Taurine protects acetaminophen-induced oxidative damage in mice kidney through APAP urinary excretion and CYP2E1 inactivation

Toxicology

Volumn 269, Issue 1, 2010, Pages 24-34

  Das, Joydeep ^a   Ghosh, Jyotirmoy ^a   Manna, Prasenjit ^a   Sil, P C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Acetaminophen; Antioxidant; Necrosis; Reactive oxygen species; Renal oxidative stress; Taurine

Indexed keywords

3,4 METHYLENEDIOXYAMPHETAMINE; ADENOSINE TRIPHOSPHATASE (POTASSIUM SODIUM); CASPASE 3; CASPASE 9; CREATININE; CYTOCHROME P450; CYTOCHROME P450 2E1; GAMMA GLUTAMYLTRANSFERASE; GLUCOSE; GLUTATHIONE; GLUTATHIONE DISULFIDE; NITRIC OXIDE; NITROGEN; PARACETAMOL; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; TAURINE; TUMOR NECROSIS FACTOR ALPHA; UREA; URIC ACID; PROTECTIVE AGENT;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DOSE TIME EFFECT RELATION; ENZYME ACTIVITY; ENZYME INACTIVATION; ENZYME INHIBITION; GLUCOSE URINE LEVEL; KIDNEY PARENCHYMA; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MOUSE; NEPHROTOXICITY; NONHUMAN; OPTIMAL DRUG DOSE; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN CARBONYLATION; PROTEIN URINE LEVEL; RENAL PROTECTION; SIGNAL TRANSDUCTION; SWISS WEBSTER MOUSE; TREATMENT DURATION; UPREGULATION; UREA NITROGEN BLOOD LEVEL; URIC ACID BLOOD LEVEL; URINARY EXCRETION; ANIMAL; CELL MEMBRANE POTENTIAL; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ENZYME ACTIVATION; KIDNEY; METABOLISM; PATHOLOGY; PHYSIOLOGY; URINE;

MUS;

ACETAMINOPHEN; ANIMALS; CYTOCHROME P-450 CYP2E1; DOSE-RESPONSE RELATIONSHIP, DRUG; ENZYME ACTIVATION; KIDNEY; MALE; MEMBRANE POTENTIALS; MICE; PROTECTIVE AGENTS; TAURINE;

EID: 77949503909     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2010.01.003     Document Type: Article

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