Structural analysis of a novel small molecule ligand bound to the CXCL12 chemokine

Journal of Medicinal Chemistry

Volumn 57, Issue 22, 2014, Pages 9693-9699

  Smith, Emmanuel W ^a   Liu, Yan ^b   Getschman, Anthony E ^c   Peterson, Francis C ^c   Ziarek, Joshua J ^c,d   Li, Rongshi ^b   Volkman, Brian F ^c   Chen, Yu ^a  

^a UNIVERSITY OF SOUTH FLORIDA   (United States)

^b UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

^c MEDICAL COLLEGE OF WISCONSIN   (United States)

^d HARVARD MEDICAL SCHOOL   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BENZENE; CHEMOKINE RECEPTOR AFFECTING AGENT; CHEMOKINE RECEPTOR CXCR4; CXCL12 CHEMOKINE SMALL MOLECULE LIGAND; GLUTAMIC ACID; STROMAL CELL DERIVED FACTOR 1; UNCLASSIFIED DRUG; ANTINEOPLASTIC AGENT; CXCL12 PROTEIN, HUMAN; CXCR4 PROTEIN, HUMAN; LIGAND; PROTEIN BINDING;

ARTICLE; BINDING SITE; CONFORMATIONAL TRANSITION; CRYSTAL STRUCTURE; DRUG DESIGN; DRUG STRUCTURE; HETERONUCLEAR MULTIPLE QUANTUM COHERENCE; HYDROGEN BOND; MOLECULAR DOCKING; SIGNAL TRANSDUCTION; STATIC ELECTRICITY; X RAY; CHEMISTRY; CHEMOTAXIS; HUMAN; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PROCEDURES; PROTEIN TERTIARY STRUCTURE; STRUCTURE ACTIVITY RELATION; X RAY CRYSTALLOGRAPHY;

ANTINEOPLASTIC AGENTS; BINDING SITES; CHEMOKINE CXCL12; CHEMOTAXIS; CRYSTALLOGRAPHY, X-RAY; DRUG DESIGN; HUMANS; LIGANDS; MAGNETIC RESONANCE SPECTROSCOPY; MOLECULAR DOCKING SIMULATION; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECEPTORS, CXCR4; SIGNAL TRANSDUCTION; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 84913593689     PISSN: 00222623     EISSN: 15204804     Source Type: Journal    
DOI: 10.1021/jm501194p     Document Type: Article

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