Protective role of arjunolic acid in response to streptozotocin-induced type-I diabetes via the mitochondrial dependent and independent pathways

Toxicology

Volumn 257, Issue 1-2, 2009, Pages 53-63

  Manna, Prasenjit ^a   Sinha, Mahua ^a   Sil, Parames C ^a  

^a BOSE INSTITUTE   (India)

Author keywords

Arjunolic acid; Mitochondrial damage and pancreatic cell death; Oxidative and nitrosative stress; Protective action; Signal transduction mechanism; Streptozotocin

Indexed keywords

ARJUNOLIC ACID; CASPASE 3; CYTOCHROME C; GLUCOSE; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN; MITOGEN ACTIVATED PROTEIN KINASE 1; MITOGEN ACTIVATED PROTEIN KINASE 3; MITOGEN ACTIVATED PROTEIN KINASE P38; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN METABOLITE; SAPONIN DERIVATIVE; STREPTOZOCIN; TUMOR NECROSIS FACTOR ALPHA; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; APOPTOSIS; ARTICLE; BODY WEIGHT; CELL DEATH; CELL PROTECTION; CONTROLLED STUDY; DOWN REGULATION; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME RELEASE; EXPERIMENTAL ANIMAL; GLUCOSE BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; LIPID PEROXIDATION; MALE; MITOCHONDRIAL MEMBRANE POTENTIAL; MITOCHONDRIAL RESPIRATION; MITOCHONDRION; NITROSATIVE STRESS; NONHUMAN; OXIDATIVE STRESS; PANCREAS; PANCREAS ISLET BETA CELL; PRIORITY JOURNAL; PROTEIN CARBONYLATION; RAT; SIGNAL TRANSDUCTION; STREPTOZOCIN DIABETES;

ANIMALS; ANTIOXIDANTS; APOPTOSIS; BLOOD GLUCOSE; CASPASE 3; CYTOCHROMES C; DIABETES MELLITUS, EXPERIMENTAL; DIABETES MELLITUS, TYPE 1; DOSE-RESPONSE RELATIONSHIP, DRUG; HYPOGLYCEMIC AGENTS; LIPID PEROXIDATION; MALE; MEMBRANE POTENTIAL, MITOCHONDRIAL; MITOCHONDRIA; MITOGEN-ACTIVATED PROTEIN KINASE 1; MITOGEN-ACTIVATED PROTEIN KINASE 3; NF-KAPPA B; OXIDATIVE STRESS; P38 MITOGEN-ACTIVATED PROTEIN KINASES; PANCREAS; PHOSPHORYLATION; PROTEIN CARBONYLATION; RATS; REACTIVE NITROGEN SPECIES; REACTIVE OXYGEN SPECIES; TIME FACTORS; TRITERPENES; TUMOR NECROSIS FACTOR-ALPHA;

ANIMALIA; RATTUS;

EID: 58649116450     PISSN: 0300483X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tox.2008.12.008     Document Type: Article

References (62)

1. Adrain C., Creagh E.M., and Martin S.J. Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2. EMBO J. 20 (2001) 6627-6636
2. Ausubel F.M., Brent R., Kingston R.E., Moore D.D., Siedman J.G., Smith J.A., and Struhl K. In: Albright L.M., Coen D.M., and Varki A. (Eds). Current Protocols in Molecular Biology (2003), Guest John Wiley and Sons, Inc.
3. Baynes J.W. Role of oxidative stress in development of complications in diabetes. Diabetes 40 (1991) 405-412
4. Bennett R.A., and Pegg A.E. Alkylation of DNA in rat tissues following administration of streptozotocin. Cancer Res. 41 (1981) 2786-2790
5. Benzie I.F.F., and Strain J.J. Ferric reducing/antioxidant power assay: direct measure of total antioxidant activity of biological fluids and modified version for simultaneous measurement of total antioxidant power and ascorbic acid concentration. Methods Enzymol. 299 (1999) 15-27
6. Blois M.S. Antioxidant determination by use of a stable free radical. Nature 29 (1958) 1199-1200
7. Bonaventura J., Schroeder W.A., and Fang S. Human erythrocyte catalase: an improved method of isolation and a revaluation of reported properties. Arch. Biochem. Biophys. 150 (1972) 606-617
8. Bradford M.M. A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72 (1976) 248-254
9. Devi R.S., Narayan S., Vani G., and Shyamala Devi C.S. Gastroprotective effect of Terminalia arjuna bark on diclofenac sodium induced gastric ulcer. Chem. Biol. Interact. 167 (2007) 71-83
10. Ellman G.L. Tissue sulfhydryl group. Arch. Biochem. Biophys. 82 (1959) 70-77
11. Elsner M., Guldbakke B., Tiedge M., Mundy R., and Lenzen S. Relative importance of transport and alkylation for pancreatic beta-cell toxicity of streptozotocin. Diabetologia 43 (2000) 1528-1533
12. Esterbauer H., and Cheeseman K.H. Determination of aldehydic lipid peroxidation products: Malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 186 (1990) 407-421
13. Evans J.L., Goldfine I.D., Maddux B.A., and Grodsky G.M. Oxidative stress and stress-activated signaling pathways: a unifying hypothesis of type 2 diabetes. Endocr. Rev. 23 (2002) 599-622
14. Flohe L., and Gunzler W.A. Assay of glutathione peroxidase. Methods Enzymol. 105 (1984) 114-121
15. Gacche R.N., Gond D.S., Dhole N.A., and Dawane B.S. Coumarin Schiff bases: as antioxidant and possibly anti-inflamatory agents. J. Enzyme Inhib. Med. Chem. 21 (2007) 157-161
16. Ghosh J., Das J., Manna P., and Sil P.C. Cytoprotective effect of arjunolic acid in response to sodium fluoride mediated oxidative stress and cell death via necrotic pathway. Toxicol. In Vitro 22 (2008) 1918-1926
17. González E., Jawerbaum A., Sinner D., Pustovrh White V., Capobianco E., Xaus C., Peralta C., and Roselló-Catafau J. Streptozotocin pancreatic damage in the rat: modulatory effect of 15-deoxy delta12,14-prostaglandin j(2) on nitridergic and prostanoid pathway. Nitric Oxide 6 (2002) 214-220
18. Green L.C., Wagner D.A., Glogowski J., Skipper P.L., Wishnok J.S., and Tannenbaum S.R. Analysis of nitrate, nitrite, and [15N] nitrate in biological fluids. Anal. Biochem. 126 (1982) 131-138
19. Habig W.H., Pabst M.J., and Jakoby W.B. Glutathione S-transferases. The first enzymatic step in mercapturic acid formation. J. Biol. Chem. 249 (1974) 7130-7139
20. Haluzik M., and Nedvidkova J. The role of nitric oxide in the development of streptozotocin-induced diabetes mellitus: experimental and clinical implications. Physiol. Res. 49 (2000) S37-S42
21. Hissin P.J., and Hilf R.A. A fluorometric method for determination of oxidized and reduced glutathione in tissues. Anal. Biochem. 74 (1976) 214-226
22. Ho E., Chen G., and Bray T.M. Alpha-phenyl-tert-butylnitrone (PBN) inhibits NFκB activation offering protection against chemically induced diabetes. Free Radic. Biol. Med. 28 (2000) 604-614
23. Hodarnau A., Dancea S., and Barzu O. Isolation of highly purified mitochondria from rat pancreas. J. Cell Biol. 59 (1973) 222-227
24. Jiang Z.Y., Hunt J.V., and Wolff S.P. Detection of lipid hydroperoxide using the FOX method. Anal. Biochem. 202 (1992) 384-389
25. Jurgensmeier J.M., Xie Z., Deveraux Q., Ellerby L., Bredesen D., and Reed J.C. Bax directly induces release of cytochrome c from isolated mitochondria. Proc. Natl. Acad. Sci. U.S.A. 95 (1998) 4997-5002
26. Kakkar P., Das B., and Viswanathan P.N. A modified spectrophotometric assay of superoxide dismutase. Indian J. Biochem. Biophys. 21 (1984) 130-132
27. Kamiya K., Hamabe W., Harada S., Murakami R., Tokuyama S., and Satake T. Chemical constituents of Morinda citrifolia roots exhibit hypoglycemic effects in streptozotocin-induced diabetic mice. Biol. Pharm. Bull. 31 (2008) 935-938
28. Keeble J.A., and Gilmore A.P. Apoptosis commitment-translating survival signals into decisions on mitochondria. Cell Res. 17 (2007) 976-984
29. Kim J.D., McCarter R.J.M., and Yu B.P. Influence of age, exercise and dietary restriction on oxidative stress in rats. Aging Clin. Exp. Res. 8 (1996) 123-129
30. Kroncke K.D., Fehsel K., Sommer A., Rodriguez M.L., and Kolb-Bachofen V. Nitric oxide generation during cellular metabolization of the diabetogenic N-methyl-N-nitroso-urea streptozotocin contributes to islet cell DNA damage. Biol. Chem. Hoppe-Seyler 376 (1995) 179-185
31. LeBel C.P., and Bondy S.C. Sensitive and rapid quantitation of oxygen reactive species formation in rat synaptosomes. Neurochem. Int. 17 (1990) 435-440
32. Lee C.Y. Glucose-6-phosphate dehydrogenase from mouse. Methods Enzymol. 89 (1982) 252-257
33. Madesh M., and Balasubramanian K.A. A microlitre plate assay for superoxide using MTT reduction method. Ind. J. Biochem. Biophys. 34 (1997) 535-539
34. Manna P., Sinha M., Pal P., and Sil P.C. Arjunolic acid, a triterpenoid saponin, ameliorates arsenic-induced cyto-toxicity in hepatocytes. Chem. Biol. Interact. 170 (2007) 187-200
35. Manna P., Sinha M., and Sil P.C. Aqueous extract of Terminalia arjuna prevents carbon tetrachloride induced hepatic and renal disorders. BMC Complement. Altern. Med. 6 (2006) 33
36. Manna P., Sinha M., and Sil P.C. Arsenic-induced oxidative myocardial injury: protective role of arjunolic acid. Arch. Toxicol. 82 (2008) 137-149
37. Manna P., Sinha M., and Sil P.C. Phytomedicinal activity of Terminalia arjuna against carbon tetrachloride induced cardiac oxidative stress. Pathophysiology 14 (2007) 71-78
38. Manna P., Sinha M., and Sil P.C. Protection of arsenic-induced hepatic disorder by arjunolic acid. Basic Clin. Pharmacol. Toxicol. 101 (2007) 333-338
39. Manna P., Sinha M., and Sil P.C. Protection of arsenic-induced testicular oxidative stress by arjunolic acid. Redox Rep. 13 (2008) 67-77
40. Mingatto F.E., Rodrigues T., Pigoso A.A., Uyemura S.A., Curti C., and Santos A.C. The critical role of mitochondrial energetic impairment in the toxicity of nimesulide to hepatocytes. J. Pharmacol. Exp. Ther. 303 (2003) 601-607
41. Nash T. The colorimetric estimation of formaldehyde by means of the Hantzsch reaction. J. Biochem. 55 (1953) 416-421
42. Nishikimi M., Rao N.A., and Yagi K. The occurrence of superoxide anion in the reaction of reduced phenazine methosulfate and molecular oxygen. Biochem. Biophys. Res. Commun. 46 (1972) 849-854
43. Nogichi H. Stem cells for the treatment of diabetes. Endocr. J. 54 (2007) 7-16
44. Oberley L.W. Free radicals and diabetes. Free Radic. Biol. Med. 5 (1988) 113-124
45. Pavana P., Monoharan S., Renju G.L., and Sethupathy S. Antihyperglycemic and antihyperlipidemic effects of Tephrosia purpurea leaf extract in streptozotocin induced diabetic rats. J. Environ. Biol. 28 (2007) 833-837
46. Peschke E., Ebelt H., Bromme H.J., and Peschke D. 'Classical' and 'new' diabetogens-comparison of their effects on isolated rat pancreatic islets in vitro. Cell Mol. Life Sci. 57 (2000) 158-164
47. Raghavan B., and Kumari S.K. Effect of Terminalia arjuna stem bark on antioxidant status in liver and kidney of alloxan diabetic rats. Indian J. Physiol. Pharmacol. 50 (2006) 133-142
48. Sabu M.C., and Kuttan R. Anti-diabetic activity of medicinal plants and its relationship with their antioxidant property. J. Ethnopharmacol. 81 (2002) 155-160
49. Sabu M.C., Smitha K., and Kuttan R. Anti-diabetic activity of green tea polyphenols and their role in reducing oxidative stress in experimental diabetes. J. Ethnopharmacol. 83 (2002) 109-116
50. Sasaki K., Matsumoto I., and Beppu M. Affinity Chromatography (1991), Tokyo Kagaku Dojin, Tokyo pp. 117-130
51. Sedlak J., and Lindsay R.H. Estimation of total, protein-bound, and non protein sulfhydryl groups in tissue with Ellman's reagent. Anal. Biochem. 24/25 (1958) 192-205
52. Siddhuraju P., and Becker K. Antioxidant properties of various solvent extracts of total phenolic constituents from three different agroclimatic origins of drumstick tree (Moringa oleifera Lam.) leaves. J. Agric. Food Chem. 51 (2003) 2144-2155
53. Singh N., and Anand S. Cell death by apoptosis. Indian J. Exp. Biol. 32 (1994) 843-847
54. Sinha M., Manna P., and Sil P.C. Aqueous extract of the bark of Terminalia arjuna plays protective role against sodium fluoride induced hepatic and renal oxidative stress. J. Nat. Med. 61 (2007) 251-260
55. Sinha M., Manna P., and Sil P.C. Arjunolic acid attenuates arsenic-induced nephrotoxicity. Pathophysiology 15 (2008) 147-156
56. Sinha M., Manna P., and Sil P.C. Protective effect of arjunolic acid against arsenic-induced oxidative stress in mouse brain. J. Biochem. Mol. Toxicol. 22 (2008) 15-26
57. Smith I.K., Vierheller T.L., and Thorne C.A. Assay of glutathione reductase in crude tissue homogenates using 5,5′-dithiobis (2-nitrobenzoic acid). Anal. Biochem. 175 (1988) 408-413
58. Szkudelski T. The mechanism of alloxan and streptozotocin action in-cells of the rat pancreas. Physiol. Res. 50 (2001) 536-546
59. Turk J., Corbett J.A., Ramanandham S., Bohrer A., and McDaniel M.L. Biochemical evidence for nitric oxide formation from streptozotocin in isolated pancreatic islets. Biochem. Biophys. Res. Commun. 197 (1993) 1458-1464
60. Uchida K., and Stadtman E.R. Covalent attachment of 4-hydroxynonenal to glyceraldehydes-3-phosphate dehydrogenase. J. Biol. Chem. 268 (1993) 6388-6393
61. Wolff S.P., Jiang Z.Y., and Hunt J.V. Protein glycation and oxidative stress in diabetes mellitus and ageing. Free Radic. Biol. Med. 10 (1991) 339-352
62. Xia Z., Dickens M., Raingeaud J., Davis R.J., and Greenberg M.E. Opposing effects of ERK and JNK-p38 MAP kinases on apoptosis. Science 270 (1995) 1326-1331