Pumilio1 haploinsufficiency leads to SCA1-like neurodegeneration by increasing wild-type Ataxin1 levels

Cell

Volumn 160, Issue 6, 2015, Pages 1087-1098

  Gennarino, Vincenzo A ^a,b   Singh, Ravi K ^a   White, Joshua J ^a,b   De Maio, Antonia ^a,b   Han, Kihoon ^a,b   Kim, Ji Yoen ^a,b   Jafar Nejad, Paymaan ^a,b,d   Di Ronza, Alberto ^a,b   Kang, Hyojin ^a,b,e   Sayegh, Layal S ^a,b,f   Cooper, Thomas A ^a   Orr, Harry T ^c   Sillitoe, Roy V ^a,b   Zoghbi, Huda Y ^a,b  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b TEXAS CHILDREN S HOSPITAL   (United States)

^c UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^d ISIS PHARMACEUTICALS   (United States)

^e Korea Institute of Science and Technology Information (KISTI)   (South Korea)

^f EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; MESSENGER RNA; MICRORNA; PUMILIO1 PROTEIN; RNA BINDING PROTEIN; UNCLASSIFIED DRUG; 3' UNTRANSLATED REGION; ATAXIN; ATXN1 PROTEIN, HUMAN; ATXN1 PROTEIN, MOUSE; LY ANTIGEN; LY6A PROTEIN, MOUSE; MEMBRANE PROTEIN; NERVE PROTEIN; NUCLEAR PROTEIN; PUMILIO 1 PROTEIN, MOUSE;

3' UNTRANSLATED REGION; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; BRAIN WEIGHT; CONTROLLED STUDY; DISEASE COURSE; HAPLOINSUFFICIENCY; MOTOR DYSFUNCTION; MOUSE; NERVE DEGENERATION; NONHUMAN; PHENOTYPE; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEIN STRUCTURE; RNA FOLDING; RNA STABILITY; WILD TYPE; ANIMAL; BRAIN; CHEMISTRY; CONFORMATION; DEGENERATIVE DISEASE; GENE TARGETING; GENETICS; HUMAN; KNOCKOUT MOUSE; METABOLISM; MUTATION; PATHOLOGY; RNA PROCESSING;

MUS;

3' UNTRANSLATED REGIONS; ANIMALS; ANTIGENS, LY; ATAXIN-1; ATAXINS; BRAIN; GENE KNOCK-IN TECHNIQUES; HAPLOINSUFFICIENCY; HUMANS; MEMBRANE PROTEINS; MICE; MICE, KNOCKOUT; MICRORNAS; MUTATION; NERVE TISSUE PROTEINS; NEURODEGENERATIVE DISEASES; NUCLEAR PROTEINS; NUCLEIC ACID CONFORMATION; RNA PROCESSING, POST-TRANSCRIPTIONAL; RNA STABILITY; RNA, MESSENGER; RNA-BINDING PROTEINS;

EID: 84924559965     PISSN: 00928674     EISSN: 10974172     Source Type: Journal    
DOI: 10.1016/j.cell.2015.02.012     Document Type: Article

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