Protective effect of arjunolic acid against atorvastatin induced hepatic and renal pathophysiology via MAPK, mitochondria and ER dependent pathways

Biochimie

Volumn 112, Issue , 2015, Pages 20-34

  Pal, Sankhadeep ^a   Sarkar, Abhijit ^a   Pal, Pabitra Bikash ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Antioxidant; Apoptosis; Arjunolic acid; Atorvastatin; Oxidative stress; ROS

Indexed keywords

ALANINE AMINOTRANSFERASE; ALKALINE PHOSPHATASE; APOPTOTIC PROTEASE ACTIVATING FACTOR 1; ARJUNOLIC ACID; ASCORBIC ACID; ATORVASTATIN; CALPAIN; CASPASE 12; CASPASE 3; CASPASE 9; CYTOCHROME C; GLUTATHIONE; MITOGEN ACTIVATED PROTEIN KINASE; PROTECTIVE AGENT; PROTEIN BAX; PROTEIN BCL 2; REACTIVE OXYGEN METABOLITE; UNCLASSIFIED DRUG; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; TRITERPENE;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; ATORVASTATIN INDUCED HEPATOTOXICITY; ATORVASTATIN INDUCED NEPHROTOXICITY; CARBON NUCLEAR MAGNETIC RESONANCE; CELL DEATH; CELL VIABILITY; CONTROLLED STUDY; CYTOSOLIC FRACTION; DNA FRAGMENTATION; DRUG EFFECT; ENDOPLASMIC RETICULUM; ENZYME ACTIVATION; HISTOPATHOLOGY; IMMUNOBLOTTING; INVESTIGATIVE PROCEDURES; KIDNEY PARENCHYMA; LIPID PEROXIDATION; LIVER; LIVER PROTECTION; LIVER TOXICITY; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRION; MOUSE; NEPHROTOXICITY; NONHUMAN; OXIDATIVE STRESS; PATHOPHYSIOLOGY; PROTEIN CARBONYLATION; PROTEIN CONTENT; PROTEIN PHOSPHORYLATION; PROTEIN URINE LEVEL; PROTON NUCLEAR MAGNETIC RESONANCE; RANDOMIZED CONTROLLED TRIAL; RENAL PROTECTION; ANIMAL; APOPTOSIS; CHEMICALLY INDUCED; DRUG EFFECTS; DRUG-INDUCED LIVER INJURY; KIDNEY; KIDNEY DISEASES; LIVER MITOCHONDRION; METABOLISM; PATHOLOGY; SIGNAL TRANSDUCTION;

MUS;

ANIMALS; APOPTOSIS; ATORVASTATIN CALCIUM; DRUG-INDUCED LIVER INJURY; ENDOPLASMIC RETICULUM; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; KIDNEY; KIDNEY DISEASES; LIVER; MALE; MAP KINASE SIGNALING SYSTEM; MICE; MITOCHONDRIA, LIVER; OXIDATIVE STRESS; TRITERPENES;

EID: 84924419281     PISSN: 03009084     EISSN: 61831638     Source Type: Journal    
DOI: 10.1016/j.biochi.2015.02.016     Document Type: Article

References (73)

1. A. Endo The discovery and development of HMG-CoA reductase inhibitors. 1992 Atheroscler Suppl. 5 2004 67 80
2. T.A. Jacobson Toward "pain-free" statin prescribing: clinical algorithm for diagnosis and management of myalgia Mayo Clin. Proc. 83 2008 687 700
3. J.A. Tobert Lovastatin and beyond: the history of the HMG-CoA reductase inhibitors Nat. Rev. Drug Discov. 2 2003 517 526
4. Z. Zhou, E. Rahme, M. Abrahamowicz, J.V. Tu, M.J. Eisenberg, and K. Humphries Effectiveness of statins for secondary prevention in elderly patients after acute myocardial infarction: an evaluation of class effect CMAJ 172 2005 1187 1194
5. E.J. Topol Intensive statin therapy-a sea change in cardiovascular prevention N. Engl. J. Med. 350 2004 1562 1564
6. J. Ma, N.L. Sehgal, J.Z. Ayanian, and R.S. Stafford National trends in statin use by coronary heart disease risk category PLoS Med. 2 2005 e123
7. C.Y. Wang, P.Y. Liu, and J.K. Liao Pleiotropic effects of statin therapy: molecular mechanisms and clinical results Trends Mol. Med. 14 2008 37 44
8. U. Landmesser, F. Bahlmann, M. Mueller, S. Spiekermann, N. Kirchhoff, S. Schulz, C. Manes, D. Fischer, K. de Groot, D. Fliser, G. Fauler, W. Marz, and H. Drexler Simvastatin versus ezetimibe: pleiotropic and lipid-lowering effects on endothelial function in humans Circulation 111 2005 2356 2363
9. O. Aktas, S. Waiczies, A. Smorodchenko, J. Dorr, B. Seeger, and T. Prozorovski Treatment of relapsing paralysis in experimental encephalomyelitis by targeting Th1 cells through atorvastatin J. Exp. Med. 197 2003 725 733
10. M.M. Barsante, E. Roffe, C.M. Yokoro, W.L. Tafuri, D.G. Souza, and V. Pinho Anti-inflammatory and analgesic effects of atorvastatin in a rat model of adjuvant-induced arthritis Eur. J. Pharmacol. 516 2005 282 289
11. T. Santodomingo-Garzón, T.M. Cunha, W.A. Verri Jr., D. Valério, C.A. Parada, S. Poole, S.H. Ferreira, and F.Q. Cunha Atorvastatin inhibits inflammatory hypernociception Br. J. Pharmacol 149 2006 14 22
12. C.K. Argo, P. Loria, S.H. Caldwell, and A. Lonardo Statins in liver disease: amolehill, an iceberg, or neither? Hepatology 48 2008 662 669
13. T.A. Jacobson Statin safety: lessons from new drug applications for marketed statins Am. J. Cardiol 97 2006 44C 51C
14. H. Bays Statin safety: an overview and assessment of the data-2005 Am. J. Cardiol. 97 2006 66C-26C
15. C. Hodel Myopathy and rhabdomyolysis with lipid-lowering drugs Toxicol. Lett. 128 2002 159 168
16. M.A. Omar, and J.P. Wilson FDA adverse event reports on statin-associated rhabdomyolysis Ann. Pharmacother. 36 2002 288 295
17. T. Phan, J.G. MeLeod, J.D. Pollard, O. Peiris, A. Rohan, and J.P. Halpern Peripheral neuropathy associated with simvastatin J. Neurol. Neurosurg. Psychiatry 58 1995 625 628
18. U. Jeppesen, D. Gaist, T. Smith, and S.H. Sindrup Statins and peripheral neuropathy Eur. J. Clin. Pharmacol 54 1999 835 838
19. V. Launay-Vacher, H. Izzedine, and G. Deray Statins' dosage in patients with renal failure and cyclosporine drug-drug interactions in transplant recipient patients Int. J. Cardiol. 101 2005 9 17
20. T. Sakaeda, K. Kadoyama, and Y. Okuno Statin-associated muscular and renal adverse events: data mining of the public version of the FDA adverse event reporting system PLoS One 6 2011 e28124
21. M. Sinha, P. Manna, and P.C. Sil Arjunolic acid attenuates arsenic-induced nephrotoxicity Pathophysiology 15 2008 147 156
22. R. Bhattacharjee, and P.C. Sil Protein isolate from the herb, Phyllanthusniruri, modulates carbon tetrachloride-induced cytotoxicity in hepatocytes Toxicol. Mech. Methods 17 2006 41 47
23. A. Ghosh, and P.C. Sil Anti-oxidative effect of a protein from Cajanus indicus L. against acetaminophen-induced hepato-nephro toxicity J. Biochem. Mol. Biol. 39 2007 1039 1049
24. S. Pal, M. Ahir, and P.C. Sil Doxorubicin-induced neurotoxicity is attenuated by a 43-kD protein from the leaves of Cajanus indicus L. via NF-κB and mitochondria dependent pathways Free Rad. Res. 46 2012 785 798
25. P.B. Pal, K. Sinha, and P.C. Sil Mangiferin, a natural xanthone, protects murine liver in Pb (II) induced hepatic damage and cell death via MAP kinase, NF-κB and mitochondria dependent pathways PloS One 8 2013 e56894
26. A. Ghosh, and P.C. Sil A protein from Cajanus indicus Spreng protects liver and kidney against mercuric chloride-induced oxidative stress Biol. Pharm. Bull. 31 2008 1651 1658
27. M. Sinha, P. Manna, and P.C. Sil Attenuation of cadmium chloride induced cytotoxicity in murine hepatocytes by a protein isolated from the leaves of the herb Cajanus indicus L Arch. Toxicol. 81 2007 397 406
28. B. Raghavan, and S.K. Kumari Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats Indian J. Physiol. Pharmacol. 50 2006 133 142
29. J.D. Djoukeng, E. Abou-Mansour, R. Tabacchi, A.L. Tapondjou, H. Bouda, and D. Lontsi Antibacterial triterpenes from Syzygiumguineense (Myrtaceae) J. Ethnopharmacol. 101 2005 283 286
30. R.S. Bhakuni, Y.N. Shukla, A.K. Tripathi, V. Prajapati, and S. Kumar Insect growth inhibitor activity of arjunolic acid isolated from Cornuscapitata Phytother. Res. 16 2002 68 70
31. P. Manna, M. Sinha, and P.C. Sil Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes Chem. Biol. Interact. 170 2007 187 200
32. P. Manna, M. Sinha, and P.C. Sil Protection of arsenic-induced hepatic disorder by arjunolic acid Basic Clin. Pharmacol. Toxicol. 101 2007 333 338
33. J. Ghosh, and P.C. Sil Arjunolic acid: a new multifunctional therapeutic promise of alternative medicine Biochimie 95 2013 1098 1109
34. P. Manna, M. Sinha, and P.C. Sil Protection of arsenic-induced testicular oxidative stress by arjunolic acid Redox Rep. 13 2008 67 77
35. M. Sinha, P. Manna, and P.C. Sil Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain J. Biochem. Mol. Toxicol. 22 2008 15 26
36. P. Manna, J. Ghosh, J. Das, and P.C. Sil Streptozotocin induced activation of oxidative stress responsive splenic cell signaling pathways: protective role of arjunolic acid Toxicol. Appl. Pharmacol. 244 2010 114 129
37. J. Ghosh, J. Das, P. Manna, and P.C. Sil The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis Biomaterials 32 2011 4857 4866
38. P. Manna, M. Sinha, and P.C. Sil Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways Toxicology 257 2009 53 63
39. P. Manna, and P.C. Sil Arjunolic acid: beneficial role in type 1 diabetes and its associated organ pathophysiology Free Radic. Res. 46 2012 815 830
40. S. Pal, P.B. Pal, J. Das, and P.C. Sil Involvement of both intrinsic and extrinsic pathways in hepatoprotection of arjunolic acid against cadmium induced acute damage in vitro Toxicology 283 2011 129 139
41. J. Ghosh, J. Das, P. Manna, and P.C. Sil Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK mediated mitochondrial protection Free Radic. Biol. Med. 48 2010 535 553
42. J. Ghosh, J. Das, P. Manna, and P.C. Sil Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway Toxicol. in Vitro 22 2008 1918 1926
43. M.M. Bradford A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding Anal. Biochem. 72 1976 248 254
44. H. Esterbauer, and K.H. Cheeseman Determination of aldehydic lipid peroxidation products: malonaldehyde and 4-hydroxynonenal Methods Enzymol. 186 1990 407 421
45. K. Uchida, and E.R. Stadtman Covalent attachment of 4-hydroxynonenal to glyceraldehydes-3-phosphate dehydrogenase J. Biol. Chem. 268 1993 6388 6393
46. C.P. LeBel, and S.C. Bondy Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes Neurochem. Int. 17 1990 435 440
47. J.O. Kim, G.D. Lee, J.H. Kwon, and K.S. Kim Anti-diabetic effects of new herbal formula in neonatally streptozotocin-induced diabetic rats Biol. Pharm. Bull. 32 2009 421 426
48. J. Das, J. Ghosh, P. Manna, M. Sinha, and P.C. Sil Taurine protects rat testes against NaAsO2-induced oxidative stress and apoptosis via mitochondrial dependent and independent pathways Toxicol. Lett. 187 2009 201 210
49. E. Eruslanov, S. Kusmartsev, and D. Armstrong Advanced Protocols in Oxidative Stress II Methods in Molecular Biology 594 2010 Humana Press, a part of Springer Science + Business Media, LLC
50. K.T. Lin, J.Y. Xue, F.F. Sun, and P.Y.K. Wong Reactive oxygen species participate in peroxinitrile induced apoptosis in HL 60 cells Biochem. Biophys. Res. Commun. 230 1997 115 119
51. K.S. Sellins, and J.J. Cohen Gene induction by gamma-irradiation leads to DNA fragmentation in lymphocytes J. Immunol. 139 1987 3199 31206
52. V. Chandrasekaran, D. Hsu, and M. Liu The protective effect of sesamol against mitochondrial oxidative stress and hepatic injury in acetaminophen-overdosed rats Shock 32 2009 89 93
53. F.E. Mingatto, T. Rodrigues, A.A. Pigoso, S.A. Uyemura, and C. Curti The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes J. Pharmacol. Exp. Ther. 303 2003 601 607
54. J. Das, J. Ghosh, P. Manna, and P.C. Sil Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation Toxicology 269 2010 24 34
55. D.R. Sliskovic, B.D. Roth, and T.M.A. Bocan Tissue selectivity of HMG-CoA reductase inhibitors DN&P 5 1992 517 533
56. A.W. Alberts, J.S. Macdonald, A.E. Till, and J.A. Tobert Lovastatin Cardiovasc. Drug Rev. 7 1989 89 109
57. X.F. Qi, L. Zheng, K.J. Lee, D.H. Kim, C.S. Kim, D.Q. Cai1, Z. Wu, J.W. Qin, Y.H. Yu, and S.K. Kim HMG-CoA reductase inhibitors induce apoptosis of lymphoma cells by promoting ROS generation and regulating Akt, Erk and p38 signals via suppression of mevalonate pathway Cell. Death Dis. 4 2013 e518
58. J. Bouitbir, A.L. Charles, A.E. Laguna, M. Kindo, F. Daussin, J. Auwerx, F. Piquard, B. Geny, and J. Zoll Opposite effects of statins on mitochondria of cardiac and skeletal muscles: a 'mitohormesis' mechanism involving reactive oxygen species and PGC-1 Euro. Heart J. 33 2012 1397 1407
59. H. Bartsch, and J. Nair Ultrasensitive and specific detection method for exocyclic DNA adducts: markers for lipid peroxidation and oxidative stress Toxicology 153 2000 105 114
60. B. Halliwell, and J.M.C. Guttteridge Free Radicals in Biology and Medicine second ed. 2007 Oxford University Press (Clarendon) Oxford 221 238
61. D. Dolphin Glutathione: Chemical, Biochemical and Medical Aspects 1989 Wiley New York (NY) Part A and B
62. M. Bras, B. Queenan, and S.A. Susin Programmed cell death via mitochondria: different modes of dying Biochemistry 70 2005 231 239
63. H. Pelicano, L. Feng, Y. Zhou, J.S. Carew, E.O. Hileman, and W. Plunkett Inhibition of mitochondrial respiration: a novel strategy to enhance drug-induced apoptosis in human leukemia cells by a reactive oxygen species-mediated mechanism J. Biol. Chem. 278 2003 37832 37839
64. J.A. Keeble, and A.P. Gilmore Apoptosis commitment-translating survival signals into decisions on mitochondria Cell. Res. 17 2007 976 984
65. H.B. Gao, M.H. Tong, Y.Q. Hu, H.Y. You, Q.S. Guo, R.S. Ge, and M.P. Hardy Mechanisms of glucocorticoid-induced Leydig cell apoptosis Mol. Cell. Endocrinol. 199 2003 153 163
66. M.O. Hengartner The biochemistry of apoptosis Nature 407 2000 770 776
67. G. Pearson, F. Robinson, and T.B. Gibson Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions Endocr. Rev. 22 2001 153 183
68. M. Festa, A. Capasso, and C.W. D'Acunto Xanthohumol induces apoptosis in human malignant glioblastoma cells by increasing reactive oxygen species and activating MAPK pathways J. Nat. Pro. 74 2011 2505 2513
69. T. Nakagawa, and J. Yuan Cross-talk between two cysteine protease families: activation of Caspase-12 by Calpain in apoptosis J. Cell Biol. 150 2000 887 894
70. T. Nakagawa, H. Zhu, N. Morishima, E. Li, J. Xu, B.A. Yankner, and J. Yuan Caspase-12 mediates endoplasmic reticulum-specific apoptosis and cytotoxicity by amyloid-β Nature 403 2000 98 103
71. N. Morishima, K. Nakanishi, H. Takenouchi, T. Shibata, and Y. Yasuhiko An endoplasmic reticulum stress-specific caspase cascade in apoptosis. Cytochrome c-independent activation of caspase-9 by caspase-12 J. Biol. Chem. 277 2002 34287 34294
72. C.G. Fraga, P.A. Motchnik, M.K. Shigenaga, H.J. Helbock, R.A. Jacob, and B.N. Ames Ascorbic acid protects against endogenous oxidative DNA damage in human sperm Proc. Natl. Acad. Sci. U. S. A. 88 1991 11003 11006
73. J. Ghosh, J. Das, P. Manna, and P.C. Sil Acetaminophen induced renal injury via oxidative stress and TNF-α production: therapeutic potential of arjunolic acid Toxicology 268 2010 8 18