The protective role of arjunolic acid against doxorubicin induced intracellular ROS dependent JNK-p38 and p53-mediated cardiac apoptosis

Biomaterials

Volumn 32, Issue 21, 2011, Pages 4857-4866

  Ghosh, Jyotirmoy ^a   Das, Joydeep ^a   Manna, Prasenjit ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Apoptosis; Arjunolic acid; Cardiac oxidative stress; Cardioprotection; Doxorubicin; P53

Indexed keywords

APOPTOSIS; ARJUNOLIC ACID; CARDIAC OXIDATIVE STRESS; CARDIOPROTECTION; DOXORUBICIN; P53;

CELL DEATH; CELL MEMBRANES; TISSUE;

HEART;

ARJUNOLIC ACID; BETA ACTIN; CASPASE; CASPASE 3; CATALASE; CYTOCHROME C; DICHLOROFLUORESCEIN; DOXORUBICIN; HYDROGEN PEROXIDE; MITOGEN ACTIVATED PROTEIN KINASE; MITOGEN ACTIVATED PROTEIN KINASE P38; NATURAL PRODUCT; NICOTINAMIDE ADENINE DINUCLEOTIDE ADENOSINE DIPHOSPHATE RIBOSYLTRANSFERASE; PROHIBITIN; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; REACTIVE OXYGEN METABOLITE; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; APOPTOSIS; ARTICLE; CARDIOTOXICITY; CELL VIABILITY; CONTROLLED STUDY; DRUG MECHANISM; ENZYME ACTIVATION; HEART MUSCLE CELL; HEART PROTECTION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; NONHUMAN; PRIORITY JOURNAL; PROTEIN FAMILY; PROTEIN LOCALIZATION; RAT; SIGNAL TRANSDUCTION;

ANIMALS; ANTIBIOTICS, ANTINEOPLASTIC; BCL-2-ASSOCIATED X PROTEIN; CELL DEATH; DOXORUBICIN; ENZYME ACTIVATION; JNK MITOGEN-ACTIVATED PROTEIN KINASES; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MOLECULAR STRUCTURE; MYOCYTES, CARDIAC; P38 MITOGEN-ACTIVATED PROTEIN KINASES; RATS; RATS, WISTAR; REACTIVE OXYGEN SPECIES; SIGNAL TRANSDUCTION; TRITERPENES; TUMOR SUPPRESSOR PROTEIN P53;

RATTUS;

EID: 79955753803     PISSN: 01429612     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.biomaterials.2011.03.048     Document Type: Article

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