Arjunolic acid, a triterpenoid saponin, prevents acetaminophen (APAP)-induced liver and hepatocyte injury via the inhibition of APAP bioactivation and JNK-mediated mitochondrial protection

Free Radical Biology and Medicine

Volumn 48, Issue 4, 2010, Pages 535-553

  Ghosh, Jyotirmoy ^a   Das, Joydeep ^a   Manna, Prasenjit ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Acetaminophen; Cytoprotection; Free radicals; Hepatotoxicity; JNK; Mitochondrial permeability transition

Indexed keywords

ADENOSINE TRIPHOSPHATE; ARJUNOLIC ACID; CYTOCHROME C; CYTOCHROME P450; GLUTATHIONE; N ACETYL 1,4 BENZOQUINONE IMINE; PARACETAMOL; PROTEIN BCL 2; PROTEIN BCL XL; REACTIVE OXYGEN METABOLITE; SAPONIN; STRESS ACTIVATED PROTEIN KINASE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CELL DEATH; CONTROLLED STUDY; DRUG MECHANISM; ENZYME INHIBITION; ENZYME RELEASE; LIVER CELL DAMAGE; LIVER INJURY; LIVER LEVEL; LIVER PARENCHYMA; LIVER PROTECTION; LIVER TOXICITY; MALE; METABOLIC INHIBITION; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL PERMEABILITY; MITOCHONDRIAL RESPIRATION; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEIN DEPLETION; PROTEIN PHOSPHORYLATION; RAT;

ACETAMINOPHEN; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; CYTOCHROME P-450 ENZYME SYSTEM; GLUTATHIONE; HEPATOCYTES; HYDROXYL RADICAL; LIVER; MALE; MAP KINASE KINASE 4; MITOCHONDRIA; OXIDATIVE STRESS; RATS; REACTIVE OXYGEN SPECIES; SAPONINS; SUPEROXIDES; TRITERPENES;

RATTUS;

EID: 74249119041     PISSN: 08915849     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.freeradbiomed.2009.11.023     Document Type: Article

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