Structural and Functional Characterization of Human CXCR4 as a Chemokine Receptor and HIV-1 Co-receptor by Mutagenesis and Molecular Modeling Studies

Journal of Biological Chemistry

Volumn 276, Issue 46, 2001, Pages 42826-42833

  Zhou, Naiming ^a,b   Luo, Zhaowen ^a   Luo, Jiansong ^a   Liu, Dongxiang ^a,c   Hall, James W ^a   Pomerantz, Roger J ^b   Huang, Ziwei ^a,c,d  

^a THOMAS JEFFERSON UNIVERSITY   (United States)

^b THOMAS JEFFERSON UNIVERSITY   (United States)

^c UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

^d UNIVERSITY OF ILLINOIS AT URBANA CHAMPAIGN   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CELLS; MOLECULAR STRUCTURE; MUTAGENESIS; PROTEINS; VIRUSES;

STRUCTURAL MODELING;

BIOCHEMISTRY;

ASPARTIC ACID; CHEMOKINE; CHEMOKINE RECEPTOR; CHEMOKINE RECEPTOR CXCR4; GLUTAMIC ACID; GLYCOPROTEIN GP 120; MACROPHAGE INFLAMMATORY PROTEIN 2; STROMAL CELL DERIVED FACTOR 1ALPHA; TYROSINE; VIRUS ENVELOPE PROTEIN; VIRUS RECEPTOR; CALCIUM; HYBRID PROTEIN; LIGAND; RECOMBINANT PROTEIN;

AMINO ACID COMPOSITION; AMINO TERMINAL SEQUENCE; ARTICLE; COMPLEX FORMATION; GENE MUTATION; HUMAN; HUMAN CELL; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS 1; LIGAND BINDING; MOLECULAR MODEL; NONHUMAN; PRIORITY JOURNAL; PROTEIN DOMAIN; PROTEIN PROTEIN INTERACTION; PROTEIN STRUCTURE; SIGNAL TRANSDUCTION; SITE DIRECTED MUTAGENESIS; CELL LINE; CHEMICAL STRUCTURE; CHEMISTRY; FLOW CYTOMETRY; GENETICS; METABOLISM; MUTATION; PHYSIOLOGY; PLASMID; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN SECONDARY STRUCTURE; PROTEIN TERTIARY STRUCTURE; REPORTER GENE; STRUCTURE ACTIVITY RELATION;

HERPESVIRIDAE; HUMAN HERPESVIRUS 8; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; RNA VIRUSES;

ASPARTIC ACID; CALCIUM; CELL LINE; CHEMOKINES; FLOW CYTOMETRY; GENES, REPORTER; GLUTAMIC ACID; HIV-1; HUMANS; LIGANDS; MODELS, MOLECULAR; MUTAGENESIS, SITE-DIRECTED; MUTATION; PLASMIDS; PROTEIN BINDING; PROTEIN CONFORMATION; PROTEIN STRUCTURE, SECONDARY; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CXCR4; RECOMBINANT FUSION PROTEINS; RECOMBINANT PROTEINS; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP; TYROSINE;

EID: 0035900771     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M106582200     Document Type: Article

References (60)

1. Wells, T. N. C., Power, C. A., Lusti-Narasimhan, M., Hoogewert, A. J., Cooke, R. M., Chung, C., Peitsch, M. C., and Proudfoot, A. E. I. (1996) J. Leukocyte Biol. 59, 53-60
2. Baggiolini, M., Dewald, B., and Moser, B. (1997) Annu. Rev. Immunol. 15, 675-705
3. Bleul, C. C., Farzan, M., Choe, H., Parolin, C., Clark-Lewis, I., and Sodroski, J. (1996) Nature 382, 829-833
4. Oberlin, E., Amara, A., Bachelerie, F., Bessia, C., Virelizier, J. L., Arenzana-Seisdedos, F., Schwartz, O., Heard, J. M., Clark-Lewis, I., Legler, D. F., Loetscher, M., Baggiolini, M., and Moser, B. (1996) Nature 382, 833-835
5. Moore, P. S., Boshoff, C., Weiss, R. A., and Chang, Y. (1996) Science 274, 1739-1744
6. Sozzani, S., Luini, W., Bianchi, G., Allavena, P., Wells, T. N. C., Napolitano, M., Bernardini, G., Vecchi, A., D'Ambrosio, D., Sinigagli, F., Santoni, A., Maggi, E., Romagnani, S., and Mantovani, A. (1998) Blood 92, 4036-4039
7. Boshoff, C., Endo, Y., Collins, P. D., Takeuchi, Y., Reeves, J. D., Schweickart, V. L., Siani, M. A., Sasaki, T., Williams, T. J., Gray, P. W., Moore, P. S., Chang, Y., and Weiss, R. A. (1997) Science 278, 290-294
8. Kledal, T. N., Rosenkilde, M. M., Coulin, F., Simmons, G., Johnsen, A. H., Alouani, S., Power, C. A., Luttichau, H. R., Gerstoft, J., Clapham, P. R., Clark-Lewis, I., Wells, T. N. C., and Schwartz, T. W. (1997) Science 277, 1656-1659
9. Murphy, P. M. (1994) Annu. Rev. Immunol. 12, 593-633
10. Nagasawa, T., Hirota, S., Tachibana, K., Takakura, N., Nishikawa, S., Kitamura, Y., Yoshida, N., Kikutani, H., and Kishimoto, T. (1996) Nature 382, 635-638
11. Zou, Y., Kottmann, A., Kuroda, M., Taniuchi, I., and Littman, D. (1998) Nature 393, 595-599
12. Ma, Q., Jones, D., Borghesani, P. R., Segal, R. A., Nagasawa, T., Kishimoto, T., Bronsoni, R. T., and Springer, T. A. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 9448-9453
13. Feng, Y., Broder, C. C., Kennedy, P. E., and Berger, E. A. (1996) Science 272, 872-877
14. Endres, M. J., Clapham, P. R., Marsh, M., Ahuja, M., Turner, J. D., McKnight, A., Thomas, J. F., Stoebenau-Haggarty, B., Choe, S., Vance, P. J., Wells, T. N., Power, C. A., Sutterwala, S. S., Doms, R. W., Landau, N. R., and Hoxie, J. A. (1996) Cell 87, 745-756
15. Picard, L., Wilkinson, D. A., McKnight, A., Gray, P. W., Hoxie, J. A., Clapham, P. R., and Weiss, R. A. (1997) Virology 231, 105-111
16. Brelot, A., Heveker, N., Pleskoff, O., Sol, N., and Alizon, M. (1997) J. Virol. 71, 4744-4751
17. Lu, Z., Berson, J. F., Chen, Y., Turner, J. D., Zhang, T., Sharron, M., Jenks, M. H., Wang, Z., Kim, J., Rucker, J., Hoxie, J. A., Peiper, S. C., and Doms, R. W. (1997) Proc. Natl. Acad. Sci. U. S. A. 94, 6426-6431
18. Wang, Z. X., Berson, J. F., Zhang, T. Y., Cen, Y. H., Sun, Y., Sharron, M., Lu, Z. H., and Peiper, S. C. (1998) J. Biol. Chem. 273, 15007-15015
19. Chabot, D. J., Zhang, P. F., Quinnan, G. V., and Broder, C. C. (1999) J. Virol. 73, 6598-6609
20. Doranz, B., Orsini, M., Turner, J., Hoffman, T., Berson, J., Hoxie, J., Peiper, S., Brass, L., and Doms, R. (1999) J. Virol. 73, 2752-2761
21. Chabot, D. J., and Broder, C. C. (2000) J. Biol. Chem. 275, 23774-23782
22. Brelot, A., Heveker, N., Montes, M., and Alizon, M. (2000) J. Biol. Chem. 275, 23736-23744
23. Kajumo, F., Thompson, D. A., Guo, Y., and Dragic, T. (2000) Virology 271, 240-247
24. Luo, Z., Butcher, D., and Huang, Z. (1997) Protein Eng. 10, 1039-1045
25. Zhou, N., Luo, Z., Hall, J. W., Luo, J., Han, X., and Huang, Z. (2000) Eur. J. Immunol. 30, 164-173
26. Lee, B., Sharron, M., Blanpain, C., Doranz, B. J., Vakili, J., Setoh, P., Berg, E., Liu, G., Guy, H. R., Durell, S. R., Parmentier, M., Chang, C. N., Price, K., Tsang, M., and Doms, R. W. (1999) J. Biol. Chem. 274, 9617-9626
27. Pelchen-Matthews, A., Signoret, N., Klasse, P. J., Fraile-Ramos, A., and Marsh, M. (1999) Immunol. Rev. 168, 33-49
28. Luecke, H., Schobert, B., Richter, H. T., Cartailler, J. P., and Lanyi, J. K. (1999) J. Mol. Biol. 291, 899-911
29. Henderson, R., Baldwin, J. M., Ceska, T. A., Zemlin, F., Beckmann, E., and Downing, K. H. (1990) J. Mol. Biol. 213, 899-929
30. Dealwis, C., Fernandez, E. J., Thompson, D. A., Simon, R. J., Siani, M. A., and Lolis, E. (1998) Proc. Natl. Acad. Sci. U. S. A. 95, 6941-6946
31. Crump, M. P., Gong, J. H., Loetscher, P., Rajarathnam, K., Amara, A., Arenzana-Seisdedos, F., Virelizier, J. L., Baggiolini, M., Sykes, B. D., and Clark-Lewis, I. (1997) EMBO J. 16, 6996-7007
32. Fernandez, E. J., Wilken, J., Thompson, D. A., Peiper, S. C., and Lolis, E. (2000) Biochemistry 39, 12837-12844
33. Liwang, A. C., Wang, Z. X., Sun, Y., Peiper, S. C., and Liwang, P. J. (1999) Protein Sci. 8, 2270-2280
34. Samanta, A. K., Oppenheim, J. J., and Matsushima, K. (1990) J. Biol. Chem. 265, 183-189
35. Doranz, B. J., Rucker, J., Yi, Y., Smyth, R. J., Samson, M., Peiper, S. C., Parmentier, M., Collman, R. G., and Doms, R. W. (1996) Cell 85, 1149-1158
36. Nussbaum, O., Broder, C. C., and Berger, E. A. (1994) J. Virol. 68, 5411-5422
37. Rucker, J., Doranz, B., Edinger, A., Long, D., Berson, J., and Doms, R. (1997) Methods Enzymol. 288, 118-133
38. Heveker, N., Montes, M., Germeroth, L., Amara, A., Trautmann, A., Alizon, M., and Schneider-Mergener, J. (1998) Curr. Biol. 8, 369-376
39. Donnadieu, E., Bismuth, G., and Trautmann, A. (1994) Curr. Biol. 4, 584-595
40. Chabot, D. J., Chen, H., Dimitrov, D. S., and Broder, C. C. (2000) J. Virol. 74, 4404-4413
41. Brelot, A., Heveker, N., Adema, K., Hosie, M. J., Willett, B., and Alizon, M. (1999) J. Virol. 73, 2576-2586
42. Amara, A., Gall, S. L., Schwartz, O., Salamero, J., Montes, M., Loetscher, P., Baggiolini, M., Virelizier, J.-L., and Arenzana-Seisdedos, F. (1997) J. Exp. Med. 186, 139-146
43. Förster, R., Kremmer, E., Schubel, A., Breitfeld, D., Kleinschmidt, A., Nerl, C., Bernhardt, G., and Lipp, M. (1998) J. Immunol. 160, 1522-1531
44. Tarasova, N. I., Stauber, R. H., Choi, J. K., Hudson, E. A., Czerwinski, G., Miller, J. L., Pavlakis, G. N., Michejda, C. J., and Wank, S. A. (1997) J. Biol. Chem. 272, 14817-14824
45. Loetscher, P., Gong, J. H., Dewald, B., Baggiolini, M., and Clark-Lewis, I. (1998) J. Biol. Chem. 273, 22279-22283
46. Luo, Z., Zhou, N., Luo, J., Hall, J. W., and Huang, Z. (1999) Biochem. Biophys. Res. Commun. 263, 691-695
47. Luo, J., Luo, Z., Zhou, N., Hall, J. W., and Huang, Z. (1999) Biochem. Biophys. Res. Commun. 264, 42-47
48. Luo, Z., Fan, X., Zhou, N., Hiraoka, M., Luo, J., Kaji, H., and Huang, Z. (2000) Biochemistry 39, 13545-13550
49. Zhou, N., Luo, Z., Luo, J., Hall, J. W., and Huang, Z. (2000) Biochemistry 39, 3782-3787
50. Crump, M. P., Elisseeva, E., Gong, J., Clark-Lewis, I., and Sykes, B. D. (2001) FEBS Lett. 489, 171-175
51. Siciliano, S. J., Rollins, T. E., DeMartino, J., Konteatis, Z., Malkowitz, L., Riper, G. V., Bondy, S., Rosen, H., and Springer, M. S. (1994) Proc. Natl. Acad. Sci. U. S. A. 91, 1214-1218
52. Hausdorff, W., Campbell, P., Ostrowski, J., Yu, S., Caron, M., and Lefkowitz, R. (1991) Proc. Natl. Acad. Sci. U. S. A. 88, 2979-2983
53. Hertel, C., Nunnally, M., Wong, S., Murphy, E., Ross, E., and Perkins, J. (1990) J. Biol. Chem. 265, 17988-17994
54. Arora, K. K., Atsushi, S., and Catt, K. J. (1995) J. Biol. Chem. 270, 22820-22826
55. Lameh, J., Philip, M., Sharma, Y., Moro, O., Ramachandran, J., and Sadee, W. (1992) J. Biol. Chem. 267, 13406-13412
56. Doranz, B. J., Grovit-Ferbas, K., Sharron, M. P., Mao, S. H., Goetz, M. B., Daar, E. S., Doms, R. W., and O'Brien, W. A. (1997) J. Exp. Med. 186, 1395-1400
57. Murakami, T., Nakajima, T., Koyanagi, Y., Tachibana, K., Fujii, N., Tamamura, H., Yoshida, N., Waki, M., Matsumoto, A., Yoshie, O., Kishimoto, T., Yamamoto, N., and Nagasawa, T. (1997) J. Exp. Med. 186, 1389-1393
58. Schols, D., Struyf, S., van Damme, J., Este, J. A., Henson, G., and De Clercq, E. (1997) J. Exp. Med. 186, 1383-1388
59. Zhou, H., and Tai, H. H. (2000) Arch. Biochem. Biophys. 373, 211-217
60. Farzan, M., Mirzabekov, T., Kolchinsky, P., Wyatt, R., Cayabyab, M., Gerard, N. P., Gerard, C., Sodroski, J., and Choe, H. (1999) Cell 96, 667-676