메뉴 건너뛰기




Volumn 48, Issue 2, 2008, Pages 662-669

Statins in liver disease: A molehill, an iceberg, or neither?

Author keywords

[No Author keywords available]

Indexed keywords

AMINOTRANSFERASE; ATORVASTATIN; FLUINDOSTATIN; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; MEVINOLIN; PRAVASTATIN; SIMVASTATIN;

EID: 49649106710     PISSN: 02709139     EISSN: None     Source Type: Journal    
DOI: 10.1002/hep.22402     Document Type: Review
Times cited : (113)

References (96)
  • 2
    • 34247636128 scopus 로고    scopus 로고
    • Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C
    • Targher G, Bertolini L, Padovani R, Rodella S, Arcaro G, Day C. Differences and similarities in early atherosclerosis between patients with non-alcoholic steatohepatitis and chronic hepatitis B and C. J Hepatol 2007; 46:1126-1132.
    • (2007) J Hepatol , vol.46 , pp. 1126-1132
    • Targher, G.1    Bertolini, L.2    Padovani, R.3    Rodella, S.4    Arcaro, G.5    Day, C.6
  • 4
    • 2142768218 scopus 로고    scopus 로고
    • Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity
    • Chalasani N, Aljadhey H, Kesterson J, Murray MD, Hall SD. Patients with elevated liver enzymes are not at higher risk for statin hepatotoxicity. Gastroenterology 2004;128:1287-1292.
    • (2004) Gastroenterology , vol.128 , pp. 1287-1292
    • Chalasani, N.1    Aljadhey, H.2    Kesterson, J.3    Murray, M.D.4    Hall, S.D.5
  • 8
    • 36348987648 scopus 로고    scopus 로고
    • Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease
    • Lewis JH, Mortensen ME, Zweig S, Fusco MJ, Medoff JR, Belder R, et al. Efficacy and safety of high-dose pravastatin in hypercholesterolemic patients with well-compensated chronic liver disease. HEPATOLOGY 2007;46: 1453-1463.
    • (2007) HEPATOLOGY , vol.46 , pp. 1453-1463
    • Lewis, J.H.1    Mortensen, M.E.2    Zweig, S.3    Fusco, M.J.4    Medoff, J.R.5    Belder, R.6
  • 9
    • 3142729178 scopus 로고    scopus 로고
    • Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines
    • Grundy SM, Cleeman JI, Metz CN, Brewer HB Jr, Clark LT, Hunninghake DB, et al. Implications of recent clinical trials for the National Cholesterol Education Program Adult Treatment Panel III guidelines. Circulation 2004; 110:227-239.
    • (2004) Circulation , vol.110 , pp. 227-239
    • Grundy, S.M.1    Cleeman, J.I.2    Metz, C.N.3    Brewer Jr, H.B.4    Clark, L.T.5    Hunninghake, D.B.6
  • 10
    • 38049175023 scopus 로고    scopus 로고
    • Statins: A new insight into their mechanisms of action and consequent pleiotropic effects
    • Jasińska M, Owczarek J, Orszulak-Michalak D. Statins: A new insight into their mechanisms of action and consequent pleiotropic effects. Pharmacol Rep 2007;59:483-499.
    • (2007) Pharmacol Rep , vol.59 , pp. 483-499
    • Jasińska, M.1    Owczarek, J.2    Orszulak-Michalak, D.3
  • 11
    • 0035963529 scopus 로고    scopus 로고
    • Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events
    • Ridker PM, Rifai N, Clearfield M, Downs JR, Weis SE, Miles JS, et al. Measurement of C-reactive protein for the targeting of statin therapy in the primary prevention of acute coronary events. N Engl J Med 2001;344: 1959-1965.
    • (2001) N Engl J Med , vol.344 , pp. 1959-1965
    • Ridker, P.M.1    Rifai, N.2    Clearfield, M.3    Downs, J.R.4    Weis, S.E.5    Miles, J.S.6
  • 12
    • 33750477284 scopus 로고    scopus 로고
    • Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease
    • Targher G. Relationship between high-sensitivity C-reactive protein levels and liver histology in subjects with non-alcoholic fatty liver disease. J Hepatol 2006;45:879-882.
    • (2006) J Hepatol , vol.45 , pp. 879-882
    • Targher, G.1
  • 13
    • 0030825512 scopus 로고    scopus 로고
    • Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation
    • Oberti F, Pilette C, Rifflet H, Maïga MY, Moreau A, Gallois Y, et al. Effects of simvastatin, pentoxifylline and spironolactone on hepatic fibrosis and portal hypertension in rats with bile duct ligation. J Hepatol 1997;26: 1363-1371.
    • (1997) J Hepatol , vol.26 , pp. 1363-1371
    • Oberti, F.1    Pilette, C.2    Rifflet, H.3    Maïga, M.Y.4    Moreau, A.5    Gallois, Y.6
  • 14
    • 34547469050 scopus 로고    scopus 로고
    • Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase
    • Trebicka J, Hennenberg M, Laleman W, Shelest N, Biecker E, Schepke M, et al. Atorvastatin lowers portal pressure in cirrhotic rats by inhibition of RhoA/Rho-kinase and activation of endothelial nitric oxide synthase. HEPATOLOGY 2007;46:242-253.
    • (2007) HEPATOLOGY , vol.46 , pp. 242-253
    • Trebicka, J.1    Hennenberg, M.2    Laleman, W.3    Shelest, N.4    Biecker, E.5    Schepke, M.6
  • 15
    • 1542317594 scopus 로고    scopus 로고
    • Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis
    • Zafra C, Abraldes JG, Turnes J, Berzigotti A, Fernández M, Garca-Pagán JC, et al. Simvastatin enhances hepatic nitric oxide production and decreases the hepatic vascular tone in patients with cirrhosis. Gastroenterology 2004;126:749-755.
    • (2004) Gastroenterology , vol.126 , pp. 749-755
    • Zafra, C.1    Abraldes, J.G.2    Turnes, J.3    Berzigotti, A.4    Fernández, M.5    Garca-Pagán, J.C.6
  • 16
    • 0024596220 scopus 로고
    • QSAR study of the role of hydrophobicity in the activity of HMGR inhibitors
    • Prabhakar YS, Saxena AK, Doss MJ. QSAR study of the role of hydrophobicity in the activity of HMGR inhibitors. Drug Des Deliv 1989;4:97-108.
    • (1989) Drug Des Deliv , vol.4 , pp. 97-108
    • Prabhakar, Y.S.1    Saxena, A.K.2    Doss, M.J.3
  • 17
    • 33748042671 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors
    • Shitara Y, Sugiyama Y. Pharmacokinetic and pharmacodynamic alterations of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase inhibitors. Pharmacol Ther 2006;112:71-105.
    • (2006) Pharmacol Ther , vol.112 , pp. 71-105
    • Shitara, Y.1    Sugiyama, Y.2
  • 18
    • 34547559566 scopus 로고    scopus 로고
    • Impact of statin dosing intensity on transaminase and creatine kinase
    • Dale KM, White CM, Henyan NN, Kluger J, Coleman CI. Impact of statin dosing intensity on transaminase and creatine kinase. Am J Med 2007;120:706-712.
    • (2007) Am J Med , vol.120 , pp. 706-712
    • Dale, K.M.1    White, C.M.2    Henyan, N.N.3    Kluger, J.4    Coleman, C.I.5
  • 19
    • 31344467118 scopus 로고    scopus 로고
    • Are statins created equal?
    • Zhou Z, Rahme E, Pilote L. Are statins created equal? Am Heart J 2006; 151:273-281.
    • (2006) Am Heart J , vol.151 , pp. 273-281
    • Zhou, Z.1    Rahme, E.2    Pilote, L.3
  • 21
    • 33644891902 scopus 로고    scopus 로고
    • Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy
    • Resch U, Tatzber F, Budinsky A, Sinzinger H. Reduction of oxidative stress and modulation of autoantibodies against modified low-density lipoprotein after rosuvastatin therapy. Br J Clin Pharmacol 2006;61:262-274.
    • (2006) Br J Clin Pharmacol , vol.61 , pp. 262-274
    • Resch, U.1    Tatzber, F.2    Budinsky, A.3    Sinzinger, H.4
  • 22
    • 4444382031 scopus 로고    scopus 로고
    • Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis
    • Chalasani N, Deeg MA, Crabb DW. Systemic levels of lipid peroxidation and its metabolic and dietary correlates in patients with nonalcoholic steatohepatitis. Am J Gastroenterol 2004;99:1497-1502.
    • (2004) Am J Gastroenterol , vol.99 , pp. 1497-1502
    • Chalasani, N.1    Deeg, M.A.2    Crabb, D.W.3
  • 23
    • 29444443126 scopus 로고    scopus 로고
    • The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients
    • Thallinger C, Urbauer E, Lackner E, Graselli U, Kostner K, Wolzt M, et al. The ability of statins to protect low density lipoprotein from oxidation in hypercholesterolemic patients. Int J Clin Pharmacol Ther 2005;43:551-557.
    • (2005) Int J Clin Pharmacol Ther , vol.43 , pp. 551-557
    • Thallinger, C.1    Urbauer, E.2    Lackner, E.3    Graselli, U.4    Kostner, K.5    Wolzt, M.6
  • 24
    • 33644651160 scopus 로고    scopus 로고
    • Liver X receptors as integrators of metabolic and inflammatory signaling
    • Zelcer N, Tontonoz P. Liver X receptors as integrators of metabolic and inflammatory signaling. J Clin Invest 2006;116:607-614.
    • (2006) J Clin Invest , vol.116 , pp. 607-614
    • Zelcer, N.1    Tontonoz, P.2
  • 26
    • 0036251153 scopus 로고    scopus 로고
    • SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver
    • Horton JD, Goldstein JL, Brown MS. SREBPs: Activators of the complete program of cholesterol and fatty acid synthesis in the liver. J Clin Invest 2002;109:1125-1131.
    • (2002) J Clin Invest , vol.109 , pp. 1125-1131
    • Horton, J.D.1    Goldstein, J.L.2    Brown, M.S.3
  • 27
    • 33747047274 scopus 로고    scopus 로고
    • Statins and hepatic steatosis: Perspectives from the Dallas Heart Study
    • Browning JD. Statins and hepatic steatosis: Perspectives from the Dallas Heart Study. HEPATOLOGY 2006;44:466-471.
    • (2006) HEPATOLOGY , vol.44 , pp. 466-471
    • Browning, J.D.1
  • 28
    • 0035578175 scopus 로고    scopus 로고
    • Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells
    • Scharnagl H, Schinker R, Gierens H, Nauck M, Wieland H, März W. Effect of atorvastatin, simvastatin, and lovastatin on the metabolism of cholesterol and triacylglycerides in HepG2 cells. Biochem Pharmacol 2001;62:1545-1555.
    • (2001) Biochem Pharmacol , vol.62 , pp. 1545-1555
    • Scharnagl, H.1    Schinker, R.2    Gierens, H.3    Nauck, M.4    Wieland, H.5    März, W.6
  • 29
    • 34547103033 scopus 로고    scopus 로고
    • Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression
    • Tamehiro N, Shigemoto-Mogami Y, Kakeya T, Okuhira K, Suzuki K, Sato R, et al. Sterol regulatory element-binding protein-2- and liver X receptor-driven dual promoter regulation of hepatic ABC transporter A1 gene expression. J Biol Chem 2007;282:21090-21099.
    • (2007) J Biol Chem , vol.282 , pp. 21090-21099
    • Tamehiro, N.1    Shigemoto-Mogami, Y.2    Kakeya, T.3    Okuhira, K.4    Suzuki, K.5    Sato, R.6
  • 31
  • 32
    • 0028231688 scopus 로고
    • Short-term effects of simvastatin on bile acid synthesis and bile lipid secretion in human subjects
    • Loria P, Bertolotti M, Cassinadri MT, Dilengite MA, Bozzoli M, Carubbi F, et al. Short-term effects of simvastatin on bile acid synthesis and bile lipid secretion in human subjects. HEPATOLOGY 1994;19:882-888.
    • (1994) HEPATOLOGY , vol.19 , pp. 882-888
    • Loria, P.1    Bertolotti, M.2    Cassinadri, M.T.3    Dilengite, M.A.4    Bozzoli, M.5    Carubbi, F.6
  • 33
    • 0025747508 scopus 로고
    • Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7 alpha-hydroxylation rates in vivo
    • Bertolotti M, Abate N, Loria P, Dilengite M, Carubbi F, Pinetti A, et al. Regulation of bile acid synthesis in humans: Effect of treatment with bile acids, cholestyramine or simvastatin on cholesterol 7 alpha-hydroxylation rates in vivo. HEPATOLOGY 1991;14:830-837.
    • (1991) HEPATOLOGY , vol.14 , pp. 830-837
    • Bertolotti, M.1    Abate, N.2    Loria, P.3    Dilengite, M.4    Carubbi, F.5    Pinetti, A.6
  • 34
    • 0036998045 scopus 로고    scopus 로고
    • Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism
    • Hillebrant CG, Nyberg B, Gustafsson U, Sahlin S, Björkhem I, Rudling M, et al. Effects of combined treatment with pravastatin and ursodeoxycholic acid on hepatic cholesterol metabolism. Ent J Clin Invest 2002;32: 528-534.
    • (2002) Ent J Clin Invest , vol.32 , pp. 528-534
    • Hillebrant, C.G.1    Nyberg, B.2    Gustafsson, U.3    Sahlin, S.4    Björkhem, I.5    Rudling, M.6
  • 35
    • 26244441014 scopus 로고    scopus 로고
    • The farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism
    • Claudel T, Staels B, Kuipers F. The farnesoid X receptor: A molecular link between bile acid and lipid and glucose metabolism. Arterioscl Thromb Vasc Biol 2005;25:2020-2030.
    • (2005) Arterioscl Thromb Vasc Biol , vol.25 , pp. 2020-2030
    • Claudel, T.1    Staels, B.2    Kuipers, F.3
  • 36
    • 33645738747 scopus 로고    scopus 로고
    • Endocrine functions of bile acids
    • Houten SM, Watanabe M, Auwerx J. Endocrine functions of bile acids. EMBO J 2006;25:1419-1425.
    • (2006) EMBO J , vol.25 , pp. 1419-1425
    • Houten, S.M.1    Watanabe, M.2    Auwerx, J.3
  • 37
    • 33847057732 scopus 로고    scopus 로고
    • Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin
    • Kobayashi M, Ikegami H, Fujisawa T, Nojima K, Kawabata Y, Noso S, et al. Prevention and treatment of obesity, insulin resistance, and diabetes by bile acid-binding resin. Diabetes 2007;56:239-247.
    • (2007) Diabetes , vol.56 , pp. 239-247
    • Kobayashi, M.1    Ikegami, H.2    Fujisawa, T.3    Nojima, K.4    Kawabata, Y.5    Noso, S.6
  • 38
    • 34447099725 scopus 로고    scopus 로고
    • The tissue biology of ductular reactions in human chronic liver disease
    • Theise ND, Kuwahara R. The tissue biology of ductular reactions in human chronic liver disease. Gastroenterology 2007;133:350-352.
    • (2007) Gastroenterology , vol.133 , pp. 350-352
    • Theise, N.D.1    Kuwahara, R.2
  • 39
    • 7944220210 scopus 로고    scopus 로고
    • Inhibition of hedgehog signaling protects adult mice from diet-induced weight gain
    • Bubman KK, Wang LC, Tang Y, Swietlicki EA, Kennedy S, Xie Y, et al. Inhibition of hedgehog signaling protects adult mice from diet-induced weight gain. J Nutr 2004;134:2979-2984.
    • (2004) J Nutr , vol.134 , pp. 2979-2984
    • Bubman, K.K.1    Wang, L.C.2    Tang, Y.3    Swietlicki, E.A.4    Kennedy, S.5    Xie, Y.6
  • 40
    • 36549011761 scopus 로고    scopus 로고
    • Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells
    • Yang L, Wang Y, Mao H, Fleig S, Omenetti A, Brown KD, et al. Sonic hedgehog is an autocrine viability factor for myofibroblastic hepatic stellate cells. J Hepatol 2008;48:98-106.
    • (2008) J Hepatol , vol.48 , pp. 98-106
    • Yang, L.1    Wang, Y.2    Mao, H.3    Fleig, S.4    Omenetti, A.5    Brown, K.D.6
  • 42
    • 0031445055 scopus 로고    scopus 로고
    • The bright liver syndrome. Prevalence and determinants of a "bright" liver echopattern
    • Lonardo A, Bellini M, Tartoni P, Tondelli E. The bright liver syndrome. Prevalence and determinants of a "bright" liver echopattern. Ital J Gastroenterol Hepatol 1997;29:351-356.
    • (1997) Ital J Gastroenterol Hepatol , vol.29 , pp. 351-356
    • Lonardo, A.1    Bellini, M.2    Tartoni, P.3    Tondelli, E.4
  • 43
    • 10644220306 scopus 로고    scopus 로고
    • Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity
    • Browning JD, Szczepaniak LS, Dobbins R, Nuremberg P, Horton JD, Cohen JC, et al. Prevalence of hepatic steatosis in an urban population in the United States: Impact of ethnicity. HEPATOLOGY 2004;40:1387-1395.
    • (2004) HEPATOLOGY , vol.40 , pp. 1387-1395
    • Browning, J.D.1    Szczepaniak, L.S.2    Dobbins, R.3    Nuremberg, P.4    Horton, J.D.5    Cohen, J.C.6
  • 44
    • 23044512117 scopus 로고    scopus 로고
    • Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease
    • Villanova N, Moscatiello S, Ramilli S, Bugianesi E, Magalotti D, Vanni E, et al. Endothelial dysfunction and cardiovascular risk profile in nonalcoholic fatty liver disease. HEPATOLOGY 2005;42:473-480.
    • (2005) HEPATOLOGY , vol.42 , pp. 473-480
    • Villanova, N.1    Moscatiello, S.2    Ramilli, S.3    Bugianesi, E.4    Magalotti, D.5    Vanni, E.6
  • 49
    • 0033542873 scopus 로고    scopus 로고
    • Medical significance of peroxisome proliferator-activated receptors
    • Vamecq J, Latruffe N. Medical significance of peroxisome proliferator-activated receptors. Lancet 1999;354:141-148.
    • (1999) Lancet , vol.354 , pp. 141-148
    • Vamecq, J.1    Latruffe, N.2
  • 50
    • 34249723258 scopus 로고    scopus 로고
    • Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages
    • Yano M, Matsumura T, Senokuchi T, Ishii N, Murata Y, Taketa K, et al. Statins activate peroxisome proliferator-activated receptor gamma through extracellular signal-regulated kinase 1/2 and p38 mitogen-activated protein kinase-dependent cyclooxygenase-2 expression in macrophages. Circ Res 2007;100:1442-1451.
    • (2007) Circ Res , vol.100 , pp. 1442-1451
    • Yano, M.1    Matsumura, T.2    Senokuchi, T.3    Ishii, N.4    Murata, Y.5    Taketa, K.6
  • 52
    • 0036451225 scopus 로고    scopus 로고
    • The effect of atorvastatin on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia
    • Koter M, Broncel M, Chojnowska-Jezierska J, Klikczynska K, Franiak I. The effect of atorvastatin on erythrocyte membranes and serum lipids in patients with type-2 hypercholesterolemia. Ent J Clin Pharmacol 2002;58: 501-506.
    • (2002) Ent J Clin Pharmacol , vol.58 , pp. 501-506
    • Koter, M.1    Broncel, M.2    Chojnowska-Jezierska, J.3    Klikczynska, K.4    Franiak, I.5
  • 53
    • 0035936527 scopus 로고    scopus 로고
    • Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study
    • Freeman DJ, Norrie J, Sattar N, Neely RD, Cobbe SM, Ford I, et al. Pravastatin and the development of diabetes mellitus: Evidence for a protective treatment effect in the West of Scotland Coronary Prevention Study. Circulation 2001;103:357-362.
    • (2001) Circulation , vol.103 , pp. 357-362
    • Freeman, D.J.1    Norrie, J.2    Sattar, N.3    Neely, R.D.4    Cobbe, S.M.5    Ford, I.6
  • 54
    • 33344471035 scopus 로고    scopus 로고
    • Effect of pravastatin and atorvastatin on glucose metabolism in nondiabetic patients with hypercholesterolemia
    • Ishikawa M, Namiki A, Kubota T, Yajima S, Fukazawa M, Moroi M, et al. Effect of pravastatin and atorvastatin on glucose metabolism in nondiabetic patients with hypercholesterolemia. Intern Med 2006;45:51-55.
    • (2006) Intern Med , vol.45 , pp. 51-55
    • Ishikawa, M.1    Namiki, A.2    Kubota, T.3    Yajima, S.4    Fukazawa, M.5    Moroi, M.6
  • 56
    • 34547596738 scopus 로고    scopus 로고
    • High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steamhepatitis (NASH) and also of the severity of fibrosis in NASH
    • Yoneda M, Mawatari H, Fujita K, Iida H, Yonemitsu K, Kato S, et al. High-sensitivity C-reactive protein is an independent clinical feature of nonalcoholic steamhepatitis (NASH) and also of the severity of fibrosis in NASH. J Gastroemetol 2007;42:573-582.
    • (2007) J Gastroemetol , vol.42 , pp. 573-582
    • Yoneda, M.1    Mawatari, H.2    Fujita, K.3    Iida, H.4    Yonemitsu, K.5    Kato, S.6
  • 58
    • 34548500220 scopus 로고    scopus 로고
    • Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease
    • Sugiyama S, Fukushima H, Kugiyama K, Maruyoshi H, Kojima S, Funahashi T, et al. Pravastatin improved glucose metabolism associated with increasing plasma adiponectin in patients with impaired glucose tolerance and coronary artery disease. Atherosclerosis 2007;194:e43-e5l
    • (2007) Atherosclerosis , vol.194
    • Sugiyama, S.1    Fukushima, H.2    Kugiyama, K.3    Maruyoshi, H.4    Kojima, S.5    Funahashi, T.6
  • 59
    • 0030606837 scopus 로고    scopus 로고
    • The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes
    • Satoh T, Isobe H, Ayukawa K, Sakai H, Nawata H. The effects of pravastatin, an HMG-CoA reductase inhibitor, on cell viability and DNA production of rat hepatocytes. Life Sci 1996;59:1103-1108.
    • (1996) Life Sci , vol.59 , pp. 1103-1108
    • Satoh, T.1    Isobe, H.2    Ayukawa, K.3    Sakai, H.4    Nawata, H.5
  • 61
    • 14644424522 scopus 로고    scopus 로고
    • HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage
    • Pääjärvi G, Roudier E, Crisby M, Högberg J, Stenius U. HMG-CoA reductase inhibitors, statins, induce phosphorylation of Mdm2 and attenuate the p53 response to DNA damage. FASEB, J 2005;19:476-478.
    • (2005) FASEB, J , vol.19 , pp. 476-478
    • Pääjärvi, G.1    Roudier, E.2    Crisby, M.3    Högberg, J.4    Stenius, U.5
  • 62
    • 33751516329 scopus 로고    scopus 로고
    • The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, famesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor
    • Moore DD, Kato S, Xie W, Mangelsdorf DJ, Schmidt DR, Xiao R, et al. The NR1H and NR1I receptors: Constitutive androstane receptor, pregnene X receptor, farnesoid X receptor alpha, famesoid X receptor beta, liver X receptor alpha, liver X receptor beta, and vitamin D receptor. Pharmacol Rev 2006;58:742-759.
    • (2006) Pharmacol Rev , vol.58 , pp. 742-759
    • Moore, D.D.1    Kato, S.2    Xie, W.3    Mangelsdorf, D.J.4    Schmidt, D.R.5    Xiao, R.6
  • 63
    • 22344439421 scopus 로고    scopus 로고
    • Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor
    • Kobayashi K, Yamanaka Y, Iwazaki N, Nakajo I, Hosokawa M, Negishi M, et al. Identification of HMG-CoA reductase inhibitors as activators for human, mouse and rat constitutive androstane receptor. Drug Metab Dispos 2005;33:924-929.
    • (2005) Drug Metab Dispos , vol.33 , pp. 924-929
    • Kobayashi, K.1    Yamanaka, Y.2    Iwazaki, N.3    Nakajo, I.4    Hosokawa, M.5    Negishi, M.6
  • 64
    • 0038555527 scopus 로고    scopus 로고
    • Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells
    • Rombouts K, Kisanga E, Hellemans K, Wielant A, Schuppan D, Geerts A. Effect of HMG-CoA reductase inhibitors on proliferation and protein synthesis by rat hepatic stellate cells. J Hepatol 2003;38:564-572.
    • (2003) J Hepatol , vol.38 , pp. 564-572
    • Rombouts, K.1    Kisanga, E.2    Hellemans, K.3    Wielant, A.4    Schuppan, D.5    Geerts, A.6
  • 65
    • 3943108870 scopus 로고    scopus 로고
    • Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets
    • Zhao A, Yu J, Lew JL, Huang L, Wright SD, Cui J. Polyunsaturated fatty acids are FXR ligands and differentially regulate expression of FXR targets. DNA Cell Biol 2004;23:519-526.
    • (2004) DNA Cell Biol , vol.23 , pp. 519-526
    • Zhao, A.1    Yu, J.2    Lew, J.L.3    Huang, L.4    Wright, S.D.5    Cui, J.6
  • 67
    • 0347917155 scopus 로고    scopus 로고
    • Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis
    • Kiyici M, Golten M, Gurel S, Nak SG, Dolar E, Savci G, et al. Ursodeoxycholic acid and atorvastatin in the treatment of nonalcoholic steatohepatitis. Can J Gastroenterol 2003;17:713-718.
    • (2003) Can J Gastroenterol , vol.17 , pp. 713-718
    • Kiyici, M.1    Golten, M.2    Gurel, S.3    Nak, S.G.4    Dolar, E.5    Savci, G.6
  • 68
    • 2342456307 scopus 로고    scopus 로고
    • Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study
    • Rallidis L, Drakoulis C, Parasi A. Pravastatin in patients with nonalcoholic steatohepatitis: Results of a pilot study. Atherosclerosis 2004;174:193-196.
    • (2004) Atherosclerosis , vol.174 , pp. 193-196
    • Rallidis, L.1    Drakoulis, C.2    Parasi, A.3
  • 71
    • 28344436469 scopus 로고    scopus 로고
    • Rosuvastatin as a novel treatment of nonalcoholic fatty liver disease in hyperlipidemic patients
    • Antonopoulos S, Mikros S, Mylonopoulou M, Kokkoris S, Giannoulis G. Rosuvastatin as a novel treatment of nonalcoholic fatty liver disease in hyperlipidemic patients. Atherosclerosis 2006;184:233-234.
    • (2006) Atherosclerosis , vol.184 , pp. 233-234
    • Antonopoulos, S.1    Mikros, S.2    Mylonopoulou, M.3    Kokkoris, S.4    Giannoulis, G.5
  • 72
    • 34249342305 scopus 로고    scopus 로고
    • Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study
    • Ekstedt M, Franzén LE, Mathiesen UL, Holmqvist M, Bodemar G, Kechagias S. Statins in non-alcoholic fatty liver disease and chronically elevated liver enzymes: A histopathological follow-up study. J Hepatol 2007;47:135-141.
    • (2007) J Hepatol , vol.47 , pp. 135-141
    • Ekstedt, M.1    Franzén, L.E.2    Mathiesen, U.L.3    Holmqvist, M.4    Bodemar, G.5    Kechagias, S.6
  • 73
    • 43749092373 scopus 로고    scopus 로고
    • Lonardo A, Loria P, Carulli N. Dysmetabolic changes associated with HCV: a distinct syndrome? Intern Emerg Med 2008;3:99-108.
    • Lonardo A, Loria P, Carulli N. Dysmetabolic changes associated with HCV: a distinct syndrome? Intern Emerg Med 2008;3:99-108.
  • 76
    • 33747050665 scopus 로고    scopus 로고
    • Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment
    • Gopal K, Johnson TC, Gopal S, Walfish A, Bang CT, Suwandhi P, et al. Correlation between beta-lipoprotein levels and outcome of hepatitis C treatment. HEPATOLOGY 2006;44:335-340.
    • (2006) HEPATOLOGY , vol.44 , pp. 335-340
    • Gopal, K.1    Johnson, T.C.2    Gopal, S.3    Walfish, A.4    Bang, C.T.5    Suwandhi, P.6
  • 77
    • 2942715265 scopus 로고    scopus 로고
    • Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts
    • Aizaki H, Lee KJ, Sung VM, Ishiko H, Lai MM. Characterization of the hepatitis C virus RNA replication complex associated with lipid rafts. Virology 2004;324:450-461.
    • (2004) Virology , vol.324 , pp. 450-461
    • Aizaki, H.1    Lee, K.J.2    Sung, V.M.3    Ishiko, H.4    Lai, M.M.5
  • 78
    • 14044265120 scopus 로고    scopus 로고
    • Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids
    • Kapadia SB, Chisari FV. Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci USA 2005; 102:2561-2566.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 2561-2566
    • Kapadia, S.B.1    Chisari, F.V.2
  • 79
    • 33745903898 scopus 로고    scopus 로고
    • Different anti-HCV profiles of statins and their potential for combination therapy with interferon
    • Ikeda M, Abe K, Yamada M, Dansako H, Naka K, Kato N. Different anti-HCV profiles of statins and their potential for combination therapy with interferon. HEPATOLOGY 2006;44:117-125.
    • (2006) HEPATOLOGY , vol.44 , pp. 117-125
    • Ikeda, M.1    Abe, K.2    Yamada, M.3    Dansako, H.4    Naka, K.5    Kato, N.6
  • 80
    • 0019418333 scopus 로고
    • Lowering plasma cholesterol by raising LDL receptors
    • Brown MS, Goldstein JL. Lowering plasma cholesterol by raising LDL receptors. N EngI J Med 1981;305:515-517.
    • (1981) N EngI J Med , vol.305 , pp. 515-517
    • Brown, M.S.1    Goldstein, J.L.2
  • 81
    • 0345251979 scopus 로고    scopus 로고
    • Low density lipoprotein receptor as a candidate receptor for hepatitis C virus
    • Monazahian M, Böhme I, Bonk S, Koch A, Scholz C, Grethe S, et al. Low density lipoprotein receptor as a candidate receptor for hepatitis C virus. J Med Virol 1999;57:223-229.
    • (1999) J Med Virol , vol.57 , pp. 223-229
    • Monazahian, M.1    Böhme, I.2    Bonk, S.3    Koch, A.4    Scholz, C.5    Grethe, S.6
  • 82
    • 0842300373 scopus 로고    scopus 로고
    • Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease
    • Lonardo A, Adinolfi LE, Loria P, Carulli N, Ruggiero G, Day CP. Steatosis and hepatitis C virus: Mechanisms and significance for hepatic and extrahepatic disease. Gastroenterology 2004;126:586-597.
    • (2004) Gastroenterology , vol.126 , pp. 586-597
    • Lonardo, A.1    Adinolfi, L.E.2    Loria, P.3    Carulli, N.4    Ruggiero, G.5    Day, C.P.6
  • 83
    • 34247378117 scopus 로고    scopus 로고
    • Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: A pilot clinical trial
    • O'Leary JG, Chan JL, McMahon CM, Chung RT. Atorvastatin does not exhibit antiviral activity against HCV at conventional doses: A pilot clinical trial. HEPATOLOGY 2007;45:895-898.
    • (2007) HEPATOLOGY , vol.45 , pp. 895-898
    • O'Leary, J.G.1    Chan, J.L.2    McMahon, C.M.3    Chung, R.T.4
  • 84
    • 0035063560 scopus 로고    scopus 로고
    • Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration
    • Del Puppo M, Galli Kienle M, Crosignani A, Petroni ML, Amati B, Zuin M, et al. Cholesterol metabolism in primary biliary cirrhosis during simvastatin and UDCA administration. J Lipid Res 2001;42:437-441.
    • (2001) J Lipid Res , vol.42 , pp. 437-441
    • Del Puppo, M.1    Galli Kienle, M.2    Crosignani, A.3    Petroni, M.L.4    Amati, B.5    Zuin, M.6
  • 85
    • 0036102527 scopus 로고    scopus 로고
    • Simvastatin in primary biliary cirrhosis: Effects on serum lipids and distinct disease markers
    • Ritzel U, Leonhardc U, Näther M, Schäfer G, Armstrong VW, Ramadori G. Simvastatin in primary biliary cirrhosis: Effects on serum lipids and distinct disease markers. J Hepatol 2002;36:454-458.
    • (2002) J Hepatol , vol.36 , pp. 454-458
    • Ritzel, U.1    Leonhardc, U.2    Näther, M.3    Schäfer, G.4    Armstrong, V.W.5    Ramadori, G.6
  • 86
    • 34548758431 scopus 로고    scopus 로고
    • Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid
    • Stojakovic T, Putz-Bankuti C, Fauler G, Scharnagl H, Wagner M, Stadlbauer V, et al. Atorvastatin in patients with primary biliary cirrhosis and incomplete biochemical response to ursodeoxycholic acid. HEPATOLOGY 2007;46:776-784.
    • (2007) HEPATOLOGY , vol.46 , pp. 776-784
    • Stojakovic, T.1    Putz-Bankuti, C.2    Fauler, G.3    Scharnagl, H.4    Wagner, M.5    Stadlbauer, V.6
  • 89
    • 28544438656 scopus 로고    scopus 로고
    • Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis
    • Katsumoto M, Shingu T, Kuwashima R, Nakata A, Nomura S, Chayama K. Biphasic effect of HMG-CoA reductase inhibitor, pitavastatin, on vascular endothelial cells and angiogenesis. Circ J 2005;69:1547-1555.
    • (2005) Circ J , vol.69 , pp. 1547-1555
    • Katsumoto, M.1    Shingu, T.2    Kuwashima, R.3    Nakata, A.4    Nomura, S.5    Chayama, K.6
  • 90
    • 2942571658 scopus 로고    scopus 로고
    • Class-specific pro-apoptotic effect of statins on human vascular endothelial cells
    • Muck AO, Seeger H, Wallwiener D. Class-specific pro-apoptotic effect of statins on human vascular endothelial cells. Z Kardiol 2004;93:398-402.
    • (2004) Z Kardiol , vol.93 , pp. 398-402
    • Muck, A.O.1    Seeger, H.2    Wallwiener, D.3
  • 92
    • 0037178736 scopus 로고    scopus 로고
    • 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA
    • Park HJ, Kong D, Iruela-Arispe L, Begley U, Tang D, Galper JB. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitors interfere with angiogenesis by inhibiting the geranylgeranylation of RhoA. Circ Res 2002; 91:143-150.
    • (2002) Circ Res , vol.91 , pp. 143-150
    • Park, H.J.1    Kong, D.2    Iruela-Arispe, L.3    Begley, U.4    Tang, D.5    Galper, J.B.6
  • 93
    • 0035834823 scopus 로고    scopus 로고
    • Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins
    • Brouer A, Sonveaux P, Dessy C, Moniotte S, Balligand JL, Peron O. Hsp90 and caveolin are key targets for the proangiogenic nitric oxide-mediated effects of statins. Circ Res 2001;89:866-873.
    • (2001) Circ Res , vol.89 , pp. 866-873
    • Brouer, A.1    Sonveaux, P.2    Dessy, C.3    Moniotte, S.4    Balligand, J.L.5    Peron, O.6
  • 94
    • 0033826581 scopus 로고    scopus 로고
    • The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals
    • Kureishi Y, Luo Z, Shiojima I, Bialik A, Fulton D, Lefer DJ, et al. The HMG-CoA reductase inhibitor simvastatin activates the protein kinase Akt and promotes angiogenesis in normocholesterolemic animals. Nat Med 2000;6:1004-1010.
    • (2000) Nat Med , vol.6 , pp. 1004-1010
    • Kureishi, Y.1    Luo, Z.2    Shiojima, I.3    Bialik, A.4    Fulton, D.5    Lefer, D.J.6


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.