alon, R.; Zipori, D.; Lapidot, T. Dependence of human stem cell engraftment and repopulation of NOD/SCID mice on CXCR4 Science 1999, 283 (5403) 845-848
-
(1999)
Science
, vol.283
, Issue.5403
, pp. 845-848
-
-
Peled, A.1
Petit, I.2
Kollet, O.3
Magid, M.4
Ponomaryov, T.5
Byk, T.6
Nagler, A.7
Ben-Hur, H.8
Many, A.9
Shultz, L.10
Lider, O.11
Alon, R.12
Zipori, D.13
Lapidot, T.14
-
15
-
-
0035282432
-
Involvement of chemokine receptors in breast cancer metastasis
-
DOI 10.1038/35065016
-
Muller, A.; Homey, B.; Soto, H.; Ge, N.; Catron, D.; Buchanan, M. E.; McClanahan, T.; Murphy, E.; Yuan, W.; Wagner, S. N.; Barrera, J. L.; Mohar, A.; Verastegui, E.; Zlotnik, A. Involvement of chemokine receptors in breast cancer metastasis Nature 2001, 410 (6824) 50-56 (Pubitemid 32225831)
-
(2001)
Nature
, vol.410
, Issue.6824
, pp. 50-56
-
-
Muller, A.1
Homey, B.2
Soto, H.3
Ge, N.4
Catron, D.5
Buchanan, M.E.6
McClanahan, T.7
Murphy, E.8
Yuan, W.9
Wagner, S.N.10
Barrera, J.L.11
Mohar, A.12
Verastegui, E.13
Zlotnik, A.14
-
16
-
-
77953090345
-
CXCL12 (SDF-1)/CXCR4 pathway in cancer
-
Teicher, B. A.; Fricker, S. P. CXCL12 (SDF-1)/CXCR4 pathway in cancer Clin. Cancer Res. 2010, 16 (11) 2927-2931
-
(2010)
Clin. Cancer Res.
, vol.16
, Issue.11
, pp. 2927-2931
-
-
Teicher, B.A.1
Fricker, S.P.2
-
17
-
-
4644227515
-
Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection
-
DOI 10.1097/01.qai.0000137371.80695.ef
-
Hendrix, C. W.; Collier, A. C.; Lederman, M. M.; Schols, D.; Pollard, R. B.; Brown, S.; Jackson, J. B.; Coombs, R. W.; Glesby, M. J.; Flexner, C. W.; Bridger, G. J.; Badel, K.; MacFarland, R. T.; Henson, G. W.; Calandra, G. Safety, pharmacokinetics, and antiviral activity of AMD3100, a selective CXCR4 receptor inhibitor, in HIV-1 infection J. Acquired Immune Defic. Syndr. 2004, 37 (2) 1253-1262 (Pubitemid 39281506)
-
(2004)
Journal of Acquired Immune Deficiency Syndromes
, vol.37
, Issue.2
, pp. 1253-1262
-
-
Hendrix, C.W.1
Collier, A.C.2
Lederman, M.M.3
Schols, D.4
Pollard, R.B.5
Brown, S.6
Jackson, J.B.7
Coombs, R.W.8
Glesby, M.J.9
Flexner, C.W.10
Bridger, G.J.11
Badel, K.12
MacFarland, R.T.13
Henson, G.W.14
Calandra, G.15
-
18
-
-
78049255337
-
Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil) and potential of other CXCR4 antagonists as stem cell mobilizers
-
De Clercq, E. Recent advances on the use of the CXCR4 antagonist plerixafor (AMD3100, Mozobil) and potential of other CXCR4 antagonists as stem cell mobilizers Pharmacol. Ther. 2010, 128 (3) 509-518
-
(2010)
Pharmacol. Ther.
, vol.128
, Issue.3
, pp. 509-518
-
-
De Clercq, E.1
-
19
-
-
58249100053
-
CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers
-
Burger, J. A.; Peled, A. CXCR4 antagonists: Targeting the microenvironment in leukemia and other cancers Leukemia 2009, 23 (1) 43-52
-
(2009)
Leukemia
, vol.23
, Issue.1
, pp. 43-52
-
-
Burger, J.A.1
Peled, A.2
-
20
-
-
78650635767
-
Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells
-
Tchernychev, B.; Ren, Y.; Sachdev, P.; Janz, J. M.; Haggis, L.; O'Shea, A.; McBride, E.; Looby, R.; Deng, Q.; McMurry, T.; Kazmi, M. A.; Sakmar, T. P.; Hunt, S., 3rd; Carlson, K. E. Discovery of a CXCR4 agonist pepducin that mobilizes bone marrow hematopoietic cells Proc. Natl. Acad. Sci. U.S.A. 2010, 107 (51) 22255-22259
-
(2010)
Proc. Natl. Acad. Sci. U.S.A.
, vol.107
, Issue.51
, pp. 22255-22259
-
-
Tchernychev, B.1
Ren, Y.2
Sachdev, P.3
Janz, J.M.4
Haggis, L.5
O'Shea, A.6
McBride, E.7
Looby, R.8
Deng, Q.9
McMurry, T.10
Kazmi, M.A.11
Sakmar, T.P.12
Hunt III, S.13
Carlson, K.E.14
-
21
-
-
39849096261
-
Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells
-
DOI 10.1038/sj.onc.1210751, PII 1210751
-
Wendt, M. K.; Cooper, A. N.; Dwinell, M. B. Epigenetic silencing of CXCL12 increases the metastatic potential of mammary carcinoma cells Oncogene 2008, 27 (10) 1461-1471 (Pubitemid 351317456)
-
(2008)
Oncogene
, vol.27
, Issue.10
, pp. 1461-1471
-
-
Wendt, M.K.1
Cooper, A.N.2
Dwinell, M.B.3
-
22
-
-
48549091884
-
Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells
-
Wendt, M. K.; Drury, L. J.; Vongsa, R. A.; Dwinell, M. B. Constitutive CXCL12 expression induces anoikis in colorectal carcinoma cells Gastroenterology 2008, 135 (2) 508-517
-
(2008)
Gastroenterology
, vol.135
, Issue.2
, pp. 508-517
-
-
Wendt, M.K.1
Drury, L.J.2
Vongsa, R.A.3
Dwinell, M.B.4
-
23
-
-
70349758088
-
Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site
-
Boulais, P. E.; Dulude, D.; Cabana, J.; Heveker, N.; Escher, E.; Lavigne, P.; Leduc, R. Photolabeling identifies transmembrane domain 4 of CXCR4 as a T140 binding site Biochem. Pharmacol. 2009, 78 (11) 1382-1390
-
(2009)
Biochem. Pharmacol.
, vol.78
, Issue.11
, pp. 1382-1390
-
-
Boulais, P.E.1
Dulude, D.2
Cabana, J.3
Heveker, N.4
Escher, E.5
Lavigne, P.6
Leduc, R.7
-
24
-
-
0035423565
-
Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1α: Implications for development of selective CXCR4 antagonists
-
DOI 10.1016/S0165-2478(01)00228-0, PII S0165247801002280
-
Gupta, S. K.; Pillarisetti, K.; Thomas, R. A.; Aiyar, N. Pharmacological evidence for complex and multiple site interaction of CXCR4 with SDF-1alpha: Implications for development of selective CXCR4 antagonists Immunol. Lett. 2001, 78 (1) 29-34 (Pubitemid 32709903)
-
(2001)
Immunology Letters
, vol.78
, Issue.1
, pp. 29-34
-
-
Gupta, S.K.1
Pillarisetti, K.2
Thomas, R.A.3
Aiyar, N.4
-
25
-
-
0030683638
-
Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1
-
Crump, M. P.; Gong, J. H.; Loetscher, P.; Rajarathnam, K.; Amara, A.; Arenzana-Seisdedos, F.; Virelizier, J. L.; Baggiolini, M.; Sykes, B. D.; Clark-Lewis, I. Solution structure and basis for functional activity of stromal cell-derived factor-1; dissociation of CXCR4 activation from binding and inhibition of HIV-1 EMBO J. 1997, 16 (23) 6996-7007 (Pubitemid 27520800)
-
(1997)
EMBO Journal
, vol.16
, Issue.23
, pp. 6996-7007
-
-
Crump, M.P.1
Gong, J.-H.2
Loetscher, P.3
Rajarathnam, K.4
Amara, A.5
Arenzana-Seisdedos, F.6
Virelizier, J.-L.7
Baggiolini, M.8
Sykes, B.D.9
Clark-Lewis, I.10
|