Duplication of Atxn1l suppresses SCA1 neuropathology by decreasing incorporation of polyglutamine-expanded ataxin-1 into native complexes

Nature Genetics

Volumn 39, Issue 3, 2007, Pages 373-379

  Bowman, Aaron B ^a,c   Lam, Yung C ^a   Jafar Nejad, Paymaan ^a   Chen, Hung Kai ^a   Richman, Ronald ^a   Samaco, Rodney C ^a   Fryer, John D ^a   Kahle, Juliette J ^a   Orr, Harry T ^b   Zoghbi, Huda Y ^a  

^a BAYLOR COLLEGE OF MEDICINE   (United States)

^b UNIVERSITY OF MINNESOTA MEDICAL SCHOOL   (United States)

^c VANDERBILT UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ATAXIN 1; ATAXIN 1 LIKE PROTEIN; GENE PRODUCT; POLYGLUTAMINE; PROTEIN; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; GENE DUPLICATION; GENE LOCUS; GENETIC ANALYSIS; MOUSE; MOUSE STRAIN; NERVE DEGENERATION; NEUROPATHOLOGY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARALOGY; PRIORITY JOURNAL; PROTEIN ANALYSIS; PROTEIN FUNCTION; SEQUENCE HOMOLOGY; SPINOCEREBELLAR DEGENERATION;

ANIMALS; CELLS, CULTURED; CEREBELLUM; DNA REPEAT EXPANSION; EMBRYONIC STEM CELLS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; MICE, TRANSGENIC; MODELS, BIOLOGICAL; MODELS, GENETIC; MOLECULAR SEQUENCE DATA; NERVE TISSUE PROTEINS; NUCLEAR PROTEINS; PEPTIDES; PURKINJE CELLS; REPRESSOR PROTEINS; SPINOCEREBELLAR ATAXIAS;

EID: 33847290297     PISSN: 10614036     EISSN: 15461718     Source Type: Journal    
DOI: 10.1038/ng1977     Document Type: Article

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